{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:04:07Z","timestamp":1770275047306,"version":"3.49.0"},"reference-count":55,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,29]],"date-time":"2019-12-29T00:00:00Z","timestamp":1577577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872687,81872693"],"award-info":[{"award-number":["81872687,81872693"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Long noncoding RNAs (lncRNAs) widely participate in human diseases by regulating gene transcription, modulating protein function, or acting as ceRNAs. Yet, their roles in rheumatoid arthritis (RA) remain obscure. In this study, the expression of three lncRNAs (H19, GAS5, and linc0597) in peripheral blood mononuclear cells (PBMCs) were detected in 77 RA patients and 78 controls using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). The association of lncRNAs related gene polymorphisms with RA were evaluated in 828 RA patients and 780 controls using TaqMan single nucleotide polymorphism (SNP) genotyping assays. We observed that the expression levels of H19, GAS5 and linc0597 were down-regulated in PBMCs of RA patients, of which GAS5 level decreased in patients with hypocomplementemia, and negatively correlated with C-reactive protein (CRP) level in RA patients. Moreover, we highlighted two related potential functional SNPs, GAS5 rs6790 and linc0597 rs2680700 for associations with RA susceptibility. The precise roles of these lncRNAs in mechanism of RA remain to be further explored.<\/jats:p>","DOI":"10.3390\/biom10010055","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T05:49:41Z","timestamp":1577684981000},"page":"55","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Decreased H19, GAS5, and linc0597 Expression and Association Analysis of Related Gene Polymorphisms in Rheumatoid Arthritis"],"prefix":"10.3390","volume":"10","author":[{"given":"Jun","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China"},{"name":"Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China"},{"name":"Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Lan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China"},{"name":"Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-Zhu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China"},{"name":"Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2453-5865","authenticated-orcid":false,"given":"Rui-Xue","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China"},{"name":"Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Feng","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China"},{"name":"Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Qing","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China"},{"name":"Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0140-6736(10)60826-4","article-title":"Rheumatoid arthritis","volume":"376","author":"Scott","year":"2010","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/postgradmedj-2017-135441","article-title":"Association of interleukin-10 gene single nucleotide polymorphisms with rheumatoid arthritis in a Chinese population","volume":"94","author":"Zhang","year":"2018","journal-title":"Postgrad. Med. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/acr.23510","article-title":"Effectiveness of a Web-Based Personalized Rheumatoid Arthritis Risk Tool With or Without a Health Educator for Knowledge of Rheumatoid Arthritis Risk Factors","volume":"70","author":"Prado","year":"2018","journal-title":"Arthritis Care Res. (Hoboken)"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1086\/516736","article-title":"Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis","volume":"80","author":"Kallberg","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1111\/j.1532-5415.2010.02965.x","article-title":"Rheumatoid arthritis: A role for immunosenescence?","volume":"58","author":"Lindstrom","year":"2010","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1093\/rheumatology\/ket414","article-title":"Rheumatoid arthritis pathophysiology: Update on emerging cytokine and cytokine-associated cell targets","volume":"53","author":"Furst","year":"2014","journal-title":"Rheumatology (Oxf.)"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/jcp.26911","article-title":"Implications of the noncoding RNAs in rheumatoid arthritis pathogenesis","volume":"234","author":"Mousavi","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nature05874","article-title":"Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project","volume":"447","author":"Consortium","year":"2007","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"Consortium","year":"2012","journal-title":"Nature"},{"key":"ref_10","first-page":"5965","article-title":"Comprehensive analysis of long non-coding RNA and mRNA expression profiles in rheumatoid arthritis","volume":"14","author":"Luo","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nsmb.2480","article-title":"Structure and function of long noncoding RNAs in epigenetic regulation","volume":"20","author":"Mercer","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1073\/pnas.0811073106","article-title":"MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells","volume":"106","author":"Ceppi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1136\/annrheumdis-2012-202815","article-title":"Association of circulating miR-223 and miR-16 with disease activity in patients with early rheumatoid arthritis","volume":"73","author":"Aradi","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1002\/art.24475","article-title":"MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis","volume":"60","author":"Nakamachi","year":"2009","journal-title":"Arthritis Rheum."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"541786","DOI":"10.1100\/2012\/541786","article-title":"Molecular mechanisms and function prediction of long noncoding RNA","volume":"2012","author":"Ma","year":"2012","journal-title":"Sci. World J."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Wang, C., Wang, L., Ding, Y., Lu, X., Zhang, G., Yang, J., Zheng, H., Wang, H., Jiang, Y., and Xu, L. (2017). LncRNA Structural Characteristics in Epigenetic Regulation. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122659"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2010.06.040","article-title":"A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response","volume":"142","author":"Huarte","year":"2010","journal-title":"Cell"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/cdd.2013.110","article-title":"Negative regulation of lncRNA GAS5 by miR-21","volume":"20","author":"Zhang","year":"2013","journal-title":"Cell Death Differ."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","article-title":"A ceRNA hypothesis: The Rosetta Stone of a hidden RNA language?","volume":"146","author":"Salmena","year":"2011","journal-title":"Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08975","article-title":"Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis","volume":"464","author":"Gupta","year":"2010","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/os.12147","article-title":"Identification of long noncoding RNA associated with osteoarthritis in humans","volume":"6","author":"Xing","year":"2014","journal-title":"Orthop. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0002-9440(10)63450-5","article-title":"Detection of oncofetal h19 RNA in rheumatoid arthritis synovial tissue","volume":"163","author":"Kunisch","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13075-015-0632-3","article-title":"Association of large intergenic noncoding RNA expression with disease activity and organ damage in systemic lupus erythematosus","volume":"17","author":"Wu","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(88)91065-3","article-title":"Genes specifically expressed at growth arrest of mammalian cells","volume":"54","author":"Schneider","year":"1988","journal-title":"Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1055\/s-0042-106898","article-title":"Differential Expression of Glucocorticoid Receptor Noncoding RNA Repressor Gas5 in Autoimmune and Inflammatory Diseases","volume":"48","author":"Mayama","year":"2016","journal-title":"Horm. Metab. Res."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Moharamoghli, M., Hassan-Zadeh, V., Dolatshahi, E., Alizadeh, Z., and Farazmand, A. (2019). The expression of GAS5, THRIL, and RMRP lncRNAs is increased in T cells of patients with rheumatoid arthritis. Clin. Rheumatol.","DOI":"10.1007\/s10067-019-04694-z"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum."},{"key":"ref_28","first-page":"799","article-title":"Thresholds for the 28-joint disease activity score (DAS28) using C-reactive protein are lower compared to DAS28 using erythrocyte sedimentation rate in early rheumatoid arthritis","volume":"35","author":"Kuriya","year":"2017","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.trecan.2015.08.010","article-title":"Long noncoding RNAs in cancer: From function to translation","volume":"1","author":"Sahu","year":"2015","journal-title":"Trends Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s00109-012-0895-y","article-title":"Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions","volume":"90","author":"Steck","year":"2012","journal-title":"J. Mol. Med. (Berl.)"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10238-013-0271-4","article-title":"PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis","volume":"15","author":"Song","year":"2015","journal-title":"Clin. Exp. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"ra8","DOI":"10.1126\/scisignal.2000568","article-title":"Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor","volume":"3","author":"Kino","year":"2010","journal-title":"Sci. Signal."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"23650","DOI":"10.18632\/oncotarget.15569","article-title":"Identification of long non-coding RNAs GAS5, linc0597 and lnc-DC in plasma as novel biomarkers for systemic lupus erythematosus","volume":"8","author":"Wu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"848790","DOI":"10.1155\/2015\/848790","article-title":"The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases","volume":"2015","author":"Sigdel","year":"2015","journal-title":"J. Immunol. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13075-015-0563-z","article-title":"Role of C-reactive protein in osteoclastogenesis in rheumatoid arthritis","volume":"17","author":"Kim","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.3389\/fimmu.2018.01057","article-title":"Complement in the Initiation and Evolution of Rheumatoid Arthritis","volume":"9","author":"Holers","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1002\/art.10623","article-title":"Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double-blind, placebo-controlled, dose-escalation trial","volume":"46","author":"Choy","year":"2002","journal-title":"Arthritis Rheum."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1002\/art.20303","article-title":"Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebo-controlled trial","volume":"50","author":"Nishimoto","year":"2004","journal-title":"Arthritis Rheum."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1073\/pnas.1313768111","article-title":"The long noncoding RNA THRIL regulates TNFalpha expression through its interaction with hnRNPL","volume":"111","author":"Li","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.clinre.2018.01.006","article-title":"Polymorphism in the promoter region of lncRNA GAS5 is functionally associated with the risk of gastric cancer","volume":"42","author":"Li","year":"2018","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"62286","DOI":"10.18632\/oncotarget.19725","article-title":"Genetic polymorphisms of long non-coding RNA GAS5 predict platinum-based concurrent chemoradiotherapy response in nasopharyngeal carcinoma patients","volume":"8","author":"Guo","year":"2017","journal-title":"Oncotarget"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"91025","DOI":"10.18632\/oncotarget.19955","article-title":"Genetic variation of lncRNA GAS5 contributes to the development of lung cancer","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neulet.2019.02.028","article-title":"GAS5 genomic variants and risk of multiple sclerosis","volume":"701","author":"Noroozi","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.15252\/embr.201643668","article-title":"LncRNA GAS5 inhibits microglial M2 polarization and exacerbates demyelination","volume":"18","author":"Sun","year":"2017","journal-title":"EMBO Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.cell.2018.06.003","article-title":"Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus","volume":"174","author":"Gao","year":"2018","journal-title":"Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cell.2018.06.014","article-title":"Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19","volume":"174","author":"Hua","year":"2018","journal-title":"Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1007\/s10067-017-3833-0","article-title":"No association of single nucleotide polymorphisms within H19 and HOX transcript antisense RNA (HOTAIR) with genetic susceptibility to systemic lupus erythematosus, rheumatoid arthritis, and primary Sjogren\u2019s syndrome in a Chinese Han population","volume":"36","author":"Huang","year":"2017","journal-title":"Clin. Rheumatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00011-017-1035-5","article-title":"A study on associations of single-nucleotide polymorphisms within H19 and HOX transcript antisense RNA (HOTAIR) with genetic susceptibility to rheumatoid arthritis in a Chinese population","volume":"66","author":"Zhou","year":"2017","journal-title":"Inflamm. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s12026-015-8756-8","article-title":"Increased expression of long noncoding RNAs LOC100652951 and LOC100506036 in T cells from patients with rheumatoid arthritis facilitates the inflammatory responses","volume":"64","author":"Lu","year":"2016","journal-title":"Immunol. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1744-313X.2007.00664.x","article-title":"Variation in the matrix metalloproteinase-3, -7, -12 and -13 genes is associated with functional status in rheumatoid arthritis","volume":"34","author":"Ye","year":"2007","journal-title":"Int. J. Immunogenet."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1002\/art.38805","article-title":"Methotrexate inhibits NF-kappaB activity via long intergenic (noncoding) RNA-p21 induction","volume":"66","author":"Spurlock","year":"2014","journal-title":"Arthritis Rheumatol. (Hoboken NJ)"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/gene.2015.54","article-title":"A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels","volume":"17","author":"Messemaker","year":"2016","journal-title":"Genes Immun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cyto.2014.03.004","article-title":"Interleukin-6 and tumour necrosis factor-alpha differentially regulate lincRNA transcripts in cells of the innate immune system in vivo in human subjects with rheumatoid arthritis","volume":"68","author":"Doring","year":"2014","journal-title":"Cytokine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1093\/nar\/gks296","article-title":"Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs","volume":"40","author":"Moran","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.addr.2015.05.012","article-title":"Basic biology and therapeutic implications of lncRNA","volume":"87","author":"Khorkova","year":"2015","journal-title":"Adv. Drug. Deliv. Rev."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/10\/1\/55\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:46:31Z","timestamp":1760190391000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/10\/1\/55"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,29]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1]]}},"alternative-id":["biom10010055"],"URL":"https:\/\/doi.org\/10.3390\/biom10010055","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,29]]}}}