{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:59:47Z","timestamp":1792789187486,"version":"4.5.0"},"reference-count":212,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jilin Province Science and Technology Department","award":["20250204060YY"],"award-info":[{"award-number":["20250204060YY"]}],"id":[{"id":"https:\/\/ror.org\/049x38272","id-type":"ROR","asserted-by":"crossref"}]},{"award":["20250204060YY"],"award-info":[{"award-number":["20250204060YY"]}],"id":[{"id":"https:\/\/ror.org\/049x38272","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Neurodegenerative diseases (NDs), including Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease, amyotrophic lateral sclerosis, and multiple sclerosis, are characterized by progressive and irreversible neuronal loss, whereas current treatments remain largely symptomatic. Ferroptosis is an iron-dependent form of regulated cell death whose execution is defined by iron-enabled phospholipid peroxidation and failure of cellular ferroptosis-defense systems. Mitochondrial metabolism can modify ferroptosis susceptibility, but its contribution varies with cell type and initiating stimulus. Converging evidence implicates ferroptosis in multiple NDs, in which affected regions commonly show iron accumulation, glutathione depletion, and increased lipid peroxidation. With their multi-component and multi-target properties, traditional Chinese medicine (TCM) interventions may modulate several nodes in this network. This review summarizes the core execution and defense mechanisms of ferroptosis, evaluates their roles in major NDs, and critically appraises bioactive herbal compounds, compound formulas, acupuncture, electroacupuncture, and moxibustion. The reported interventions mainly engage the Nrf2\/GPX4 antioxidant axis, TFR1\/FPN1\/FTH1\/NCOA4-mediated iron handling, ACSL4-dependent lipid peroxidation, and GPX4-independent defense systems. Because most studies are preclinical and many infer ferroptosis from non-specific markers, the evidence is graded here as direct, supportive, indirect, mixed, or complementary. Translation will require standardized formulations, causal ferroptosis validation, pharmacokinetic and brain-exposure data, validated human biomarkers, and rigorously designed clinical trials.<\/jats:p>","DOI":"10.3390\/biology15191760","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:39:34Z","timestamp":1790948374000},"page":"1760","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Ferroptosis in Neurodegenerative Diseases: Therapeutic Potential and Mechanistic Insights of Traditional Chinese Medicine"],"prefix":"10.3390","volume":"15","author":[{"given":"Pan","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmacy, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Meng","family":"Qi","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Zhen","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Scientific Research Department, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yu","sequence":"additional","affiliation":[{"name":"Innovation Practice Center, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Giri, P.M., Banerjee, A., Ghosal, A., and Layek, B. (2024). Neuroinflammation in Neurodegenerative Disorders: Current Knowledge and Therapeutic Implications. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073995"},{"key":"ref_2","unstructured":"GBD 2019 Dementia Forecasting Collaborators (2022). Estimation of the Global Prevalence of Dementia in 2019 and Forecasted Prevalence in 2050: An Analysis for the Global Burden of Disease Study 2019. Lancet Public Health, 7, e105\u2013e125."},{"key":"ref_3","unstructured":"World Health Organization (2021). Global Status Report on the Public Health Response to Dementia, World Health Organization. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789240033245."},{"key":"ref_4","unstructured":"World Health Organization (2026). Dementia [Fact Sheet], World Health Organization. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Mor\u00e9n, C., deSouza, R.M., Giraldo, D.M., and Uff, C. (2022). Antioxidant Therapeutic Strategies in Neurodegenerative Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169328"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3892\/mmr.2025.13557","article-title":"The Role of Ferroptosis in Alzheimer\u2019s Disease: Mechanisms and Therapeutic Potential (Review)","volume":"32","author":"Zeng","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: Mechanisms, Biology and Role in Disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 Dictates Ferroptosis Sensitivity by Shaping Cellular Lipid Composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized Arachidonic and Adrenic PEs Navigate Cells to Ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of Ferroptotic Cancer Cell Death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ Oxidoreductase FSP1 Acts Parallel to GPX4 to Inhibit Ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 Is a Glutathione-Independent Ferroptosis Suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","article-title":"DHODH-Mediated Ferroptosis Defence Is a Targetable Vulnerability in Cancer","volume":"593","author":"Mao","year":"2021","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of Mitochondria in Ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-020-00428-9","article-title":"Ferroptosis: Mechanisms and Links with Diseases","volume":"6","author":"Yan","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Yan, N., and Zhang, J. (2020). Iron Metabolism, Ferroptosis, and the Links with Alzheimer\u2019s Disease. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.01443"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gao, G., You, L., Zhang, J., Chang, Y.-Z., and Yu, P. (2023). Brain Iron Metabolism, Redox Balance and Neurological Diseases. Antioxidants, 12.","DOI":"10.3390\/antiox12061289"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1007\/s00018-009-0051-1","article-title":"Mammalian Iron Transport","volume":"66","author":"Anderson","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/ng1658","article-title":"Identification of a Ferrireductase Required for Efficient Transferrin-Dependent Iron Uptake in Erythroid Cells","volume":"37","author":"Ohgami","year":"2005","journal-title":"Nat. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lei, P., Bai, T., and Sun, Y. (2019). Mechanisms of Ferroptosis and Relations with Regulated Cell Death: A Review. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.00139"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.freeradbiomed.2017.04.024","article-title":"Iron and Thiol Redox Signaling in Cancer: An Exquisite Balance to Escape Ferroptosis","volume":"108","author":"Toyokuni","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cmet.2005.01.003","article-title":"The Iron Exporter Ferroportin\/Slc40a1 Is Essential for Iron Homeostasis","volume":"1","author":"Donovan","year":"2005","journal-title":"Cell Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/cr.2016.95","article-title":"Ferroptosis Is an Autophagic Cell Death Process","volume":"26","author":"Gao","year":"2016","journal-title":"Cell Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.tem.2021.04.010","article-title":"Ferritinophagy and Ferroptosis in the Management of Metabolic Diseases","volume":"32","author":"Ajoolabady","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1021\/acscentsci.0c01592","article-title":"Inhibiting Ferroptosis through Disrupting the NCOA4-FTH1 Interaction: A New Mechanism of Action","volume":"7","author":"Fang","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.freeradbiomed.2023.09.004","article-title":"TFEB Regulates Cellular Labile Iron and Prevents Ferroptosis in a TfR1-Dependent Manner","volume":"208","author":"Chen","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","article-title":"Ferroptosis at the Intersection of Lipid Metabolism and Cellular Signaling","volume":"82","author":"Liang","year":"2022","journal-title":"Mol. Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The Metabolic Underpinnings of Ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41556-021-00818-3","article-title":"PKC\u03b2II Phosphorylates ACSL4 to Amplify Lipid Peroxidation to Induce Ferroptosis","volume":"24","author":"Zhang","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Rochette, L., Dogon, G., Rigal, E., Zeller, M., Cottin, Y., and Vergely, C. (2023). Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010449"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.tips.2017.02.005","article-title":"Ferroptosis Inhibition: Mechanisms and Opportunities","volume":"38","author":"Angeli","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"32433","DOI":"10.1073\/pnas.2006828117","article-title":"Polyunsaturated Fatty Acid Biosynthesis Pathway Determines Ferroptosis Sensitivity in Gastric Cancer","volume":"117","author":"Lee","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.cell.2019.03.032","article-title":"Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke","volume":"177","author":"Alim","year":"2019","journal-title":"Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","article-title":"Role of GPX4 in Ferroptosis and Its Pharmacological Implication","volume":"133","author":"Seibt","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"115241","DOI":"10.1016\/j.bcp.2022.115241","article-title":"The Amino Acid Transporter SLC7A11-Mediated Crosstalk Implicated in Cancer Therapy and the Tumor Microenvironment","volume":"205","author":"He","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening Horizons: The Role of Ferroptosis in Cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Reichert, C.O., de Freitas, F.A., Sampaio-Silva, J., Rokita-Rosa, L., Barros, P.d.L., Levy, D., and Bydlowski, S.P. (2020). Ferroptosis Mechanisms Involved in Neurodegenerative Diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228765"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: Molecular Mechanisms and Health Implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Degirmenci, U., Wang, M., and Hu, J. (2020). Targeting Aberrant RAS\/RAF\/MEK\/ERK Signaling for Cancer Therapy. Cells, 9.","DOI":"10.3390\/cells9010198"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.bbrc.2016.08.034","article-title":"CISD1 Inhibits Ferroptosis by Protection against Mitochondrial Lipid Peroxidation","volume":"478","author":"Yuan","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a Target for Protection against Cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1042\/EBC20210017","article-title":"Ferroptosis and NRF2: An Emerging Battlefield in the Neurodegeneration of Alzheimer\u2019s Disease","volume":"65","author":"Lane","year":"2021","journal-title":"Essays Biochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"eabm5500","DOI":"10.1126\/sciadv.abm5500","article-title":"G9a Dictates Neuronal Vulnerability to Inflammatory Stress via Transcriptional Control of Ferroptosis","volume":"8","author":"Rothammer","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_45","unstructured":"Liu, X.-Y. (2021). Study on the Mechanism of Electroacupuncture Delaying the Progression of Alzheimer\u2019s Disease by Regulating Autophagy, Glucose Metabolism and Ferroptosis through Long Non-Coding RNA SNHG1. [Ph.D. Thesis, Nanchang University]. (In Chinese)."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"102035","DOI":"10.1016\/j.arr.2023.102035","article-title":"Research on Ferroptosis as a Therapeutic Target for the Treatment of Neurodegenerative Diseases","volume":"91","author":"Wang","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bbr.2017.12.036","article-title":"Why Should Neuroscientists Worry about Iron? The Emerging Role of Ferroptosis in the Pathophysiology of Neuroprogressive Diseases","volume":"341","author":"Morris","year":"2018","journal-title":"Behav. Brain Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1038\/s41418-020-0542-z","article-title":"Alpha Synuclein Aggregation Drives Ferroptosis: An Interplay of Iron, Calcium and Lipid Peroxidation","volume":"27","author":"Angelova","year":"2020","journal-title":"Cell Death Differ."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41583-025-00930-5","article-title":"Neuroferroptosis in Health and Diseases","volume":"26","author":"Lei","year":"2025","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e12295","DOI":"10.1002\/trc2.12295","article-title":"Alzheimer\u2019s Disease Drug Development Pipeline: 2022","volume":"8","author":"Cummings","year":"2022","journal-title":"Alzheimer\u2019s Dement. Transl. Res. Clin. Interv."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jalz.2007.04.381","article-title":"Forecasting the Global Burden of Alzheimer\u2019s Disease","volume":"3","author":"Brookmeyer","year":"2007","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/jnc.15030","article-title":"Amyloid-\u03b2 Oligomers in Cellular Models of Alzheimer\u2019s Disease","volume":"155","author":"Fontana","year":"2020","journal-title":"J. Neurochem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1038\/s41380-019-0375-7","article-title":"Brain Iron Is Associated with Accelerated Cognitive Decline in People with Alzheimer Pathology","volume":"25","author":"Ayton","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1021\/acschemneuro.8b00194","article-title":"Increased Iron Deposition on Brain Quantitative Susceptibility Mapping Correlates with Decreased Cognitive Function in Alzheimer\u2019s Disease","volume":"9","author":"Du","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s40035-022-00313-1","article-title":"The Emerging Role of Furin in Neurodegenerative and Neuropsychiatric Diseases","volume":"11","author":"Zhang","year":"2022","journal-title":"Transl. Neurodegener."},{"key":"ref_56","first-page":"2615","article-title":"Brain Iron Dyshomeostasis and Ferroptosis in Alzheimer\u2019s Disease Pathophysiology: Two Faces of the Same Coin","volume":"16","author":"Mezzanotte","year":"2025","journal-title":"Aging Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.7150\/ijbs.72251","article-title":"Emerging Mechanisms and Targeted Therapy of Ferroptosis in Neurological Diseases and Neuro-Oncology","volume":"18","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Ferr\u00e9-Gonz\u00e1lez, L., Pe\u00f1a-Bautista, C., Baquero, M., and Ch\u00e1fer-Peric\u00e1s, C. (2022). Assessment of Lipid Peroxidation in Alzheimer\u2019s Disease Differential Diagnosis and Prognosis. Antioxidants, 11.","DOI":"10.3390\/antiox11030551"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.redox.2017.01.021","article-title":"Ablation of Ferroptosis Regulator Glutathione Peroxidase 4 in Forebrain Neurons Promotes Cognitive Impairment and Neurodegeneration","volume":"12","author":"Hambright","year":"2017","journal-title":"Redox Biol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Dou, Y., and Zhao, D. (2022). Targeting Emerging Pathogenic Mechanisms by Natural Molecules as Potential Therapeutics for Neurodegenerative Diseases. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14112287"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.brainresbull.2022.11.016","article-title":"NLRP3 Inflammasome Deficiency Attenuates Cerebral Ischemia-Reperfusion Injury by Inhibiting Ferroptosis","volume":"193","author":"Wang","year":"2023","journal-title":"Brain Res. Bull."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"101890","DOI":"10.1016\/j.pneurobio.2020.101890","article-title":"Ferroptosis and Its Potential Role in the Physiopathology of Parkinson\u2019s Disease","volume":"196","author":"Bouchaoui","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1136\/jnnp-2019-322338","article-title":"Parkinson\u2019s Disease: Etiopathogenesis and Treatment","volume":"91","author":"Jankovic","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson\u2019s Disease","volume":"5","author":"Breteler","year":"2006","journal-title":"Lancet Neurol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","article-title":"Global, Regional, and National Burden of Parkinson\u2019s Disease, 1990\u20132016: A Systematic Analysis for the Global Burden of Disease Study 2016","volume":"17","author":"Dorsey","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.nbd.2016.05.011","article-title":"Ferroptosis, a Newly Characterized Form of Cell Death in Parkinson\u2019s Disease That Is Regulated by PKC","volume":"94","author":"Gouel","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.freeradbiomed.2022.09.015","article-title":"\u03b1-Syn Overexpression, NRF2 Suppression, and Enhanced Ferroptosis Create a Vicious Cycle of Neuronal Loss in Parkinson\u2019s Disease","volume":"192","author":"Anandhan","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/1673-5374.343892","article-title":"DL-3-n-Butylphthalide Alleviates Motor Disturbance by Suppressing Ferroptosis in a Rat Model of Parkinson\u2019s Disease","volume":"18","author":"Hu","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.freeradbiomed.2024.04.240","article-title":"Microglial Gp91phox-Mediated Neuroinflammation and Ferroptosis Contributes to Learning and Memory Deficits in Rotenone-Treated Mice","volume":"220","author":"Tian","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington\u2019s Disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/ene.13413","article-title":"Huntington\u2019s Disease: A Clinical Review","volume":"25","author":"McColgan","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/mds.25075","article-title":"The Incidence and Prevalence of Huntington\u2019s Disease: A Systematic Review and Meta-Analysis","volume":"27","author":"Pringsheim","year":"2012","journal-title":"Mov. Disord."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.freeradbiomed.2018.04.002","article-title":"Brain Mitochondrial Iron Accumulates in Huntington\u2019s Disease, Mediates Mitochondrial Dysfunction, and Can Be Removed Pharmacologically","volume":"120","author":"Agrawal","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.redox.2015.02.002","article-title":"Neonatal Iron Supplementation Potentiates Oxidative Stress, Energetic Dysfunction and Neurodegeneration in the R6\/2 Mouse Model of Huntington\u2019s Disease","volume":"4","author":"Berggren","year":"2015","journal-title":"Redox Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1196\/annals.1306.019","article-title":"Brain Ferritin Iron as a Risk Factor for Age at Onset in Neurodegenerative Diseases","volume":"1012","author":"Bartzokis","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3233\/JHD-170242","article-title":"Amyloid Precursor Protein Haploinsufficiency Preferentially Mediates Brain Iron Accumulation in Mice Transgenic for the Huntington\u2019s Disease Mutation","volume":"6","author":"Berggren","year":"2017","journal-title":"J. Huntington\u2019s Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.freeradbiomed.2013.04.017","article-title":"Role of Oxidative DNA Damage in Mitochondrial Dysfunction and Huntington\u2019s Disease Pathogenesis","volume":"62","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.bbrc.2007.05.093","article-title":"Increased Oxidative Damage and Mitochondrial Abnormalities in the Peripheral Blood of Huntington\u2019s Disease Patients","volume":"359","author":"Chen","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1021\/ja411006a","article-title":"Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models","volume":"136","author":"Skouta","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1056\/NEJMra1603471","article-title":"Amyotrophic Lateral Sclerosis","volume":"377","author":"Brown","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s40263-016-0317-8","article-title":"Advances in the Development of Disease-Modifying Treatments for Amyotrophic Lateral Sclerosis","volume":"30","author":"Moujalled","year":"2016","journal-title":"CNS Drugs"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.2174\/1570159X16666180110130253","article-title":"Understanding the Role of Hypoxia Inducible Factor during Neurodegeneration for New Therapeutics Opportunities","volume":"16","author":"Merelli","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/jnnp.2010.224501","article-title":"Rate of Familial Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis","volume":"82","author":"Byrne","year":"2011","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1523\/JNEUROSCI.5443-08.2009","article-title":"Dysregulation of Iron Homeostasis in the CNS Contributes to Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis","volume":"29","author":"Jeong","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41418-022-01089-7","article-title":"SPY1 Inhibits Neuronal Ferroptosis in Amyotrophic Lateral Sclerosis by Reducing Lipid Peroxidation through Regulation of GCH1 and TFR1","volume":"30","author":"Wang","year":"2023","journal-title":"Cell Death Differ."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/s41418-021-00910-z","article-title":"Ferroptosis Mediates Selective Motor Neuron Death in Amyotrophic Lateral Sclerosis","volume":"29","author":"Wang","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"12890","DOI":"10.1038\/s41598-021-92369-8","article-title":"Overexpression of Ferroptosis Defense Enzyme Gpx4 Retards Motor Neuron Disease of SOD1G93A Mice","volume":"11","author":"Chen","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s12640-021-00469-0","article-title":"The Gpx4NIKO Mouse Is a Versatile Model for Testing Interventions Targeting Ferroptotic Cell Death of Spinal Motor Neurons","volume":"40","author":"Evans","year":"2022","journal-title":"Neurotoxic. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"8217663","DOI":"10.1155\/2022\/8217663","article-title":"MPO\/HOCl Facilitates Apoptosis and Ferroptosis in the SOD1G93A Motor Neuron of Amyotrophic Lateral Sclerosis","volume":"2022","author":"Peng","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3164\/jcbn.17-62","article-title":"How Is Edaravone Effective against Acute Ischemic Stroke and Amyotrophic Lateral Sclerosis?","volume":"62","author":"Watanabe","year":"2018","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00401-016-1653-y","article-title":"An Updated Histological Classification System for Multiple Sclerosis Lesions","volume":"133","author":"Kuhlmann","year":"2017","journal-title":"Acta Neuropathol."},{"key":"ref_92","first-page":"527","article-title":"Progressive Multiple Sclerosis: From Pathogenic Mechanisms to Treatment","volume":"140","author":"Correale","year":"2017","journal-title":"Brain"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising Prevalence of Multiple Sclerosis Worldwide: Insights from the Atlas of MS, Third Edition","volume":"26","author":"Walton","year":"2020","journal-title":"Mult. Scler."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrneurol.2014.118","article-title":"Iron in Multiple Sclerosis: Roles in Neurodegeneration and Repair","volume":"10","author":"Stephenson","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"9327","DOI":"10.1523\/JNEUROSCI.1749-20.2020","article-title":"Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination","volume":"40","author":"Jhelum","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/jnc.14604","article-title":"Reduced Expression of the Ferroptosis Inhibitor Glutathione Peroxidase-4 in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis","volume":"148","author":"Hu","year":"2019","journal-title":"J. Neurochem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1038\/s41418-023-01195-0","article-title":"Ferroptosis Contributes to Multiple Sclerosis and Its Pharmacological Targeting Suppresses Experimental Disease Progression","volume":"30","author":"Debruyne","year":"2023","journal-title":"Cell Death Differ."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/s41423-022-00883-0","article-title":"Ferroptosis Promotes T-Cell Activation-Induced Neurodegeneration in Multiple Sclerosis","volume":"19","author":"Luoqian","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1016\/j.neuron.2024.05.025","article-title":"Neurodegeneration and Demyelination in Multiple Sclerosis","volume":"112","author":"Garton","year":"2024","journal-title":"Neuron"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"31474","DOI":"10.1038\/s41598-024-82938-y","article-title":"EGCG Activates Keap1\/P62\/Nrf2 Pathway, Inhibits Iron Deposition and Apoptosis in Rats with Cerebral Hemorrhage","volume":"14","author":"Hao","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_101","first-page":"221","article-title":"Mechanism of Tongdu Tiaoshen acupuncture in regulating mitochondrial ferroptosis in stroke rats","volume":"44","author":"Sun","year":"2026","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"6943438","DOI":"10.1155\/2022\/6943438","article-title":"Electroacupuncture Reduces Cerebral Hemorrhage Injury in Rats by Improving Cerebral Iron Metabolism","volume":"2022","author":"Chen","year":"2022","journal-title":"Mediat. Inflamm."},{"key":"ref_103","first-page":"1239","article-title":"Eye-Acupuncture Ameliorates Ferroptosis of Cerebral Neuronal Cells in CIRI Rats by Up-Regulating System xc(-)-GSH-GPX4 Antioxidant Functional Axis Activities","volume":"49","author":"Cao","year":"2024","journal-title":"Acupunct. Res."},{"key":"ref_104","first-page":"2872","article-title":"Progress in Traditional Chinese Medicine for the Prevention and Treatment of Neurodegenerative Diseases Based on Ferroptosis","volume":"42","author":"Li","year":"2025","journal-title":"Chin. J. Mod. Appl. Pharm."},{"key":"ref_105","first-page":"1325","article-title":"Research progress on therapeutic targets and drug development for neurodegenerative diseases via modulation of ferroptosis and neuroinflammation","volume":"60","author":"Li","year":"2025","journal-title":"Acta Pharm. Sin."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s10020-022-00442-3","article-title":"Eriodictyol Ameliorates Cognitive Dysfunction in APP\/PS1 Mice by Inhibiting Ferroptosis via Vitamin D Receptor-Mediated Nrf2 Activation","volume":"28","author":"Li","year":"2022","journal-title":"Mol. Med."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Jiang, Y., Xie, G., Alimujiang, A., Xie, H., Yang, W., Yin, F., and Huang, D. (2023). Protective Effects of Querectin against MPP+-Induced Dopaminergic Neurons Injury via the Nrf2 Signaling Pathway. Front. Biosci. (Landmark Ed.), 28.","DOI":"10.31083\/j.fbl2803042"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"15107","DOI":"10.1038\/s41598-024-62910-6","article-title":"Myricetin Mitigates Motor Disturbance and Decreases Neuronal Ferroptosis in a Rat Model of Parkinson\u2019s Disease","volume":"14","author":"Gu","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"109375","DOI":"10.1016\/j.bioorg.2025.109375","article-title":"Herbacetin Alleviates Parkinson\u2019s Disease by Inhibiting Ferroptosis in PC12 Cells through the Nrf2\/GPX4 Pathway","volume":"169","author":"Liu","year":"2026","journal-title":"Bioorg. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"109691","DOI":"10.1016\/j.abb.2023.109691","article-title":"Silibinin Ameliorates STING-Mediated Neuroinflammation via Downregulation of Ferroptotic Damage in a Sporadic Alzheimer\u2019s Disease Model","volume":"744","author":"Liu","year":"2023","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"414","DOI":"10.26599\/FSHW.2022.9250035","article-title":"Total Flavonoids of Astragalus membranaceus Protect against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurotoxicity in Mice by Inhibiting Ferroptosis through SLC7A11\/GPX-4 Signaling Pathway","volume":"13","author":"Gao","year":"2024","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_112","first-page":"11546","article-title":"Icariin Improves Cognitive Impairment by Inhibiting Ferroptosis of Nerve Cells","volume":"15","author":"Yang","year":"2023","journal-title":"Aging"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"105705","DOI":"10.1016\/j.neuint.2024.105705","article-title":"Icariin, Astragaloside A and Puerarin Mixture Attenuates Cognitive Impairment in APP\/PS1 Mice via Inhibition of Ferroptosis-Lipid Peroxidation","volume":"175","author":"Zhang","year":"2024","journal-title":"Neurochem. Int."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4103\/cjop.CJOP-D-23-00107","article-title":"Icariside II Suppresses Ferroptosis to Protect against MPP+-Induced Parkinson\u2019s Disease through Keap1\/Nrf2\/GPX4 Signaling","volume":"66","author":"Fan","year":"2023","journal-title":"Chin. J. Physiol."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Liu, R.-Z., Zhang, S., Zhang, W., Zhao, X.-Y., and Du, G.-H. (2023). Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson\u2019s Disease in Rats. Antioxidants, 12.","DOI":"10.3390\/antiox12010012"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Wang, Q., Wang, Z., Li, Y., Wang, Q., Chen, Y., Xu, B., and Xu, H. (2025). Baicalein Improves Motor Dysfunction and Cognitive Impairment While Promoting Remyelination in an Animal Model of Multiple Sclerosis through the Antioxidant Mechanism. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1659631"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/ijnp\/pyaa060","article-title":"Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3\/Caspase-1\/GSDMD Pathway in MPTP Induced Mice Model of Parkinson\u2019s Disease","volume":"23","author":"Rui","year":"2020","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"115215","DOI":"10.1016\/j.biopha.2023.115215","article-title":"Kaempferol, a Potential Neuroprotective Agent in Neurodegenerative Diseases: From Chemistry to Medicine","volume":"165","author":"Jin","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1038\/s41598-017-03115-y","article-title":"The Effects of Brazilian Green Propolis That Contains Flavonols against Mutant Copper-Zinc Superoxide Dismutase-Mediated Toxicity","volume":"7","author":"Ueda","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"eado8499","DOI":"10.1126\/sciadv.ado8499","article-title":"Amyloid Fibril Structures and Ferroptosis Activation Induced by ALS-Causing SOD1 Mutations","volume":"10","author":"Wang","year":"2024","journal-title":"Sci. Adv."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Valverde-Salazar, V., Ruiz-Gabarre, D., and Garc\u00eda-Escudero, V. (2023). Alzheimer\u2019s Disease and Green Tea: Epigallocatechin-3-Gallate as a Modulator of Inflammation and Oxidative Stress. Antioxidants, 12.","DOI":"10.3390\/antiox12071460"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1097\/NEN.0b013e31818b4906","article-title":"Nuclear Erythroid 2-Related Factor 2-Antioxidative Response Element Signaling Pathway in Motor Cortex and Spinal Cord in Amyotrophic Lateral Sclerosis","volume":"67","author":"Sarlette","year":"2008","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Yang, C., Wu, A., Tan, L., Tang, D., Chen, W., Lai, X., Gu, K., Chen, J., Chen, D., and Tang, Q. (2023). Epigallocatechin-3-Gallate Alleviates Liver Oxidative Damage Caused by Iron Overload in Mice through Inhibiting Ferroptosis. Nutrients, 15.","DOI":"10.3390\/nu15081993"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12935-024-03391-5","article-title":"Epigallocatechin Gallate Modulates Ferroptosis through Downregulation of tsRNA-13502 in Non-Small Cell Lung Cancer","volume":"24","author":"Wang","year":"2024","journal-title":"Cancer Cell Int."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.freeradbiomed.2023.12.005","article-title":"Inhibition of Ferroptosis Underlies EGCG Mediated Protection against Parkinson\u2019s Disease in a Drosophila Model","volume":"211","author":"Xia","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1471-4159.2006.03770.x","article-title":"Reduction of Iron-Regulated Amyloid Precursor Protein and \u03b2-Amyloid Peptide by (\u2013)-Epigallocatechin-3-Gallate in Cell Cultures: Implications for Iron Chelation in Alzheimer\u2019s Disease","volume":"97","author":"Reznichenko","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neuroscience.2018.03.008","article-title":"Fisetin Exerts Antioxidant and Neuroprotective Effects in Multiple Mutant hSOD1 Models of Amyotrophic Lateral Sclerosis by Activating ERK","volume":"379","author":"Wang","year":"2018","journal-title":"Neuroscience"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Hassan, S.S.U., Samanta, S., Dash, R., Karpi\u0144ski, T.M., Habibi, E., Sadiq, A., Ahmadi, A., and Bungau, S. (2022). The Neuroprotective Effects of Fisetin, a Natural Flavonoid in Neurodegenerative Diseases: Focus on the Role of Oxidative Stress. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1015835"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Yang, H., Hong, Y., Gong, M., Cai, S., Yuan, Z., Feng, S., Chen, Q., Liu, X., and Mei, Z. (2024). Fisetin Exerts Neuroprotective Effects in Vivo and in Vitro by Inhibiting Ferroptosis and Oxidative Stress after Traumatic Brain Injury. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1480345"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13020-022-00634-3","article-title":"Salidroside Attenuates Neuronal Ferroptosis by Activating the Nrf2\/HO1 Signaling Pathway in A\u03b21-42-Induced Alzheimer\u2019s Disease Mice and Glutamate-Injured HT22 Cells","volume":"17","author":"Yang","year":"2022","journal-title":"Chin. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"154762","DOI":"10.1016\/j.phymed.2023.154762","article-title":"Salidroside Alleviates Cognitive Impairment by Inhibiting Ferroptosis via Activation of the Nrf2\/GPX4 Axis in SAMP8 Mice","volume":"114","author":"Yang","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"100802","DOI":"10.1016\/j.phyplu.2025.100802","article-title":"Salidroside Alleviates A\u03b21\u201342-Induced Ferroptosis in Human Neuroblastoma Cells by AKT\/GSK-3\u03b2 Activation via Inhibiting VDAC1","volume":"5","author":"Zhang","year":"2025","journal-title":"Phytomed. Plus"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s11064-024-04116-w","article-title":"Salidroside Mediated the Nrf2\/GPX4 Pathway to Attenuates Ferroptosis in Parkinson\u2019s Disease","volume":"49","author":"Shen","year":"2024","journal-title":"Neurochem. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"108002","DOI":"10.1016\/j.intimp.2021.108002","article-title":"Tetrahydroxy Stilbene Glycoside Ameliorates Alzheimer\u2019s Disease in APP\/PS1 Mice via Glutathione Peroxidase Related Ferroptosis","volume":"99","author":"Gao","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1002\/ptr.7946","article-title":"Paeoniflorin Suppresses Neuronal Ferroptosis to Improve the Cognitive Behaviors in Alzheimer\u2019s Disease Mice","volume":"37","author":"Zhai","year":"2023","journal-title":"Phytother. Res."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Li, M., Zhang, J., Jiang, L., Wang, W., Feng, X., Liu, M., and Yang, D. (2023). Neuroprotective Effects of Morroniside from Cornus officinalis Sieb. et Zucc. against Parkinson\u2019s Disease via Inhibiting Oxidative Stress and Ferroptosis. BMC Complement. Med. Ther., 23.","DOI":"10.1186\/s12906-023-03967-0"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"110290","DOI":"10.1016\/j.intimp.2023.110290","article-title":"Sennoside A Restrains TRAF6 Level to Modulate Ferroptosis, Inflammation and Cognitive Impairment in Aging Mice with Alzheimer\u2019s Disease","volume":"120","author":"Li","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"7725","DOI":"10.1021\/acs.jafc.4c10497","article-title":"Saponins from Astragalus membranaceus (Fisch.) Bge Alleviated Neuronal Ferroptosis in Alzheimer\u2019s Disease by Regulating the NOX4\/Nrf2 Signaling Pathway","volume":"73","author":"Wang","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1248\/bpb.b19-00824","article-title":"Gastrodin Inhibits H2O2-Induced Ferroptosis through Its Antioxidative Effect in Rat Glioma Cell Line C6","volume":"43","author":"Jiang","year":"2020","journal-title":"Biol. Pharm. Bull."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.7150\/ijbs.69714","article-title":"Forsythoside a Mitigates Alzheimer\u2019s-like Pathology by Inhibiting Ferroptosis-Mediated Neuroinflammation via Nrf2\/GPX4 Axis Activation","volume":"18","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/j.fshw.2023.02.035","article-title":"Isoforsythiaside Confers Neuroprotection against Alzheimer\u2019s Disease by Attenuating Ferroptosis and Neuroinflammation in Vivo and in Vitro","volume":"12","author":"Wang","year":"2023","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1002\/ptr.8152","article-title":"Curculigoside, a Traditional Chinese Medicine Monomer, Ameliorates Oxidative Stress in Alzheimer\u2019s Disease Mouse Model via Suppressing Ferroptosis","volume":"38","author":"Gong","year":"2024","journal-title":"Phytother. Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.freeradbiomed.2024.07.018","article-title":"Acteoside Alleviates Lipid Peroxidation by Enhancing Nrf2-Mediated Mitophagy to Inhibit Ferroptosis for Neuroprotection in Parkinson\u2019s Disease","volume":"223","author":"Han","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"115084","DOI":"10.1016\/j.expneurol.2024.115084","article-title":"Acteoside Alleviates Salsolinol-Induced Parkinson\u2019s Disease by Inhibiting Ferroptosis via Activating Nrf2\/SLC7A11\/GPX4 Pathway","volume":"385","author":"Wang","year":"2025","journal-title":"Exp. Neurol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1002\/ptr.7930","article-title":"Tenuifolin in the Prevention of Alzheimer\u2019s Disease-Like Phenotypes: Investigation of the Mechanisms from the Perspectives of Calpain System, Ferroptosis, and Apoptosis","volume":"37","author":"Li","year":"2023","journal-title":"Phytother. Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"6983","DOI":"10.1007\/s12035-022-03014-y","article-title":"Senegenin Rescues PC12 Cells with Oxidative Damage through Inhibition of Ferroptosis","volume":"59","author":"Zhang","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"9427","DOI":"10.1039\/D3SC02350H","article-title":"A Natural Polyphenol Activates and Enhances GPX4 to Mitigate Amyloid-\u03b2 Induced Ferroptosis in Alzheimer\u2019s Disease","volume":"14","author":"Baruah","year":"2023","journal-title":"Chem. Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"105773","DOI":"10.1016\/j.neuint.2024.105773","article-title":"Ferroptosis: A New Strategy for Targeting Alzheimer\u2019s Disease","volume":"178","author":"Qiang","year":"2024","journal-title":"Neurochem. Int."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3233\/JAD-170354","article-title":"The Natural Product Curcumin as a Potential Coadjuvant in Alzheimer\u2019s Treatment","volume":"60","author":"Morales","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Russo, A., Putaggio, S., Tellone, E., Calderaro, A., Cirmi, S., Lagan\u00e0, G., Ficarra, S., Barreca, D., and Patan\u00e8, G.T. (2025). Emerging Ferroptosis Involvement in Amyotrophic Lateral Sclerosis Pathogenesis: Neuroprotective Activity of Polyphenols. Molecules, 30.","DOI":"10.3390\/molecules30061211"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"137346","DOI":"10.1016\/j.neulet.2023.137346","article-title":"Alpha Lipoic Acid Ameliorates Motor Deficits by Inhibiting Ferroptosis in Parkinson\u2019s Disease","volume":"810","author":"Zheng","year":"2023","journal-title":"Neurosci. Lett."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1021\/acschemneuro.5c00035","article-title":"Corilagin Attenuates Neuronal Apoptosis and Ferroptosis of Parkinson\u2019s Disease through Regulating the TLR4\/Src\/NOX2 Signaling Pathway","volume":"16","author":"Lei","year":"2025","journal-title":"ACS Chem. Neurosci."},{"key":"ref_153","unstructured":"Zhu, H.-M., Wang, Y.-X., Zhao, Z.-T., Wang, Z.-J., and Ge, C. (2026). Research progress on the correlation between cuproptosis and neurodegenerative diseases and the intervention of traditional Chinese medicine. Chin. J. Exp. Tradit. Med. Formulae, (In Chinese)."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"156275","DOI":"10.1016\/j.phymed.2024.156275","article-title":"Wolfberry (Lycium barbarum) Glycopeptide Attenuates Dopaminergic Neurons Loss by Inhibiting Lipid Peroxidation in Parkinson\u2019s Disease","volume":"136","author":"Lin","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"e14456","DOI":"10.1111\/cns.14456","article-title":"Neutral Polysaccharide from Gastrodia Elata Alleviates Cerebral Ischemia-Reperfusion Injury by Inhibiting Ferroptosis-Mediated Neuroinflammation via the NRF2\/HO-1 Signaling Pathway","volume":"30","author":"Zhang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/s41401-024-01378-6","article-title":"Artemisinin Inhibits Neuronal Ferroptosis in Alzheimer\u2019s Disease Models by Targeting KEAP1","volume":"46","author":"Deng","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"111459","DOI":"10.1016\/j.cbi.2025.111459","article-title":"The Anti-Alzheimer\u2019s Disease Effects of Ganoderic Acid A by Inhibiting Ferroptosis-Lipid Peroxidation via Activation of the NRF2\/SLC7A11\/GPX4 Signaling Pathway","volume":"412","author":"Lu","year":"2025","journal-title":"Chem.-Biol. Interact."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"118363","DOI":"10.1016\/j.jep.2024.118363","article-title":"Ganoderic Acid A Mitigates Dopaminergic Neuron Ferroptosis via Inhibiting NCOA4-Mediated Ferritinophagy in Parkinson\u2019s Disease Mice","volume":"332","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_159","first-page":"177","article-title":"Modulation of Iron Death by Poric Acid through Nrf2\/SLC7A11\/GPX4 Signal Pathway in the Improvement of Cognitive Impairment of Alzheimer\u2019s Disease Rats","volume":"27","author":"Fan","year":"2024","journal-title":"Chin. Gen. Pract."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"117196","DOI":"10.1016\/j.jep.2023.117196","article-title":"Buddlejasaponin IVb Ameliorates Ferroptosis of Dopaminergic Neuron by Suppressing IRP2-Mediated Iron Overload in Parkinson\u2019s Disease","volume":"319","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"116729","DOI":"10.1016\/j.jep.2023.116729","article-title":"Saikosaponin B2 Ameliorates Depression-Induced Microglia Activation by Inhibiting Ferroptosis-Mediated Neuroinflammation and ER Stress","volume":"316","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"102134","DOI":"10.1016\/j.redox.2021.102134","article-title":"The Nrf2-NLRP3-Caspase-1 Axis Mediates the Neuroprotective Effects of Celastrol in Parkinson\u2019s Disease","volume":"47","author":"Zhang","year":"2021","journal-title":"Redox Biol."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Wang, S., Chen, Z., Tang, H., Gong, J., Xu, K., and Wang, K. (2026). Research Progress on the Mechanism of Ginsenosides in the Treatment of Parkinson\u2019s Disease. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27104544"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"102229","DOI":"10.1016\/j.redox.2022.102229","article-title":"Cognitive Enhancement and Neuroprotective Effects of OABL, a Sesquiterpene Lactone in 5xFAD Alzheimer\u2019s Disease Mice Model","volume":"50","author":"Tang","year":"2022","journal-title":"Redox Biol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"33","DOI":"10.31083\/j.jin2202033","article-title":"Quantitative Proteomics Reveals Neuroprotective Mechanism of Ginkgolide B in A\u03b21-42-Induced N2a Neuroblastoma Cells","volume":"22","author":"Zhang","year":"2023","journal-title":"J. Integr. Neurosci."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"156780","DOI":"10.1016\/j.phymed.2025.156780","article-title":"Schisandrin B Ameliorates Alzheimer\u2019s Disease by Suppressing Neuronal Ferroptosis and Ensuing Microglia M1 Polarization","volume":"142","author":"Ding","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"119335","DOI":"10.1016\/j.jep.2025.119335","article-title":"Lignans from Schisandra Chinensis (Turcz.) Baill Ameliorates Cognitive Impairment in Alzheimer\u2019s Disease and Alleviates Ferroptosis by Activating the Nrf2\/FPN1 Signaling Pathway and Regulating Iron Levels","volume":"341","author":"Meng","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.1080\/14786419.2025.2502155","article-title":"Emodin Ameliorates Dopaminergic Neuron Loss in the MPP+ Induced Parkinson\u2019s Disease Model: Significant Inhibition of Ferroptosis by Activating UQCRC1 Protein","volume":"40","author":"Yusun","year":"2026","journal-title":"Nat. Prod. Res."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s13205-023-03769-8","article-title":"Chrysophanol Improves Memory Impairment and Cell Injury by Reducing the Level of Ferroptosis in A\u03b225\u201335 Treated Rat and PC12 Cells","volume":"13","author":"Luo","year":"2023","journal-title":"3 Biotech"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.freeradbiomed.2022.08.011","article-title":"Hinokitiol Functions as a Ferroptosis Inhibitor to Confer Neuroprotection","volume":"190","author":"Xi","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"114550","DOI":"10.1016\/j.intimp.2025.114550","article-title":"Berberine Alleviates Alzheimer\u2019s Disease by Activating Autophagy and Inhibiting Ferroptosis through the JNK-p38MAPK Signaling Pathway","volume":"155","author":"Sun","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.freeradbiomed.2025.07.052","article-title":"Muscone Inhibits Ferroptosis for Neuroprotection in a Parkinson\u2019s Disease Model","volume":"239","author":"Xu","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"100046","DOI":"10.1016\/j.molpha.2025.100046","article-title":"Cyclovirobuxine Inhibits Ferroptosis to Mitigate Alzheimer Disease in Glutamate-Induced SH-SY5Y Cell: The Role of the Liquid-Liquid Phase Separation of FTH1","volume":"107","author":"Wang","year":"2025","journal-title":"Mol. Pharmacol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"6161","DOI":"10.7150\/thno.98172","article-title":"A Novel Ferroptosis Inhibitor, Thonningianin A, Improves Alzheimer\u2019s Disease by Activating GPX4","volume":"14","author":"Yong","year":"2024","journal-title":"Theranostics"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"101672","DOI":"10.1016\/j.redox.2020.101672","article-title":"Increases of iASPP-Keap1 Interaction Mediated by Syringin Enhance Synaptic Plasticity and Rescue Cognitive Impairments via Stabilizing Nrf2 in Alzheimer\u2019s Models","volume":"36","author":"Wang","year":"2020","journal-title":"Redox Biol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"117937","DOI":"10.1016\/j.jep.2024.117937","article-title":"Water Extract of Moschus Alleviates Erastin-Induced Ferroptosis by Regulating the Keap1\/Nrf2 Pathway in HT22 Cells","volume":"326","author":"Song","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1039\/D4MH00023D","article-title":"Polycatechols Inhibit Ferroptosis and Modulate Tau Liquid\u2013Liquid Phase Separation to Mitigate Alzheimer\u2019s Disease","volume":"11","author":"Moorthy","year":"2024","journal-title":"Mater. Horiz."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"103119","DOI":"10.1016\/j.redox.2024.103119","article-title":"Hybrid Molecules Synergistically Mitigate Ferroptosis and Amyloid-Associated Toxicities in Alzheimer\u2019s Disease","volume":"71","author":"Padhi","year":"2024","journal-title":"Redox Biol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"121138","DOI":"10.1016\/j.jep.2025.121138","article-title":"Neuroprotective Effects of ZiYin XiFeng Formula against Parkinson\u2019s Disease via Nrf2\/SLC7A11\/GPX4-Mediated Ferroptosis Inhibition","volume":"359","author":"Guo","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Gong, K., Zhou, S., Xiao, L., Xu, M., Zhou, Y., Lu, K., Yu, X., Zhu, J., Liu, C., and Zhu, Q. (2025). Danggui Shaoyao San Ameliorates Alzheimer\u2019s Disease by Regulating Lipid Metabolism and Inhibiting Neuronal Ferroptosis through the AMPK\/Sp1\/ACSL4 Signaling Pathway. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1588375"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13020-025-01135-9","article-title":"Dingzhen Pills Inhibit Neuronal Ferroptosis and Neuroinflammation by Inhibiting the cGAS-STING Pathway for Parkinson\u2019s Disease Mice","volume":"20","author":"Fu","year":"2025","journal-title":"Chin. Med."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"117679","DOI":"10.1016\/j.jep.2023.117679","article-title":"SuanZaoRen Decoction Alleviates Neuronal Loss, Synaptic Damage and Ferroptosis of AD via Activating DJ-1\/Nrf2 Signaling Pathway","volume":"323","author":"Long","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"161","DOI":"10.14715\/cmb\/2024.70.7.23","article-title":"Linggui Zhugan Decoction as a Potential Medicine for Neuroprotection in Alzheimer\u2019s Disease via AMPK Pathway","volume":"70","author":"Fan","year":"2024","journal-title":"Cell. Mol. Biol."},{"key":"ref_184","first-page":"28","article-title":"Effects of the ethanol extract of Xiao-Xu-Ming decoction on glutamate-induced ferroptosis in mouse hippocampal neuronal cells","volume":"54","author":"Zhao","year":"2023","journal-title":"Fujian J. Tradit. Chin. Med."},{"key":"ref_185","unstructured":"Guo, Y.-T. (2022). Preliminary Study on Tianma Gouteng Decoction Delaying the Progression of Parkinson\u2019s Disease by Regulating ACSL4-Mediated Lipid Peroxidation and Inhibiting Ferroptosis. [Master\u2019s Thesis, Anhui University of Chinese Medicine]. (In Chinese)."},{"key":"ref_186","first-page":"798","article-title":"Research progress on the treatment of central nervous system diseases by acupuncture regulation of ferroptosis","volume":"43","author":"Wang","year":"2026","journal-title":"Tianjin J. Tradit. Chin. Med."},{"key":"ref_187","first-page":"96","article-title":"Mechanisms of ferroptosis in regulating neurodegenerative diseases and stroke and research progress of acupuncture intervention","volume":"41","author":"Hou","year":"2025","journal-title":"J. Clin. Acupunct. Moxibustion"},{"key":"ref_188","first-page":"97","article-title":"Research progress of acupuncture in the treatment of Alzheimer\u2019s disease by regulating programmed cell death","volume":"42","author":"Li","year":"2026","journal-title":"J. Clin. Acupunct. Moxibustion"},{"key":"ref_189","first-page":"6668249","article-title":"Moxibustion Protects Dopaminergic Neurons in Parkinson\u2019s Disease through Antiferroptosis","volume":"2021","author":"Huang","year":"2021","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_190","first-page":"1236","article-title":"Effects of \u201cTongdu Qishen\u201d acupuncture on the expression of ferroptosis-related factors in the hippocampus of APPswe\/PS1dE9 mice","volume":"48","author":"Li","year":"2023","journal-title":"Acupunct. Res."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"148744","DOI":"10.1016\/j.brainres.2023.148744","article-title":"Electroacupuncture Improves Cognitive Function in APP\/PS1 Mice by Inhibiting Oxidative Stress Related Hippocampal Neuronal Ferroptosis","volume":"1831","author":"Chen","year":"2024","journal-title":"Brain Res."},{"key":"ref_192","first-page":"1851","article-title":"Effects of electroacupuncture-treated serum on ferroptosis of HT22 neurons after oxygen-glucose deprivation\/reoxygenation","volume":"31","author":"Chen","year":"2025","journal-title":"J. Hainan Med. Univ."},{"key":"ref_193","first-page":"1242","article-title":"Effects of electroacupuncture on ferroptosis-induced oxidative stress and apoptosis in mice with Parkinson\u2019s disease","volume":"48","author":"Ma","year":"2023","journal-title":"Acupunct. Res."},{"key":"ref_194","first-page":"689","article-title":"Effects of electroacupuncture on cognitive function and neuronal autophagy in rats with D-galactose induced Alzheimer\u2019s disease","volume":"45","author":"Zheng","year":"2020","journal-title":"Acupunct. Res."},{"key":"ref_195","first-page":"611","article-title":"Effects of electroacupuncture on learning and memory ability and hippocampal cell apoptosis in mice with Alzheimer\u2019s disease","volume":"45","author":"Zhang","year":"2020","journal-title":"Acupunct. Res."},{"key":"ref_196","first-page":"24","article-title":"Effects of acupuncture preconditioning on ferroptosis of nerve cells in ischemic stroke","volume":"33","author":"Gao","year":"2025","journal-title":"Chin. J. Arterioscler."},{"key":"ref_197","first-page":"1048","article-title":"Effects of electroacupuncture on the expression of \u03b2-amyloid and autophagy-related proteins in hippocampal cells of mice with Alzheimer\u2019s disease","volume":"47","author":"Tan","year":"2022","journal-title":"Acupunct. Res."},{"key":"ref_198","first-page":"84","article-title":"Mechanism of acupuncture on learning and memory function in rats with Alzheimer\u2019s disease","volume":"40","author":"Zhang","year":"2024","journal-title":"J. Clin. Acupunct. Moxibustion"},{"key":"ref_199","first-page":"44","article-title":"Regulation of acupuncture on ferroptosis in brain tissue after cerebral hemorrhage based on the p62\/Keap1\/NRF2 signaling pathway","volume":"41","author":"Dai","year":"2024","journal-title":"Inf. Tradit. Chin. Med."},{"key":"ref_200","unstructured":"Fan, J.-Q. (2023). Study on Tiaoshen Acupuncture Improving Cognitive Function of APP\/PS1 Mice by Regulating Mitophagy. [Doctoral Dissertation, Guangzhou University of Chinese Medicine]. (In Chinese)."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2147\/NDT.S279304","article-title":"Bushen Huoxue Acupuncture Inhibits NLRP1 Inflammasome-Mediated Neuronal Pyroptosis in SAMP8 Mouse Model of Alzheimer\u2019s Disease","volume":"17","author":"Zhang","year":"2021","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_202","first-page":"34","article-title":"Intervention effect of scalp point-to-point penetration acupuncture on rats with Alzheimer\u2019s disease based on the NF-kappaB\/NLRP3\/Caspase-1 pathway","volume":"42","author":"Pan","year":"2024","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"key":"ref_203","first-page":"1037","article-title":"\u201cShugan Tiaoshen\u201d acupuncture regulates lipid peroxidation and inhibits ferroptosis of prefrontal cortex neurons to improve post-stroke depression in rats","volume":"50","author":"Wu","year":"2025","journal-title":"Acupunct. Res."},{"key":"ref_204","first-page":"1376","article-title":"Mechanism of \u201cShugan Tiaoshen\u201d acupuncture in regulating hippocampal neuronal ferroptosis to improve comorbid chronic inflammatory pain and depression","volume":"50","author":"Liu","year":"2025","journal-title":"Acupunct. Res."},{"key":"ref_205","first-page":"1121","article-title":"Effects of \u201cTongdu Tiaoshen\u201d acupuncture on hippocampal neuronal ferroptosis in depression model rats based on the SLC7A11\/GPX4 signaling pathway","volume":"45","author":"Qian","year":"2025","journal-title":"Chin. Acupunct. Moxibustion"},{"key":"ref_206","first-page":"736","article-title":"Moxibustion improves motor function by down-regulating SNX5 and inhibiting ferroptosis in neurons of corpus striatum in mice with Parkinson\u2019s disease","volume":"49","author":"Gao","year":"2024","journal-title":"Acupunct. Res."},{"key":"ref_207","first-page":"2573","article-title":"Effects of eye acupuncture on cuproptosis of nerve cells in rats with cerebral ischemia-reperfusion injury based on the CTR1\/FDX1 pathway","volume":"36","author":"Sun","year":"2025","journal-title":"Lishizhen Med. Mater. Medica Res."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1016\/j.celrep.2020.02.049","article-title":"Transferrin Receptor Is a Specific Ferroptosis Marker","volume":"30","author":"Feng","year":"2020","journal-title":"Cell Rep."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1056\/NEJMoa2209254","article-title":"Trial of Deferiprone in Parkinson\u2019s Disease","volume":"387","author":"Devos","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/ars.2013.5593","article-title":"Targeting Chelatable Iron as a Therapeutic Modality in Parkinson\u2019s Disease","volume":"21","author":"Devos","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1001\/jamaneurol.2024.3733","article-title":"Deferiprone in Alzheimer Disease: A Randomized Clinical Trial","volume":"82","author":"Ayton","year":"2025","journal-title":"JAMA Neurol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S1474-4422(19)30142-5","article-title":"Safety and efficacy of deferiprone for pantothenate kinase-associated neurodegeneration: A randomised, double-blind, controlled trial and an open-label extension study","volume":"18","author":"Klopstock","year":"2019","journal-title":"Lancet Neurol."}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/15\/19\/1760\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T04:11:28Z","timestamp":1791691888000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/15\/19\/1760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":212,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["biology15191760"],"URL":"https:\/\/doi.org\/10.3390\/biology15191760","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,2]]}}}