{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:04:24Z","timestamp":1790514264751,"version":"4.1.0"},"reference-count":59,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T00:00:00Z","timestamp":1455494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Light of short wavelengths has been shown to play a key role in non-image forming responses. Due to aging, the ocular lens becomes more yellow reducing the transmission of short wavelengths in the elderly. In the present study, we make use of cataract surgery to investigate the effects of a relative increase of short wavelength transmission on melatonin- and sleep-wake rhythms (N = 14). We observed, on average, a delay of the sleep-wake and the nocturnal melatonin rhythms after cataract surgery. This delay is tentatively attributed to a relatively large increase of light transmittance in the evening hours more than an increase of the already relatively high light intensities found in the daytime. The later phase that we observed after cataract surgery (clear lens) as compared to the earlier phase observed before cataract (yellowish lens) is in agreement with the general later phase reported in the young (clear lens) population.<\/jats:p>","DOI":"10.3390\/biology5010012","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T06:23:07Z","timestamp":1455517387000},"page":"12","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Melatonin and Sleep-Wake Rhythms before and after Ocular Lens Replacement in Elderly Humans"],"prefix":"10.3390","volume":"5","author":[{"given":"Marina","family":"Gim\u00e9nez","sequence":"first","affiliation":[{"name":"Department of Chronobiology, GeLifes, University of Groningen, Groningen 9747 AG, The Netherlands"},{"name":"Chrono@Work B.V., Groningen 9747 AT, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8007-790X","authenticated-orcid":false,"given":"Domien","family":"Beersma","sequence":"additional","affiliation":[{"name":"Department of Chronobiology, GeLifes, University of Groningen, Groningen 9747 AG, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Daan","sequence":"additional","affiliation":[{"name":"Department of Chronobiology, GeLifes, University of Groningen, Groningen 9747 AG, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Pol","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Medical Centre Groningen, Groningen 9713 GZ, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn","family":"Kanis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Medical Centre Utrecht, Utrecht 3584 CX, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Van Norren","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Medical Centre Utrecht, Utrecht 3584 CX, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijke","family":"Gordijn","sequence":"additional","affiliation":[{"name":"Department of Chronobiology, GeLifes, University of Groningen, Groningen 9747 AG, The Netherlands"},{"name":"Chrono@Work B.V., Groningen 9747 AT, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6405","DOI":"10.1523\/JNEUROSCI.21-16-06405.2001","article-title":"Action spectrum for melatonin regulation in humans: Evidence for a novel circadian photoreceptor","volume":"21","author":"Brainard","year":"2001","journal-title":"J. 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