{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:32:13Z","timestamp":1787790733245,"version":"build-2784847793"},"reference-count":54,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["17K11355"],"award-info":[{"award-number":["17K11355"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Background: The pathological features of chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) tissues include an eosinophilic infiltration pattern (eosinophilic CRS (ECRS)) or a less eosinophilic pattern (non-ECRS). Recently, it has been suggested that 15-lipoxygenase 1 (15-LOX-1) may have significant roles in allergic disease; however, the significance of 15-LOX-1 in CRS is not well understood. The objective of this study was to demonstrate the expression of 15-LOX-1 in CRS. Methods: The mRNA expression levels of 15-LOX-1 and periostin in nasal tissues were measured by quantitative real-time polymerase chain reaction. We also performed an immunofluorescence study of nasal tissues. Cells of the Eol-1 eosinophilic leukemic cell line were stimulated with interleukin-33 to test the induction of 15-LOX-1. Results: The expression level of 15-LOX-1 mRNA in nasal polyps (NPs) was significantly higher in ECRS patients than in non-ECRS patients. The immunofluorescence study revealed that both airway epithelial cells and eosinophils in NPs expressed 15-LOX-1. A significant correlation was seen between the number of eosinophils and the mRNA expression levels of 15-LOX-1 and periostin in nasal polyps. Moreover, interleukin-33 enhanced 15-LOX-1 expression in Eol-1 cells. Conclusions: 15-LOX-1 was shown to be a significant molecule that facilitates eosinophilic inflammation in ECRS.<\/jats:p>","DOI":"10.3390\/biom10111568","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T09:59:47Z","timestamp":1605693587000},"page":"1568","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Enhanced 15-Lipoxygenase 1 Production is Related to Periostin Expression and Eosinophil Recruitment in Eosinophilic Chronic Rhinosinusitis"],"prefix":"10.3390","volume":"10","author":[{"given":"Yoshimasa","family":"Imoto","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Takabayashi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Sakashita","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukinori","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Kidoguchi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Ogi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeharu","family":"Fujieda","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1177\/000348941112000701","article-title":"Incremental Health Care Utilization and Expenditures for Chronic Rhinosinusitis in the United States","volume":"120","author":"Bhattacharyya","year":"2011","journal-title":"Ann. 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