{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T08:43:10Z","timestamp":1792312990838,"version":"4.4.0"},"reference-count":78,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:00:00Z","timestamp":1586476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cantro Studi Termali Pietro D'Abano","award":["LA_R_EPPR18_01"],"award-info":[{"award-number":["LA_R_EPPR18_01"]}]},{"name":"Centro Studi Termali Pietro D\u2019Abano","award":["DALL_EPPR18_01"],"award-info":[{"award-number":["DALL_EPPR18_01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The Euganean Thermal District (Italy) represents the oldest and largest thermal center in Europe, and its therapeutic mud is considered a unique product whose beneficial effects have been documented since Ancient Roman times. Mud properties depend on the heat and electrolytes of the thermal water, as well as on the bioactive molecules produced by its biotic component, mainly represented by cyanobacteria. The investigation of the healing effects of compounds produced by the Euganean cyanobacteria represents an important goal for scientific validation of Euganean mud therapies and for the discovering of new health beneficial biomolecules. In this work, we evaluated the therapeutic potential of exopolysaccharides (EPS) produced by Phormidium sp. ETS05, the most abundant cyanobacterium of the Euganean mud. Specifically, Phormidium EPS resulted in exerting anti-inflammatory and pro-resolution activities in chemical and injury-induced zebrafish inflammation models as demonstrated using specific transgenic zebrafish lines and morphometric and expression analyses. Moreover, in vivo and in vitro tests showed no toxicity at all for the EPS concentrations tested. The results suggest that these EPS, with their combined anti-inflammatory and pro-resolution activities, could be one of the most important therapeutic molecules present in the Euganean mud and confirm the potential of these treatments for chronic inflammatory disease recovery.<\/jats:p>","DOI":"10.3390\/biom10040582","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T05:31:16Z","timestamp":1586496676000},"page":"582","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Anti-Inflammatory Activity of Exopolysaccharides from Phormidium sp. ETS05, the Most Abundant Cyanobacterium of the Therapeutic Euganean Thermal Muds, Using the Zebrafish Model"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4245-8699","authenticated-orcid":false,"given":"Raffaella Margherita","family":"Zampieri","sequence":"first","affiliation":[{"name":"Department of Biology, University of Padova, Via U. Bassi 58\/b, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6144-644X","authenticated-orcid":false,"given":"Alessandra","family":"Adessi","sequence":"additional","affiliation":[{"name":"Department of Agriculture, Food, Environment and Forestry (DAGRI), University of Florence, Via Maragliano 77, 50144 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Caldara","sequence":"additional","affiliation":[{"name":"Pietro d\u2019Abano Thermal Studies Center, Via Jappelli 5, Abano Terme, 35031 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Codato","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Padova, Via U. Bassi 58\/b, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Furlan","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Padova, Via U. Bassi 58\/b, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Rampazzo","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Padova, Via U. Bassi 58\/b, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7398-3536","authenticated-orcid":false,"given":"Roberto","family":"De Philippis","sequence":"additional","affiliation":[{"name":"Department of Agriculture, Food, Environment and Forestry (DAGRI), University of Florence, Via Maragliano 77, 50144 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4866-5952","authenticated-orcid":false,"given":"Nicoletta","family":"La Rocca","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Padova, Via U. Bassi 58\/b, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8097-6369","authenticated-orcid":false,"given":"Luisa","family":"Dalla Valle","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Padova, Via U. Bassi 58\/b, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,10]]},"reference":[{"key":"ref_1","unstructured":"BUR (2015). Regolamento d\u2019Uso del Marchio Collettivo d\u2019Origine Fango D.O.C.\u2014Thermae Abano Montegrotto\u2014Regione Veneto, Bollettino Ufficiale Regione del Veneto. venerd\u00ec 27 marzo 2015. Anno XLVI\u2013N. 30."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/iroh.19750600606","article-title":"The Algal Flora in the Thermal Baths of Montegrotto Terme (Padua). Its Distribution Over One-Year Period","volume":"60","author":"Andreoli","year":"1975","journal-title":"Int. Rev. 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