{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:24:02Z","timestamp":1760239442688,"version":"build-2065373602"},"reference-count":75,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T00:00:00Z","timestamp":1605398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Croatian-USA collaborative project","award":["The translational study of the association between aggression and genetic variants in serotonin and testosterone-relevant genes in male adolescents and animal models (TRANSRAGE)"],"award-info":[{"award-number":["The translational study of the association between aggression and genetic variants in serotonin and testosterone-relevant genes in male adolescents and animal models (TRANSRAGE)"]}]},{"DOI":"10.13039\/100015526","name":"Ministarstvo znanosti i obrazovanja","doi-asserted-by":"publisher","award":["098-0982522-2455; Molecular basis and treatment of psychiatric and stress-related disorders"],"award-info":[{"award-number":["098-0982522-2455; Molecular basis and treatment of psychiatric and stress-related disorders"]}],"id":[{"id":"10.13039\/100015526","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Juvenile delinquency is related to several biological factors, yet very few vulnerability biomarkers have been identified. Previous data suggest that the enzyme monoamine oxidase B (MAO-B) influences several personality traits linked to the propensity to engage in delinquent behavior. Building on this evidence, we assessed whether conduct disorder (CD), juvenile delinquency adjudications, or detention in a correctional facility were associated with either platelet MAO-B activity or the MAOB rs1799836 polymorphism. The study enrolled 289 medication-free male youths, including 182 individuals detained in a correctional facility (with or without a diagnosis of CD). Of the remaining 107 participants, 26 subjects had a diagnosis of CD, and 81 were mentally healthy controls. Platelet MAO-B activity was determined by spectrophotofluorometry, while MAOB rs1799836 was genotyped using qPCR. Platelet MAO-B activity, corrected for age and smoking, was significantly higher in juvenile detainees (p &lt; 0.001), irrespective of CD diagnosis. MAOB rs1799836 was not associated with platelet MAO-B activity or with detention in a correctional facility, CD diagnosis, or delinquent behavior. These data suggest that detention in a juvenile correctional facility increases platelet MAO-B activity in male adolescents. Future studies are needed to determine the mechanisms and functional significance of MAO-B peripheral elevation in juvenile male detainees.<\/jats:p>","DOI":"10.3390\/biom10111555","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T21:48:52Z","timestamp":1605563332000},"page":"1555","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Detention in Juvenile Correctional Facilities Is Associated with Higher Platelet Monoamine Oxidase B Activity in Males"],"prefix":"10.3390","volume":"10","author":[{"given":"Josip","family":"Podobnik","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Psychiatric Hospital for Children and Youth Zagreb, Kukuljeviceva 11, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3113-0778","authenticated-orcid":false,"given":"Matea","family":"Nikolac Perkovic","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka cesta 54, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordana","family":"Nedic Erjavec","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka cesta 54, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Dodig Curkovic","sequence":"additional","affiliation":[{"name":"Department for Child and Adolescent Psychiatry, Clinical Hospital Center Osijek, J. Huttlera 4, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Curkovic","sequence":"additional","affiliation":[{"name":"Family Medicine, Osijek Health Center, Park Kralja Petra Kre\u0161imira IV. 6, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vlatka","family":"Kovac","sequence":"additional","affiliation":[{"name":"Department for Child and Adolescent Psychiatry, Clinical Hospital Center Osijek, J. Huttlera 4, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6200-2405","authenticated-orcid":false,"given":"Dubravka","family":"Svob Strac","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka cesta 54, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melita","family":"Cusek","sequence":"additional","affiliation":[{"name":"Juvenile Correctional Facility Ivanec, Pahinsko 6, 42240 Ivanec, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Bortolato","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology, College of Pharmacy, Salt Lake City, 30 South 2000 East, UT 84112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nela","family":"Pivac","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka cesta 54, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/jpepsy\/jsm005","article-title":"Attention-deficit\/hyperactivity disorder: Diagnosis, lifespan, comorbidities, and neurobiology","volume":"32","author":"Spencer","year":"2007","journal-title":"J. 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