{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:18:31Z","timestamp":1793650711424,"version":"4.5.1"},"reference-count":283,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PGC2018-096177-B-00"],"award-info":[{"award-number":["PGC2018-096177-B-00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015496","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas","doi-asserted-by":"publisher","award":["Jes\u00fas \u00c1vila"],"award-info":[{"award-number":["Jes\u00fas \u00c1vila"]}],"id":[{"id":"10.13039\/501100015496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010784","name":"Banco Santander","doi-asserted-by":"publisher","award":["Centro de Biolog\u00eda Molecular \"Severo Ochoa\""],"award-info":[{"award-number":["Centro de Biolog\u00eda Molecular \"Severo Ochoa\""]}],"id":[{"id":"10.13039\/100010784","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008054","name":"Fundaci\u00f3n Ram\u00f3n Areces","doi-asserted-by":"publisher","award":["Centro de Biolog\u00eda Molecular \"Severo Ochoa\""],"award-info":[{"award-number":["Centro de Biolog\u00eda Molecular \"Severo Ochoa\""]}],"id":[{"id":"10.13039\/100008054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Microglia are the cells that comprise the innate immune system in the brain. First described more than a century ago, these cells were initially assigned a secondary role in the central nervous system (CNS) with respect to the protagonists, neurons. However, the latest advances have revealed the complexity and importance of microglia in neurodegenerative conditions such as Alzheimer\u2019s disease (AD), the most common form of dementia associated with aging. This pathology is characterized by the accumulation of amyloid-\u03b2 peptide (A\u03b2), which forms senile plaques in the neocortex, as well as by the aggregation of hyperphosphorylated tau protein, a process that leads to the development of neurofibrillary tangles (NFTs). Over the past few years, efforts have been focused on studying the interaction between A\u03b2 and microglia, together with the ability of the latter to decrease the levels of this peptide. Given that most clinical trials following this strategy have failed, current endeavors focus on deciphering the molecular mechanisms that trigger the tau-induced inflammatory response of microglia. In this review, we summarize the most recent studies on the physiological and pathological functions of tau protein and microglia. In addition, we analyze the impact of microglial AD-risk genes (APOE, TREM2, and CD33) in tau pathology, and we discuss the role of extracellular soluble tau in neuroinflammation.<\/jats:p>","DOI":"10.3390\/biom10101439","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T21:42:21Z","timestamp":1602798141000},"page":"1439","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Microglia in Alzheimer\u2019s Disease in the Context of Tau Pathology"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7607-8814","authenticated-orcid":false,"given":"Juan Ram\u00f3n","family":"Perea","sequence":"first","affiliation":[{"name":"Department of Molecular Neuropathology, Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CSIC-UAM), 1 Nicol\u00e1s Cabrera, 28049 Madrid, Spain"},{"name":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), 5 Valderrebollo, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Bol\u00f3s","sequence":"additional","affiliation":[{"name":"Department of Molecular Neuropathology, Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CSIC-UAM), 1 Nicol\u00e1s Cabrera, 28049 Madrid, Spain"},{"name":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), 5 Valderrebollo, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6288-0571","authenticated-orcid":false,"given":"Jes\u00fas","family":"Avila","sequence":"additional","affiliation":[{"name":"Department of Molecular Neuropathology, Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CSIC-UAM), 1 Nicol\u00e1s Cabrera, 28049 Madrid, Spain"},{"name":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), 5 Valderrebollo, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1001\/archneur.1976.00500040001001","article-title":"The prevalence and malignancy of Alzheimer disease. 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