{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:33:21Z","timestamp":1789580001998,"version":"build-2803163510"},"reference-count":161,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Solidago virgaurea L. (European goldenrod, Woundwort), Asteraceae, is a familiar medicinal plant in Europe and other parts of the world, widely used and among the most researched species from its genus. The aerial parts of European goldenrod have long been used for urinary tract conditions and as an anti-inflammatory agent in the traditional medicine of different peoples. Its main chemical constituents are flavonoids (mainly derived from quercetin and kaempferol), C6-C1 and C6-C3 compounds, terpenes (mostly from the essential oil), and a large number of saponin molecules (mainly virgaureasaponins and solidagosaponins). Published research on its potential activities is critically reviewed here: antioxidant, anti-inflammatory, analgesic, spasmolitic, antihypertensive, diuretic, antibacterial, antifungal, antiparasite, cytotoxic and antitumor, antimutagenic, antiadipogenic, antidiabetic, cardioprotective, and antisenescence. The evidence concerning its potential benefits is mainly derived from non-clinical studies, some effects are rather modest, whereas others are more promising, but need more confirmation in both non-clinical models and clinical trials.<\/jats:p>","DOI":"10.3390\/biom10121619","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T20:10:22Z","timestamp":1606767022000},"page":"1619","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Solidago virgaurea L.: A Review of Its Ethnomedicinal Uses, Phytochemistry, and Pharmacological Activities"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0692-6819","authenticated-orcid":false,"given":"Cornelia","family":"Fursenco","sequence":"first","affiliation":[{"name":"Departament of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmacy, Nicolae Testemitanu SUMPh, 66 M\u0103lina Mic\u0103 Street, MD-2025 Chisinau, Moldova"},{"name":"Scientific Center of Medicines, Faculty of Pharmacy, Nicolae Testemitanu SUMPh, 66 M\u0103lina Mic\u0103 Street, MD-2025 Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Calalb","sequence":"additional","affiliation":[{"name":"Departament of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmacy, Nicolae Testemitanu SUMPh, 66 M\u0103lina Mic\u0103 Street, MD-2025 Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3453-2243","authenticated-orcid":false,"given":"Livia","family":"Uncu","sequence":"additional","affiliation":[{"name":"Scientific Center of Medicines, Faculty of Pharmacy, Nicolae Testemitanu SUMPh, 66 M\u0103lina Mic\u0103 Street, MD-2025 Chisinau, Moldova"},{"name":"Departament of Pharmaceutical and Toxicological Chemistry, Faculty of Pharmacy, Nicolae Testemitanu SUMPh, 66 M\u0103lina Mic\u0103 Street, MD-2025 Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Dinu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany and Cell Biology, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, Sector 2, 020956 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Ancuceanu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany and Cell Biology, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, Sector 2, 020956 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"key":"ref_1","unstructured":"World Flora Online (2020, August 03). Consortium WFO (2020): World Flora Online. Available online: http:\/\/www.worldfloraonline.org."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1300093","DOI":"10.3732\/apps.1300093","article-title":"Genus-Wide Microsatellite Primers for the Goldenrods (Solidago; Asteraceae)","volume":"2","author":"Beck","year":"2014","journal-title":"Appl. Plant Sci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Toiu, A., Vlase, L., Vodnar, D.C., Gheldiu, A.-M., and Oniga, I. (2019). Solidago graminifolia L. Salisb. (Asteraceae) as a Valuable Source of Bioactive Polyphenols: HPLC Profile, In Vitro Antioxidant and Antimicrobial Potential. Molecules, 24.","DOI":"10.3390\/molecules24142666"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e1800023","DOI":"10.1002\/cbdv.201800023","article-title":"Comparison of Polyphenol Profile and Antimutagenic and Antioxidant Activities in Two Species Used as Source of Solidaginis herba\u2014Goldenrod","volume":"15","author":"Domaradzki","year":"2018","journal-title":"Chem. Biodivers."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jep.2007.07.003","article-title":"Anti-inflammatory evaluation of Solidago chilensis Meyen in a murine model of pleurisy","volume":"113","author":"Goulart","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"ref_6","unstructured":"Tutin, T.G., Heywood, V.H., Burges, N.A., Moore, D.M., Valentine, D.H., Walters, S.M., and Webb, D.A. (1976). Flora Europaea. Volume 4. Plantaginaceae to Compositae (and Rubiaceae), Zenodo."},{"key":"ref_7","unstructured":"Native Plant Trust (2020, September 01). Go Botany. Available online: https:\/\/gobotany.nativeplanttrust.org\/species\/euthamia\/graminifolia\/."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"460602","DOI":"10.1016\/j.chroma.2019.460602","article-title":"Distinction and valorization of 30 root extracts of five goldenrod (Solidago) species","volume":"1611","author":"Darcsi","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"ref_9","unstructured":"European Medicines Agency (2008). Assessment Report on Solidago virgaurea L., Herba, European Medicines Agency."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1080\/13880209.2016.1190381","article-title":"In vivo anti-inflammatory activity of caffeoylquinic acid derivatives from Solidago virgaurea in rats","volume":"54","author":"Ezzat","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00345-002-0293-0","article-title":"Botanical medicines for the urinary tract","volume":"20","author":"Yarnell","year":"2002","journal-title":"World J. Urol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s00345-013-1173-5","article-title":"Solidago, orthosiphon, birch and cranberry extracts can decrease microbial colonization and biofilm development in indwelling urinary catheter: A microbiologic and ultrastructural pilot study","volume":"32","author":"Cai","year":"2014","journal-title":"World J. Urol."},{"key":"ref_13","first-page":"4","article-title":"The morpho-anatomical study of Solidago virgaurea L. species from the flora of Republic of Moldova","volume":"2-1","author":"Calalb","year":"2018","journal-title":"East Eur. Sci. J."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Szymura, M., and Wolski, K. (2011). Leaf Epidermis Traits as Tools to Identify Solidago L. Taxa in Poland. Acta Biol. Crac. Ser. Bot., 53.","DOI":"10.2478\/v10182-011-0006-3"},{"key":"ref_15","first-page":"41","article-title":"Criteria for Solidago Species Differentiation","volume":"8","author":"Dobjanschi","year":"2005","journal-title":"Acta Univ. Cibiniensis Ser. F Chem."},{"key":"ref_16","unstructured":"Buynov, M., Goryachkina, Y., and Fedoseyeva, G. (2013). Otlichitel\u2019nyye Morfologicheskiye i Anatomo-Diagnosticheskiye Priznaki Vidov Zolotarnikov\u2014Kanadskogo, Obyknovennogo, Daurskogo: Uchebnoye Posobiye, IGMU."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1590\/0001-3765201720160280","article-title":"Anatomical, phytochemical and histochemical study of Solidago chilensis Meyen","volume":"90","author":"Souza","year":"2018","journal-title":"An. Acad. Bras. Ci\u00eanc."},{"key":"ref_18","unstructured":"Fedotova, V., and Chelombit\u2019sh, V. (2012). Anatomo-diagnosticheskoye izucheniye zolotarnika kavkazskogo (Solidago caucasica Kem.-Nath.) flory Severnogo Kavkaza. Razrabotka, Issledovaniye i Marketing Novoy Farmatsevticheskoy Produktsii: Sb. nauch. tr., The Publisher of Medicine and Pharmacy Institute of Pyatigorsk. Vyp. 67."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/ardp.18501130112","article-title":"Ueber Verwechselung der herba Solidaginis virgaureae mit herba Senecion. nemorensis","volume":"113","author":"Bley","year":"1850","journal-title":"Arch. Pharm."},{"key":"ref_20","first-page":"1","article-title":"An intuitive phylogeny and summary of chromosome number variation in the goldenrod genus Solidago (Asteraceae: Astereae)","volume":"32","author":"Semple","year":"2016","journal-title":"Phytoneuron"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/aob\/mcx182","article-title":"Phylogeographic analysis of the East Asian goldenrod (Solidago virgaurea complex, Asteraceae) reveals hidden ecological diversification with recurrent formation of ecotypes","volume":"121","author":"Sakaguchi","year":"2018","journal-title":"Ann. Bot."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s12224-013-9180-2","article-title":"Taxonomy of the Solidago virgaurea Group (Asteraceae) in Poland, with Special Reference to Variability along an Altitudinal Gradient","volume":"49","author":"Mirek","year":"2014","journal-title":"Folia Geobot."},{"key":"ref_23","unstructured":"Shishkin, B. (1959). Zolotarnik\u2013Solidago L.. Flora SSSR 25, Izdatel\u2019stvo Akademii Nauk SSSR."},{"key":"ref_24","unstructured":"Slav\u00edk, B., and \u0160t\u011bp\u00e1nkov\u00e1, J. (2004). Solidago L.\u2013zlatob\u00fdl. Kv\u011btena \u010cesk\u00e9 Republiky 7 (Flora of the Czech Republic 7), Academia."},{"key":"ref_25","unstructured":"Botanical Society of Britain and Ireland, Biological Records Center, UK Center for Ecology and Hydrology, and Joint Nature Conservation Committee (2020, August 28). Online Atlas of the British and Irish Flora\u2014Solidago virgaurea, Available online: https:\/\/www.brc.ac.uk\/plantatlas\/plant\/solidago-virgaurea."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1111\/nph.14744","article-title":"Simultaneous evaluation of the effects of geographic, environmental and temporal isolation in ecotypic populations of Solidago virgaurea","volume":"216","author":"Sakaguchi","year":"2017","journal-title":"New Phytol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3417\/2014023","article-title":"A Multivariate Morphometric Analysis of the Solidago chilensis Group in South America and Related Taxa in North America (Asteraceae, Astereae) 1","volume":"100","author":"Laphitz","year":"2015","journal-title":"Ann. Mo. Bot. Gard."},{"key":"ref_28","unstructured":"American Botanical Council (2020, August 28). Solidago virgaurea L.. Available online: http:\/\/cms.herbalgram.org\/MedPlantID\/BotanicalEntries\/Solidago_virgaurea.html."},{"key":"ref_29","unstructured":"European Medicines Agency (2020, August 28). Community Herbal Monograph on Solidago virgaurea L. Herba, EMEA\/HMPC\/285758\/2007 2008. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/herbal-monograph\/final-community-herbal-monograph-solidago-virgaurea-l-herba_en.pdf."},{"key":"ref_30","first-page":"431","article-title":"Goldenrod has increasing importance as a herbal drug","volume":"35","author":"Blum","year":"1999","journal-title":"Gemuse"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00210-004-0869-x","article-title":"Extracts from Rhois aromatica and Solidaginis virgaurea inhibit rat and human bladder contraction","volume":"369","author":"Borchert","year":"2004","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"8202","DOI":"10.1021\/acs.analchem.6b02007","article-title":"Effect-Directed Discovery of Bioactive Compounds Followed by Highly Targeted Characterization, Isolation and Identification, Exemplarily Shown for Solidago virgaurea","volume":"88","author":"Ott","year":"2016","journal-title":"Anal. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10354-004-0118-4","article-title":"Goldenrod\u2014A classical exponent in the urological phytotherapy","volume":"154","author":"Melzig","year":"2004","journal-title":"Wien. Med. Wochenschr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1207\/S15327914NC431_9","article-title":"Antineoplastic activity of Solidago virgaurea on prostatic tumor cells in an SCID mouse model","volume":"43","author":"Gross","year":"2002","journal-title":"Nutr. Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/10412905.2006.9699382","article-title":"Volatile Oil-Bearing Flora of Siberia VIII: Essential Oil Composition and Antimicrobial Activity of Wild Solidago virgaurea L. from the Russian Altai","volume":"18","author":"Tkachev","year":"2006","journal-title":"J. Essent. Oil Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Heger, M. (2003). Entz\u00fcndliche Erkrankungen der Urogenitalorgane. Naturheilverfahren in der Urologie, Springer.","DOI":"10.1007\/978-3-662-08919-4_2"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1055\/s-2006-958038","article-title":"The Main Saponins from the Aerial Parts and the Roots of Solidago virgaurea subsp. virgaurea *","volume":"61","author":"Bader","year":"1995","journal-title":"Planta Med."},{"key":"ref_38","unstructured":"(2020, August 28). A. Vogel. Plant Encylopedia Solidago virgaurea L.. Available online: https:\/\/www.avogel.com\/plant-encyclopaedia\/solidago_virgaurea.php."},{"key":"ref_39","first-page":"11","article-title":"U\u017e\u00edv\u00e1n\u00ed p\u0159\u00edpravk\u016f ze zlatob\u00fdlu obecn\u00e9ho (Solidago virgaurea) neovliv\u0148uje metabolizmus sou\u010dasn\u011b pod\u00e1van\u00fdch l\u00e9\u010div","volume":"30","author":"Anzenbacher","year":"2016","journal-title":"Klin Farm. Farm"},{"key":"ref_40","unstructured":"(2020, August 28). Naw\u0142o\u0107 pospolita (Solidago virgaurea). Available online: https:\/\/www.plantago-sklep.pl\/blog\/nawloc-pospolita\/."},{"key":"ref_41","unstructured":"Malankina, Y. (2020, August 28). Zolotarnik: Lekarstvennyye svoystva i primeneniye. Available online: https:\/\/www.greeninfo.ru\/grassy\/solidago_canadensis.html\/Article\/_\/aID\/5959."},{"key":"ref_42","first-page":"142","article-title":"The historical background and prospects of Canadian goldenrod (Solidago canadensis L.) herb medicinal use","volume":"19","author":"Suleymanova","year":"2017","journal-title":"J. Sci. Artic. Health Educ. Millenn."},{"key":"ref_43","first-page":"44","article-title":"Name\u2013Text\u2013Ritual: The Role of Plant Characteristics in Slavic Folk Medicine","volume":"X","author":"Kolosova","year":"2005","journal-title":"Folklorika"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/ptr.1985","article-title":"Correlation between theIn Vitro antioxidant activity and polyphenol content of aqueous extracts from bulgarian herbs","volume":"20","author":"Kiselova","year":"2006","journal-title":"Phytother. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2478\/abmj-2018-0003","article-title":"Comparative phytochemical research of Solidago genus: S. graminifolia. Note I. Flavonoids","volume":"1","author":"Dobjanschi","year":"2018","journal-title":"Acta Biol. Marisiensis"},{"key":"ref_46","unstructured":"Calalb, T., and Bodrug, M. (2009). Botanica Faramaceutic\u0103, CEP Medicina."},{"key":"ref_47","first-page":"75","article-title":"Ac\u0163iunea diuretic\u0103 a unor specii de Solidago","volume":"62","author":"Tamas","year":"1989","journal-title":"Clujul Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13002-020-00364-6","article-title":"Historical ethnobotanical review of medicinal plants used to treat children diseases in Romania (1860s\u20131970s)","volume":"16","author":"Petran","year":"2020","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF02980100","article-title":"Pytochemical constituents of the aerial parts from Solidago virga-aurea var","volume":"27","author":"Choi","year":"2004","journal-title":"gigantea. Arch. Pharmacal. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/BF02975338","article-title":"Cytotoxic constituents from Solidago virga-aurea var","volume":"22","author":"Sung","year":"1999","journal-title":"gigantea MIQ. Arch. Pharmacal. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1248\/cpb.39.2037","article-title":"Studies on the Constituents of Solidago virga-aurea L. I. Structural Elucidation of Saponins in the Herb","volume":"39","author":"Inose","year":"1991","journal-title":"Chem. Pharm. Bull."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ecoleng.2014.07.053","article-title":"Phytoremediation of zinc contaminated soils using silver birch (Betula pendula Roth)","volume":"71","author":"Dmuchowski","year":"2014","journal-title":"Ecol. Eng."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e8175","DOI":"10.7717\/peerj.8175","article-title":"The accumulation of Mn and Cu in the morphological parts of Solidago canadensis under different soil conditions","volume":"7","author":"Bielecka","year":"2019","journal-title":"PeerJ"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"36942","DOI":"10.1007\/s11356-019-06690-x","article-title":"Solidago canadensis as a bioaccumulator and phytoremediator of Pb and Zn","volume":"26","author":"Bielecka","year":"2019","journal-title":"Environ. Sci. Pollut Res. Int."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Oldroyd, B.P. (2007). What\u2019s Killing American Honey Bees?. PLoS Biol., 5.","DOI":"10.1371\/journal.pbio.0050168"},{"key":"ref_56","first-page":"869","article-title":"Antiphlogistic and analgesic effects of leiocarposide, a phenolic bisglucoside of Solidago virgaurea L.","volume":"39","author":"Metzner","year":"1984","journal-title":"Pharmazie"},{"key":"ref_57","first-page":"181","article-title":"Effect of leiocarposide on experimental urinary calculi in rats","volume":"45","author":"Chodera","year":"1988","journal-title":"Acta Pol. Pharm."},{"key":"ref_58","first-page":"277","article-title":"Phenolic compounds in two Solidago L. species from in vitro culture","volume":"58","author":"Thiem","year":"2001","journal-title":"Acta Pol. Pharm."},{"key":"ref_59","first-page":"55","article-title":"Chemical characteristics of European goldenrod (Solidago virgaurea L. subsp. virgaurea) from natural sites in central and Eastern Poland","volume":"13","author":"Roslon","year":"2014","journal-title":"Acta Sci. Pol. Hortorum Cultus"},{"key":"ref_60","first-page":"491","article-title":"Polyphenolic Compounds in Herbs of the Species Solidago L.","volume":"19","author":"Borkowski","year":"1962","journal-title":"Acta Pol. Pharm."},{"key":"ref_61","first-page":"230","article-title":"Flavonoid patterns in the genus Solidago","volume":"9","author":"Budzianowski","year":"1987","journal-title":"Pharm. Weekbl. Method."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0021-9673(91)80135-4","article-title":"High-performance liquid chromatographic analysis of flavonol glycosides of Solidago virgaurea","volume":"558","author":"Pietta","year":"1991","journal-title":"J. Chromatogr. A"},{"key":"ref_63","unstructured":"Tamas, M. (1986). Cercet\u0103ri chemotaxonomice la genul Solidago. Contrib. Bot. (Cluj-Napoca), 110\u2013113."},{"key":"ref_64","first-page":"1571","article-title":"Comparative study of the morphological and phytochemical characterization of Romanian Solidago species","volume":"32","author":"Dobjanschi","year":"2019","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_65","first-page":"35","article-title":"Effect of flavonoid fractions of Solidago virgaurea L. on diuresis and levels of electrolytes","volume":"48","author":"Chodera","year":"1991","journal-title":"Acta Pol. Pharm."},{"key":"ref_66","first-page":"140","article-title":"The antifungal action of triterpene saponins of Solidago virgaurea L.","volume":"42","author":"Bader","year":"1987","journal-title":"Die Pharm."},{"key":"ref_67","first-page":"618","article-title":"Zur antimyzetischen Wirksamkeit von polygalas\u00e4ureglycosiden","volume":"45","author":"Bader","year":"1990","journal-title":"Pharmazie"},{"key":"ref_68","unstructured":"Bader, G., Plohmann, B., and Franz, G. (1996, January 3\u20137). Saponin from Solidago virgaurea L. Possible Agents for Therapy of Cancer?. Proceedings of the 44th Annual Congress of the Society for Medicinal Plant Research and a Joint Meeting with the Czech Biotechnology Society, Prague, Czech Republic. Abstracts of Lectures and Poster Presentations."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0031-9422(97)01039-X","article-title":"Enzymatic hydrolysis of the cytotoxic triterpenoid glycoside virgaureasaponin 1","volume":"49","author":"Bader","year":"1998","journal-title":"Phytochemistry"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1248\/cpb.40.946","article-title":"Studies on the Constituents of Solidago virga-aurea L. II. Structures of Solidagosaponins X-XX","volume":"40","author":"Inose","year":"1992","journal-title":"Chem. Pharm. Bull."},{"key":"ref_71","first-page":"56","article-title":"The thin layer chromatography analysis of saponins belonging to Solidago species","volume":"21","author":"Dobjanschi","year":"2013","journal-title":"Fasc. Prot. Mediu."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1099\/jmm.0.041699-0","article-title":"Inhibition of Candida albicans yeast\u2013hyphal transition and biofilm formation by Solidago virgaurea water extracts","volume":"61","author":"Chevalier","year":"2012","journal-title":"J. Med. Microbiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.phytochem.2012.10.004","article-title":"Triterpenoid saponins from the aerial parts of Solidago virgaurea alpestris with inhibiting activity of Candida albicans yeast-hyphal conversion","volume":"86","author":"Sarrazin","year":"2013","journal-title":"Phytochemistry"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/(SICI)1099-1026(199811\/12)13:6<373::AID-FFJ749>3.0.CO;2-G","article-title":"Constituents of the essential oil of Solidago virgaurea L.","volume":"13","author":"Kalemba","year":"1998","journal-title":"Flavour Fragr. J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/ffj.1271","article-title":"Constituents of the essential oils of four micropropagated Solidago species","volume":"19","author":"Kalemba","year":"2004","journal-title":"Flavour Fragr. J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1271\/nogeikagaku1924.64.1729","article-title":"Miscellaneous contributions to the essential oils of plants from various territories. Components of the essential oils of Solidago virgaurea Linn. ssp","volume":"64","author":"Fujita","year":"1990","journal-title":"Nippon Nogei Kagaku Kaishi"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/10412905.1999.9701114","article-title":"Constituents of the Essential Oil of Solidago litoralis, an Endemic Plant from Northern Tuscany (Italy)","volume":"11","author":"Bertoli","year":"1999","journal-title":"J. Essent. Oil Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.phytochem.2009.09.032","article-title":"Antibacterial clerodane diterpenes from Goldenrod (Solidago virgaurea)","volume":"71","author":"Starks","year":"2010","journal-title":"Phytochemistry"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/BF00598770","article-title":"Dynamics of the amount and characteristics of the polysaccharides of Solidago virgaurea","volume":"23","author":"Pychenkova","year":"1987","journal-title":"Chem. Nat. Compd."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0031-9422(00)94712-5","article-title":"Polyacetylenes of Solidago virgaurea: Their seasonal variation and NMR long-range spin coupling constants","volume":"10","author":"Lam","year":"1971","journal-title":"Phytochemistry"},{"key":"ref_81","unstructured":"Council of Europe (2019). European Pharmacopoeia (Ph. Eur.), Council of Europe. [10th ed.]."},{"key":"ref_82","first-page":"128","article-title":"Isolierung Von Quercitrin Aus Solidago Virga Aurea L., S. Serotina Ait und S. Canadensis L.","volume":"17","author":"Fuchs","year":"1949","journal-title":"Sci. Pharm."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0731-7085(03)00207-3","article-title":"Herbal remedies of Solidago\u2014correlation of phytochemical characteristics and antioxidative properties","volume":"32","author":"Papp","year":"2003","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jff.2017.07.049","article-title":"Biorefining of goldenrod (Solidago virgaurea L.) leaves by supercritical fluid and pressurized liquid extraction and evaluation of antioxidant properties and main phytochemicals in the fractions and plant material","volume":"37","author":"Pukalskas","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_85","first-page":"471","article-title":"Phenolic acids in four Solidago species","volume":"47","author":"Kalemba","year":"1992","journal-title":"Pharmazie"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1007\/s12161-018-1332-9","article-title":"Determination of Flavonoids and Phenolic Acids in Plant Materials Using SLE-SPE-UHPLC-MS\/MS Method","volume":"11","author":"Bajkacz","year":"2018","journal-title":"Food Anal. Methods"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"10812","DOI":"10.1021\/jf102175x","article-title":"Simultaneous Quantification of Flavonoids and Phenolic Acids in Plant Materials by a Newly Developed Isocratic High-Performance Liquid Chromatography Approach","volume":"58","author":"Haghi","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"112123","DOI":"10.1016\/j.indcrop.2020.112123","article-title":"Antioxidant profiles of leaves and inflorescences of native, invasive and hybrid Solidago species","volume":"145","author":"Marksa","year":"2020","journal-title":"Ind. Crops Prod."},{"key":"ref_89","first-page":"181","article-title":"Caffeoyl Derivatives: Major Antioxidant Compounds of Some Wild Herbs of the Asteraceae Family","volume":"02","author":"Fraisse","year":"2011","journal-title":"Food Nutr. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.phytochem.2011.02.027","article-title":"Determination of the hydroxycinnamate profile of 12 members of the Asteraceae family","volume":"72","author":"Jaiswal","year":"2011","journal-title":"Phytochemistry"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2478\/s11532-009-0125-9","article-title":"Comparison of pressurised fluid and ultrasonic extraction methods for analysis of plant antioxidants and their antioxidant capacity","volume":"8","author":"Adam","year":"2010","journal-title":"Open Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0031-9422(00)85038-4","article-title":"Clerodanes from Solidago virgaurea","volume":"23","author":"Goswami","year":"1984","journal-title":"Phytochemistry"},{"key":"ref_93","first-page":"67","article-title":"European goldenrod as an anti-inflammatory drug: Investigations into the cyto-and molecular pharmacology for a better understanding of the anti-inflammatory activity of preparations from Solidago virgaurea","volume":"21","author":"Melzig","year":"2000","journal-title":"Z. Phytother."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Vuolo, M.M., Lima, V.S., and Junior, M.R.M. (2019). Phenolic compounds: Structure, classification, and antioxidant power. Bioactive Compounds, Elsevier.","DOI":"10.1016\/B978-0-12-814774-0.00002-5"},{"key":"ref_95","first-page":"2","article-title":"Antioxidant and antimicrobial activities of Solidago virgaurea extracts","volume":"8","author":"Demir","year":"2009","journal-title":"Afr. J. Biotechnol."},{"key":"ref_96","first-page":"174","article-title":"Antioxidative properties of alcoholic extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea","volume":"45","author":"Meyer","year":"1995","journal-title":"Arzneimittel-forschung"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/0306-3623(93)90159-U","article-title":"Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships","volume":"24","author":"Duarte","year":"1993","journal-title":"Gen. Pharmacol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/chir.23041","article-title":"Flavonoids enantiomer distribution in different parts of goldenrod (Solidago virgaurea L.), lucerne (Medicago sativa L.) and phacelia (Phacelia tanacetifolia Benth.)","volume":"31","author":"Kruk","year":"2019","journal-title":"Chirality"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1399-3054.1958.tb08433.x","article-title":"Preliminary Observations on Anthocyanins and Other Flavonoid Compounds and Respiration Rates in Different Ecotypes of Solidago virgaurea","volume":"11","author":"Bjorkman","year":"1958","journal-title":"Physiol. Plant."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Jang, Y., Wang, Z., Lee, J.-M., Lee, J.-Y., and Lim, S. (2016). Screening of Korean Natural Products for Anti-Adipogenesis Properties and Isolation of Kaempferol-3-O-rutinoside as a Potent Anti-Adipogenetic Compound from Solidago virgaurea. Molecules, 21.","DOI":"10.3390\/molecules21020226"},{"key":"ref_101","first-page":"795","article-title":"Virgaureoside aa new bisdesmosidic phenol glycoside from Solidago virgaurea","volume":"40","author":"Hiller","year":"1985","journal-title":"Die Pharm."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.hermed.2016.08.001","article-title":"Verbascum phlomoides and Solidago virgaureae herbs as natural source for preventing neurodegenerative diseases","volume":"6","author":"Paun","year":"2016","journal-title":"J. Herb. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/978-3-662-08614-8_23","article-title":"Solidago L. Species (Goldenrod): In Vitro Regeneration and Biologically Active Secondary Metabolites","volume":"Volume 43","author":"Bajaj","year":"1999","journal-title":"Medicinal and Aromatic Plants XI"},{"key":"ref_104","first-page":"380","article-title":"Zur quantitativen Bestimmung von Leiocaposid in Solidago virgaurea L.","volume":"45","author":"Bader","year":"1990","journal-title":"Die Pharm."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Nkuimi Wandjou, J.G., Quassinti, L., Gud\u017einskas, Z., Nagy, D.U., Cianfaglione, K., Bramucci, M., and Maggi, F. (2020). Chemical composition and antiproliferative effect of essential oils of four Solidago species (S. canadensis, S. gigantea, S. virgaurea and S.\u00d7 niederederi). Chem. Biodivers.","DOI":"10.1002\/cbdv.202000685"},{"key":"ref_106","first-page":"188","article-title":"Zur Kenntnis der Saponine der Gattung Solidago. 1 Mitteilung: Uber die Saponine von Solidago virgaurea L.","volume":"30","author":"Hiller","year":"1975","journal-title":"Pharmazie"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0031-9422(92)90047-T","article-title":"Virgaureasaponin 3, a 3,28-bisdesmosidic triterpenoid saponin from Solidago virgaurea","volume":"31","author":"Bader","year":"1992","journal-title":"Phytochemistry"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1248\/cpb.42.617","article-title":"Studies on the Constituents of Solidago virga-aurea L. III. Structures of Solidagosaponins XXI-XXIX","volume":"42","author":"Miyase","year":"1994","journal-title":"Chem. Pharm. Bull."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0031-9422(91)83740-C","article-title":"Bellissaponins BA1 and BA2, acylated saponins from Bellis perennis","volume":"30","author":"Wray","year":"1991","journal-title":"Phytochemistry"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.ijbiomac.2010.09.007","article-title":"The effect of polyphenolic-polysaccharide conjugates from selected medicinal plants of Asteraceae family on the peroxynitrite-induced changes in blood platelet proteins","volume":"47","author":"Pawlaczyk","year":"2010","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Salehi, B., Martorell, M., Arbiser, J.L., Sureda, A., Martins, N., Maurya, P.K., Sharifi-Rad, M., Kumar, P., and Sharifi-Rad, J. (2018). Antioxidants: Positive or Negative Actors?. Biomolecules, 8.","DOI":"10.3390\/biom8040124"},{"key":"ref_112","first-page":"123","article-title":"Influence of Applied Pressure and Heat Treatment on Antioxidant Activities of Young Leaves from Achillea alpina and Solidago virgaurea subsp. gigantea","volume":"23","author":"Woo","year":"2010","journal-title":"Korean J. Plant Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5851\/kosfa.2013.33.1.1","article-title":"Antioxidant activity of goldenrod (Solidago virgaurea) leaf and stem powder on raw ground pork during chilled storage","volume":"33","author":"Kim","year":"2013","journal-title":"Korean J. Food Sci. Anim. Resour."},{"key":"ref_114","unstructured":"Choe, J., Choi, Y., Kim, H., Han, D., Kim, H., Kim, Y., Park, J., Chung, H., and Kim, C. (2011, January 7\u201312). Effects of goldenrod (Solidago virgaurea) leaf and stem extracts on oxidative stability in cooked ground pork during chilled storage. Proceedings of the International Congress of Meat Science and Technology, Ghent, Belgium."},{"key":"ref_115","first-page":"380","article-title":"Zum antiexsudativen verhalten einiger triterpensaponine","volume":"37","author":"Jacker","year":"1982","journal-title":"Pharmazie"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF02975135","article-title":"Immunobioloical activity of a new benzyl benzoate from the aerial parts of Solidago virga-aurea var. gigantea","volume":"28","author":"Choi","year":"2005","journal-title":"Arch. Pharmacal. Res."},{"key":"ref_117","first-page":"333","article-title":"Study of the anti-inflammatory activity of Populus tremula, Solidago virgaurea and Fraxinus excelsior","volume":"42","author":"Khayyal","year":"1992","journal-title":"Arzneimittel-forschung"},{"key":"ref_118","first-page":"172","article-title":"Inhibition of dihydrofolate reductase activity by alcoholic extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea","volume":"45","author":"Strehl","year":"1995","journal-title":"Arzneimittel-forschung"},{"key":"ref_119","unstructured":"(2003). ESCOP Solidago virgaurea. Monographs on the Medicinal Uses of Plant Drugs, European Scientific Cooperative on Phytotherapy Thieme."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1096\/fasebj.4.8.2185970","article-title":"Dihydrofolate reductase as a therapeutic target","volume":"4","author":"Schweitzer","year":"1990","journal-title":"FASEB J."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"152868","DOI":"10.1016\/j.phymed.2019.152868","article-title":"Anti-inflammatory effects of Phytodolor\u00ae (STW 1) and components (poplar, ash and goldenrod) on human monocytes\/macrophages","volume":"58","author":"Bonaterra","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_122","first-page":"169","article-title":"A combination of Populus tremula, Solidago virgaurea and Fraxinus excelsior as an anti-inflammatory and antirheumatic drug. A short review","volume":"45","author":"Schneider","year":"1995","journal-title":"Arzneimittel-forschung"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/(SICI)1099-1573(200002)14:1<24::AID-PTR537>3.0.CO;2-9","article-title":"Ethnomedicinally selected plants as sources of potential analgesic compounds: Indication ofin vitro biological activity in receptor binding assays","volume":"14","author":"Sampson","year":"2000","journal-title":"Phytother. Res."},{"key":"ref_124","first-page":"40","article-title":"Spasmolytische und kontraktile Einfl\u00fcsse eines pflanzlichen Kombinations-pr\u00e4parates auf die glatte Muskulatur des isolierten Meerschweinchendarms","volume":"31","author":"Westendorf","year":"1981","journal-title":"Arzneimittel-forschung\/Drug Res."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"R\u00e1cz, G., R\u00e1cz-Kotilla, E., and J\u00f3zsa, J. (1979, January 16\u201322). Hypotensive Activity-A Possible Pharmacotaxonomic Character of Solidago L.. Proceedings of the II International Symposium on Spices and Medicinal Plants, Budapest, Hungary.","DOI":"10.17660\/ActaHortic.1980.96.39"},{"key":"ref_126","first-page":"300","article-title":"Hypotensive and sedative effect of extracts obtained from Soldidago virgaurea L. [golden rod, drug plants]","volume":"33","author":"Raczkotilla","year":"1978","journal-title":"Planta Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF00365512","article-title":"Effects on rats of aqueous extracts of plants used in folk medicine as antihypertensive agents","volume":"70","author":"Lasserre","year":"1983","journal-title":"Naturwissenschaften"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1093\/eurheartj\/ehs262","article-title":"Neutral endopeptidase inhibition and the natriuretic peptide system: An evolving strategy in cardiovascular therapeutics","volume":"34","author":"Mangiafico","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_129","first-page":"R495","article-title":"Diuretic effects of extracts and fractions obtained from different Solidago species","volume":"358","author":"Kaspers","year":"1998","journal-title":"Naunyn-Schmiedebergs Arch. Pharmacol."},{"key":"ref_130","first-page":"199","article-title":"Diuretic effect of the glycoside from a plant of the Solidago L. genus","volume":"42","author":"Chodera","year":"1985","journal-title":"Acta Pol. Pharm."},{"key":"ref_131","first-page":"112","article-title":"Biological activity of Leiocarposide from Solidago L.","volume":"34","author":"Chodera","year":"1985","journal-title":"Acta Agron. Acad. Sci. Hung"},{"key":"ref_132","first-page":"20","article-title":"Die urologische Wirkung des Leiocarposids","volume":"12","author":"Budzianowski","year":"1999","journal-title":"Drogenreport"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Edwards, S.E., Rocha, I., Williamson, E.M., and Heinrich, M. (2015). Phytopharmacy: An Evidence-Based Guide to Herbal Medical Products, Wiley Blackwell.","DOI":"10.1002\/9781118543436"},{"key":"ref_134","first-page":"6770","article-title":"Antibacterial and antimutagenic activity of extracts aboveground parts of three Solidago species: Solidago virgaurea L., Solidago canadensis L. and Solidago gigantea Ait","volume":"5","author":"Kolodziej","year":"2011","journal-title":"J. Med. Plants Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jep.2010.07.048","article-title":"Minimum inhibitory concentrations of medicinal plants used in Northern Peru as antibacterial remedies","volume":"132","author":"Bussmann","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"308980","DOI":"10.1155\/2013\/308980","article-title":"Which approach is more effective in the selection of plants with antimicrobial activity?","volume":"2013","author":"Silva","year":"2013","journal-title":"Evid.-Based Complementary Altern. Med. ECAM"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.5897\/AJPP11.428","article-title":"In vitro evaluation of antioxidant, antimicrobial and toxicity properties of extracts of Schinopsis brasiliensis Engl. (Anacardiaceae)","volume":"5","author":"Saraiva","year":"2011","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Bueno, J. (2012). In Vitro Antimicrobial Activity of Natural Products Using Minimum Inhibitory Concentrations: Looking for New Chemical Entities or Predicting Clinical Response. Med. Aromat. Plants, 1.","DOI":"10.4172\/2167-0412.1000113"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0367-326X(02)00180-6","article-title":"Antimicrobial activity of Solidago virgaurea L. from in vitro cultures","volume":"73","author":"Thiem","year":"2002","journal-title":"Fitoterapia"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0378-8741(94)90096-5","article-title":"Antibacterial activity of plant extracts used externally in traditional medicine","volume":"44","author":"Brantner","year":"1994","journal-title":"J. Ethnopharmacol."},{"key":"ref_141","first-page":"27","article-title":"Die antimikrobielle Wirkung von Solidago- haltigen Phytourologica","volume":"12","author":"Brantner","year":"1999","journal-title":"Drogen-Report"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/15228940802152836","article-title":"Antibacterial Activity of Some Plant Extracts Used in Folk Medicine","volume":"7","author":"Nair","year":"2008","journal-title":"J. Herb. Pharmacother."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1590\/S0074-02762000000300012","article-title":"Biological screening of Brazilian medicinal plants","volume":"95","author":"Alves","year":"2000","journal-title":"Mem\u00f3rias Do Inst. Oswaldo Cruz"},{"key":"ref_144","first-page":"1","article-title":"Constituents and biological activity of the essential oils of some Solidago and Artemisia species","volume":"857","author":"Kalemba","year":"2000","journal-title":"Sci. Pap. Tech. Univ. Lodz"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"132","DOI":"10.2174\/0929867321666140916113443","article-title":"Antibacterial activities of flavonoids: Structure-activity relationship and mechanism","volume":"22","author":"Xie","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Liu, J., Du, C., Beaman, H.T., and Monroe, M.B.B. (2020). Characterization of Phenolic Acid Antimicrobial and Antioxidant Structure\u2013Property Relationships. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12050419"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Guimar\u00e3es, A.C., Meireles, L.M., Lemos, M.F., Guimar\u00e3es, M.C.C., Endringer, D.C., Fronza, M., and Scherer, R. (2019). Antibacterial Activity of Terpenes and Terpenoids Present in Essential Oils. Molecules, 24.","DOI":"10.3390\/molecules24132471"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Wi\u0144ska, K., M\u0105czka, W., \u0141yczko, J., Grabarczyk, M., Czubaszek, A., and Szumny, A. (2019). Essential Oils as Antimicrobial Agents\u2014Myth or Real Alternative?. Molecules, 24.","DOI":"10.3390\/molecules24112130"},{"key":"ref_149","first-page":"72","article-title":"Cytotoxicity of triterpenoid saponins. Part 2: Relationships between the structures of glycosides of polygalacic acid and their activities against pathogenic Candida species","volume":"55","author":"Bader","year":"2000","journal-title":"Pharmazie"},{"key":"ref_150","unstructured":"Pepeljnjak, S., Ku\u0161trak, D., and Vuku\u0161i\u0107, I. (1997, January 7\u201312). Investigation of the Antimycotic Activities of Solidago virgaurea and Solidago gigantea Exstracts. Proceedings of the 45th Annual Congress of the Society for Medicinal Plant Research, Regensburg, Germany. Program and Abstracts."},{"key":"ref_151","first-page":"223","article-title":"Studies on chemical structures and pharmacological activities of triterpene saponins","volume":"53","author":"Matsuda","year":"1999","journal-title":"Nat. Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00436-008-1277-9","article-title":"Plant extracts as natural amoebicidal agents","volume":"104","author":"Derda","year":"2009","journal-title":"Parasitol. Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.exppara.2018.10.009","article-title":"Ovicidal and larvicidal activity of extracts from medicinal-plants against Haemonchus contortus","volume":"195","author":"Hodges","year":"2018","journal-title":"Exp. Parasitol."},{"key":"ref_154","first-page":"953","article-title":"Immunomodulatory and antitumoral effects of triterpenoid saponins","volume":"52","author":"Plohmann","year":"1997","journal-title":"Die Pharm."},{"key":"ref_155","first-page":"414","article-title":"Cytotoxicity of triterpenoid saponins. Part 1: Activities against tumor cells in vitro and hemolytical index","volume":"51","author":"Bader","year":"1996","journal-title":"Pharmazie"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cbi.2011.08.006","article-title":"Cell cycle arrest and apoptosis induced by methyl 3,5-dicaffeoyl quinate in human colon cancer cells: Involvement of the PI3K\/Akt and MAP kinase pathways","volume":"194","author":"Hu","year":"2011","journal-title":"Chem.-Biol. Interact."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"104683","DOI":"10.1016\/j.fitote.2020.104683","article-title":"Constituents from Solidago virgaurea var. gigantea and their inhibitory effect on lipid accumulation","volume":"146","author":"Jang","year":"2020","journal-title":"Fitoterapia"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1273479","DOI":"10.1080\/16546628.2016.1273479","article-title":"Anti-obesity effect of Solidago virgaurea var. g igantea extract through regulation of adipogenesis and lipogenesis pathways in high-fat diet-induced obese mice (C57BL\/6N)","volume":"61","author":"Wang","year":"2017","journal-title":"Food Nutr. Res."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Sanad, F.A.-A., Ahmed, S.F., and El-Tantawy, W.H. (2020). Antidiabetic and hypolipidemic potentials of Solidago virgaurea extract in alloxan-induced diabetes type 1. Arch. Physiol. Biochem., 1\u20138.","DOI":"10.1080\/13813455.2020.1722705"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s13105-013-0277-0","article-title":"Biochemical effects of Solidago virgaurea extract on experimental cardiotoxicity","volume":"70","year":"2014","journal-title":"J. Physiol. Biochem."},{"key":"ref_161","first-page":"1","article-title":"Blocking negative effects of senescence in human skin fibroblasts with a plant extract","volume":"4","author":"Schosserer","year":"2018","journal-title":"NPJ Aging Mech. Dis."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/10\/12\/1619\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:39:46Z","timestamp":1760179186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/10\/12\/1619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,30]]},"references-count":161,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["biom10121619"],"URL":"https:\/\/doi.org\/10.3390\/biom10121619","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints202010.0277.v1","asserted-by":"object"}]},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,30]]}}}