{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:17:06Z","timestamp":1790623026949,"version":"4.1.0"},"reference-count":109,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Council of Science and Technology (Korea Government)","award":["CCL-19-17-KRIBB"],"award-info":[{"award-number":["CCL-19-17-KRIBB"]}]},{"name":"Marie Sklodowska Curie Initial Training Network","award":["TRACT (TRAining in Cancer mechanisms and Treatment)"],"award-info":[{"award-number":["TRACT (TRAining in Cancer mechanisms and Treatment)"]}]},{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"publisher","award":["Creative-pioneering researchers program"],"award-info":[{"award-number":["Creative-pioneering researchers program"]}],"id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research Foundation (Korea Government)","award":["2019R1C1C1009685"],"award-info":[{"award-number":["2019R1C1C1009685"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Elucidating the structural details of proteins is highly valuable and important for the proper understanding of protein function. In the case of intrinsically disordered proteins (IDPs), however, obtaining the structural details is quite challenging, as the traditional structural biology tools have only limited use. Nuclear magnetic resonance (NMR) is a unique experimental tool that provides ensemble conformations of IDPs at atomic resolution, and when studying IDPs, a slightly different experimental strategy needs to be employed than the one used for globular proteins. We address this point by reviewing many NMR investigations carried out on the \u03b1-synuclein protein, the aggregation of which is strongly correlated with Parkinson\u2019s disease.<\/jats:p>","DOI":"10.3390\/biom10030428","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T11:59:36Z","timestamp":1583841576000},"page":"428","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Salient Features of Monomeric Alpha-Synuclein Revealed by NMR Spectroscopy"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8633-8728","authenticated-orcid":false,"given":"Do-Hyoung","family":"Kim","sequence":"first","affiliation":[{"name":"Core Facility Management Center, Division of KRIBB Strategic Projects, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongchan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3663-2002","authenticated-orcid":false,"given":"K.","family":"Mok","sequence":"additional","affiliation":[{"name":"Trinity Biomedical Sciences Institute (TBSI), School of Biochemistry &amp; Immunology, Trinity College Dublin, The University of Dublin, Dublin 2, Ireland"},{"name":"Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Dublin 2, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Seoul National University, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8829-6157","authenticated-orcid":false,"given":"Kyou-Hoon","family":"Han","sequence":"additional","affiliation":[{"name":"Genome Editing Research Center, Division of Biomedical Sciences, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1523\/JNEUROSCI.08-08-02804.1988","article-title":"Synuclein: A neuron-specific protein localized to the nucleus and presynaptic nerve terminal","volume":"8","author":"Maroteaux","year":"1988","journal-title":"J. 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