{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:21:13Z","timestamp":1790292073242,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:00:00Z","timestamp":1577923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31672069"],"award-info":[{"award-number":["31672069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903514"],"award-info":[{"award-number":["81903514"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&amp;D Program of China","award":["2018YFD0200500"],"award-info":[{"award-number":["2018YFD0200500"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The phytochemical investigation of Fraxinus hupehensis led to the isolation and characterization of ten compounds which were identified as fraxin (1), fraxetin (2), esculetin (3), cichoriin (4), euphorbetin (5), kaempferol-3-O-\u03b2-rutinoside (6), oleuropein (7), linoleic acid (8), methyl linoleate (9), and \u03b2-sitosterol (10). Structures of the isolated constituents were characterized by 1H NMR, 13C NMR and HRMS. All the compounds, except compounds 3 and 4, were isolated for the first time from this plant. Further, this was the first report for the occurrence of compound 5 in the Fraxinus species. Antifungal activity evaluation showed that compound 2 exhibited significant inhibitory effects against Bipolaris maydis, Sclerotium rolfsii, and Alternaria solani with EC50 values of 0.31 \u00b1 0.01 mmol\/L, 10.50 \u00b1 0.02 mmol\/L, and 0.40 \u00b1 0.02 mmol\/L respectively, compared to the positive control, Carbendazim, with its EC50 values of 0.74 \u00b1 0.01 mmol\/L, 1.78 \u00b1 0.01 mmol\/L and 1.41 \u00b1 0.00 mmol\/L. Herbicidal activity tests showed that compounds 8\u201310 had strong inhibitory effects against the roots of Echinochloa crus-galli with EC50 values of 1.16 \u00b1 0.23 mmol\/L, 1.28 \u00b1 0.58 mmol\/L and 1.33 \u00b1 0.35 mmol\/L respectively, more potently active than that of the positive control, Cyanazine, with its EC50 values of 1.56 \u00b1 0.44 mmol\/L. However, none of the compounds proved to be active against the tested bacteria (Erwinia carotovora, Pseudomonas syringae, and Ralstonia solanacearum).<\/jats:p>","DOI":"10.3390\/biom10010074","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T11:55:07Z","timestamp":1578052507000},"page":"74","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Chemical Constituents from Fraxinus hupehensis and Their Antifungal and Herbicidal Activities"],"prefix":"10.3390","volume":"10","author":[{"given":"Chi-Na","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Agriculture, Yangtze University, Jingzhou 434020, China"},{"name":"Institute of Pesticides, Yangtze University, Jingzhou 434020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zong-Li","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Agriculture, Yangtze University, Jingzhou 434020, China"},{"name":"Institute of Pesticides, Yangtze University, Jingzhou 434020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Agriculture, Yangtze University, Jingzhou 434020, China"},{"name":"Institute of Pesticides, Yangtze University, Jingzhou 434020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ke","sequence":"additional","affiliation":[{"name":"School of Agriculture, Yangtze University, Jingzhou 434020, China"},{"name":"Institute of Pesticides, Yangtze University, Jingzhou 434020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6209-7798","authenticated-orcid":false,"given":"Qing-Lai","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Agriculture, Yangtze University, Jingzhou 434020, China"},{"name":"Institute of Pesticides, Yangtze University, Jingzhou 434020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Kai","family":"Li","sequence":"additional","affiliation":[{"name":"School of Agriculture, Yangtze University, Jingzhou 434020, China"},{"name":"Institute of Pesticides, Yangtze University, Jingzhou 434020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Dong","family":"Zhou","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,2]]},"reference":[{"key":"ref_1","first-page":"146","article-title":"A new specie of the genus Fraxinus Linn. from Hubei province","volume":"21","author":"Qu","year":"1979","journal-title":"J. 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