{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:33:46Z","timestamp":1793352826796,"version":"4.5.0"},"reference-count":235,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T00:00:00Z","timestamp":1488844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Ornithine \u03b4-aminotransferase (OAT, E.C. 2.6.1.13) catalyzes the transfer of the \u03b4-amino group from ornithine (Orn) to \u03b1-ketoglutarate (aKG), yielding glutamate-5-semialdehyde and glutamate (Glu), and vice versa. In mammals, OAT is a mitochondrial enzyme, mainly located in the liver, intestine, brain, and kidney. In general, OAT serves to form glutamate from ornithine, with the notable exception of the intestine, where citrulline (Cit) or arginine (Arg) are end products. Its main function is to control the production of signaling molecules and mediators, such as Glu itself, Cit, GABA, and aliphatic polyamines. It is also involved in proline (Pro) synthesis. Deficiency in OAT causes gyrate atrophy, a rare but serious inherited disease, a further measure of the importance of this enzyme.<\/jats:p>","DOI":"10.3390\/biology6010018","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T11:12:32Z","timestamp":1488885152000},"page":"18","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Ornithine Aminotransferase, an Important Glutamate-Metabolizing Enzyme at the Crossroads of Multiple Metabolic Pathways"],"prefix":"10.3390","volume":"6","author":[{"given":"Antonin","family":"Ginguay","sequence":"first","affiliation":[{"name":"Clinical Chemistry, Cochin Hospital, GH HUPC, AP-HP, 75014 Paris, France"},{"name":"Laboratory of Biological Nutrition, EA 4466 PRETRAM, Facult\u00e9 de Pharmacie, Universit\u00e9 Paris Descartes, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Cynober","sequence":"additional","affiliation":[{"name":"Clinical Chemistry, Cochin Hospital, GH HUPC, AP-HP, 75014 Paris, France"},{"name":"Laboratory of Biological Nutrition, EA 4466 PRETRAM, Facult\u00e9 de Pharmacie, Universit\u00e9 Paris Descartes, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8382-1493","authenticated-orcid":false,"given":"Emmanuel","family":"Curis","sequence":"additional","affiliation":[{"name":"Laboratoire de biomath\u00e9matiques, plateau iB\u00b2, Facult\u00e9 de Pharmacie, Universit\u00e9 Paris Descartes, 75006 Paris, France"},{"name":"UMR 1144, INSERM, Universit\u00e9 Paris Descartes, 75006 Paris, France"},{"name":"UMR 1144, Universit\u00e9 Paris Descartes, 75006 Paris, France"},{"name":"Service de biostatistiques et d\u2019informatique m\u00e9dicales, h\u00f4pital Saint-Louis, Assistance publique-h\u00f4pitaux de Paris, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7207-7689","authenticated-orcid":false,"given":"Ioannis","family":"Nicolis","sequence":"additional","affiliation":[{"name":"Laboratoire de biomath\u00e9matiques, plateau iB\u00b2, Facult\u00e9 de Pharmacie, Universit\u00e9 Paris Descartes, 75006 Paris, France"},{"name":"EA 4064 \"\u00c9pid\u00e9miologie environnementale: Impact sanitaire des pollutions\", Facult\u00e9 de Pharmacie, Universit\u00e9 Paris Descartes, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cynober, L.A. 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