{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:54:13Z","timestamp":1790884453309,"version":"4.1.0"},"reference-count":74,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Postgraduate Research Institute of Science, Technology, Environment and Medicine, Cyprus"},{"name":"Russian Federal Ministry of Science and Higher Education","award":["FWGF-2026-0009"],"award-info":[{"award-number":["FWGF-2026-0009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Aspirin is one of the most widely used pharmaceuticals, yet its long-term use is associated with some side effects, including iron-deficiency anemia, which has been mainly linked to the iron-chelating properties of its major metabolite, salicyluric acid (SUA). In this study, the chelating and redox properties of SUA in the presence of iron (Fe3+), copper (Cu2+), and aluminum (Al3+), under neutral pH conditions were investigated using UV-Vis spectrophotometry, Job plot analysis, and 1H NMR spectroscopy. The stability constants determined for SUA complexes with Cu2+ and Al3+ were K = 9.9 \u00d7 106 and 1.40 \u00d7 104 M\u22121, respectively, classifying SUA as a moderate-affinity chelator. No detectable complexes of SUA with Fe2+ or Cu+ were observed, indicating selectivity of SUA for higher oxidation states. Competition experiments with the chelating drug deferiprone (L1) confirmed the quantitative displacement of SUA from metal coordination spheres. In a Fenton-initiated lipid peroxidation model using linoleic acid micelles, SUA\u2013copper and iron metal complexes accelerated lipid oxidation, demonstrating pro-oxidant activity. However, the combination of SUA and vitamin C resulted in a net decrease in the lipid peroxidation rate compared to the system containing SUA alone, suggesting a complex interplay between chelation and redox modulation.<\/jats:p>","DOI":"10.3390\/biology15191740","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:43:24Z","timestamp":1790880204000},"page":"1740","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interactions of Salicyluric Acid with Metal Ions and Ascorbic Acid: Possible Biological and Toxicity Implications in Aspirin Use"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8753-5304","authenticated-orcid":false,"given":"Viktor A.","family":"Timoshnikov","sequence":"first","affiliation":[{"name":"Institute of Chemical Kinetics & Combustion, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7503-000X","authenticated-orcid":false,"given":"Aleksandr A.","family":"Deriskiba","sequence":"additional","affiliation":[{"name":"Institute of Chemical Kinetics & Combustion, 630090 Novosibirsk, Russia"},{"name":"Department of Physics, Novosibirsk State University, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"software","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Vladimir E.","family":"Koshman","sequence":"additional","affiliation":[{"name":"Institute of Chemical Kinetics & Combustion, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3666-7750","authenticated-orcid":false,"given":"Nikolay E.","family":"Polyakov","sequence":"additional","affiliation":[{"name":"Institute of Chemical Kinetics & Combustion, 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3364-7340","authenticated-orcid":false,"given":"George J.","family":"Kontoghiorghes","sequence":"additional","affiliation":[{"name":"Postgraduate Research Institute of Science, Technology, Environment and Medicine, CY-3021 Limassol, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Werz, O., Stettler, H., Theurer, C., and Seibel, J. 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