{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:32:09Z","timestamp":1790620329696,"version":"4.1.0"},"reference-count":100,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grants from the Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq), Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES), Funda\u00e7\u00e3o de Apoio a Pesquisa do Estado de Santa Catarina (FAPESC), Programa INCT-INOVAMED","award":["Grant no. 465430\/2014-7"],"award-info":[{"award-number":["Grant no. 465430\/2014-7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Depression has a multifactorial etiology that arises from environmental, psychological, genetic, and biological factors. Environmental stress and genetic factors acting through immunological and endocrine responses generate structural and functional changes in the brain, inducing neurogenesis and neurotransmission dysfunction. Terpineol, monoterpenoid alcohol, has shown immunomodulatory and neuroprotective effects, but there is no report about its antidepressant potential. Herein, we used a single lipopolysaccharide (LPS) injection to induce a depressive-like effect in the tail suspension test (TST) and the splash test (ST) for a preventive and therapeutic experimental schedule. Furthermore, we investigated the antidepressant-like mechanism of action of terpineol while using molecular and pharmacological approaches. Terpineol showed a coherent predicted binding mode mainly against CB1 and CB2 receptors and also against the D2 receptor during docking modeling analyses. The acute administration of terpineol produced the antidepressant-like effect, since it significantly reduced the immobility time in TST (100\u2013200 mg\/kg, p.o.) as compared to the control group. Moreover, terpineol showed an antidepressant-like effect in the preventive treatment that was blocked by a nonselective dopaminergic receptor antagonist (haloperidol), a selective dopamine D2 receptor antagonist (sulpiride), a selective CB1 cannabinoid receptor antagonist\/inverse agonist (AM281), and a potent and selective CB2 cannabinoid receptor inverse agonist (AM630), but it was not blocked by a nonselective adenosine receptor antagonist (caffeine) or a \u03b2-adrenoceptor antagonist (propranolol). In summary, molecular docking suggests that CB1 and CB2 receptors are the most promising targets of terpineol action. Our data showed terpineol antidepressant-like modulation by CB1 and CB2 cannabinoid receptors and D2-dopaminergic receptors to further corroborate our molecular evidence.<\/jats:p>","DOI":"10.3390\/biom10050792","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T10:37:38Z","timestamp":1589971058000},"page":"792","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Antidepressant-Like Effect of Terpineol in an Inflammatory Model of Depression: Involvement of the Cannabinoid System and D2 Dopamine Receptor"],"prefix":"10.3390","volume":"10","author":[{"given":"Graziela","family":"Vieira","sequence":"first","affiliation":[{"name":"Laboratory of Autoimmunity and Immunopharmacology (LAIF), Department of Health Sciences, Campus Ararangu\u00e1, Universidade Federal de Santa Catarina, Ararangu\u00e1 88906-072, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Cavalli","sequence":"additional","affiliation":[{"name":"Laboratory of Autoimmunity and Immunopharmacology (LAIF), Department of Health Sciences, Campus Ararangu\u00e1, Universidade Federal de Santa Catarina, Ararangu\u00e1 88906-072, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine C. D.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Laboratory of Autoimmunity and Immunopharmacology (LAIF), Department of Health Sciences, Campus Ararangu\u00e1, Universidade Federal de Santa Catarina, Ararangu\u00e1 88906-072, Brazil"},{"name":"Post-Graduate Program of Neuroscience, Center of Biological Science, Campus Florian\u00f3polis, Universidade Federal de Santa Catarina, Florian\u00f3polis 88040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo F. P.","family":"Braga","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Modelagem Molecular e Planejamento de F\u00e1rmacos, Departamento de Bioqu\u00edmica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela S.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Modelagem Molecular e Planejamento de F\u00e1rmacos, Departamento de Bioqu\u00edmica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adair R. S.","family":"Santos","sequence":"additional","affiliation":[{"name":"Post-Graduate Program of Neuroscience, Center of Biological Science, Campus Florian\u00f3polis, Universidade Federal de Santa Catarina, Florian\u00f3polis 88040-900, Brazil"},{"name":"Laboratory of Neurobiology of Pain and Inflammation, Department of Physiological Sciences, Center of Biological Sciences, Universidade Federal de Santa Catarina, Florian\u00f3polis 88040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00edra","family":"Cola","sequence":"additional","affiliation":[{"name":"Laboratory of Autoimmunity and Immunopharmacology (LAIF), Department of Health Sciences, Campus Ararangu\u00e1, Universidade Federal de Santa Catarina, Ararangu\u00e1 88906-072, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1dia R. B.","family":"Raposo","sequence":"additional","affiliation":[{"name":"Center for Research and Innovation in Health Sciences (NUPICS), Faculty of Pharmacy, Universidade Federal de Juiz de Fora, Juiz de For a 36036-330, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-1822","authenticated-orcid":false,"given":"Raffaele","family":"Capasso","sequence":"additional","affiliation":[{"name":"Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy"},{"name":"Endocannabinoid Research Group, 80078 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6938-2161","authenticated-orcid":false,"given":"Rafael C.","family":"Dutra","sequence":"additional","affiliation":[{"name":"Laboratory of Autoimmunity and Immunopharmacology (LAIF), Department of Health Sciences, Campus Ararangu\u00e1, Universidade Federal de Santa Catarina, Ararangu\u00e1 88906-072, Brazil"},{"name":"Post-Graduate Program of Neuroscience, Center of Biological Science, Campus Florian\u00f3polis, Universidade Federal de Santa Catarina, Florian\u00f3polis 88040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s11121-011-0231-8","article-title":"The Public Health Impact of Major Depression: A Call for Interdisciplinary Prevention Efforts","volume":"12","author":"McLaughlin","year":"2011","journal-title":"Prev. 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