{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:14:49Z","timestamp":1789906489344,"version":"4.0.1"},"reference-count":308,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/00119 to M.R-O, PI17\/01495, DTS17\/00203 and DTS19\/00093 to J.E, PI16\/02057, PI19\/00815 to A.O, PI 15\/00120 to R.S; PI18\/0610 to J.M.V; and Red de Investigaci\u00f3n Renal (REDINREN): RD16\/0009 to M.R-O, A.O, R.S, J.M.V"],"award-info":[{"award-number":["PI17\/00119 to M.R-O, PI17\/01495, DTS17\/00203 and DTS19\/00093 to J.E, PI16\/02057, PI19\/00815 to A.O, PI 15\/00120 to R.S; PI18\/0610 to J.M.V; and Red de Investigaci\u00f3n Renal (REDINREN): RD16\/0009 to M.R-O, A.O, R.S, J.M.V"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondos FEDER European Union","award":["PI17\/00119 to M.R-O, PI17\/01495, DTS17\/00203 and DTS19\/00093 to J.E, PI16\/02057, PI19\/00815 to A.O, PI 15\/00120 to R.S; PI18\/0610 to J.M.V; and Red de Investigaci\u00f3n Renal (REDINREN): RD16\/0009 to M.R-O, A.O, R.S, J.M.V"],"award-info":[{"award-number":["PI17\/00119 to M.R-O, PI17\/01495, DTS17\/00203 and DTS19\/00093 to J.E, PI16\/02057, PI19\/00815 to A.O, PI 15\/00120 to R.S; PI18\/0610 to J.M.V; and Red de Investigaci\u00f3n Renal (REDINREN): RD16\/0009 to M.R-O, A.O, R.S, J.M.V"]}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["\u201cNOVELREN\u201d B2017\/BMD\u00ad3751 to M.R-O, B2017\/BMD-3686 CIFRA2-CM to A.O);"],"award-info":[{"award-number":["\u201cNOVELREN\u201d B2017\/BMD\u00ad3751 to M.R-O, B2017\/BMD-3686 CIFRA2-CM to A.O);"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the \u201cJuan de la Cierva Formacion\u201d training program of the Ministerio de Economia, Industria y Competitividad (MINECO) supported the salary of SR-M","award":["FJCI-2016-29050"],"award-info":[{"award-number":["FJCI-2016-29050"]}]},{"name":"\u201cConvocatoria Dinamizaci\u00f3n Europa Investigaci\u00f3n 2019\u201d MINECO","award":["EIN2019-103294 to M.R-O and SR-M"],"award-info":[{"award-number":["EIN2019-103294 to M.R-O and SR-M"]}]},{"DOI":"10.13039\/100015883","name":"Sociedad Espa\u00f1ola de Nefrologia","doi-asserted-by":"publisher","award":["S.E.N. to M.R-O"],"award-info":[{"award-number":["S.E.N. to M.R-O"]}],"id":[{"id":"10.13039\/100015883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015682","name":"ERA","doi-asserted-by":"publisher","award":["ERA-PerMed-JTC2018 (KIDNEY ATTACK AC18\/00064 and PERSTIGAN AC18\/00071) and DTS18\/00032 to A.O;"],"award-info":[{"award-number":["ERA-PerMed-JTC2018 (KIDNEY ATTACK AC18\/00064 and PERSTIGAN AC18\/00071) and DTS18\/00032 to A.O;"]}],"id":[{"id":"10.13039\/100015682","id-type":"DOI","asserted-by":"publisher"}]},{"name":"IMPROVE-PD project (\u201cIdentification and Management of Patients at Risk\u2013Outcome and Vascular Events in Peritoneal Dialysis\u201d) funding from the European Union\u2019s Horizon 2020 research and innovation program under the Marie Sk\u0142odowska-Curie Grant","award":["Agreement No. 812699 to M.R.O. , M.L-C. and D.F."],"award-info":[{"award-number":["Agreement No. 812699 to M.R.O. , M.L-C. and D.F."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Chronic kidney disease (CKD) is a health problem reaching epidemic proportions. There is no cure for CKD, and patients may progress to end-stage renal disease (ESRD). Peritoneal dialysis (PD) is a current replacement therapy option for ESRD patients until renal transplantation can be achieved. One important problem in long-term PD patients is peritoneal membrane failure. The mechanisms involved in peritoneal damage include activation of the inflammatory and immune responses, associated with submesothelial immune infiltrates, angiogenesis, loss of the mesothelial layer due to cell death and mesothelial to mesenchymal transition, and collagen accumulation in the submesothelial compact zone. These processes lead to fibrosis and loss of peritoneal membrane function. Peritoneal inflammation and membrane failure are strongly associated with additional problems in PD patients, mainly with a very high risk of cardiovascular disease. Among the inflammatory mediators involved in peritoneal damage, cytokine IL-17A has recently been proposed as a potential therapeutic target for chronic inflammatory diseases, including CKD. Although IL-17A is the hallmark cytokine of Th17 immune cells, many other cells can also produce or secrete IL-17A. In the peritoneum of PD patients, IL-17A-secreting cells comprise Th17 cells, \u03b3\u03b4 T cells, mast cells, and neutrophils. Experimental studies demonstrated that IL-17A blockade ameliorated peritoneal damage caused by exposure to PD fluids. This article provides a comprehensive review of recent advances on the role of IL-17A in peritoneal membrane injury during PD and other PD-associated complications.<\/jats:p>","DOI":"10.3390\/biom10101361","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T08:33:03Z","timestamp":1600936383000},"page":"1361","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["IL-17A as a Potential Therapeutic Target for Patients on Peritoneal Dialysis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2767-0229","authenticated-orcid":false,"given":"Vanessa","family":"Marchant","sequence":"first","affiliation":[{"name":"Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundaci\u00f3n Instituto de Investigaci\u00f3n Sanitaria-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-Universidad Aut\u00f3noma Madrid, 28040 Madrid, Spain"},{"name":"Red de 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Madrid, Spain"},{"name":"Red de Investigaci\u00f3n Renal (REDINREN), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Egido","sequence":"additional","affiliation":[{"name":"Renal, Vascular and Diabetes Research Laboratory, Fundaci\u00f3n Instituto de Investigaci\u00f3n Sanitaria-Fundaci\u00f3n Jim\u00e9nez D\u00edaz-Universidad Aut\u00f3noma Madrid, 28040 Madrid, Spain"},{"name":"Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-9523","authenticated-orcid":false,"given":"Alberto","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Red de Investigaci\u00f3n Renal (REDINREN), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Renal, Vascular and Diabetes Research Laboratory, Fundaci\u00f3n Instituto de 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