{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:33:31Z","timestamp":1787027611636,"version":"build-2736575974"},"reference-count":152,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Scientific Research at King Saud University","award":["RG-1436-004"],"award-info":[{"award-number":["RG-1436-004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>This study was designed to assess the nephroprotective effects of Pleurotus ostreatus and Agaricus bisporus aqueous extracts and carvedilol on hyperoxaluria-induced urolithiasis and to scrutinize the possible roles of NF-\u03baB, p53, Bcl-2, Bax and Bak. Phytochemical screening and GC-MS analysis of mushrooms\u2019 aqueous extracts were also performed and revealed the presence of multiple antioxidant and anti-inflammatory components. Hyperoxaluria was induced in Wistar rats through the addition of 0.75% (v\/v) ethylene glycol in drinking water for nine weeks. The ethylene glycol-administered rats were orally treated with Pleurotus ostreatus and Agaricus bisporus aqueous extracts (100 mg\/kg) and carvedilol (30 mg\/kg) daily during the last seven weeks. The study showed that Pleurotus ostreatus, Agaricus bisporus and carvedilol all successfully inhibited ethylene glycol-induced histological perturbations and the elevation of serum creatinine, serum urea, serum and urinary uric acid, serum, urinary and kidney oxalate, urine specific gravity, kidney calcium, kidney NF-\u03baB, NF-\u03baB p65, NF-\u03baB p50, p53, Bax and Bak expressions as well as serum TNF-\u03b1 and IL-1\u03b2 levels. Moreover, the treatment decreased the reduction in urinary creatinine, urinary urea, ratios of urinary creatinine to serum creatinine and urinary urea to serum urea, Fex Urea and Bcl-2 expression in kidney. In conclusion, although Pleurotus ostreatus and Agaricus bisporus extracts and carvedilol all significantly inhibited the progression of nephrolithiasis and showed nephroprotective effects against ethylene glycol-induced kidney dysfunction, Pleurotus ostreatus and Agaricus bisporus seemed to be more effective than carvedilol. Moreover, the nephroprotective effects may be mediated via affecting NF-\u03baB activation, extrinsic apoptosis and intrinsic apoptosis pathways.<\/jats:p>","DOI":"10.3390\/biom10091317","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T09:04:53Z","timestamp":1600074293000},"page":"1317","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Nephroprotective Effect of Pleurotus ostreatus and Agaricus bisporus Extracts and Carvedilol on Ethylene Glycol-Induced Urolithiasis: Roles of NF-\u03baB, p53, Bcl-2, Bax and Bak"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-9709","authenticated-orcid":false,"given":"Osama M.","family":"Ahmed","sequence":"first","affiliation":[{"name":"Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef P.O. 62521, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossam","family":"Ebaid","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia"},{"name":"Department of Zoology, Faculty of Science, El-Minia University, Minya P.O. 61519, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El-Shaymaa","family":"El-Nahass","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef P.O. 62521, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Ragab","sequence":"additional","affiliation":[{"name":"Sohag General Hospital, Sohag 42511, Egypt"},{"name":"The Scientific Office of Pharma Net Egypt Pharmaceutical Company, Nasr City, Cairo 11371, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0058-1629","authenticated-orcid":false,"given":"Ibrahim M.","family":"Alhazza","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, P.O. 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