{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:21:20Z","timestamp":1790709680000,"version":"4.1.0"},"reference-count":70,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Autour des Williams","award":["Elastin production stimulation"],"award-info":[{"award-number":["Elastin production stimulation"]}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["TELASTAR, 5th PCRD, No. QLK6-CT-2001-00332"],"award-info":[{"award-number":["TELASTAR, 5th PCRD, No. QLK6-CT-2001-00332"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["ELAST-AGE, 6th PCRD, No. LSHM-CT-2005-018960"],"award-info":[{"award-number":["ELAST-AGE, 6th PCRD, No. LSHM-CT-2005-018960"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["Arterylastic: ANR-18-CE18-0001"],"award-info":[{"award-number":["Arterylastic: ANR-18-CE18-0001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"R\u00e9gion Rh\u00f4ne-Alpes","award":["Fellowship to W.F."],"award-info":[{"award-number":["Fellowship to W.F."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Elastic fibers (90% elastin, 10% fibrillin-rich microfibrils) are synthesized only in early life and adolescence mainly by the vascular smooth muscle cells through the cross-linking of its soluble precursor, tropoelastin. Elastic fibers endow the large elastic arteries with resilience and elasticity. Normal vascular aging is associated with arterial remodeling and stiffening, especially due to the end of production and degradation of elastic fibers, leading to altered cardiovascular function. Several pharmacological treatments stimulate the production of elastin and elastic fibers. In particular, dill extract (DE) has been demonstrated to stimulate elastin production in vitro in dermal equivalent models and in skin fibroblasts to increase lysyl oxidase\u2013like-1 (LOXL-1) gene expression, an enzyme contributing to tropoelastin crosslinking and elastin formation. Here, we have investigated the effects of a chronic treatment (three months) of aged male mice with DE (5% or 10% v\/v, in drinking water) on the structure and function of the ascending aorta. DE treatment, especially at 10%, of aged mice protected pre-existing elastic lamellae, reactivated tropoelastin and LOXL-1 expressions, induced elastic fiber neo-synthesis, and decreased the stiffness of the aging aortic wall, probably explaining the reversal of the age-related cardiac hypertrophy also observed following the treatment. DE could thus be considered as an anti-aging product for the cardiovascular system.<\/jats:p>","DOI":"10.3390\/biom10020173","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T10:36:02Z","timestamp":1579775762000},"page":"173","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dill Extract Induces Elastic Fiber Neosynthesis and Functional Improvement in the Ascending Aorta of Aged Mice with Reversal of Age-Dependent Cardiac Hypertrophy and Involvement of Lysyl Oxidase-Like-1"],"prefix":"10.3390","volume":"10","author":[{"given":"Wassim","family":"Fhayli","sequence":"first","affiliation":[{"name":"Univ. Grenoble Alpes, Inserm, CHU Grenoble Alpes, HP2, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Bo\u00ebt\u00e9","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, Inserm, CHU Grenoble Alpes, HP2, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadjib","family":"Kihal","sequence":"additional","affiliation":[{"name":"Laboratoire de Phytochimie et de Pharmacologie, D\u00e9partement de Chimie, Universit\u00e9 de Jijel, Jijel 18000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Cenizo","sequence":"additional","affiliation":[{"name":"L\u2019Occitane en Provence, 04100 Manosque, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Sommer","sequence":"additional","affiliation":[{"name":"Institut de Biologie et Chimie des Prot\u00e9ines UMR5305\u2014LBTI, CNRS, 69367 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter A.","family":"Boyle","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Division, Washington University School of Medicine, St Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Paule","family":"Jacob","sequence":"additional","affiliation":[{"name":"INSERM, U1148, and Hopital Bichat-Claude Bernard, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Faury","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, Inserm, CHU Grenoble Alpes, HP2, 38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1007\/s10439-009-9724-z","article-title":"An experimental and theoretical study on the anisotropy of elastin network","volume":"37","author":"Zou","year":"2009","journal-title":"Ann. Biomed. Eng."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1017\/erm.2013.9","article-title":"Elastic fibres in health and disease","volume":"15","author":"Baldwin","year":"2013","journal-title":"Expert Rev. Mol. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1051\/jbio\/2012009","article-title":"Elastin and microfibrils in vascular development and ageing: Complementary or opposite roles?","volume":"206","author":"Fhayli","year":"2012","journal-title":"Biol. 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