{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:12:30Z","timestamp":1760238750042,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>It has also become increasingly necessary to diversify the production of cellulose for biomedical applications. In this study, cellulose-green-synthesized from Sesamum indicum (GSC)\u2014was administered orally to rats for 14 days as follows: control, 100, 200 and 400 mg\/kg GSC. The impact of GSC on the antioxidant status and histomorphology of the testes and epididymis were studied. GSC had no effects on organ weights and organosomatic indices. In the testes, GSC caused nonsignificant changes in superoxide dismutase, catalase, reduced glutathione and nitric oxide levels, whereas it significantly decreased glutathione peroxidase and malondialdehyde levels. In the epididymis, GSC significantly decreased superoxide dismutase and nitric oxide levels, but caused a significant increase in glutathione peroxidase and reduced glutathione levels. Furthermore, at \u00d7200 magnification, testicular morphology appeared normal at all doses, however, extravasation of the germinal epithelium of the epididymis was observed at doses of 200 and 400 mg\/kg GSC. Conversely, at \u00d7400 magnification, spermatogenic arrest (testes) and chromatolytic alterations (epididymis) were observed at the higher doses (200 and 400 mg\/kg GSC). This study reports on the effect of green-synthesized cellulose on testicular and epididymal histology and redox status and further extends the frontiers of research on cellulose.<\/jats:p>","DOI":"10.3390\/biology9090246","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T09:24:56Z","timestamp":1598347496000},"page":"246","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histomorphological and Redox Delineations in the Testis and Epididymis of Albino Rats Fed with Green-Synthesized Cellulose"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2393-1409","authenticated-orcid":false,"given":"Chiagoziem A.","family":"Otuechere","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Redeemer\u2019s University, Ede, Osun State 232102, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adewale","family":"Adewuyi","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, Redeemer\u2019s University, Ede, Osun State 232102, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3086-7919","authenticated-orcid":false,"given":"Olusegun L.","family":"Adebayo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Redeemer\u2019s University, Ede, Osun State 232102, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9482-7102","authenticated-orcid":false,"given":"Emmanuel","family":"Yawson","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Redeemer\u2019s University, Ede, Osun State 232102, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omolara","family":"Kabiawu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Redeemer\u2019s University, Ede, Osun State 232102, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Al-Rashed","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blessing","family":"Okubio","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Redeemer\u2019s University, Ede, Osun State 232102, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amany M.","family":"Beshbishy","sequence":"additional","affiliation":[{"name":"National Research Center for Protozoan Disease, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada-cho, Obihiro 080-8555, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-425X","authenticated-orcid":false,"given":"Gaber El-Saber","family":"Batiha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, AlBeheira 22511, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"ref_1","unstructured":"(2020, May 15). 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