{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:44:09Z","timestamp":1790711049807,"version":"4.1.0"},"reference-count":77,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Objective: Type 2 diabetes (T2D) occurs by deterioration in pancreatic \u03b2-cell function and\/or progressive loss of pancreatic \u03b2-cell mass under the context of insulin resistance. \u03b17 nicotinic acetylcholine receptor (nAChR) may contribute to insulin sensitivity but its role in the pathogenesis of T2D remains undefined. We investigated whether the systemic lack of \u03b17 nAChR was sufficient to impair glucose homeostasis. Methods: We used an \u03b17 nAChR knock-out (\u03b17\u2212\/\u2212) mouse model fed a standard chow diet. The effects of the lack of \u03b17 nAChR on islet mass, insulin secretion, glucose and insulin tolerance, body composition, and food behaviour were assessed in vivo and ex vivo experiments. Results: Young \u03b17\u2212\/\u2212 mice display a chronic mild high glycemia combined with an impaired glucose tolerance and a marked deficit in \u03b2-cell mass. In addition to these metabolic disorders, old mice developed adipose tissue inflammation, elevated plasma free fatty acid concentrations and presented glycolytic muscle insulin resistance in old mice. Finally, \u03b17\u2212\/\u2212 mice, fed a chow diet, exhibited a late-onset excessive gain in body weight through increased fat mass associated with higher food intake. Conclusion: Our work highlights the important role of \u03b17 nAChR in glucose homeostasis. The constitutive lack of \u03b17 nAChR suggests a novel pathway influencing the pathogenesis of T2D.<\/jats:p>","DOI":"10.3390\/biom10071057","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T10:59:38Z","timestamp":1595242778000},"page":"1057","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Constitutive Lack of \u03b17 Nicotinic Receptor Leads to Metabolic Disorders in Mouse"],"prefix":"10.3390","volume":"10","author":[{"given":"Blandine","family":"Gausser\u00e8s","sequence":"first","affiliation":[{"name":"Biology and Pathology of the Endocrine Pancreas, Universit\u00e9 de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3763-730X","authenticated-orcid":false,"given":"Junjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Biology and Pathology of the Endocrine Pancreas, Universit\u00e9 de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewout","family":"Foppen","sequence":"additional","affiliation":[{"name":"Regulation of Glycemia by Central Nervous System, Universit\u00e9 de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Tourrel-Cuzin","sequence":"additional","affiliation":[{"name":"Biology and Pathology of the Endocrine Pancreas, Universit\u00e9 de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6002-2779","authenticated-orcid":false,"given":"Ana","family":"Rodriguez Sanchez-Archidona","sequence":"additional","affiliation":[{"name":"Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Delangre","sequence":"additional","affiliation":[{"name":"Biology and Pathology of the Endocrine Pancreas, Universit\u00e9 de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2562-5360","authenticated-orcid":false,"given":"C\u00e9line","family":"Cruciani-Guglielmacci","sequence":"additional","affiliation":[{"name":"Regulation of Glycemia by Central Nervous System, Universit\u00e9 de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Pons","sequence":"additional","affiliation":[{"name":"Institut Pasteur, UMR 3571, CNRS, Department of Neuroscience, Integrative Neurobiology of Cholinergic Systems, CEDEX 15, 75724 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Maskos","sequence":"additional","affiliation":[{"name":"Institut Pasteur, UMR 3571, CNRS, Department of Neuroscience, Integrative Neurobiology of Cholinergic Systems, CEDEX 15, 75724 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Thorens","sequence":"additional","affiliation":[{"name":"Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7044-2571","authenticated-orcid":false,"given":"Christophe","family":"Magnan","sequence":"additional","affiliation":[{"name":"Regulation of Glycemia by Central Nervous System, Universit\u00e9 de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamileh","family":"Movassat","sequence":"additional","affiliation":[{"name":"Biology and Pathology of the Endocrine Pancreas, Universit\u00e9 de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5723-6338","authenticated-orcid":false,"given":"Kamel","family":"Maouche","sequence":"additional","affiliation":[{"name":"Biology and Pathology of the Endocrine Pancreas, Universit\u00e9 de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diabres.2013.11.002","article-title":"Global estimates of diabetes prevalence for 2013 and projections for 2035","volume":"103","author":"Guariguata","year":"2014","journal-title":"Diabetes Res. 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