{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:05:18Z","timestamp":1790805918793,"version":"4.1.0"},"reference-count":134,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Components of the extracellular matrix (ECM) are key players in regulating cellular functions throughout the whole organism. In fact, ECM components not only participate in tissue organization but also contribute to processes such as cellular maintenance, proliferation, and migration, as well as to support for various signaling pathways. In the central nervous system (CNS), proteoglycans of the lectican family, such as versican, aggrecan, brevican, and neurocan, are important constituents of the ECM. In recent years, members of this family have been found to be involved in the maintenance of CNS homeostasis and to participate directly in processes such as the organization of perineural nets, the regulation of brain plasticity, CNS development, brain injury repair, axonal guidance, and even the altering of synaptic responses. ADAMTSs are a family of \u201cA disintegrin and metalloproteinase with thrombospondin motifs\u201d proteins that have been found to be involved in a multitude of processes through the degradation of lecticans and other proteoglycans. Recently, alterations in ADAMTS expression and activity have been found to be involved in neuronal disorders such as stroke, neurodegeneration, schizophrenia, and even Alzheimer\u2019s disease, which in turn may suggest their potential use as therapeutic targets. Herein, we summarize the different roles of ADAMTSs in regulating CNS events through interactions and the degradation of ECM components (more specifically, the lectican family of proteoglycans).<\/jats:p>","DOI":"10.3390\/biom10030403","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T07:33:46Z","timestamp":1583480026000},"page":"403","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["New Insights into ADAMTS Metalloproteases in the Central Nervous System"],"prefix":"10.3390","volume":"10","author":[{"given":"Yamina","family":"Mohamedi","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain"},{"name":"Departamento de Biolog\u00eda Funcional, \u00c1rea de Fisiolog\u00eda, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain"},{"name":"Instituto Universitario de Oncolog\u00eda, IUOPA, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Fontanil","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain"},{"name":"Departamento de Biolog\u00eda Funcional, \u00c1rea de Fisiolog\u00eda, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain"},{"name":"Instituto Universitario de Oncolog\u00eda, IUOPA, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain"},{"name":"Departamento de Investigaci\u00f3n, Instituto Ord\u00f3\u00f1ez, 33012 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Cobo","sequence":"additional","affiliation":[{"name":"Departamento de Cirug\u00eda y Especialidades M\u00e9dico-Quir\u00fargicas, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain"},{"name":"Instituto Asturiano de Odontolog\u00eda, 33006 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Cal","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain"},{"name":"Instituto Universitario de Oncolog\u00eda, IUOPA, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro J.","family":"Obaya","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Funcional, \u00c1rea de Fisiolog\u00eda, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain"},{"name":"Instituto Universitario de Oncolog\u00eda, IUOPA, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat. 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