{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:56:02Z","timestamp":1792788962076,"version":"4.5.0"},"reference-count":39,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Agency of Sciences and Technology ANPCyT","award":["PICT 2020-1963"],"award-info":[{"award-number":["PICT 2020-1963"]}]},{"award":["PICT 2020-1963"],"award-info":[{"award-number":["PICT 2020-1963"]}],"id":[{"id":"https:\/\/ror.org\/03stxzb56","id-type":"ROR","asserted-by":"publisher"}]},{"name":"University of Buenos Aires","award":["UBACyT 20020090200034"],"award-info":[{"award-number":["UBACyT 20020090200034"]}],"id":[{"id":"https:\/\/ror.org\/0081fs513","id-type":"ROR","asserted-by":"crossref"}]},{"award":["UBACyT 20020090200034"],"award-info":[{"award-number":["UBACyT 20020090200034"]}],"id":[{"id":"https:\/\/ror.org\/0081fs513","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas","award":["CONICET PIP 2022-2024 GI"],"award-info":[{"award-number":["CONICET PIP 2022-2024 GI"]}],"id":[{"id":"https:\/\/ror.org\/03cqe8w59","id-type":"ROR","asserted-by":"crossref"}]},{"award":["CONICET PIP 2022-2024 GI"],"award-info":[{"award-number":["CONICET PIP 2022-2024 GI"]}],"id":[{"id":"https:\/\/ror.org\/03cqe8w59","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Background: Decidualization alters the endometrial stromal cells (EnSC) secretome, allowing sterile inflammation associated with embryo implantation, but mechanisms that lead to alterations in this process are still unknown. We evaluated whether impaired IRE1\u03b1-mediated endoplasmic reticulum (ER) stress signalling contributes to defective angiogenic decidual programming in patients with recurrent implantation failure (RIF). Methods: Candidate pathways were identified with bioinformatic analyses of endometrial arrays and validated in endometrial biopsies from fertile and RIF women (secretory phase) by RT-qPCR and in isolated EnSC by flow cytometry. Functional alterations were evaluated using trophoblast spheroid and endothelial cell migration assays. ER stress was pharmacologically induced in EnSC using thapsigargin. Results: RIF endometria displayed impaired in vivo decidualization, with reduced expression of IGFBP1 and PGR, together with altered expression of molecules involved in blastocyst adhesion. Conditioned media from RIF-derived EnSC-impaired trophoblast outgrowth. RIF samples displayed an anti-angiogenic and altered inflammatory profile, characterized by reduced intracellular IL-1\u03b2 accumulation, decreased VEGFA, and increased sFlt1 expression. Bioinformatic analyses identified IRE1\u03b1 pathway as a central altered network associated with angiogenesis. Consistently, RIF samples showed reduced expression of IRE1\u03b1, sXBP1, and NLRP3. Moreover, ER stress induction in EnSC promoted endothelial cell migration. Conclusions: RIF is associated with defective angiogenic decidual programming linked to impaired IRE1\u03b1-mediated ER stress signalling. These findings identify the IRE1\u03b1 axis as a potential pathway of interest for future therapeutic exploration in recurrent implantation failure.<\/jats:p>","DOI":"10.3390\/biology15191693","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:20:46Z","timestamp":1790155246000},"page":"1693","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered IRE1\u03b1-Dependent Decidual Programming Links Impaired Inflammation and Angiogenesis in Recurrent Implantation Failure"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1705-768X","authenticated-orcid":false,"given":"Lara","family":"Castagnola","sequence":"first","affiliation":[{"name":"Laboratorio de Inmunofarmacolog\u00eda, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2179-4532","authenticated-orcid":false,"given":"Lourdes","family":"Materazzi","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunofarmacolog\u00eda, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Daniel","family":"Paparini","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunofarmacolog\u00eda, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Ana","family":"Schafir","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunofarmacolog\u00eda, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"}]},{"given":"Marcela","family":"Irigoyen","sequence":"additional","affiliation":[{"name":"Fertilis Medicina Reproductiva, Buenos Aires B1609JEC, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7629-977X","authenticated-orcid":false,"given":"Esteban","family":"Grasso","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunofarmacolog\u00eda, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"given":"Nancy","family":"Char\u00f3","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Experimental (IMEX), Buenos Aires C1425AUM, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0418-2772","authenticated-orcid":false,"given":"Daiana","family":"Vota","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunofarmacolog\u00eda, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"given":"Agustina","family":"Marcial","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunofarmacolog\u00eda, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Diego","family":"Gnocchi","sequence":"additional","affiliation":[{"name":"Fertilis Medicina Reproductiva, Buenos Aires B1609JEC, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"given":"Alejandro Gustavo","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Fertilis Medicina Reproductiva, Buenos Aires B1609JEC, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Antonio","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Fertilis Medicina Reproductiva, Buenos Aires B1609JEC, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"given":"Lautaro","family":"Tessari","sequence":"additional","affiliation":[{"name":"Fertilis Medicina Reproductiva, Buenos Aires B1609JEC, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"given":"Vanesa","family":"Hauk","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunofarmacolog\u00eda, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"given":"Soledad","family":"Gori","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunofarmacolog\u00eda, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4222-817X","authenticated-orcid":false,"given":"Rosanna","family":"Ramhorst","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunofarmacolog\u00eda, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/humrep\/10.suppl_2.14","article-title":"Decidua in Human Implantation","volume":"10","author":"Loke","year":"1995","journal-title":"Hum. Reprod."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sun, B., and Yeh, J. (2022). Non-Invasive and Mechanism-Based Molecular Assessment of Endometrial Receptivity During the Window of Implantation: Current Concepts and Future Prospective Testing Directions. Front. Reprod. Health, 4.","DOI":"10.3389\/frph.2022.863173"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"R203","DOI":"10.1530\/REP-19-0391","article-title":"Immunoregulation of the Decidualization Program: Focus on the Endoplasmic Reticulum Stress","volume":"159","author":"Soczewski","year":"2020","journal-title":"Reproduction"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Massimiani, M., Lacconi, V., La Civita, F., Ticconi, C., Rago, R., and Campagnolo, L. (2019). Molecular Signaling Regulating Endometrium\u2013Blastocyst Crosstalk. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010023"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s41584-019-0277-8","article-title":"The IL-1 Family of Cytokines and Receptors in Rheumatic Diseases","volume":"15","author":"Dinarello","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/19396368.2021.1985186","article-title":"Mucosal Biomarkers for Endometrial Receptivity: A Promising yet Underexplored Aspect of Reproductive Medicine","volume":"68","author":"Jain","year":"2022","journal-title":"Syst. Biol. Reprod. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Maldonado Rosas, I., Mottola, F., Palmieri, I., Ibello, L., Kalita, J.C., and Roychoudhury, S. (2026). Molecular Biomarkers of Endometrial Function and Receptivity in Natural and Stimulated Assisted Reproductive Technology (ART) Cycles. Reprod. Med., 7.","DOI":"10.3390\/reprodmed7010002"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Pantos, K., Grigoriadis, S., Maziotis, E., Pistola, K., Xystra, P., Pantou, A., Kokkali, G., Pappas, A., Lambropoulou, M., and Sfakianoudis, K. (2022). The Role of Interleukins in Recurrent Implantation Failure: A Comprehensive Review of the Literature. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042198"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.placenta.2024.04.010","article-title":"Interleukin-1 Beta Signals through the ERK Signalling Pathway to Modulate Human Placental Trophoblast Migration and Invasion in the First Trimester of Pregnancy","volume":"151","author":"Gan","year":"2024","journal-title":"Placenta"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41574-020-0372-6","article-title":"Tracking Placental Development in Health and Disease","volume":"16","author":"Aplin","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1038\/srep03894","article-title":"Uterine Selection of Human Embryos at Implantation","volume":"4","author":"Brosens","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"12274","DOI":"10.1038\/s41598-018-29779-8","article-title":"Impact of the Reticular Stress and Unfolded Protein Response on the Inflammatory Response in Endometrial Stromal Cells","volume":"8","author":"Grasso","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"115478","DOI":"10.5493\/wjem.v16.i1.115478","article-title":"Deciphering the Interplay between Hypoxia, Angiogenesis, and Endoplasmic Reticulum Stress in Carcinogenesis: A Narrative Review","volume":"16","author":"Bhardwaj","year":"2026","journal-title":"World J. Exp. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.7150\/ijms.120874","article-title":"Endoplasmic Reticulum Stress in Cancer Progression: A Comprehensive Review of Its Role and Mechanisms","volume":"22","author":"Yu","year":"2025","journal-title":"Int. J. Med. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.ajpath.2012.12.020","article-title":"Targeting the IRE1\u03b1\/XBP1 and ATF6 Arms of the Unfolded Protein Response Enhances VEGF Blockade to Prevent Retinal and Choroidal Neovascularization","volume":"182","author":"Liu","year":"2013","journal-title":"Am. J. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1161\/CIRCULATIONAHA.112.001337","article-title":"Vascular Endothelial Cell Growth\u2013Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis","volume":"127","author":"Zeng","year":"2013","journal-title":"Circulation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic Decidualization of the Human Endometrium in Reproductive Health and Failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocr. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"ESHRE Working Group on Recurrent Implantation Failure, Cimadomo, D., De Los Santos, M.J., Griesinger, G., Lainas, G., Le Clef, N., McLernon, D.J., Montjean, D., Toth, B., and Vermeulen, N. (2023). ESHRE Good Practice Recommendations on Recurrent Implantation Failure. Hum. Reprod. Open, 2023, hoad023.","DOI":"10.1093\/hropen\/hoad023"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1095\/biolreprod.114.122846","article-title":"The Human Endometrium as a Sensor of Embryo Quality1","volume":"91","author":"Macklon","year":"2014","journal-title":"Biol. Reprod."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Li, J., Qi, J., Yao, G., Zhu, Q., Li, X., Xu, R., Zhu, Z., Zhao, H., Wang, Y., and Ding, Y. (2021). Deficiency of Sirtuin 1 Impedes Endometrial Decidualization in Recurrent Implantation Failure Patients. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.598364"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e2028","DOI":"10.21769\/BioProtoc.2028","article-title":"Isolation and Primary Culture of Various Cell Types from Whole Human Endometrial Biopsies","volume":"6","author":"Barros","year":"2016","journal-title":"Bio-Protocol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mce.2017.07.006","article-title":"VIP Induces the Decidualization Program and Conditions the Immunoregulation of the Implantation Process","volume":"460","author":"Grasso","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/jimmun\/vkae065","article-title":"Exacerbated Endoplasmic Reticulum Stress Transmitted by Endometrial Stromal Cells Alters the Conditioning of Tolerogenic Dendritic Cells Affecting Trophoblast Migration","volume":"214","author":"Soczewski","year":"2025","journal-title":"J. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/jth.13223","article-title":"Extracellular Histones Reduce Survival and Angiogenic Responses of Late Outgrowth Progenitor and Mature Endothelial Cells","volume":"14","author":"Mena","year":"2016","journal-title":"J. Thromb. Haemost."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"110948","DOI":"10.1016\/j.mce.2020.110948","article-title":"VIP Conditions Human Endometrial Receptivity by Privileging Endoplasmic Reticulum Stress through ATF6\u03b1 Pathway","volume":"516","author":"Soczewski","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"26364","DOI":"10.1038\/srep26364","article-title":"Vasoactive Intestinal Peptide Modulates Trophoblast-Derived Cell Line Function and Interaction with Phagocytic Cells through Autocrine Pathways","volume":"6","author":"Vota","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cmet.2012.07.007","article-title":"IRE1\u03b1 Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress","volume":"16","author":"Lerner","year":"2012","journal-title":"Cell Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"104173","DOI":"10.1016\/j.jri.2023.104173","article-title":"NLRP3 Inflammasome Pathway, the Hidden Balance in Pregnancy: A Comprehensive Review","volume":"161","author":"Balci","year":"2024","journal-title":"J. Reprod. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ma, J., Gao, W., and Li, D. (2023). Recurrent Implantation Failure: A Comprehensive Summary from Etiology to Treatment. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.1061766"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/humupd\/dmad010","article-title":"Opening the Black Box: Why Do Euploid Blastocysts Fail to Implant? A Systematic Review and Meta-Analysis","volume":"29","author":"Cimadomo","year":"2023","journal-title":"Hum. Reprod. Update"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1038\/s41598-017-01764-7","article-title":"Integrin Beta8 (ITGB8) Activates VAV-RAC1 Signaling via FAK in the Acquisition of Endometrial Epithelial Cell Receptivity for Blastocyst Implantation","volume":"7","author":"Kumar","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/19336918.2015.1135285","article-title":"Decoding the Chemokine Network That Links Leukocytes with Decidual Cells and the Trophoblast during Early Implantation","volume":"10","author":"Ramhorst","year":"2016","journal-title":"Cell Adhes. Migr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1242\/jcs.175943","article-title":"Embryo\u2013Epithelium Interactions during Implantation at a Glance","volume":"130","author":"Aplin","year":"2017","journal-title":"J. Cell Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s40104-023-00918-0","article-title":"Integrins and Their Potential Roles in Mammalian Pregnancy","volume":"14","author":"Johnson","year":"2023","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1530\/REP-11-0364","article-title":"Expression of Mesenchymal-Related Genes by the Bovine Trophectoderm Following Conceptus Attachment to the Endometrial Epithelium","volume":"143","author":"Yamakoshi","year":"2012","journal-title":"Reproduction"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.3390\/cimb46040220","article-title":"Inflammasome Molecular Insights in Autoimmune Diseases","volume":"46","author":"Bild","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s11658-023-00462-9","article-title":"The NLRP3 Inflammasome: Contributions to Inflammation-Related Diseases","volume":"28","author":"Chen","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"gaab056","DOI":"10.1093\/molehr\/gaab056","article-title":"NLRP3 Promotes Endometrial Receptivity by Inducing Epithelial\u2013Mesenchymal Transition of the Endometrial Epithelium","volume":"27","author":"Cheng","year":"2021","journal-title":"Mol. Hum. Reprod."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"20230796","DOI":"10.1515\/med-2023-0796","article-title":"Knockdown of NUPR1 Inhibits Angiogenesis in Lung Cancer through IRE1\/XBP1 and PERK\/eIF2\u03b1\/ATF4 Signaling Pathways","volume":"18","author":"Wang","year":"2023","journal-title":"Open Med."}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/15\/19\/1693\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:20:44Z","timestamp":1790310044000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/15\/19\/1693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":39,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["biology15191693"],"URL":"https:\/\/doi.org\/10.3390\/biology15191693","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]}}}