{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:53:40Z","timestamp":1760237620534,"version":"build-2065373602"},"reference-count":86,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T00:00:00Z","timestamp":1590796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Kidney transplantation is a well-established therapy for patients with end-stage renal disease. While a significant improvement of short-term results has been achieved in the short-term, similar results were not reported in the long-term. Heme-oxygenase (HO) is the rate-limiting enzyme in heme catabolism, converting heme to iron, carbon monoxide, and biliverdin. Heme-oxygenase overexpression may be observed in all phases of transplant processes, including brain death, recipient management, and acute and chronic rejection. HO induction has been proved to provide a significant reduction of inflammatory response and a reduction of ischemia and reperfusion injury in organ transplantation, as well as providing a reduction of incidence of acute rejection. In this review, we will summarize data on HO and kidney transplantation, suggesting possible clinical applications in the near future to improve the long-term outcomes.<\/jats:p>","DOI":"10.3390\/biom10060840","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T09:19:27Z","timestamp":1591089567000},"page":"840","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy?"],"prefix":"10.3390","volume":"10","author":[{"given":"Daniela","family":"Corona","sequence":"first","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"},{"name":"Organ Transplant Unit, University Hospital of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0741-8007","authenticated-orcid":false,"given":"Burcin","family":"Ekser","sequence":"additional","affiliation":[{"name":"Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46077, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3608-6187","authenticated-orcid":false,"given":"Rossella","family":"Gioco","sequence":"additional","affiliation":[{"name":"General Surgery Unit, University Hospital of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4412-2080","authenticated-orcid":false,"given":"Massimo","family":"Caruso","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3322-8349","authenticated-orcid":false,"given":"Chiara","family":"Schipa","sequence":"additional","affiliation":[{"name":"General Surgery Unit, University Hospital of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4965-7137","authenticated-orcid":false,"given":"Pierfrancesco","family":"Veroux","sequence":"additional","affiliation":[{"name":"Organ Transplant Unit, University Hospital of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Giaquinta","sequence":"additional","affiliation":[{"name":"Organ Transplant Unit, University Hospital of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Granata","sequence":"additional","affiliation":[{"name":"Nephrology Unit, Cannizzaro Hospital, 95026 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2780-6421","authenticated-orcid":false,"given":"Massimiliano","family":"Veroux","sequence":"additional","affiliation":[{"name":"Organ Transplant Unit, University Hospital of Catania, 95123 Catania, Italy"},{"name":"General Surgery Unit, University Hospital of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,30]]},"reference":[{"key":"ref_1","first-page":"75","article-title":"Kidney transplantation: Future challenges","volume":"64","author":"Veroux","year":"2009","journal-title":"Minerva Chir."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1046\/j.1523-1755.2002.00424.x","article-title":"Post-transplant renal function in the first year predicts long-term kidney transplant survival","volume":"62","author":"Hariharan","year":"2002","journal-title":"Kidney Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/TP.0000000000002275","article-title":"Association Between Duration of Delayed Graft Function, Acute Rejection, and Allograft Outcome After Deceased Donor Kidney Transplantation","volume":"103","author":"Lim","year":"2019","journal-title":"Transplantation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.5527\/wjn.v1.i1.4","article-title":"Cytoprotection behind heme oxygenase-1 in renal diseases","volume":"1","author":"Amano","year":"2012","journal-title":"World J. 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