{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:58:29Z","timestamp":1781765909569,"version":"3.54.5"},"reference-count":22,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Age-related macular degeneration (AMD) is one of the leading causes of visual loss in western countries, it has no cure, and its incidence will grow in the future, for the overall population aging. Albino rats with retinal degeneration induced by exposure to high-intensity light (light-damage, LD) have been extensively used as a model of AMD to test neuroprotective agents. Among them, trophic factors (NGF and BDNF) have been shown to play a significant role in photoreceptors\u2019 survival. Interestingly, cord blood serum (CBS) is an extract full of chemokines and trophic factors; we, therefore, hypothesized that CBS could be an excellent candidate for neuroprotection. Here, we investigate whether CBS-based eye drops might mitigate the effects of light-induced retinal degeneration in albino rats. CBS treatment significantly preserved flash-electroretinogram (f-ERG) response after LD and reduced the \u201chot-spot\u201d extension. Besides, CBS-treated animals better preserved the morphology of the outer nuclear layer, together with a reduction in microglia migration and activation. Interestingly, the treatment did not modulate reactive gliosis and activation of the self-protective mechanism (FGF2). In conclusion, our results suggest that CBS-based eye drops might be successfully used to mitigate retinal neurodegenerative processes such as AMD.<\/jats:p>","DOI":"10.3390\/biom10050678","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T10:30:58Z","timestamp":1588069858000},"page":"678","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cord Blood Serum (CBS)-Based Eye Drops Modulate Light-Induced Neurodegeneration in Albino Rat Retinas"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4847-6270","authenticated-orcid":false,"given":"Stefano","family":"Di Marco","sequence":"first","affiliation":[{"name":"Department of Applied Clinical Science and Biotechnology, University of L\u2019Aquila, Via Vetoio, Coppito II, 67100 L\u2019Aquila, Italy"},{"name":"Istituto Nazionale di Biostrutture e Biosistemi (INBB), Via Medaglie d\u2019Oro 305, 00136 Roma, Italy"},{"name":"Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi, 16132 Genova, Italy"},{"name":"IRCCS, Ospedale Policlinico San Martino, Largo Rosanna Benzi, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4369-4586","authenticated-orcid":false,"given":"Serena","family":"Riccitelli","sequence":"additional","affiliation":[{"name":"Department of Applied Clinical Science and Biotechnology, University of L\u2019Aquila, Via Vetoio, Coppito II, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Di Paolo","sequence":"additional","affiliation":[{"name":"Department of Applied Clinical Science and Biotechnology, University of L\u2019Aquila, Via Vetoio, Coppito II, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Campos","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, University of Bologna and S. Orsola-Malpighi Teaching Hospital, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Buzzi","sequence":"additional","affiliation":[{"name":"Emilia Romagna, Cord Blood Bank-Transfusion Service, S. Orsola-Malpighi Teaching Hospital, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bisti","sequence":"additional","affiliation":[{"name":"Department of Applied Clinical Science and Biotechnology, University of L\u2019Aquila, Via Vetoio, Coppito II, 67100 L\u2019Aquila, Italy"},{"name":"Istituto Nazionale di Biostrutture e Biosistemi (INBB), Via Medaglie d\u2019Oro 305, 00136 Roma, Italy"},{"name":"NetS3 Laboratory, Istituto Italiano di Tecnologia, Via Morego, 30, 16163 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera","family":"Versura","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, University of Bologna and S. Orsola-Malpighi Teaching Hospital, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0896-6273(93)90072-Y","article-title":"Apoptosis: Final common pathway of photoreceptor death in rd, rds, and mutant mice","volume":"11","author":"Chang","year":"1993","journal-title":"Neuron"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.preteyeres.2009.11.004","article-title":"Retinal light damage: Mechanisms and protection","volume":"29","author":"Organisciak","year":"2010","journal-title":"Prog. Retin. 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