{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:03:28Z","timestamp":1792271008864,"version":"4.4.0"},"reference-count":210,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Spice plants have a great influence on world history. For centuries, different civilizations have used them to condiment the foods of kings and nobles and applied them as embalming preservatives, perfumes, cosmetics, and medicines in different regions of the world. In general, these plants have formed the basis of traditional medicine and some of their derived substances have been utilized to treat different human diseases. Essential oils (EOs) obtained from these plants have been also used as therapeutic agents and have shown supportive uses in remedial practices. The discovery and development of bioactive compounds from these natural products, based on their traditional uses, play an important role in developing the scientific evidence of their potential pharmaceutical, cosmetic, and food applications. In the present review, using recent studies, we exhibit a general overview of the main aspects related to the importance of spice plants widely used in traditional medicine: Cinnamomum zeylanicum (true cinnamon), Mentha piperita (peppermint), Ocimum basilicum (basil), Origanum vulgare (oregano), Piper nigrum (black pepper), Rosmarinus officinalis (rosemary), and Thymus vulgaris (thyme); and we discuss new findings of the bioactive compounds obtained from their EOs, their potential applications, as well as their molecular mechanisms of action, focusing on their antioxidant activity. We also exhibit the main in vitro methods applied to determine the antioxidant activities of these natural products.<\/jats:p>","DOI":"10.3390\/biom10070988","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T05:00:08Z","timestamp":1593666008000},"page":"988","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":414,"title":["Bioactive Natural Compounds and Antioxidant Activity of Essential Oils from Spice Plants: New Findings and Potential Applications"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1370-4472","authenticated-orcid":false,"given":"Lidiane","family":"Diniz do Nascimento","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Engenharia de Recursos Naturais da Amaz\u00f4nia, Instituto de Tecnologia, Universidade Federal do Par\u00e1, Bel\u00e9m 66075110, Brazil"},{"name":"Laborat\u00f3rio Adolpho Ducke, Coordena\u00e7\u00e3o de Bot\u00e2nica, Museu Paraense Em\u00edlio Goeldi, Bel\u00e9m 66077-830, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4586-8308","authenticated-orcid":false,"given":"Angelo Ant\u00f4nio Barbosa de","family":"Moraes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Adolpho Ducke, Coordena\u00e7\u00e3o de Bot\u00e2nica, Museu Paraense Em\u00edlio Goeldi, Bel\u00e9m 66077-830, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2735-8016","authenticated-orcid":false,"given":"Kau\u00ea Santana da","family":"Costa","sequence":"additional","affiliation":[{"name":"Instituto de Biodiversidade, Universidade Federal do Oeste do Par\u00e1, Vera Paz Street, w\/n Sal\u00e9, Santar\u00e9m 68040-255, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Marcos","family":"Pereira Gal\u00facio","sequence":"additional","affiliation":[{"name":"Instituto de Biodiversidade, Universidade Federal do Oeste do Par\u00e1, Vera Paz Street, w\/n Sal\u00e9, Santar\u00e9m 68040-255, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo S\u00e9rgio","family":"Taube","sequence":"additional","affiliation":[{"name":"Instituto de Biodiversidade, Universidade Federal do Oeste do Par\u00e1, Vera Paz Street, w\/n Sal\u00e9, Santar\u00e9m 68040-255, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane Maria Leal","family":"Costa","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Engenharia Qu\u00edmica, Instituto de Tecnologia, Universidade Federal do Par\u00e1, Bel\u00e9m 66075110, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0529-3714","authenticated-orcid":false,"given":"Jorddy","family":"Neves Cruz","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Adolpho Ducke, Coordena\u00e7\u00e3o de Bot\u00e2nica, Museu Paraense Em\u00edlio Goeldi, Bel\u00e9m 66077-830, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloisa Helena","family":"de Aguiar Andrade","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Adolpho Ducke, Coordena\u00e7\u00e3o de Bot\u00e2nica, Museu Paraense Em\u00edlio Goeldi, Bel\u00e9m 66077-830, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00eanio Jos\u00e9 Guerreiro de","family":"Faria","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Engenharia de Recursos Naturais da Amaz\u00f4nia, Instituto de Tecnologia, Universidade Federal do Par\u00e1, Bel\u00e9m 66075110, Brazil"},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Engenharia Qu\u00edmica, Instituto de Tecnologia, Universidade Federal do Par\u00e1, Bel\u00e9m 66075110, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Freedman, P. 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