{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:10:55Z","timestamp":1788966655973,"version":"build-2803163510"},"reference-count":61,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012013","name":"R\u00e9seau de Recherche en Sant\u00e9 Buccodentaire et Osseuse","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/100012013","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Al Awn Foundation for Development, Yemen","award":["-"],"award-info":[{"award-number":["-"]}]},{"name":"Funds de Recherche Qu\u00e9bec - Sant\u00e9","award":["257709"],"award-info":[{"award-number":["257709"]}]},{"name":"Alpha Omega Foundation of Canada","award":["-"],"award-info":[{"award-number":["-"]}]},{"DOI":"10.13039\/100008919","name":"Faculty of Dentistry, McGill University","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/100008919","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fonds de recherche du Qu\u00e9bec (FRQS) Research Scholar","award":["-"],"award-info":[{"award-number":["-"]}]},{"name":"Canada Research Chair Program","award":["-"],"award-info":[{"award-number":["-"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Donepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate Alzheimer\u2019s disease. Its use has been associated with increased bone mass in humans and animals. However, the effect of postoperative administration of donepezil on bone healing remains unknown. Therefore, this study aimed to assess the impact of postoperative injection of donepezil on bone healing, titanium-implant osseointegration, and soft tissue healing. Twenty-two Sprague-Dawley rats were randomly assigned to receive a daily dose of either donepezil (0.6 mg\/kg) or saline as a control. In each rat, a uni-cortical defect was created in the right tibia metaphysis and a custom-made titanium implant was placed in the left tibiae. After two weeks, rats were euthanized, and their bones were analysed by Micro-CT and histology. The healing of bone defect and implant osseointegration in the rats treated with donepezil were significantly reduced compared to the saline-treated rats. Histomorphometric analysis showed lower immune cell infiltration in bone defects treated with donepezil compared to the saline-treated defects. On the other hand, the healing time of soft tissue wounds was significantly shorter in donepezil-treated rats compared to the controls. In conclusion, short-term administration of donepezil hinders bone healing whereas enhancing soft tissue healing.<\/jats:p>","DOI":"10.3390\/biom10091318","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T09:04:53Z","timestamp":1600074293000},"page":"1318","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Postoperative Administration of the Acetylcholinesterase Inhibitor, Donepezil, Interferes with Bone Healing and Implant Osseointegration in a Rat Model"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9451-0452","authenticated-orcid":false,"given":"Faez Saleh","family":"Al-Hamed","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, McGill University, Montreal, QC H3A0C7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola M.","family":"Maria","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, McGill University, Montreal, QC H3A0C7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Phan","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, McGill University, Montreal, QC H3A0C7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Al Subaie","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, McGill University, Montreal, QC H3A0C7, Canada"},{"name":"College of Dentistry, Imam Abdulrahman bin Faisal University, Dammam 34212, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2771-1147","authenticated-orcid":false,"given":"Qiman","family":"Gao","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, McGill University, Montreal, QC H3A0C7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Mansour","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, McGill University, Montreal, QC H3A0C7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Abu Nada","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, McGill University, Montreal, QC H3A0C7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imane","family":"Boukhatem","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Pharmacie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1J4, Canada"},{"name":"Research Center, Montreal Heart Institute, Montreal, QC H1T 1C8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4875-7534","authenticated-orcid":false,"given":"Osama A.","family":"Elkashty","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, McGill University, Montreal, QC H3A0C7, Canada"},{"name":"Faculty of Dentistry, Mansoura University, Mansoura 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5594-359X","authenticated-orcid":false,"given":"Simon D.","family":"Tran","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, McGill University, Montreal, QC H3A0C7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7418-6766","authenticated-orcid":false,"given":"Marie","family":"Lordkipanidz\u00e9","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Pharmacie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1J4, Canada"},{"name":"Research Center, Montreal Heart Institute, Montreal, QC H1T 1C8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2592-4333","authenticated-orcid":false,"given":"Zahi","family":"Badran","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, McGill University, Montreal, QC H3A0C7, Canada"},{"name":"Department of Periodontology (CHU\/Rmes Inserm U1229\/UIC11), Faculty of Dental Surgery, University of Nantes, 44042 Nantes, France"},{"name":"College of Dental Medicine, University of Sharjah, Sharjah, P.O. 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