{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:48:51Z","timestamp":1793249331616,"version":"4.5.0"},"reference-count":164,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54MD007595"],"award-info":[{"award-number":["U54MD007595"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Acute and chronic skin wounds due to burns, pressure injuries, and trauma represent a substantial challenge to healthcare delivery with particular impacts on geriatric, paraplegic, and quadriplegic demographics worldwide. Nevertheless, the current standard of care relies extensively on preventive measures to mitigate pressure injury, surgical debridement, skin flap procedures, and negative pressure wound vacuum measures. This article highlights the potential of adipose-, blood-, and cellulose-derived products (cells, decellularized matrices and scaffolds, and exosome and secretome factors) as a means to address this unmet medical need. The current status of this research area is evaluated and discussed in the context of promising avenues for future discovery.<\/jats:p>","DOI":"10.3390\/biom10101373","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T08:02:58Z","timestamp":1601280178000},"page":"1373","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels"],"prefix":"10.3390","volume":"10","author":[{"given":"Trivia","family":"Frazier","sequence":"first","affiliation":[{"name":"Obatala Sciences Inc., New Orleans, LA 70148, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Alarcon","sequence":"additional","affiliation":[{"name":"Obatala Sciences Inc., New Orleans, LA 70148, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiying","family":"Wu","sequence":"additional","affiliation":[{"name":"Obatala Sciences Inc., New Orleans, LA 70148, USA"},{"name":"LaCell LLC, New Orleans, LA 70148, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omair A.","family":"Mohiuddin","sequence":"additional","affiliation":[{"name":"Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Science, University of Karachi, Karachi 75270, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Motherwell","sequence":"additional","affiliation":[{"name":"Walter Reed National Military Medical Center, Bethesda, MD 29814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders H.","family":"Carlsson","sequence":"additional","affiliation":[{"name":"United States Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, TX 78234, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Christy","sequence":"additional","affiliation":[{"name":"United States Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, TX 78234, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judson V.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Southern Regional Research Center-USDA-ARS, New Orleans, LA 70124, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1303-7393","authenticated-orcid":false,"given":"Robert T.","family":"Mackin","sequence":"additional","affiliation":[{"name":"Southern Regional Research Center-USDA-ARS, New Orleans, LA 70124, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette","family":"Prevost","sequence":"additional","affiliation":[{"name":"Southern Regional Research Center-USDA-ARS, New Orleans, LA 70124, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gloster","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangdi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, State College, Pennsylvania State University, Centre County, PA 16802, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Gimble","sequence":"additional","affiliation":[{"name":"Obatala Sciences Inc., New Orleans, LA 70148, USA"},{"name":"LaCell LLC, New Orleans, LA 70148, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1097\/SCS.0b013e3181f3ed9c","article-title":"Management of war-related burn injuries: Lessons learned from recent ongoing conflicts providing exceptional care in unusual places","volume":"21","author":"Atiyeh","year":"2010","journal-title":"J. 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