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Medicinal plants hold great promise as a source of effective treatments, including anthelmintic therapy. They have been used traditionally for centuries and are mostly safe (if not, their toxicity is well-known). However, in most medicinal plants the compounds active against nematodes have not been identified thus far. The free-living nematode C. elegans was demonstrated to be an excellent model system for the discovery of new anthelmintics and for characterizing their mechanism of action or resistance. The compounds discussed in this review are of botanical origin and were published since 2002. Most of them need further studies of their toxicity, mechanisms and structure-activity relationship to assess more fully their potential as drugs.<\/jats:p>","DOI":"10.3390\/biom10030426","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T11:59:36Z","timestamp":1583841576000},"page":"426","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes"],"prefix":"10.3390","volume":"10","author":[{"given":"Maoxuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Biology, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3123-1218","authenticated-orcid":false,"given":"Sujogya Kumar","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Biology, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Luyten","sequence":"additional","affiliation":[{"name":"Department of Biology, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1186\/s13071-019-3828-6","article-title":"Multiple drug resistance in the canine hookworm Ancylostoma caninum: An emerging threat?","volume":"12","author":"Howell","year":"2019","journal-title":"Parasites Vectors"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.vetpar.2009.07.044","article-title":"Prevalence of intestinal parasites in pet dogs in the United States","volume":"166","author":"Little","year":"2009","journal-title":"Vet. 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