{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:42:33Z","timestamp":1790199753278,"version":"4.1.0"},"reference-count":577,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:00:00Z","timestamp":1609372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The incidence of brain pathologies has increased during last decades. Better diagnosis (autism spectrum disorders) and longer life expectancy (Parkinson\u2019s disease, Alzheimer\u2019s disease) partly explain this increase, while emerging data suggest pollutant exposures as a possible but still underestimated cause of major brain disorders. Taking into account that the brain parenchyma is rich in gap junctions and that most pollutants inhibit their function; brain disorders might be the consequence of gap-junctional alterations due to long-term exposures to pollutants. In this article, this hypothesis is addressed through three complementary aspects: (1) the gap-junctional organization and connexin expression in brain parenchyma and their function; (2) the effect of major pollutants (pesticides, bisphenol A, phthalates, heavy metals, airborne particles, etc.) on gap-junctional and connexin functions; (3) a description of the major brain disorders categorized as neurodevelopmental (autism spectrum disorders, attention deficit hyperactivity disorders, epilepsy), neurobehavioral (migraines, major depressive disorders), neurodegenerative (Parkinson\u2019s and Alzheimer\u2019s diseases) and cancers (glioma), in which both connexin dysfunction and pollutant involvement have been described. Based on these different aspects, the possible involvement of pollutant-inhibited gap junctions in brain disorders is discussed for prenatal and postnatal exposures.<\/jats:p>","DOI":"10.3390\/biom11010051","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T20:18:47Z","timestamp":1609445927000},"page":"51","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Brain Disorders and Chemical Pollutants: A Gap Junction Link?"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4922-0365","authenticated-orcid":false,"given":"Marc","family":"Mesnil","sequence":"first","affiliation":[{"name":"Laboratoire STIM, ERL7003 CNRS-Universit\u00e9 de Poitiers, 1 rue G. Bonnet\u2013TSA 51 106, 86073 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7504-7538","authenticated-orcid":false,"given":"Norah","family":"Defamie","sequence":"additional","affiliation":[{"name":"Laboratoire STIM, ERL7003 CNRS-Universit\u00e9 de Poitiers, 1 rue G. Bonnet\u2013TSA 51 106, 86073 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Naus","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Cellular &amp; Physiological Sciences, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7927-9643","authenticated-orcid":false,"given":"Denis","family":"Sarrouilhe","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiologie Humaine, Facult\u00e9 de M\u00e9decine et Pharmacie, 6 rue de La Mil\u00e9trie, b\u00e2t D1, TSA 51115, 86073 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,31]]},"reference":[{"key":"ref_1","unstructured":"GBD 2016 Neurology Collaborators (2019). Global, regional, and national burden of neurological disorders, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol., 18, 459\u2013480."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Alzheimer\u2019s Association (2020). 2020 Alzheimer\u2019s disease facts and figures. Alzheimers Dement., 16, 391\u2013460.","DOI":"10.1002\/alz.12068"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.12688\/f1000research.14506.1","article-title":"Current understanding of Alzheimer\u2019s disease diagnosis and treatment","volume":"7","author":"Weller","year":"2018","journal-title":"F1000Research"},{"key":"ref_4","unstructured":"Stewart, B.W., and Wild, C.P. (2014). Tumours of the nervous system. World Cancer Report 2014, International Agency for Research on Cancer."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1126\/science.aav6885","article-title":"Adult neurogenesis in mammals","volume":"364","author":"Gage","year":"2019","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fnhum.2019.00042","article-title":"A Review of Heterogeneity in Attention Deficit\/Hyperactivity Disorder (ADHD)","volume":"13","author":"Luo","year":"2019","journal-title":"Front Hum Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/jcpp.12381","article-title":"Annual research review: A meta-analysis of the worldwide prevalence of mental disorders in children and adolescents","volume":"56","author":"Polanczyk","year":"2015","journal-title":"J. Child Psychol. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-3-030-30402-7_4","article-title":"Neuropsychopathology of Autism Spectrum Disorder: Complex Interplay of Genetic, Epigenetic, and Environmental Factors","volume":"24","author":"Bhandari","year":"2020","journal-title":"Adv. Neurobiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev-publhealth-031816-044318","article-title":"The Changing Epidemiology of Autism Spectrum Disorders","volume":"20","author":"Lyall","year":"2017","journal-title":"Annu. Rev. Public Health"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/aur.239","article-title":"Global Prevalence of Autism and Other Pervasive Developmental Disorders","volume":"5","author":"Elsabbagh","year":"2012","journal-title":"Autism Res."},{"key":"ref_11","unstructured":"(2019, June 20). Epilepsy. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/epilepsy."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1056\/NEJMsa1204629","article-title":"Monetary costs of dementia in the United States","volume":"368","author":"Hurd","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00702-017-1686-y","article-title":"Epidemiology of Parkinson\u2019s disease","volume":"124","author":"Tysnes","year":"2017","journal-title":"J. Neural. Transm."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2741\/S415","article-title":"Parkinson\u2019s disease: A review","volume":"6","author":"Beitz","year":"2014","journal-title":"Front. Biosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.psychres.2017.01.060","article-title":"Prevalence and correlates of DSM-5 major depressive and related disorders in the community","volume":"250","author":"Vandeleur","year":"2017","journal-title":"Psychiatry Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s10597-014-9793-9","article-title":"Rate and Predictors of Persistent Major Depressive Disorder in a Nationally Representative Sample","volume":"51","author":"Walker","year":"2015","journal-title":"Community Ment. Health J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e12116","DOI":"10.1002\/1348-9585.12116","article-title":"Shift work and migraine: A systematic review","volume":"62","author":"Leso","year":"2020","journal-title":"J. Occup. Health"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1515\/BC.2002.076","article-title":"Structural and functional diversity of connexin genes in the mouse and human genome","volume":"383","author":"Willecke","year":"2002","journal-title":"Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbamem.2004.01.009","article-title":"Gap junctions and neurological disorders of the central nervous system","volume":"1662","author":"Nakase","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"REPORTS4027","DOI":"10.1186\/gb-2001-2-11-reports4027","article-title":"Learning the language of cell-cell communication through connexin channels","volume":"2","author":"Bruzzone","year":"2001","journal-title":"Genome Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4161\/chan.2.2.6003","article-title":"Connexin and pannexin hemichannels of neurons and astrocytes","volume":"2","author":"Thompson","year":"2008","journal-title":"Channels"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.mcn.2007.09.003","article-title":"Expression of connexin30.2 in interneurons of the central nervous system in the mouse","volume":"37","author":"Kreuzberg","year":"2008","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.neuroscience.2008.01.077","article-title":"Connexin31.1 deficiency in the mouse impairs object memory and modulates open-field exploration, acetylcholine esterase levels in the striatum, and cAMP response element-binding protein levels in the striatum and piriform cortex","volume":"153","author":"Dere","year":"2008","journal-title":"Neuroscience"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Swayne, L.A., and Bennett, S.A.L. (2016). Connexins and pannexins in neuronal development and adult neurogenesis. BMC Cell Biol., 17.","DOI":"10.1186\/s12860-016-0089-5"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0006-8993(00)02300-3","article-title":"Expression of connexin36 in the adult and developing rat brain","volume":"865","author":"Belluardo","year":"2000","journal-title":"Brain Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0165-0173(99)00068-5","article-title":"Expression of Cx36 in mammalian neurons","volume":"32","author":"Condorelli","year":"2000","journal-title":"Brain Res. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbamem.2017.05.019","article-title":"Electrical synapses in mammalian CNS: Past eras, present focus and future directions","volume":"1860","author":"Nagy","year":"2018","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbrc.2008.01.054","article-title":"ATP release by way of connexin 36 hemichannels mediates ischemic tolerance in vitro","volume":"368","author":"Schock","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1113\/jphysiol.2004.065672","article-title":"Electrical and chemical transmission between striatal GABAergic output neurones in rat brain slices","volume":"559","author":"Venance","year":"2004","journal-title":"J. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1111\/j.1460-9568.2006.05052.x","article-title":"Localization of heterotypic gap junctions composed of connexin45 and connexin36 in the rod pathway of the mouse retina","volume":"24","author":"Dedek","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/cne.20621","article-title":"Connexin45 mediates gap junctional coupling of bistratified ganglion cells in the mouse retina","volume":"490","author":"Schubert","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/cne.20873","article-title":"Spatiotemporal distribution of Connexin45 in the olivocerebellar system","volume":"495","author":"Maxeiner","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1111\/j.0953-816X.2004.03360.x","article-title":"Functional expression of connexin57 in horizontal cells of the mouse retina","volume":"19","author":"Hombach","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1113\/jphysiol.2009.171496","article-title":"Gating, permselectivity and pH-dependent modulation of channels formed by connexin57, a major connexin of horizontal cells in the mouse retina","volume":"587","author":"Sonntag","year":"2009","journal-title":"J. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.neuroscience.2007.06.003","article-title":"Spatial relationships of connexin36, connexin57 and zonula occludens-1 in the outer plexiform layer of mouse retina","volume":"148","author":"Ciolofan","year":"2007","journal-title":"Neuroscience"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bbr.2004.06.023","article-title":"Stimulus complexity dependent memory impairment and changes in motor performance after deletion of the neuronal gap junction protein connexin36 in mice","volume":"157","author":"Frisch","year":"2005","journal-title":"Behav. Brain Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neulet.2011.07.018","article-title":"Deletion of neuronal gap junction protein connexin 36 impairs hippocampal LTP","volume":"502","author":"Wang","year":"2011","journal-title":"Neurosci. Lett."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.eplepsyres.2006.06.021","article-title":"Confirmatory evidence for an association of the connexin-36 gene with juvenile myoclonic epilepsy","volume":"71","author":"Hempelmann","year":"2006","journal-title":"Epilepsy Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1136\/jmg.2003.017954","article-title":"Association of the connexin36 gene with juvenile myoclonic epilepsy","volume":"41","author":"Mas","year":"2004","journal-title":"J. Med. Genet."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0306-4522(98)00191-2","article-title":"Connexin30 in rodent, cat and human brain: Selective expression in gray matter astrocytes, co-localization with connexin43 at gap junctions and late developmental appearance","volume":"88","author":"Nagy","year":"1999","journal-title":"Neuroscience"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1523\/JNEUROSCI.21-06-01983.2001","article-title":"Cell-specific expression of connexins and evidence of restricted gap junctional coupling between glial cells and between neurons","volume":"21","author":"Nagy","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5207","DOI":"10.1523\/JNEUROSCI.5100-07.2008","article-title":"Gap junction-mediated astrocytic networks in the mouse barrel cortex","volume":"28","author":"Houades","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1111\/j.1460-9568.2003.03042.x","article-title":"A reporter allele for investigating connexin 26 gene expression in the mouse brain","volume":"18","author":"Filippov","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neuroscience.2014.11.048","article-title":"Hemichannels: New pathways for gliotransmitter release","volume":"286","author":"Montero","year":"2015","journal-title":"Neuroscience"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/jcbfm.2011.149","article-title":"Sweet sixteen for ANLS","volume":"32","author":"Pellerin","year":"2012","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"ref_46","first-page":"1045","article-title":"Potassium buffering in the central nervous system","volume":"129","author":"Kofuji","year":"2004","journal-title":"Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1523\/JNEUROSCI.0037-06.2006","article-title":"The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus","volume":"26","author":"Wallraff","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"8467","DOI":"10.1073\/pnas.1016650108","article-title":"Astroglial networks scale synaptic activity and plasticity","volume":"108","author":"Pannasch","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/jcbfm.2012.45","article-title":"Deletion of astroglial connexins weakens the blood-brain barrier","volume":"32","author":"Ezan","year":"2012","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"13781","DOI":"10.1523\/JNEUROSCI.2042-07.2007","article-title":"Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia","volume":"27","author":"Retamal","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/glia.22785","article-title":"Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes","volume":"63","author":"Abudara","year":"2015","journal-title":"Glia"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"pe4","DOI":"10.1126\/scisignal.2002799","article-title":"Depletion of extracellular Ca2+ prompts astroglia to moderate synaptic network activity","volume":"5","author":"Rusakov","year":"2012","journal-title":"Sci. Signal."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"11388","DOI":"10.1073\/pnas.1434298100","article-title":"Gating and regulation of connexin 43 (Cx43) hemichannels","volume":"100","author":"Contreras","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.bbamem.2017.08.014","article-title":"Role of astrocyte connexin hemichannels in cortical spreading depression","volume":"1860","author":"Rovegno","year":"2018","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.bbamcr.2014.04.016","article-title":"The dual face of connexin-based astroglial Ca(2+) communication: A key player in brain physiology and a prime target in pathology","volume":"1843","author":"Decrock","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"20130596","DOI":"10.1098\/rstb.2013.0596","article-title":"Astroglial connexin 43 sustains glutamatergic synaptic efficacy","volume":"369","author":"Chever","year":"2014","journal-title":"Philos. Trans. R Soc. Lond. B Biol. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1523\/JNEUROSCI.23-03-00766.2003","article-title":"Accelerated hippocampal spreading depression and enhanced locomotory activity in mice with astrocyte-directed inactivation of connexin43","volume":"23","author":"Theis","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1046\/j.1460-9568.2003.02971.x","article-title":"Mice with astrocyte-directed inactivation of connexin43 exhibit increased exploratory behaviour, impaired motor capacities, and changes in brain acetylcholine levels","volume":"18","author":"Frisch","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1046\/j.1460-9568.2003.02784.x","article-title":"Connexin30-deficient mice show increased emotionality and decreased rearing activity in the open-field along with neurochemical changes","volume":"18","author":"Dere","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1523\/JNEUROSCI.0341-09.2009","article-title":"Deletion of astrocyte connexins 43 and 30 leads to a dysmyelinating phenotype and hippocampal CA1 vacuolation","volume":"29","author":"Lutz","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_61","first-page":"120","article-title":"Neurological manifestations of oculodentodigital dysplasia: A Cx43 channelopathy of the central nervous system?","volume":"4","author":"Kerrebrouck","year":"2013","journal-title":"Front. Pharm."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.neuroscience.2004.03.063","article-title":"Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain","volume":"126","author":"Li","year":"2004","journal-title":"Neuroscience"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuroscience.2005.08.027","article-title":"Connexin-47 and connexin-32 in gap junctions of oligodendrocyte somata, myelin sheaths, paranodal loops and Schmidt-Lanterman incisures: Implications for ionic homeostasis and potassium siphoning","volume":"136","author":"Kamasawa","year":"2005","journal-title":"Neuroscience"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.neuropharm.2015.05.021","article-title":"Oxaliplatin-induced neurotoxicity is mediated through gap junction channels and hemichannels and can be prevented by octanol","volume":"97","author":"Kagiava","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/glia.10278","article-title":"Coupling of astrocyte connexins Cx26, Cx30, Cx43 to oligodendrocyte Cx29, Cx32, Cx47: Implications from normal and connexin32 knockout mice","volume":"44","author":"Nagy","year":"2003","journal-title":"Glia"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1523\/JNEUROSCI.23-11-04549.2003","article-title":"Connexin 47 (Cx47)-deficient mice with enhanced green fluorescent protein reporter gene reveal predominant oligodendrocytic expression of Cx47 and display vacuolized myelin in the CNS","volume":"23","author":"Odermatt","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/glia.20991","article-title":"Oligodendrocytes in mouse corpus callosum are coupled via gap junction channels formed by connexin47 and connexin32","volume":"58","author":"Maglione","year":"2010","journal-title":"Glia"},{"key":"ref_68","first-page":"83","article-title":"The oligodendroglial precursor cell line Oli-neu represents a cell culture system to examine functional expression of the mouse gap junction gene connexin29 (Cx29)","volume":"4","author":"Hombach","year":"2013","journal-title":"Front. Pharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s12038-018-9811-0","article-title":"Connexin 43\/47 channels are important for astrocyte\/ oligodendrocyte cross-talk in myelination and demyelination","volume":"43","author":"Basu","year":"2018","journal-title":"J. Biosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"10984","DOI":"10.1523\/JNEUROSCI.0304-06.2006","article-title":"Genetic and physiological evidence that oligodendrocyte gap junctions contribute to spatial buffering of potassium released during neuronal activity","volume":"26","author":"Menichella","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/glia.20315","article-title":"Expression pattern and functional characterization of connexin29 in transgenic mice","volume":"53","author":"Eiberger","year":"2006","journal-title":"Glia"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/cercor\/10.7.684","article-title":"Myelination defects and neuronal hyperexcitability in the neocortex of connexin32-deficient mice","volume":"10","author":"Sutor","year":"2000","journal-title":"Cereb. Cortex."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5963","DOI":"10.1523\/JNEUROSCI.23-13-05963.2003","article-title":"Connexins are critical for normal myelination in the CNS","volume":"23","author":"Menichella","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7499","DOI":"10.1523\/JNEUROSCI.0392-12.2012","article-title":"Panglial gap junctional communication is essential for maintenance of myelin in the CNS","volume":"32","author":"Tress","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1126\/science.8266101","article-title":"Connexin mutations in X-linked Charcot-Marie-Tooth disease","volume":"262","author":"Bergoffen","year":"1993","journal-title":"Science"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10048-015-0442-4","article-title":"A start codon CMT1X mutation associated with transient encephalomyelitis causes complete loss of Cx32","volume":"16","author":"Sargiannidou","year":"2015","journal-title":"Neurogenetics"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.mcn.2007.01.010","article-title":"Loss-of-function GJA12\/Connexin47 mutations cause Pelizaeus-Merzbacher-like disease","volume":"34","author":"Enriquez","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ymgme.2013.12.001","article-title":"GJC2 promoter mutations causing Pelizaeus-Merzbacher-like disease","volume":"111","author":"Gotoh","year":"2014","journal-title":"Mol. Genet. Metab."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1006\/cbir.1998.0392","article-title":"Ultrastructure, histological distribution, and freeze-fracture immunocytochemistry of gap junctions in rat brain and spinal cord","volume":"22","author":"Rash","year":"1998","journal-title":"Cell Biol. Int."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.febslet.2014.02.060","article-title":"A new angle on blood-CNS interfaces: A role for connexins?","volume":"588","author":"Vandenbroucke","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/jcp.20647","article-title":"Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells","volume":"208","author":"Nagasawa","year":"2006","journal-title":"J. Cell Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12944-018-0727-3","article-title":"Polymorphism of CONNEXIN37 gene is a risk factor for ischemic stroke in Han Chinese population","volume":"17","author":"Li","year":"2018","journal-title":"Lipids Health Dis."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.2337\/diabetes.51.10.3107","article-title":"Pericytes and the pathogenesis of diabetic retinopathy","volume":"51","author":"Hammes","year":"2002","journal-title":"Diabetes"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nature05193","article-title":"Bidirectional control of CNS capillary diameter by pericytes","volume":"443","author":"Peppiatt","year":"2006","journal-title":"Nature"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fnene.2010.00005","article-title":"Pericyte-mediated regulation of capillary diameter: A component of neurovascular coupling in health and disease","volume":"2","author":"Hamilton","year":"2010","journal-title":"Front. Neuroenergetics"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0847-6","article-title":"Brain microvascular pericytes in health and disease","volume":"122","author":"Dalkara","year":"2011","journal-title":"Acta Neuropathol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"21362","DOI":"10.1074\/jbc.M600504200","article-title":"Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner","volume":"281","author":"Takeuchi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/jnr.20650","article-title":"Human and mouse microglia express connexin36, and functional gap junctions are formed between rodent microglia and neurons","volume":"82","author":"Dobrenis","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.neuint.2012.02.023","article-title":"AGEs-RAGE mediated up-regulation of connexin43 in activated human microglial CHME-5 cells","volume":"60","author":"Shaikh","year":"2012","journal-title":"Neurochem. Int."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1073\/pnas.051634298","article-title":"Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha","volume":"98","author":"Eckardt","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1471-4159.2005.03384.x","article-title":"Staphylococcus aureus-derived peptidoglycan induces Cx43 expression and functional gap junction intercellular communication in microglia","volume":"95","author":"Garg","year":"2005","journal-title":"J. Neurochem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.1523\/JNEUROSCI.6417-10.2011","article-title":"Amyloid \u03b2-induced death in neurons involves glial and neuronal hemichannels","volume":"31","author":"Orellana","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/glia.20381","article-title":"Differential activation of microglia in neurogenic versus non-neurogenic regions of the forebrain","volume":"54","author":"Goings","year":"2006","journal-title":"Glia"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neuroscience.2012.08.053","article-title":"Immunological regulation of neurogenic niches in the adult brain","volume":"226","year":"2012","journal-title":"Neuroscience"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1038\/nn.3233","article-title":"Neural progenitor cells regulate microglia functions and activity","volume":"15","author":"Mosher","year":"2012","journal-title":"Nat. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/j.1471-4159.2009.06548.x","article-title":"The more you have, the less you get: The functional role of inflammation on neuronal differentiation of endogenous and transplanted neural stem cells in the adult brain","volume":"112","author":"Mathieu","year":"2010","journal-title":"J. Neurochem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1523\/JNEUROSCI.1619-13.2014","article-title":"Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone","volume":"34","author":"Hoshikawa","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.4049\/jimmunol.0900861","article-title":"Direct antigen presentation and gap junction mediated cross-presentation during apoptosis","volume":"183","author":"Pang","year":"2009","journal-title":"J. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/35102174","article-title":"The development of neural stem cells","volume":"414","author":"Temple","year":"2001","journal-title":"Nature"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.tins.2009.09.003","article-title":"Molecular layers underlying cytoskeletal remodelling during cortical development","volume":"33","author":"Heng","year":"2010","journal-title":"Trends Neurosci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: Significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.conb.2004.03.001","article-title":"Functional significance of adult neurogenesis","volume":"14","author":"Kempermann","year":"2004","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1101\/gad.187336.112","article-title":"Orchestrating transcriptional control of adult neurogenesis","volume":"26","author":"Hsieh","year":"2012","journal-title":"Genes Dev."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis","volume":"132","author":"Zhao","year":"2008","journal-title":"Cell"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1476-069X-11-S1-S5","article-title":"Chlorpyrifos and neurodevelopmental effects: A literature review and expert elicitation on research and policy","volume":"11","author":"Saunders","year":"2012","journal-title":"Environ. Health"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.pbiomolbio.2007.03.005","article-title":"Gap junctional communication in morphogenesis","volume":"94","author":"Levin","year":"2007","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1523\/JNEUROSCI.17-09-03096.1997","article-title":"Differential expression of connexins during neocortical development and neuronal circuit formation","volume":"17","author":"Nadarajah","year":"1997","journal-title":"J. Neurosci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/cne.21426","article-title":"Expression of connexins in embryonic mouse neocortical development","volume":"504","author":"Cina","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1097\/00001756-200011270-00045","article-title":"Cx36 is dynamically expressed during early development of mouse brain and nervous system","volume":"11","author":"Gulisano","year":"2000","journal-title":"Neuroreport"},{"key":"ref_110","first-page":"973","article-title":"The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development","volume":"382","author":"Eiberger","year":"2001","journal-title":"Biol. Chem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF02110114","article-title":"The role of gap junction membrane channels in development","volume":"28","author":"Lo","year":"1996","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.pbiomolbio.2007.03.011","article-title":"Connexin channel permeability to cytoplasmic molecules","volume":"94","author":"Harris","year":"2007","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/nature06063","article-title":"Gap junction adhesion is necessary for radial migration in the neocortex","volume":"448","author":"Elias","year":"2007","journal-title":"Nature"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"11836","DOI":"10.1074\/jbc.M109.058750","article-title":"The carboxyl-terminal domain of connexin43 is a negative modulator of neuronal differentiation","volume":"285","author":"Santiago","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Hartfield, E.M., Rinaldi, F., Glover, CP., Wong, L.F., Caldwell, M.A., and Uney, J.B. (2011). Connexin 36 expression regulates neuronal differentiation from neural progenitor cells. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0014746"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0014-5793(98)00479-7","article-title":"The murine gap junction gene connexin36 is highly expressed in mouse retina and regulated during brain development","volume":"428","author":"Degen","year":"1998","journal-title":"FEBS Lett."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1046\/j.1460-9568.2003.02910.x","article-title":"Cellular expression of connexins in the rat brain: Neuronal localization, effects of kainate-induced seizures and expression in apoptotic neuronal cells","volume":"18","author":"Condorelli","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0896-6273(01)00373-7","article-title":"Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing connexin36","volume":"31","author":"Deans","year":"2001","journal-title":"Neuron"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.tins.2008.02.007","article-title":"Gap junctions: Multifaceted regulators of embryonic cortical development","volume":"31","author":"Elias","year":"2008","journal-title":"Trends Neurosci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1523\/JNEUROSCI.5025-08.2009","article-title":"Involvement of the cytoplasmic C-terminal domain of connexin43 in neuronal migration","volume":"29","author":"Cina","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1007\/s12035-015-9190-6","article-title":"Phosphorylation of Connexin 43 by Cdk5 Modulates Neuronal Migration During Embryonic Brain Development","volume":"53","author":"Qi","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fncel.2019.00003","article-title":"Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease","volume":"13","author":"Vejar","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1152\/jn.2001.85.2.620","article-title":"Immature neocortical neurons exist as extensive syncytial networks linked by dendrodendritic electrical connections","volume":"85","author":"Peinado","year":"2001","journal-title":"J. Neurophysiol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0896-6273(93)90246-N","article-title":"Extensive dye coupling between rat neocortical neurons during the period of circuit formation","volume":"10","author":"Peinado","year":"1993","journal-title":"Neuron"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nn844","article-title":"Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons","volume":"5","author":"Song","year":"2002","journal-title":"Nat. Neurosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.neuron.2004.08.015","article-title":"Calcium waves propagate through radial glial cells and modulate proliferation in the developing neocortex","volume":"43","author":"Weissman","year":"2004","journal-title":"Neuron"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.1496379","article-title":"Neuronal domains in developing neocortex","volume":"257","author":"Yuste","year":"1992","journal-title":"Science"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0896-6273(95)90236-8","article-title":"Neuronal domains in developing neocortex: Mechanisms of coactivation","volume":"14","author":"Yuste","year":"1995","journal-title":"Neuron"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1523\/JNEUROSCI.18-04-01419.1998","article-title":"Coordination of neuronal activity in developing visual cortex by gap junction-mediated biochemical communication","volume":"18","author":"Kandler","year":"1998","journal-title":"J. Neurosci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.semcdb.2011.02.007","article-title":"Purinergic signaling in neural development","volume":"22","author":"Zimmermann","year":"2011","journal-title":"Semin. Cell. Dev. Biol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fncel.2015.00211","article-title":"Purinergic signaling: A common pathway for neural and mesenchymal stem cell maintenance and differentiation","volume":"9","author":"Cavaliere","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuropharm.2013.05.017","article-title":"P2X7 receptors at adult neural progenitor cells of the mouse subventricular zone","volume":"73","author":"Messemer","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/j.1471-4159.2009.06008.x","article-title":"Neural progenitor cell death is induced by extracellular ATP via ligation of P2X7 receptor","volume":"109","author":"Delarasse","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/stem.1864","article-title":"P2X7 receptors mediate innate phagocytosis by human neural precursor cells and neuroblasts","volume":"33","author":"Lovelace","year":"2015","journal-title":"Stem Cells"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/glia.20484","article-title":"A role for Connexin43 during neurodevelopment","volume":"55","author":"Djukic","year":"2007","journal-title":"Glia"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/wrna.1289","article-title":"Post-transcriptional regulation in corticogenesis: How RNA-binding proteins help build the brain","volume":"6","author":"Pilaz","year":"2015","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/cne.21974","article-title":"Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain","volume":"513","author":"Azevedo","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"ref_138","first-page":"31","article-title":"The Human Brain in Numbers: A Linearly Scaled-up Primate Brain","volume":"3","year":"2009","journal-title":"Front Hum. Neurosci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fnmol.2018.00118","article-title":"Connexin-Mediated Functional and Metabolic Coupling Between Astrocytes and Neurons","volume":"11","author":"Mayorquin","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-1-60761-938-3_4","article-title":"The blood-cerebrospinal fluid barrier: Structure and functional significance","volume":"686","author":"Johanson","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/(SICI)1097-0029(19980401)41:1<2::AID-JEMT2>3.0.CO;2-Z","article-title":"Ependymal development, proliferation, and functions: A review","volume":"41","author":"Bruni","year":"1998","journal-title":"Microsc. Res. Tech."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/glia.440140102","article-title":"The ependyma: A protective barrier between brain and cerebrospinal fluid","volume":"14","year":"1995","journal-title":"Glia"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00401-009-0624-y","article-title":"Ependymal cells: Biology and pathology","volume":"119","year":"2010","journal-title":"Acta Neuropathol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"11298","DOI":"10.1038\/ncomms11298","article-title":"Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity","volume":"7","author":"Battefeld","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"ra6","DOI":"10.1126\/scisignal.aad3066","article-title":"Astroglial networks promote neuronal coordination","volume":"9","author":"Chever","year":"2016","journal-title":"Sci Signal."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/glia.21073","article-title":"Functional heterotypic interactions between astrocyte and oligodendrocyte connexins","volume":"59","author":"Magnotti","year":"2011","journal-title":"Glia"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.nbd.2011.03.003","article-title":"Cx32 and Cx47 mediate oligodendrocyte:astrocyte and oligodendrocyte:oligodendrocyte gap junction coupling","volume":"42","author":"Wasseff","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/nrn3708","article-title":"Electrical synapses and their functional interactions with chemical synapses","volume":"15","author":"Pereda","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"7573","DOI":"10.1073\/pnas.97.13.7573","article-title":"Immunogold evidence that neuronal gap junctions in adult rat brain and spinal cord contain connexin-36 but not connexin-32 or connexin-43","volume":"97","author":"Rash","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1523\/JNEUROSCI.18-05-01753.1998","article-title":"Changes in the properties of gap junctions during neuronal differentiation of hippocampal progenitor cells","volume":"18","author":"Rozental","year":"1998","journal-title":"J. Neurosci."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1006\/cbir.1998.0388","article-title":"Connexin expression in Huntington\u2019s diseased human brain","volume":"22","author":"Vis","year":"1998","journal-title":"Cell. Biol. Int."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.molbrainres.2004.09.026","article-title":"Expression of neural connexins and pannexin1 in the hippocampus and inferior olive: A quantitative approach","volume":"133","author":"Weickert","year":"2005","journal-title":"Mol. Brain Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0006-8993(83)90943-5","article-title":"Neuronal gap junctions in the polymorph layer of the rat dentate gyrus","volume":"277","author":"Kosaka","year":"1983","journal-title":"Brain Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1523\/JNEUROSCI.20-04-01519.2000","article-title":"Gap junctions linking the dendritic network of GABAergic interneurons in the hippocampus","volume":"20","author":"Fukuda","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0168-0102(00)00163-2","article-title":"The dual network of GABAergic interneurons linked by both chemical and electrical synapses: A possible infrastructure of the cerebral cortex","volume":"38","author":"Fukuda","year":"2000","journal-title":"Neurosci. Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1038\/nn.3569","article-title":"Regulation of interneuron excitability by gap junction coupling with principal cells","volume":"16","author":"Apostolides","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/47029","article-title":"A network of fast-spiking cells in the neocortex connected by electrical synapses","volume":"402","author":"Galarreta","year":"1999","journal-title":"Nature"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1152\/jn.00843.2014","article-title":"Asymmetry and modulation of spike timing in electrically coupled neurons","volume":"113","author":"Sevetson","year":"2015","journal-title":"J. Neurophysiol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2014.01.007","article-title":"The coupling features of electrical synapses modulate neuronal synchrony in hypothalamic superachiasmatic nucleus","volume":"1550","author":"Wang","year":"2014","journal-title":"Brain Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1523\/JNEUROSCI.22-03-01002.2002","article-title":"Electrical synapses in the thalamic reticular nucleus","volume":"22","author":"Landisman","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.neures.2006.08.013","article-title":"Connexin mRNA expression in single dopaminergic neurons of substantia nigra pars compacta","volume":"56","author":"Vandecasteele","year":"2006","journal-title":"Neurosci. Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.neubiorev.2006.03.006","article-title":"Habituation in rodents: A review of behavior, neurobiology, and genetics","volume":"30","author":"Leussis","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.tins.2013.04.004","article-title":"Emerging role for astroglial networks in information processing: From synapse to behavior","volume":"36","author":"Pannasch","year":"2013","journal-title":"Trends Neurosci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"13949","DOI":"10.1523\/JNEUROSCI.3395-07.2007","article-title":"Two Distinct Heterotypic Channels Mediate Gap Junction Coupling between Astrocyte and Oligodendrocyte Connexins","volume":"27","author":"Freidin","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0006-8993(90)90415-8","article-title":"LM and EM immunolocalization of the gap junctional protein connexin 43 in rat brain","volume":"508","author":"Yamamoto","year":"1990","journal-title":"Brain Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/cne.903020414","article-title":"On the organization of astrocytic gap junctions in rat brain as suggested by LM and EM immunohistochemistry of connexin43 expression","volume":"302","author":"Yamamoto","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0166-2236(96)10046-1","article-title":"Control of gap-junctional communication in astrocytic networks","volume":"19","author":"Giaume","year":"1996","journal-title":"Trends Neurosci."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1152\/physiolgenomics.00062.2003","article-title":"Array analysis of gene expression in connexin-43 null astrocytes","volume":"15","author":"Iacobas","year":"2003","journal-title":"Physiol. Genom."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1093\/cercor\/bhu157","article-title":"Characterization of Panglial Gap Junction Networks in the Thalamus, Neocortex, and Hippocampus Reveals a Unique Population of Glial Cells","volume":"25","author":"Griemsmann","year":"2015","journal-title":"Cereb. Cortex"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0074-7696(08)62161-0","article-title":"Structure\u2014Function relationships in gap junctions","volume":"157","author":"Wolburg","year":"1995","journal-title":"Int. Rev. Cytol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/(SICI)1096-9861(19971117)388:2<265::AID-CNE6>3.0.CO;2-#","article-title":"Grid-mapped freeze-fracture analysis of gap junctions in gray and white matter of adult rat central nervous system, with evidence for a \u201cpanglial syncytium\u201d that is not coupled to neurons","volume":"388","author":"Rash","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1126\/science.1164022","article-title":"Astroglial metabolic networks sustain hippocampal synaptic transmission","volume":"322","author":"Rouach","year":"2008","journal-title":"Science"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"10625","DOI":"10.1073\/pnas.91.22.10625","article-title":"Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization","volume":"91","author":"Pellerin","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/glia.22924","article-title":"Gap junction coupling confers isopotentiality on astrocyte syncytium","volume":"64","author":"Ma","year":"2016","journal-title":"Glia"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"44065","DOI":"10.1074\/jbc.M405985200","article-title":"Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes","volume":"279","author":"Hibino","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1523\/JNEUROSCI.17-01-00171.1997","article-title":"Specialized membrane domains for water transport in glial cells: High-resolution immunogold cytochemistry of aquaporin-4 in rat brain","volume":"17","author":"Nielsen","year":"1997","journal-title":"J. Neurosci."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.neuroscience.2004.06.076","article-title":"Freeze-fracture and immunogold analysis of aquaporin-4 (AQP4) square arrays, with models of AQP4 lattice assembly","volume":"129","author":"Rash","year":"2004","journal-title":"Neuroscience"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"323","DOI":"10.4161\/chan.3.5.9568","article-title":"Carbenoxolone inhibits volume-regulated anion conductance in cultured rat cortical astroglia","volume":"3","author":"Benfenati","year":"2009","journal-title":"Channels"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"6897","DOI":"10.1523\/JNEUROSCI.19-16-06897.1999","article-title":"Three-dimensional relationships between hippocampal synapses and astrocytes","volume":"19","author":"Ventura","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fneng.2013.00007","article-title":"The blood-brain barrier: An engineering perspective","volume":"6","author":"Wong","year":"2013","journal-title":"Front. Neuroeng."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00401-009-0482-7","article-title":"Microvessel lengthdensity, total length, and length perneuron in five subcortical regionsin schizophrenia","volume":"117","author":"Kreczmanski","year":"2009","journal-title":"Acta Neuropathol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s00401-005-1003-y","article-title":"Stereological studies of capillarylength density in the frontal cortexof schizophrenics","volume":"109","author":"Kreczmanski","year":"2005","journal-title":"Acta Neuropathol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.tins.2005.02.001","article-title":"Neurovascular mechanisms of Alzheimer\u2019s neurodegeneration","volume":"28","author":"Zlokovic","year":"2005","journal-title":"Trends Neurosci."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/pr.57.2.4","article-title":"The blood-brain barrier\/neurovascular unit in health and disease","volume":"57","author":"Hawkins","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1096\/fasebj.7.11.8370472","article-title":"Pericyte physiology","volume":"7","author":"Shepro","year":"1993","journal-title":"FASEB J."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2045-8118-8-8","article-title":"The CNS microvascular pericyte: Pericyte-astrocyte crosstalk in the regulation of tissue survival","volume":"8","author":"Bonkowski","year":"2011","journal-title":"Fluids Barriers CNS"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1084\/jem.20142290","article-title":"A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules","volume":"212","author":"Aspelund","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The Glymphatic System: A Beginner\u2019s Guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3109\/09687688.2014.937468","article-title":"The blood-brain barrier: Structure, function and therapeutic approaches to cross it","volume":"31","author":"Tajes","year":"2014","journal-title":"Mol. Membr. Biol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2015.11.017","article-title":"Immunoregulation at the gliovascular unit in the healthy brain: A focus on Connexin 43","volume":"56","author":"Boulay","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1096\/fj.201700699R","article-title":"Connexin 43 gap junctions contribute to brain endothelial barrier hyperpermeability in familial cerebral cavernous malformations type III by modulating tight junction structure","volume":"32","author":"Johnson","year":"2018","journal-title":"FASEB J."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.expneurol.2019.03.014","article-title":"Impairment of pericyte-endothelium crosstalk leads to blood-brain barrier dysfunction following traumatic brain injury","volume":"317","author":"Bhowmick","year":"2019","journal-title":"Exp. Neurol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/glia.22960","article-title":"Into rather unexplored terrain-transcellular transport across the blood-brain barrier","volume":"64","author":"Vandenbroucke","year":"2016","journal-title":"Glia"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1515\/revneuro-2017-0092","article-title":"Gliotransmitters and cytokines in the control of blood-brain barrier permeability","volume":"29","author":"Osipova","year":"2018","journal-title":"Rev. Neurosci."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1749-6632.1999.tb07821.x","article-title":"The blood-brain barrier and cerebrovascular pathology in Alzheimer\u2019s disease","volume":"893","author":"Kalaria","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1750-3639.2005.tb00103.x","article-title":"Neurovascular pathways and Alzheimer amyloid beta-peptide","volume":"15","author":"Zlokovic","year":"2005","journal-title":"Brain Pathol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3727\/000000007783464731","article-title":"Blood-brain barrier pathology in Alzheimer\u2019s and Parkinson\u2019s disease: Implications for drug therapy","volume":"16","author":"Desai","year":"2007","journal-title":"Cell Transplant."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.neurobiolaging.2006.05.016","article-title":"Microvascular injury and blood-brain barrier leakage in Alzheimer\u2019s disease","volume":"28","author":"Zipser","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1073\/pnas.0709788105","article-title":"Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer\u2019s disease","volume":"105","author":"Meyer","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/ana.20369","article-title":"Blood-brain barrier dysfunction in parkinsonian midbrain in vivo","volume":"57","author":"Kortekaas","year":"2005","journal-title":"Ann. Neurol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"272","DOI":"10.2741\/4206","article-title":"Disruption of the blood-brain barrier in Parkinson\u2019s disease: Curse or route to a cure?","volume":"19","author":"Lee","year":"2014","journal-title":"Front. Biosci."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00702-008-0030-y","article-title":"Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson\u2019s disease, PSP and MSA","volume":"115","author":"Bartels","year":"2008","journal-title":"J. Neural. Transm."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"7829","DOI":"10.1523\/JNEUROSCI.1751-04.2004","article-title":"Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex","volume":"24","author":"Seiffert","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1111\/j.1528-1167.2006.00817.x","article-title":"The blood-brain barrier and epilepsy","volume":"47","author":"Oby","year":"2006","journal-title":"Epilepsia"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/brain\/awh682","article-title":"Molecular and cellular mechanisms of pharmacoresistance in epilepsy","volume":"129","author":"Remy","year":"2006","journal-title":"Brain"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1046\/j.1469-7580.2002.00065.x","article-title":"Blood-brain barrier breakdown in septic encephalopathy and brain tumours","volume":"200","author":"Davies","year":"2002","journal-title":"J. Anat."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.neuroscience.2004.05.044","article-title":"Molecular mechanisms of brain tumor edema","volume":"129","author":"Papadopoulos","year":"2004","journal-title":"Neuroscience"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"11419","DOI":"10.1158\/0008-5472.CAN-05-1271","article-title":"ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier","volume":"65","author":"Bronger","year":"2005","journal-title":"Cancer Res."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Reddy, O.C., and van der Werf, Y.D. (2020). The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices. Brain Sci., 10.","DOI":"10.3390\/brainsci10110868"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"557384","DOI":"10.3389\/fnagi.2020.557384","article-title":"Aging of the Vascular System and Neural Diseases","volume":"12","author":"Watanabe","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.semcdb.2019.01.005","article-title":"Neural stem cell niche heterogeneity","volume":"95","author":"Andreotti","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.pneurobio.2018.04.001","article-title":"Regulation and function of neurogenesis in the adult mammalian hypothalamus","volume":"170","author":"Yoo","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-0173(85)90016-5","article-title":"Ependyma: Normal and pathological. A review of the literature","volume":"356","author":"Bruni","year":"1985","journal-title":"Brain Res."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/gt.2009.58","article-title":"Analysis of neuronal proliferation, migration and differentiation in the postnatal brain using equine infectious anemia virus-based lentiviral vectors","volume":"16","author":"Jacquet","year":"2009","journal-title":"Gene Ther."},{"key":"ref_216","first-page":"3661","article-title":"Mcidas and GemC1 are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche","volume":"142","author":"Kyrousi","year":"2015","journal-title":"Development"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.stem.2008.07.004","article-title":"Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain","volume":"3","author":"Mirzadeh","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuron.2011.05.029","article-title":"Ank3-dependent SVZ niche assembly is required for the continued production of new neurons","volume":"71","author":"Abdi","year":"2011","journal-title":"Neuron"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1523\/JNEUROSCI.1108-04.2005","article-title":"Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis","volume":"25","author":"Spassky","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)80783-7","article-title":"Subventricular zone astrocytes are neural stem cells in the adult mammalian brain","volume":"97","author":"Doetsch","year":"1999","journal-title":"Cell"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.neuro.051508.135600","article-title":"The glial nature of embryonic and adult neural stem cells","volume":"32","author":"Kriegstein","year":"2009","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1523\/JNEUROSCI.17-13-05046.1997","article-title":"Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain","volume":"17","author":"Doetsch","year":"1997","journal-title":"J. Neurosci."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/(SICI)1097-4695(199808)36:2<234::AID-NEU10>3.0.CO;2-E","article-title":"Architecture and cell types of the adult subventricular zone: In search of the stem cells","volume":"36","author":"Doetsch","year":"1998","journal-title":"J. Neurobiol."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1523\/JNEUROSCI.5531-11.2012","article-title":"Astrocytes control the development of the migration-promoting vasculature scaffold in the postnatal brain via VEGF signaling","volume":"32","author":"Bozoyan","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.neuron.2010.03.009","article-title":"NMDA receptors activated by subventricular zone astrocytic glutamate are critical for neuroblast survival prior to entering a synaptic network","volume":"65","author":"Platel","year":"2010","journal-title":"Neuron"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"7654","DOI":"10.1523\/JNEUROSCI.21-19-07654.2001","article-title":"Extracellular signals that regulate the tangential migration of olfactory bulb neuronal precursors: Inducers, inhibitors, and repellents","volume":"21","author":"Mason","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1093\/cercor\/bhv074","article-title":"Extended Production of Cortical Interneurons into the Third Trimester of Human Gestation","volume":"26","author":"Arshad","year":"2016","journal-title":"Cereb. Cortex"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"aaf7073","DOI":"10.1126\/science.aaf7073","article-title":"Extensive migration of young neurons into the infant human frontal lobe","volume":"354","author":"Paredes","year":"2016","journal-title":"Science"},{"key":"ref_229","first-page":"382","article-title":"Corridors of migrating neurons in the human brain and their decline during infancy","volume":"478","author":"Sanai","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.neuron.2012.03.030","article-title":"The age of olfactory bulb neurons in humans","volume":"74","author":"Bergmann","year":"2012","journal-title":"Neuron"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/cne.20798","article-title":"Cellular composition and cytoarchitecture of the adult human subventricular zone: A niche of neural stem cells","volume":"494","author":"Sanai","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/cr.2011.83","article-title":"Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain","volume":"21","author":"Wang","year":"2011","journal-title":"Cell Res."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.conb.2012.03.006","article-title":"OSVZ progenitors in the human cortex: An updated perspective on neurodevelopmental disease","volume":"22","author":"LaMonica","year":"2012","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cell.2011.06.030","article-title":"Development and evolution of the human neocortex","volume":"146","author":"Lui","year":"2011","journal-title":"Cell"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.1523\/JNEUROSCI.1299-06.2006","article-title":"Origin of oligodendrocytes in the subventricular zone of the adult brain","volume":"26","author":"Menn","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1002\/stem.119","article-title":"Epidermal growth factor induces the progeny of subventricular zone type B cells to migrate and differentiate into oligodendrocytes","volume":"27","year":"2009","journal-title":"Stem Cells"},{"key":"ref_237","first-page":"411","article-title":"Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells","volume":"9","author":"Escamilla","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/dneu.20737","article-title":"Gap junctions are involved in cell migration in the early postnatal subventricular zone","volume":"69","author":"Marins","year":"2009","journal-title":"Dev. Neurobiol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1002\/dneu.22005","article-title":"Dye coupling and connexin expression by cortical radial glia in the early postnatal subventricular zone","volume":"72","author":"Freitas","year":"2012","journal-title":"Dev. Neurobiol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1111\/j.1460-9568.2011.07901.x","article-title":"Gap junction-mediated calcium waves define communication networks among murine postnatal neural progenitor cells","volume":"34","author":"Lacar","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/glia.20392","article-title":"GFAP-expressing cells in the postnatal subventricular zone display a unique glial phenotype intermediate between radial glia and astrocytes","volume":"54","author":"Liu","year":"2006","journal-title":"Glia"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s004410050749","article-title":"Expression of the gap junction protein connexin43 in the subependymal layer and the rostral migratory stream of the mouse: Evidence for an inverse correlation between intensity of connexin43 expression and cell proliferation activity","volume":"287","author":"Miragall","year":"1997","journal-title":"Cell. Tissue Res."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"20107","DOI":"10.1073\/pnas.1217103109","article-title":"Connexin45 modulates the proliferation of transit-amplifying precursor cells in the mouse subventricular zone","volume":"109","author":"Khodosevich","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1242\/jcs.115.16.3241","article-title":"Cell coupling and Cx43 expression in embryonic mouse neural progenitor cells","volume":"115","author":"Duval","year":"2002","journal-title":"J. Cell Sci."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/glia.22630","article-title":"Implanted neural progenitor cells regulate glial reaction to brain injury and establish gap junctions with host glial cells","volume":"62","author":"Matarredona","year":"2014","journal-title":"Glia"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ydbio.2004.04.031","article-title":"Gap junctional communication is required to maintain mouse cortical neural progenitor cells in a proliferative state","volume":"272","author":"Cheng","year":"2004","journal-title":"Dev. Biol."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1016\/j.cellsig.2013.08.030","article-title":"Involvement of connexin43 in the EGF\/EGFR signalling during self-renewal and differentiation of neural progenitor cells","volume":"25","author":"Lemcke","year":"2013","journal-title":"Cell. Signal."},{"key":"ref_248","doi-asserted-by":"crossref","unstructured":"Imbeault, S., Gauvin, L.G., Toeg, H.D., Pettit, A., Sorbara, C.D., Migahed, L., DesRoches, R., Menzies, A.S., Nishii, K., and Paul, D.L. (2009). The extracellular matrix controls gap junction protein expression and function in postnatal hippocampal neural progenitor cells. BMC Neurosci., 10.","DOI":"10.1186\/1471-2202-10-13"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1006\/dbio.1995.1029","article-title":"Differentiation of hippocampal progenitor cells in vitro: Temporal expression of intercellular coupling and voltage- and ligand-gated responses","volume":"167","author":"Rozental","year":"1995","journal-title":"Dev. Biol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0165-0173(99)00096-X","article-title":"Temporal expression of neuronal connexins during hippocampal ontogeny","volume":"32","author":"Rozental","year":"2000","journal-title":"Brain Res. Rev."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"11336","DOI":"10.1073\/pnas.0813160106","article-title":"Connexin expression by radial glia-like cells is required for neurogenesis in the adult dentate gyrus","volume":"106","author":"Kunze","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1096\/fj.04-3491fje","article-title":"Mechanism of the defect in gap-junctional communication by expression of a connexin 26 mutant associated with dominant deafness","volume":"19","author":"Chen","year":"2005","journal-title":"FASEB J."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.1073\/pnas.0511118103","article-title":"S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: Induction by oxidant stress and reversal by reducing agents","volume":"103","author":"Retamal","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_254","first-page":"953","article-title":"Post-natal origin of microneurones in the rat brain","volume":"207","author":"Altman","year":"1965","journal-title":"Nat. Cell Biol."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1083\/jcb.200505072","article-title":"The cell cycle-apoptosis connection revisited in the adult brain","volume":"171","author":"Bauer","year":"2005","journal-title":"J. Cell Biol."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(02)38067-1","article-title":"Neurogenesis in adult primates","volume":"138","author":"Rakic","year":"2002","journal-title":"Prog. Brain Res."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41591-019-0375-9","article-title":"Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer\u2019s disease","volume":"25","author":"Cafini","year":"2019","journal-title":"Nat. Med."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.stem.2012.05.012","article-title":"Adult neural stem cells bridge their niche","volume":"10","author":"Fuentealba","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1194637","article-title":"Fate mapping analysis reveals that adult microglia derive from primitive macrophages","volume":"330","author":"Ginhoux","year":"2010","journal-title":"Science"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fncel.2013.00045","article-title":"Origin and differentiation of microglia","volume":"7","author":"Ginhoux","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0166-2236(96)10049-7","article-title":"Microglia: A sensor for pathological events in the CNS","volume":"19","author":"Kreutzberg","year":"1996","journal-title":"Trends Neurosci."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/nn1997","article-title":"Microglia: Active sensor and versatile effector cells in the normal and pathologic brain","volume":"10","author":"Hanisch","year":"2007","journal-title":"Nat. Neurosci."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.immunol.021908.132528","article-title":"Microglial physiology: Unique stimuli, specialized responses","volume":"27","author":"Ransohoff","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nri.2017.125","article-title":"Microglia and macrophages in brain homeostasis and disease","volume":"18","author":"Li","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/glia.22389","article-title":"The \u201cquad-partite\u201d synapse: Microglia-synapse interactions in the developing and mature CNS","volume":"61","author":"Schafer","year":"2013","journal-title":"Glia"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.tins.2012.11.007","article-title":"Microglia: Actively surveying and shaping neuronal circuit structure and function","volume":"36","author":"Wake","year":"2013","journal-title":"Trends Neurosci."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.it.2015.08.008","article-title":"Microglia: Dynamic Mediators of Synapse Development and Plasticity","volume":"36","author":"Wu","year":"2015","journal-title":"Trends Immunol."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nm.4397","article-title":"Microglia emerge as central players in brain disease","volume":"23","author":"Salter","year":"2017","journal-title":"Nat. Med."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neuron.2012.12.023","article-title":"Microglia: New roles for the synaptic stripper","volume":"77","author":"Kettenmann","year":"2013","journal-title":"Neuron"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/nature04671","article-title":"Synaptic scaling mediated by glial TNF-alpha","volume":"440","author":"Stellwagen","year":"2006","journal-title":"Nature"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/glia.20459","article-title":"Microglial control of neuronal death and synaptic properties","volume":"55","author":"Bessis","year":"2007","journal-title":"Glia"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1523\/JNEUROSCI.4363-08.2009","article-title":"Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals","volume":"29","author":"Wake","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_273","first-page":"32","article-title":"Microglial control of neuronal activity","volume":"7","author":"Bessis","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"ref_274","first-page":"101","article-title":"Immunocytochemical and RT-PCR analysis of connexin36 in cultures of mammalian glial cells","volume":"140","author":"Parenti","year":"2002","journal-title":"Arch. Ital. Biol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/cns.12352","article-title":"In Rasmussen encephalitis, hemichannels associated with microglial activation are linked to cortical pyramidal neuron coupling: A possible mechanism for cellular hyperexcitability","volume":"21","author":"Cepeda","year":"2015","journal-title":"CNS Neurosci. Ther."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3389\/fncel.2018.00268","article-title":"Interactions Between Neural Progenitor Cells and Microglia in the Subventricular Zone: Physiological Implications in the Neurogenic Niche and After Implantation in the Injured Brain","volume":"12","author":"Matarredona","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jneuroim.2014.02.005","article-title":"Activated microglia do not form functional gap junctions in vivo","volume":"269","author":"Wasseff","year":"2014","journal-title":"J. Neuroimmunol."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0006-8993(02)02621-5","article-title":"Identification of second messengers that induce expression of functional gap junctions in microglia cultured from newborn rats","volume":"943","author":"Bennett","year":"2002","journal-title":"Brain Res."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1523\/JNEUROSCI.5966-09.2010","article-title":"Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate","volume":"30","author":"Maezawa","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_280","first-page":"216402","article-title":"ATP is required and advances cytokine-induced gap junction formation in microglia in vitro","volume":"2013","author":"Shoji","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nrn1908","article-title":"The therapeutic potential of neural stem cells","volume":"7","author":"Martino","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"11848","DOI":"10.1523\/JNEUROSCI.1217-15.2015","article-title":"A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone","volume":"35","author":"Kress","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fncel.2015.00037","article-title":"Ontogeny of CX3CR1-EGFP expressing cells unveil microglia as an integral component of the postnatal subventricular zone","volume":"9","author":"Xavier","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1089\/scd.2015.0319","article-title":"Neurogenic Niche Microglia Undergo Positional Remodeling and Progressive Activation Contributing to Age-Associated Reductions in Neurogenesis","volume":"25","author":"Mahesula","year":"2016","journal-title":"Stem Cells Dev."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"15983","DOI":"10.1073\/pnas.2237050100","article-title":"Migration and differentiation of neural precursor cells can be directed by microglia","volume":"100","author":"Aarum","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/glia.20419","article-title":"Microglia instruct subventricular zone neurogenesis","volume":"54","author":"Walton","year":"2006","journal-title":"Glia"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/j.1460-9568.2009.06870.x","article-title":"IGF-I promotes neuronal migration and positioning in the olfactory bulb and the exit of neuroblasts from the subventricular zone","volume":"30","author":"Bulfone","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.stem.2010.08.014","article-title":"Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis","volume":"7","author":"Sierra","year":"2010","journal-title":"Cell Stem Cell"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.febslet.2014.01.036","article-title":"Distinct permeation profiles of the connexin 30 and 43 hemichannels","volume":"588","author":"Hansen","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_290","doi-asserted-by":"crossref","unstructured":"Medina-Ceja, L., Salazar-S\u00e1nchez, J.C., Ortega-Ibarra, J., and Morales-Villagr\u00e1n, A. (2019). Connexins-Based Hemichannels\/Channels and Their Relationship with Inflammation, Seizures and Epilepsy. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20235976"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1096\/fj.11-198416","article-title":"Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala","volume":"26","author":"Stehberg","year":"2012","journal-title":"FASEB J."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbamem.2017.03.018","article-title":"Connexins and Pannexins in cerebral ischemia","volume":"1860","author":"Kim","year":"2018","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mcn.2010.05.007","article-title":"Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective","volume":"45","author":"Froger","year":"2010","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/1073858405278321","article-title":"Reactive astrocytes in neural repair and protection","volume":"11","author":"Sofroniew","year":"2005","journal-title":"Neuroscientist"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.semcdb.2019.05.017","article-title":"Microglia-neuron crosstalk: Signaling mechanism and control of synaptic transmission","volume":"94","author":"Marinelli","year":"2019","journal-title":"Semin Cell Dev Biol."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"12105","DOI":"10.1523\/JNEUROSCI.5369-12.2013","article-title":"Interleukin-1\u03b2 alters glutamate transmission at purkinje cell synapses in a mouse model of multiple sclerosis","volume":"33","author":"Mandolesi","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/1742-2094-9-275","article-title":"L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: The \u2018collusion\u2019 hypothesis for increased extracellular L-glutamate concentration in neuroinflammation","volume":"9","author":"Takaki","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1523\/JNEUROSCI.5247-10.2011","article-title":"Neuroinflammation leads to region-dependent alterations in astrocyte gap junction communication and hemichannel activity","volume":"31","author":"Karpuk","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.neuron.2014.01.024","article-title":"NMDA receptor activation strengthens weak electrical coupling in mammalian brain","volume":"81","author":"Turecek","year":"2014","journal-title":"Neuron"},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.neuroscience.2004.09.053","article-title":"The neurobiology of glia in the context of water and ion homeostasis","volume":"129","author":"Simard","year":"2004","journal-title":"Neuroscience"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1093\/hmg\/ddu725","article-title":"Transgenic replacement of Cx32 in gap junction-deficient oligodendrocytes rescues the phenotype of a hypomyelinating leukodystrophy model","volume":"24","author":"Schiza","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"7985","DOI":"10.1523\/JNEUROSCI.5874-12.2013","article-title":"Connexin47 protein phosphorylation and stability in oligodendrocytes depend on expression of Connexin43 protein in astrocytes","volume":"33","author":"May","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_304","first-page":"565","article-title":"Inhibition of cell-cell communication by tumour promoters","volume":"7","author":"Trosko","year":"1982","journal-title":"Carcinog. Compr. Surv."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00756491","article-title":"Cell culture assays for chemicals with tumour-promoting or tumour-inhibiting activity based on the modulation of intercellular communication","volume":"10","author":"Budunova","year":"1994","journal-title":"Cell. Biol. Toxicol."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/bmc.161","article-title":"Determination of bisphenol A in rat brain by microdialysis and column switching high-performance liquid chromatography with fluorescence detection","volume":"16","author":"Sun","year":"2002","journal-title":"Biomed. Chromatogr."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neuro.2015.11.003","article-title":"The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the development and function of the blood-brain barrier","volume":"52","author":"Miyazaki","year":"2016","journal-title":"Neurotoxicology"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.bbamem.2011.09.023","article-title":"The modulation of gap-junctional intercellular communication by lipid rafts","volume":"1818","author":"Defamie","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4196\/kjpp.2015.19.1.73","article-title":"Bisphenol A and 4-tert-Octylphenol Inhibit Cx46 Hemichannel","volume":"19","author":"Oh","year":"2015","journal-title":"Currents Korean J. Physiol. Pharmacol."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4161\/spmg.1.1.13971","article-title":"Environmental toxicants and male reproductive function","volume":"1","author":"Cheng","year":"2011","journal-title":"Spermatogenesis"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4161\/spmg.1.2.15745","article-title":"Regulation of blood-testis barrier dynamics by desmosome, gap junction, hemidesmosome and polarity proteins: An unexpected turn of events","volume":"1","author":"Cheng","year":"2011","journal-title":"Spermatogenesis"},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/BF01060757","article-title":"Cytotoxic, Mutagenic, and Cell-Cell Communication Inhibitory Properties of DDT, Lindane, and Chlordane on Chinese Hamster Cells in vitro","volume":"12","author":"Tsushimoto","year":"1983","journal-title":"Arch. Environ. Contain. Toxicol."},{"key":"ref_313","first-page":"192","article-title":"Inhibition of gap junctional intercellular communication in normal human breast epithelial cells after treatment with pesticides, PCBs, and PBBs, alone or in mixtures","volume":"104","author":"Kang","year":"1996","journal-title":"Environ. Health Persp."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/BF00117849","article-title":"Effects of tumor promoters, genotoxic carcinogens and hepatocytotoxins on mouse hepatocyte intercellular communication","volume":"2","author":"Ruch","year":"1986","journal-title":"Cell. Biol. Toxicol."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1006\/taap.1995.1033","article-title":"Lindane inhibition of gap junctional communication in myometrial myocytes is partially dependent on phosphoinositide-generated second messengers","volume":"130","author":"Criswell","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/taap.1995.1011","article-title":"Changes in gap junction permeability, gap junction number, and connexin43 expression in lindane-treated rat liver epithelial cells","volume":"130","author":"Guan","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1093\/carcin\/22.9.1537","article-title":"Disruption of gap junctional intercellular communication by lindane is associated with aberrant localization of connexin43 and zonula occludens-1 in 42GPA9 Sertoli cells","volume":"22","author":"Defamie","year":"2001","journal-title":"Carcinogenesis"},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.taap.2010.05.006","article-title":"Inhibition of connexin43 gap junction channels by the endocrine disruptor ioxynil","volume":"247","author":"Leithe","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/jat.3717","article-title":"Effects of bisphenol A on gap junctions in HaCaT cells as mediated by the estrogen receptor pathway","volume":"39","author":"Zhang","year":"2019","journal-title":"J. Appl. Toxicol."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tox.2009.09.012","article-title":"Neonatal exposure of male rats to Bisphenol A impairs fertility and expression of sertoli cell junctional proteins in the testis","volume":"265","author":"Salian","year":"2009","journal-title":"Toxicology"},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/toxsci\/kfn202","article-title":"The 2,2\u2032,4,4\u2032,5,5\u2032-hexachlorobiphenyl-enhanced degradation of connexin 43 involves both proteasomal and lysosomal activities","volume":"107","author":"Machala","year":"2009","journal-title":"Toxicol. Sci."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/BF02977615","article-title":"Inhibitory effect of bisphenol A on gap junctional intercellular communication in an epithelial cell line of rat mammary tissue","volume":"30","author":"Lee","year":"2007","journal-title":"Arch Pharm Res."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.reprotox.2013.08.008","article-title":"Bisphenol A and human health: A review of the literature","volume":"42","author":"Rochester","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"ref_324","doi-asserted-by":"crossref","unstructured":"Sovadinova, I., Babica, P., B\u00f6ke, H., Kumar, E., Wilke, A., Park, J.S., Trosko, J.E., and Upham, B.L. (2015). Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0124454"},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1093\/toxsci\/kfw114","article-title":"Methoxychlor and Vinclozolin Induce Rapid Changes in Intercellular and Intracellular Signaling in Liver Progenitor Cells","volume":"153","author":"Babica","year":"2016","journal-title":"Toxicol. Sci."},{"key":"ref_326","doi-asserted-by":"crossref","unstructured":"\u010ctver\u00e1\u010dkov\u00e1, L., Jan\u010dula, D., Ra\u0161ka, J., Babica, P., and Sovadinov\u00e1, I. (2020). Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176069"},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/toxsci\/kfg209","article-title":"Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated biphenyls: Inhibitory potencies and screening for potential mode(s) of action","volume":"76","author":"Machala","year":"2003","journal-title":"Toxicol. Sci."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00204-016-1750-7","article-title":"Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: Its role in Cx43-formed gap junction impairment","volume":"91","author":"Pierucci","year":"2017","journal-title":"Arch. Toxicol."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.1349-7006.2008.00752.x","article-title":"Tumor promoting properties of a cigarette smoke prevalent polycyclic aromatic hydrocarbon as indicated by the inhibition of gap junctional intercellular communication via phosphatidylcholine-specific phospholipase C","volume":"99","author":"Upham","year":"2008","journal-title":"Cancer Sci."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.taap.2008.11.020","article-title":"Regulation of gap junctional intercellular communication by TCDD in HMEC and MCF-7 breast cancer cells","volume":"235","author":"Gakhar","year":"2009","journal-title":"Toxicol. Appl. Pharm."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0304-3835(81)90100-2","article-title":"Inhibition of intercellular communication between liver cells by the liver tumor promoter l,l,1-trichloro-2,2-bis(p-chlorophenyl) ethane","volume":"11","author":"Williams","year":"1981","journal-title":"Cancer Lett."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.envres.2014.02.007","article-title":"Hazard identification of the potential for dieldrin carcinogenicity to humans","volume":"131","author":"Stern","year":"2014","journal-title":"Environ. Res."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/carcin\/3.10.1175","article-title":"Epigenetic membrane effects of a possible tumor promoting type on cultured liver cells by the non-genotoxic organochlorine pesticides chlordane and heptachlor","volume":"3","author":"Telang","year":"1982","journal-title":"Carcinogenesis"},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/carcin\/11.7.1097","article-title":"Inhibition of hepatocyte gap junctional intercellular communication by endosulfan, chlordane and heptachlor","volume":"11","author":"Ruch","year":"1990","journal-title":"Carcinogenesis"},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0890-6238(98)00068-9","article-title":"Inhibitory effects of organochlorine pesticides on intercellular transfer of lucifer yellow in cultured bovine oviductal cells","volume":"13","author":"Tiemann","year":"1999","journal-title":"Reprod. Toxicol."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1093\/carcin\/bgg093","article-title":"Aberrant Connexin 43 endocytosis by the carcinogen lindane involves activation of the ERK\/mitogen-activated protein kinase pathway","volume":"24","author":"Mograbi","year":"2003","journal-title":"Carcinogenesis"},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/0041-008X(82)90252-6","article-title":"Inhibition of intercellular communication by chlordecone (kepone) and mirex in Chinese hamster V79 cells in vitro","volume":"64","author":"Tsushimoto","year":"1982","journal-title":"Toxicol. Appl. Pharm."},{"key":"ref_338","first-page":"113","article-title":"Chlordecone rapidly and reversibly inhibits gap junctional communication in human embryonic palatal mesenchyme cells","volume":"5","author":"Caldwell","year":"1992","journal-title":"In Vitro Toxicol."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.reprotox.2017.01.003","article-title":"A protective role of cumulus cells after short-term exposure of rat cumulus cell-oocyte complexes to lifestyle or environmental contaminants","volume":"69","author":"Campen","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.taap.2018.02.011","article-title":"Bisphenol A alters oocyte maturation by prematurely closing gap junctions in the cumulus cell-oocyte complex","volume":"344","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0304-3835(88)90215-7","article-title":"Inhibition of mouse hepatocyte intercellular communication by phthalate monoesters","volume":"43","author":"Klaunig","year":"1988","journal-title":"Cancer Lett."},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/toxsci\/54.2.312","article-title":"Comparative in vivo hepatic effects of Di-isononyl phthalate (DINP) and related C7-C11 dialkyl phthalates on gap junctional intercellular communication (GJIC), peroxisomal beta-oxidation (PBOX), and DNA synthesis in rat and mouse liver","volume":"54","author":"Smith","year":"2000","journal-title":"Toxicol. Sci."},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1080\/152873902317349736","article-title":"Comparative effects of phthalate monoesters on gap junctional intercellular communication and peroxisome proliferation in rodent and primate hepatocytes","volume":"65","author":"Kamendulis","year":"2002","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1021\/tx030034v","article-title":"Toxicity of hydroxylated and quinoid PCB metabolites: Inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells","volume":"17","author":"Machala","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1289\/ehp.8137179","article-title":"PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: Its potential as a tumor promoter","volume":"37","author":"Trosko","year":"1981","journal-title":"Environ. Health Perspect."},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/carcin\/3.2.181","article-title":"Inhibition of metabolic cooperation in Chinese hamster V79 cells in culture by various polybrominated biphenyl (PBB) congeners","volume":"3","author":"Tsushimoto","year":"1982","journal-title":"Carcinogenesis"},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/toxsci\/65.1.43","article-title":"Inhibition of gap-junctional intercellular communication by environmentally occurring polycyclic aromatic hydrocarbons","volume":"65","author":"Upham","year":"2002","journal-title":"Toxicol. Sci."},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00204-012-0963-7","article-title":"Aryl hydrocarbon receptor-mediated disruption of contact inhibition is associated with connexin43 downregulation and inhibition of gap junctional intercellular communication","volume":"87","author":"Kohoutek","year":"2013","journal-title":"Arch. Toxicol."},{"key":"ref_349","first-page":"26","article-title":"Effect of PM2.5 collected during the dust and non-dust periods on the viability and gap junctional intercellular communication in human lung fibroblasts","volume":"35","author":"Wang","year":"2006","journal-title":"Wei Sheng Yan Jiu"},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00441-002-0639-3","article-title":"Aluminum impairs gap junctional intercellular communication between astroglial cells in vitro","volume":"310","author":"Theiss","year":"2002","journal-title":"Cell Tissue Res."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s002040050487","article-title":"Methylmercury inhibits gap junctional intercellular communication in primary cultures of rat proximal tubular cells","volume":"72","author":"Yoshida","year":"1998","journal-title":"Arch. Toxicol."},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s12010-016-2214-5","article-title":"The Environmental Issues of DDT Pollution and Bioremediation: A Multidisciplinary Review","volume":"181","author":"Mansouri","year":"2017","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_353","doi-asserted-by":"crossref","unstructured":"Matsushima, A. (2018). A Novel Action of Endocrine-Disrupting Chemicals on Wildlife; DDT and Its Derivatives Have Remained in the Environment. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19051377"},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3109\/10408449709089899","article-title":"Methoxychlor as a model for environmental estrogens","volume":"27","author":"Cummings","year":"1997","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_355","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risk to Humans (2018). DDT, Lindane, and 2,4-D. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, World Health Organization."},{"key":"ref_356","doi-asserted-by":"crossref","unstructured":"Brokamp, C., Todd, J., Montemagno, C., and Wendell, D. (2012). Electrophysiology of single and aggregate Cx43 hemichannels. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047775"},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0048-9697(78)90002-5","article-title":"Kepone\u2014Hazard evaluation","volume":"9","author":"Epstein","year":"1978","journal-title":"Sci. Total Environ."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.envres.2012.07.006","article-title":"Cognitive, visual, and motor development of 7-month-old Guadeloupean infants exposed to chlordecone","volume":"118","author":"Dallaire","year":"2012","journal-title":"Environ. Res."},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.neuro.2013.01.007","article-title":"Exposure to an organochlorine pesticide (chlordecone) and development of 18-month-old infants","volume":"35","author":"Boucher","year":"2013","journal-title":"Neurotoxicology"},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12940-016-0160-x","article-title":"Public health and chronic low chlordecone exposure in Guadeloupe, Part 1: Hazards, exposure-response functions, and exposures","volume":"15","author":"Nedellec","year":"2016","journal-title":"Environ. Health"},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00216-006-0757-y","article-title":"Advances in the environmental analysis of polychlorinated naphthalenes and toxaphene","volume":"386","author":"Kucklick","year":"2006","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.envint.2007.07.013","article-title":"Endocrine disrupting pesticides: Implications for risk assessment","volume":"34","author":"McKinlay","year":"2008","journal-title":"Environ. Int."},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.toxlet.2013.03.029","article-title":"Vinclozolin: A case study on the identification of endocrine active substances in the past and a future perspective","volume":"223","author":"Kolle","year":"2013","journal-title":"Toxicol. Lett."},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.reprotox.2007.07.010","article-title":"Human exposure to bisphenol A (BPA)","volume":"24","author":"Vandenberg","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.3390\/ijerph9082694","article-title":"Non-genomic effects of xenoestrogen mixtures","volume":"9","author":"Vinas","year":"2012","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.reprotox.2004.01.002","article-title":"Sertoli cell junctional proteins as early targets for different classes of reproductive toxicants","volume":"18","author":"Fiorini","year":"2004","journal-title":"Reprod. Toxicol."},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1016\/j.biocel.2009.05.016","article-title":"Disruption of the blood-testis barrier integrity by bisphenol A in vitro: Is this a suitable model for studying blood-testis barrier dynamics?","volume":"41","author":"Li","year":"2009","journal-title":"Int. J. Biochem Cell Biol."},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbrc.2004.11.024","article-title":"Estrogen and bisphenol A disrupt spontaneous [Ca(2+)](i) oscillations in mouse oocytes","volume":"326","author":"Mohri","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"24642","DOI":"10.1007\/s11356-016-7648-3","article-title":"A systematic review on the adverse health effects of di-2-ethylhexyl phthalate","volume":"23","author":"Zarean","year":"2016","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_370","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.tox.2010.03.020","article-title":"An assessment of the ability of phthalates to influence immune and allergic responses","volume":"271","author":"Kimber","year":"2010","journal-title":"Toxicology"},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.anai.2014.03.013","article-title":"Effects of phthalates on the development and expression of allergic disease and asthma","volume":"112","author":"North","year":"2014","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2605.2005.00607.x","article-title":"Di(2-ethylhexyl)phthalate (DEHP): Human. Metabolism and internal exposure\u2014An update and latest results","volume":"29","author":"Koch","year":"2006","journal-title":"Int. J. Androl."},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3109\/10408448409023762","article-title":"Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): Biochemistry, toxicology, and mechanism of action","volume":"13","author":"Safe","year":"1984","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1093\/carcin\/16.10.2321","article-title":"Inhibition of gap junctional intercellular communication by 2,3,78-tetrachlorodibenzo-p-dioxin (TCDD) in rat hepatocytes","volume":"16","author":"Baker","year":"1995","journal-title":"Carcinogenesis"},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ecoenv.2016.01.030","article-title":"The health effects of ambient PM2.5 and potential mechanisms","volume":"128","author":"Feng","year":"2016","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_376","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.chemosphere.2018.10.101","article-title":"Genome-wide identification and functional analysis of long non-coding RNAs in human endothelial cell line after incubation with PM2.5","volume":"216","author":"Wang","year":"2019","journal-title":"Chemosphere"},{"key":"ref_377","first-page":"492","article-title":"Neuropathological Consequences of Gestational Exposure to Concentrated Ambient Fine and Ultrafine Particles in the Mouse","volume":"156","author":"Klocke","year":"2017","journal-title":"Toxicol. Sci."},{"key":"ref_378","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/15287399109531463","article-title":"Inhibition of metabolic coupling by metals","volume":"32","author":"Corcos","year":"1991","journal-title":"J. Toxicol. Environ. Health"},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ntt.2018.08.001","article-title":"Accelerated functional losses in ageing congenital Minamata disease patients","volume":"69","author":"Yorifuji","year":"2018","journal-title":"Neurotoxicol. Teratol."},{"key":"ref_380","doi-asserted-by":"crossref","first-page":"13322","DOI":"10.57187\/smw.2012.13322","article-title":"A review of epidemiological studies on neuropsychological effects of air pollution","volume":"141","author":"Guxens","year":"2012","journal-title":"Swiss Med Wkly."},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1001\/jama.295.10.1127","article-title":"Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases","volume":"295","author":"Dominici","year":"2006","journal-title":"JAMA"},{"key":"ref_382","doi-asserted-by":"crossref","first-page":"26","DOI":"10.47102\/annals-acadmedsg.18087","article-title":"Impact of Air Pollution and Seasonal Haze on Neurological Conditions","volume":"49","author":"Rocha","year":"2020","journal-title":"Ann. Acad. Med. Singap."},{"key":"ref_383","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.neuro.2008.12.011","article-title":"Neurobehavioral effects of ambient air pollution on cognitive performance in US adults","volume":"30","author":"Chen","year":"2009","journal-title":"Neurotoxicology"},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1289\/ehp.1408803","article-title":"Prenatal and Childhood Traffic-Related Pollution Exposure and Childhood Cognition in the Project Viva Cohort (Massachusetts, USA)","volume":"123","author":"Harris","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"ref_385","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.envres.2011.12.011","article-title":"Effects of prenatal polycyclic aromatic hydrocarbon exposure and environmental tobacco smoke on child IQ in a Chinese cohort","volume":"114","author":"Perera","year":"2012","journal-title":"Environ. Res."},{"key":"ref_386","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1289\/ehp.1408322","article-title":"Traffic-Related Air Pollution and Dementia Incidence in Northern Sweden: A Longitudinal Study","volume":"124","author":"Oudin","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"ref_387","doi-asserted-by":"crossref","first-page":"e010004","DOI":"10.1136\/bmjopen-2015-010004","article-title":"Association between neighbourhood air pollution concentrations and dispensed medication for psychiatric disorders in a large longitudinal cohort of Swedish children and adolescents","volume":"6","author":"Oudin","year":"2016","journal-title":"BMJ Open"},{"key":"ref_388","first-page":"228","article-title":"Air Pollution and Cognitive Development at Age 7 in a Prospective Italian Birth Cohort","volume":"27","author":"Porta","year":"2016","journal-title":"Epidemiology"},{"key":"ref_389","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/aje\/kwm308","article-title":"Association of black carbon with cognition among children in a prospective birth cohort study","volume":"167","author":"Suglia","year":"2008","journal-title":"Am. J. Epidemiol."},{"key":"ref_390","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1001\/jamapsychiatry.2013.266","article-title":"Traffic-related air pollution, particulate matter, and autism","volume":"70","author":"Volk","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"ref_391","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1289\/ehp.0800023","article-title":"Association of traffic-related air pollution with children\u2019s neurobehavioral functions in Quanzhou, China","volume":"117","author":"Wang","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"ref_392","first-page":"1","article-title":"Estimated Prevalence of Autism and Other Developmental Disabilities Following Questionnaire Changes in the 2014 National Health Interview Survey","volume":"87","author":"Zablotsky","year":"2015","journal-title":"Natl. Health Stat Rep."},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.intell.2015.08.009","article-title":"In France, are secular IQ losses biologically caused? A comment on Dutton and Lynn","volume":"53","author":"Dunkel","year":"2015","journal-title":"Intelligence"},{"key":"ref_394","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev-publhealth-040218-044106","article-title":"Environmental Exposures and Depression: Biological Mechanisms and Epidemiological Evidence","volume":"40","year":"2019","journal-title":"Annu. Rev. Public Health"},{"key":"ref_395","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.scitotenv.2017.12.219","article-title":"Urinary phthalate metabolites concentrations and symptoms of depression in an elderly population","volume":"625","author":"Lee","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_396","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.psychres.2018.12.050","article-title":"Exploration of NO2 and PM2.5 air pollution and mental health problems using high-resolution data in London-based children from a UK longitudinal cohort study","volume":"272","author":"Roberts","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref_397","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1001\/jamapsychiatry.2019.0056","article-title":"Association of Air Pollution Exposure with Psychotic Experiences During Adolescence","volume":"76","author":"Newbury","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"ref_398","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S1474-4422(13)70278-3","article-title":"Neurobehavioural effects of developmental toxicity","volume":"13","author":"Grandjean","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_399","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuro.2018.12.002","article-title":"Genetic effects of welding fumes on the progression of neurodegenerative diseases","volume":"71","author":"Rana","year":"2019","journal-title":"Neurotoxicology"},{"key":"ref_400","doi-asserted-by":"crossref","first-page":"1","DOI":"10.24095\/hpcdp.37.1.01","article-title":"Environmental factors associated with autism spectrum disorder: A scoping review for the years 2003\u20132013","volume":"37","author":"Ng","year":"2017","journal-title":"Health Promot. Chronic Dis. Prev. Can."},{"key":"ref_401","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.lfs.2015.11.006","article-title":"Potential role of organochlorine pesticides in the pathogenesis of neurodevelopmental, neurodegenerative, and neurobehavioral disorders: A review","volume":"145","author":"Dehpour","year":"2016","journal-title":"Life Sci."},{"key":"ref_402","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.envpol.2017.04.039","article-title":"The association of environmental toxicants and autism spectrum disorders in children","volume":"227","author":"Ye","year":"2017","journal-title":"Environ. Pollut."},{"key":"ref_403","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ijheh.2016.05.001","article-title":"Environmental pollutants and child health-A review of recent concerns","volume":"219","author":"Vrijheid","year":"2016","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_404","first-page":"30197","article-title":"Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products","volume":"186","author":"Carter","year":"2016","journal-title":"Neurochem. Int."},{"key":"ref_405","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.envint.2017.02.012","article-title":"Exposure to ambient PM10 and nitrogen dioxide and ADHD risk: A reply to Min & Min (2017)","volume":"103","author":"Fluegge","year":"2017","journal-title":"Environ. Int."},{"key":"ref_406","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/syn.20519","article-title":"Expression of astrocytic markers aquaporin 4 and connexin 43 is altered in brains of subjects with autism","volume":"62","author":"Fatemi","year":"2008","journal-title":"Synapse"},{"key":"ref_407","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1111\/j.1651-2227.2007.00430.x","article-title":"Environmental risk factors for attention-deficit hyperactivity disorder","volume":"96","author":"Banerjee","year":"2007","journal-title":"Acta Paediatr."},{"key":"ref_408","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s11920-011-0221-3","article-title":"Update on environmental risk factors for attention-deficit\/hyperactivity disorder","volume":"13","author":"Froehlich","year":"2011","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_409","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1289\/ehp.1205940","article-title":"Associations between traffic-related black carbon exposure and attention in a prospective birth cohort of urban children","volume":"121","author":"Chiu","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"ref_410","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1289\/ehp.1205555","article-title":"Traffic-related air pollution exposure in the first year of life and behavioral scores at 7 years of age","volume":"121","author":"Newman","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"ref_411","doi-asserted-by":"crossref","unstructured":"Sunyer, J., Esnaola, M., Alvarez-Pedrerol, M., Forns, J., Rivas, I., L\u00f3pez-Vicente, M., Suades-Gonz\u00e1lez, E., Foraster, M., Garcia-Esteban, R., and Basaga\u00f1a, X. (2015). Association between traffic-related air pollution in schools and cognitive development in primary school children: A prospective cohort study. PLoS Med., 12.","DOI":"10.1371\/journal.pmed.1001792"},{"key":"ref_412","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.envint.2016.11.022","article-title":"Exposure to ambient PM 10 and NO 2 and the incidence of attention-deficit hyperactivity disorder in childhood","volume":"99","author":"Min","year":"2017","journal-title":"Environ. Int."},{"key":"ref_413","doi-asserted-by":"crossref","unstructured":"Fluegge, K.R., and Fluegge, K.R. (2015). Glyphosate Use Predicts ADHD Hospital Discharges in the Healthcare Cost and Utilization Project Net (HCUPnet): A Two-Way Fixed-Effects Analysis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0133525"},{"key":"ref_414","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00787-010-0090-z","article-title":"Molecular genetics of attention-deficit\/hyperactivity disorder: An overview","volume":"19","author":"Banaschewski","year":"2010","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"ref_415","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.envint.2010.03.008","article-title":"Air pollution and hospitalization for epilepsy in Chile","volume":"36","author":"Cakmak","year":"2010","journal-title":"Environ. Int."},{"key":"ref_416","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1097\/EDE.0000000000000739","article-title":"Increase in Medical Emergency Calls and Calls for Central Nervous System Symptoms During a Severe Air Pollution Event, January 2013, Jinan City, China","volume":"28","author":"Cui","year":"2017","journal-title":"Epidemiology"},{"key":"ref_417","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.eplepsyres.2019.02.012","article-title":"Association between ambient air pollution and hospital admission for epilepsy in Eastern China","volume":"152","author":"Bao","year":"2019","journal-title":"Epilepsy Res."},{"key":"ref_418","doi-asserted-by":"crossref","unstructured":"Xu, C., Fan, Y.N., Kan, H.D., Chen, R.J., Liu, J.H., Li, Y.F., Zhang, Y., Ji, A.L., and Cai, T.J. (2016). The Novel Relationship between Urban Air Pollution and Epilepsy: A Time Series Study. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0165902"},{"key":"ref_419","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neuro.2014.12.007","article-title":"Developmental PCB exposure increases susceptibility to audiogenic seizures in adulthood","volume":"46","author":"Poon","year":"2015","journal-title":"Neurotoxicology"},{"key":"ref_420","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/toxsci\/kfv237","article-title":"Developmental PCB Exposure Increases Audiogenic Seizures and Decreases Glutamic Acid Decarboxylase in the Inferior Colliculus","volume":"149","author":"Bandara","year":"2016","journal-title":"Toxicol. Sci."},{"key":"ref_421","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12940-015-0021-z","article-title":"Long-term health effects of early life exposure to tetrachloroethylene (PCE)-contaminated drinking water: A retrospective cohort study","volume":"14","author":"Aschengrau","year":"2015","journal-title":"Environ. Health"},{"key":"ref_422","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/brain\/awv067","article-title":"Astrocyte uncoupling as a cause of human temporal lobe epilepsy","volume":"138","author":"Bedner","year":"2015","journal-title":"Brain"},{"key":"ref_423","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/jnr.23726","article-title":"Experimental febrile seizures impair interastrocytic gap junction coupling in juvenile mice","volume":"94","author":"Khan","year":"2016","journal-title":"J. Neurosci. Res."},{"key":"ref_424","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3171\/jns.2006.105.1.77","article-title":"Altered expression of connexin subtypes in mesial temporal lobe epilepsy in humans","volume":"105","author":"Collignon","year":"2006","journal-title":"J. Neurosurg."},{"key":"ref_425","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.envint.2018.09.022","article-title":"Ambient air pollution exposure and risk of migraine: Synergistic effect with high temperature","volume":"121","author":"Lee","year":"2018","journal-title":"Environ. Int."},{"key":"ref_426","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0165-0173(99)00083-1","article-title":"Perspectives on spreading depression","volume":"32","author":"Nedergaard","year":"2000","journal-title":"Brain Res. Rev."},{"key":"ref_427","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuro.2015.06.002","article-title":"Bisphenol A: Human exposure and neurobehavior","volume":"49","author":"Mustieles","year":"2015","journal-title":"Neurotoxicology"},{"key":"ref_428","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1289\/ehp.1104492","article-title":"Prenatal bisphenol a exposure and child behavior in an inner-city cohort","volume":"120","author":"Perera","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"ref_429","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.envres.2016.07.028","article-title":"Bisphenol A exposure and symptoms of anxiety and depression among inner city children at 10\u201312 years of age","volume":"151","author":"Perera","year":"2016","journal-title":"Environ. Res."},{"key":"ref_430","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/jes.2016.8","article-title":"Bisphenol A exposure and children\u2019s behavior: A systematic review","volume":"27","author":"Ejaredar","year":"2017","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"ref_431","doi-asserted-by":"crossref","first-page":"17095","DOI":"10.1007\/s11356-015-4944-2","article-title":"Urinary heavy metals, phthalates and polyaromatic hydrocarbons independent of health events are associated with adult depression: USA NHANES, 2011\u20132012","volume":"22","author":"Shiue","year":"2015","journal-title":"Environ. Sci. Pollut. Res"},{"key":"ref_432","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3389\/fncel.2015.00490","article-title":"Attenuated Levels of Hippocampal Connexin 43 and its Phosphorylation Correlate with Antidepressant- and Anxiolytic-Like Activities in Mice","volume":"9","author":"Quesseveur","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_433","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ijheh.2018.12.006","article-title":"Air pollution and Parkinson\u2019s disease: A systematic review and meta-analysis up to 2018","volume":"222","author":"Kasdagli","year":"2019","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_434","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-pharmtox-011613-135937","article-title":"Environmental toxins and Parkinson\u2019s disease","volume":"54","author":"Goldman","year":"2014","journal-title":"Annu. Rev. Pharm. Toxicol."},{"key":"ref_435","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuro.2017.09.008","article-title":"Bisphenol A glucuronidation in patients with Parkinson\u2019s disease","volume":"63","author":"Landolfi","year":"2017","journal-title":"Neurotoxicology"},{"key":"ref_436","first-page":"124","article-title":"Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases","volume":"9","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_437","doi-asserted-by":"crossref","first-page":"659","DOI":"10.4103\/1673-5374.155444","article-title":"Connexin: A potential novel target for protecting the central nervous system?","volume":"10","author":"Xie","year":"2015","journal-title":"Neural Regen. Res."},{"key":"ref_438","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.brainresbull.2018.04.009","article-title":"Involvement of gap junctions in astrocyte impairment induced by manganese exposure","volume":"140","author":"Lu","year":"2018","journal-title":"Brain Res. Bull."},{"key":"ref_439","doi-asserted-by":"crossref","unstructured":"Wang, J., Ma, T., Ma, D., Li, H., Hua, L., He, Q., and Deng, X. (2020). The Impact of Air Pollution on Neurodegenerative Diseases. Ther. Drug Monit.","DOI":"10.1097\/FTD.0000000000000818"},{"key":"ref_440","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bj.2018.06.001","article-title":"The emerging risk of exposure to air pollution on cognitive decline and Alzheimer\u2019s disease\u2014Evidence from epidemiological and animal studies","volume":"41","author":"Kilian","year":"2018","journal-title":"Biomed. J."},{"key":"ref_441","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1038\/cdd.2016.63","article-title":"Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer\u2019s disease","volume":"23","author":"Yi","year":"2016","journal-title":"Cell Death Differ."},{"key":"ref_442","doi-asserted-by":"crossref","first-page":"9526","DOI":"10.1523\/JNEUROSCI.3686-14.2015","article-title":"Hemichannels Are Required for Amyloid \u03b2-Peptide-Induced Degranulation and Are Activated in Brain Mast Cells of APPswe\/PS1dE9 Mice","volume":"35","author":"Harcha","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_443","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.1038\/ncomms6422","article-title":"Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer\u2019s disease mouse model","volume":"5","author":"Delekate","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_444","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nature06616","article-title":"Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer\u2019s disease","volume":"451","author":"Prada","year":"2008","journal-title":"Nature"},{"key":"ref_445","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.neurol.2019.08.004","article-title":"Environmental risk factors of primary brain tumors: A review","volume":"175","author":"Tafani","year":"2019","journal-title":"Rev. Neurol."},{"key":"ref_446","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/(SICI)1097-0274(199809)34:3<252::AID-AJIM7>3.0.CO;2-X","article-title":"Meta-analyses of brain cancer and farming","volume":"34","author":"Khuder","year":"1998","journal-title":"Am. J. Ind. Med."},{"key":"ref_447","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.envint.2013.02.011","article-title":"Parental occupational exposure to pesticides as risk factor for brain tumors in children and young adults: A systematic review and meta-analysis","volume":"56","author":"Hoet","year":"2013","journal-title":"Environ. Int."},{"key":"ref_448","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.envint.2017.05.018","article-title":"Residential exposure to pesticides as risk factor for childhood and young adult brain tumors: A systematic review and meta-analysis","volume":"106","author":"Lison","year":"2017","journal-title":"Environ. Int."},{"key":"ref_449","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1292\/jvms.63.1183","article-title":"Effects and neuro-toxic mechanisms of 2, 2\u2032, 4, 4\u2032, 5, 5\u2032-hexachlorobiphenyl and endosulfan in neuronal stem cells","volume":"63","author":"Kang","year":"2001","journal-title":"J. Vet. Med Sci."},{"key":"ref_450","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nrn1870","article-title":"Astrocyte dysfunction in neurological disorders: A molecular perspective","volume":"7","author":"Seifert","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_451","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.spen.2013.10.004","article-title":"Astrocytes: The missing link in neurologic disease?","volume":"20","author":"Deneen","year":"2013","journal-title":"Semin Pediatr. Neurol."},{"key":"ref_452","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/WCO.0b013e328336a01f","article-title":"Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders","volume":"23","author":"Herbert","year":"2010","journal-title":"Curr. Opin. Neurol."},{"key":"ref_453","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ntt.2012.12.001","article-title":"Neuronal connectivity as a convergent target of gene \u00d7 environment interactions that confer risk for Autism Spectrum Disorders","volume":"36","author":"Stamou","year":"2013","journal-title":"Neurotoxicol. Teratol."},{"key":"ref_454","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3389\/fnmol.2017.00320","article-title":"Connexin43- and Pannexin-Based Channels in Neuroinflammation and Cerebral Neuropathies","volume":"10","author":"Sarrouilhe","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"ref_455","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijdevneu.2004.09.006","article-title":"Neuroanatomic observations of the brain in autism: A review and future directions","volume":"23","author":"Bauman","year":"2005","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_456","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ijdevneu.2005.01.003","article-title":"Brain overgrowth in autism during a critical time in development: Implications for frontal pyramidal neuron and interneuron development and connectivity","volume":"23","author":"Courchesne","year":"2005","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_457","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1177\/088307389601100204","article-title":"Neurologic abnormalities in infantile autism","volume":"11","author":"Haas","year":"1996","journal-title":"J. Child Neurol."},{"key":"ref_458","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1017\/S1355617700001715","article-title":"Visual attention abnormalities in autism: Delayed orienting to location","volume":"2","author":"Townsend","year":"1996","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"ref_459","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1177\/1362361306066564","article-title":"The pattern of sensory processing abnormalities in autism","volume":"10","author":"Kern","year":"2006","journal-title":"Autism"},{"key":"ref_460","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/1362361307075702","article-title":"Sensory correlations in autism","volume":"11","author":"Kern","year":"2007","journal-title":"Autism"},{"key":"ref_461","doi-asserted-by":"crossref","unstructured":"Adams, J.B., Johansen, L.J., Powell, L.D., Quig, D., and Rubin, R.A. (2011). Gastrointestinal flora and gastrointestinal status in children with autism\u2014Comparisons to typical children and correlation with autism severity. BMC Gastroenterol., 11.","DOI":"10.1186\/1471-230X-11-22"},{"key":"ref_462","first-page":"242","article-title":"The second brain in autism spectrum disorder: Could connexin43 expressed in enteric glial cells play a role?","volume":"9","author":"Parpura","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_463","first-page":"173","article-title":"Influence of acupuncture of \u201cChangqiang\u201d (GV 1) on learning-memory ability and gap junction-related protein expression in the prefrontal cortex in autism rats","volume":"39","author":"Hong","year":"2014","journal-title":"Zhen Ci Yan Jiu"},{"key":"ref_464","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.schres.2016.05.022","article-title":"The association among smoking, HSV-1 exposure, and cognitive functioning in schizophrenia, bipolar disorder, and non-psychiatric controls","volume":"176","author":"Dickerson","year":"2016","journal-title":"Schizophr. Res."},{"key":"ref_465","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa0805384","article-title":"Recurrent rearrangements of chromosome 1q21.1 and variable pediatric phenotypes","volume":"359","author":"Mefford","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_466","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1038\/ng.279","article-title":"Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities","volume":"40","author":"Berg","year":"2008","journal-title":"Nat. Genet."},{"key":"ref_467","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/gim.2015.78","article-title":"Clinical phenotype of the recurrent 1q21.1 copy-number variant","volume":"18","author":"Bernier","year":"2016","journal-title":"Genet. Med."},{"key":"ref_468","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1056\/NEJMoa052800","article-title":"Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation","volume":"354","author":"Gollob","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_469","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1161\/01.RES.0000130528.72330.5c","article-title":"Chromosome 1q21.1 contiguous gene deletion is associated with congenital heart disease","volume":"94","author":"Christiansen","year":"2004","journal-title":"Circ. Res."},{"key":"ref_470","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1093\/hmg\/ddr589","article-title":"Phenotype-specific effect of chromosome 1q21.1 rearrangements and GJA5 duplications in 2436 congenital heart disease patients and 6760 controls","volume":"21","author":"Soemedi","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_471","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ejhg.2012.109","article-title":"A variant in the carboxyl-terminus of connexin 40 alters GAP junctions and increases risk for tetralogy of Fallot","volume":"21","author":"Guida","year":"2013","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_472","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40246-014-0019-6","article-title":"Exome sequencing identifies novel and recurrent mutations in GJA8 and CRYGD associated with inherited cataract","volume":"8","author":"Mackay","year":"2014","journal-title":"Hum. Genom."},{"key":"ref_473","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3892\/ijmm.2015.2325","article-title":"Mutation analysis of the genes associated with anterior segment dysgenesis, microcornea and microphthalmia in 257 patients with glaucoma","volume":"36","author":"Huang","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_474","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/ejhg.2013.268","article-title":"Exome sequencing in developmental eye disease leads to identification of causal variants in GJA8, CRYGC, PAX6 and CYP1B1","volume":"22","author":"Prokudin","year":"2014","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_475","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s11910-017-0758-6","article-title":"The New Classification of Seizures by the International League Against Epilepsy 2017","volume":"17","author":"Fisher","year":"2017","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_476","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neulet.2017.11.036","article-title":"Endogenous sulfur dioxide regulates hippocampal neuron apoptosis in developing epileptic rats and is associated with the PERK signaling pathway","volume":"665","author":"Niu","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_477","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/enrs.1995.1052","article-title":"Increased limbic system symptomatology and sensitizability of young adults with chemical and noise sensitivities","volume":"70","author":"Bell","year":"1995","journal-title":"Environ. Res."},{"key":"ref_478","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.neurol.2019.07.013","article-title":"Respiratory gases, air pollution and epilepsy","volume":"175","author":"Fernandes","year":"2019","journal-title":"Rev. Neurol."},{"key":"ref_479","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.3390\/toxins2071646","article-title":"Neurological disease rises from ocean to bring model for human epilepsy to life","volume":"2","author":"Ramsdell","year":"2010","journal-title":"Toxins"},{"key":"ref_480","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.toxlet.2010.07.011","article-title":"Low-concentration tributyltin perturbs inhibitory synaptogenesis and induces neuronal death in immature but not mature neurons","volume":"198","author":"Yamada","year":"2010","journal-title":"Toxicol. Lett."},{"key":"ref_481","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2131\/jts.34.569","article-title":"Neurotoxicity of perfluorooctane sulfonate (PFOS) in rats and mice after single oral exposure","volume":"34","author":"Sato","year":"2009","journal-title":"J. Toxicol. Sci."},{"key":"ref_482","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2131\/jts.36.55","article-title":"Ultrasonic-induced tonic convulsion in rats after subchronic exposure to perfluorooctane sulfonate (PFOS)","volume":"36","author":"Kawamoto","year":"2011","journal-title":"J. Toxicol. Sci."},{"key":"ref_483","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cellsig.2019.03.010","article-title":"The role and therapeutic potential of connexins, pannexins and their channels in Parkinson\u2019s disease","volume":"58","author":"Ahmadian","year":"2019","journal-title":"Cell. Signal."},{"key":"ref_484","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuroscience.2009.01.080","article-title":"Modulation of connexin 43 in rotenone-induced model of Parkinson\u2019s disease","volume":"160","author":"Kawasaki","year":"2009","journal-title":"Neuroscience"},{"key":"ref_485","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3892\/mmr.2013.1535","article-title":"Gastrodin ameliorates Parkinson\u2019s disease by downregulating connexin 43","volume":"8","author":"Wang","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"ref_486","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/glia.23631","article-title":"Connexin 43 hemichannels and pannexin-1 channels contribute to the \u03b1-synuclein-induced dysfunction and death of astrocytes","volume":"67","author":"Labra","year":"2019","journal-title":"Glia"},{"key":"ref_487","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pharmthera.2019.03.005","article-title":"Gene-environment interactions in Alzheimer\u2019s disease: A potential path to precision medicine","volume":"199","author":"Eid","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"ref_488","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1016\/0197-4580(94)90190-2","article-title":"Alzheimer\u2019s disease beyond 1994: The path to therapeutics","volume":"15","author":"Selkoe","year":"1994","journal-title":"Neurobiol. Aging"},{"key":"ref_489","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3233\/JAD-170744","article-title":"MacPherson REK. Examining the Relationship between Trace Lithium in Drinking Water and the Rising Rates of Age-Adjusted Alzheimer\u2019s Disease Mortality in Texas","volume":"61","author":"Fajardo","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"ref_490","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/j.neurobiolaging.2014.01.005","article-title":"Comorbid A\u03b2 toxicity and stroke: Hippocampal atrophy, pathology, and cognitive deficit","volume":"35","author":"Amtul","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_491","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: Biology and pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol."},{"key":"ref_492","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0006-8993(95)01526-4","article-title":"Elevated connexin43 immunoreactivity at sites of amyloid plaques in Alzheimer\u2019s disease","volume":"717","author":"Nagy","year":"1996","journal-title":"Brain Res."},{"key":"ref_493","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1559-0275-10-5","article-title":"Semiquantitative proteomic analysis of human hippocampal tissues from Alzheimer\u2019s disease and age-matched control brains","volume":"10","author":"Begcevic","year":"2013","journal-title":"Clin. Proteom."},{"key":"ref_494","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1093\/cercor\/bht101","article-title":"Altered expression of diabetes-related genes in Alzheimer\u2019s disease brains: The Hisayama study","volume":"24","author":"Hokama","year":"2014","journal-title":"Cereb. Cortex"},{"key":"ref_495","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neuroscience.2010.08.001","article-title":"Astroglial connexin immunoreactivity is specifically altered at \u03b2-amyloid plaques in \u03b2-amyloid precursor protein\/presenilin1 mice","volume":"171","author":"Mei","year":"2010","journal-title":"Neuroscience"},{"key":"ref_496","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1016\/j.bbamem.2011.10.001","article-title":"Glial connexin expression and function in the context of Alzheimer\u2019s disease","volume":"1818","author":"Koulakoff","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_497","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1002\/glia.23182","article-title":"Inhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer\u2019s disease","volume":"65","author":"Yi","year":"2017","journal-title":"Glia"},{"key":"ref_498","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cellsig.2017.10.018","article-title":"Involvement of glucose related energy crisis and endoplasmic reticulum stress: Insinuation of streptozotocin induced Alzheimer\u2019s like pathology","volume":"42","author":"Biswas","year":"2018","journal-title":"Cell. Signal."},{"key":"ref_499","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainres.2007.07.034","article-title":"Brain mast cell relationship to neurovasculature during development","volume":"1171","author":"Khalil","year":"2007","journal-title":"Brain Res."},{"key":"ref_500","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1007\/s00011-006-0508-8","article-title":"Distribution of tryptase-containing mast cells and metallothionein reactive astrocytes in human brains with amyloid deposits","volume":"56","author":"Maslinska","year":"2007","journal-title":"Inflamm. Res."},{"key":"ref_501","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1152\/physrev.1997.77.4.1033","article-title":"Mast cells","volume":"77","author":"Metcalfe","year":"1997","journal-title":"Physiol. Rev."},{"key":"ref_502","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1177\/039463200902200224","article-title":"Amyloid beta peptides trigger CD47-dependent mast cell secretory and phagocytic responses","volume":"22","author":"Niederhoffer","year":"2009","journal-title":"Int. J. Immunopathol Pharm."},{"key":"ref_503","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2174\/187152711794653869","article-title":"Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions","volume":"10","author":"Orellana","year":"2011","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_504","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/acel.12054","article-title":"Ca(2+) -dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid \u03b2-treated astrocytes and in a model of Alzheimer\u2019s disease","volume":"12","author":"Alberdi","year":"2013","journal-title":"Aging Cell."},{"key":"ref_505","doi-asserted-by":"crossref","first-page":"e623","DOI":"10.1038\/cddis.2013.145","article-title":"Amyloid-\u03b2 and Alzheimer\u2019s disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions","volume":"4","author":"Grolla","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_506","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1523\/JNEUROSCI.23-09-03588.2003","article-title":"Functional hemichannels in astrocytes: A novel mechanism of glutamate release","volume":"23","author":"Ye","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_507","doi-asserted-by":"crossref","first-page":"10347","DOI":"10.1074\/jbc.M704153200","article-title":"Stimulated efflux of amino acids and glutathione from cultured hippocampal slices by omission of extracellular calcium: Likely involvement of connexin hemichannels","volume":"283","author":"Stridh","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_508","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.1523\/JNEUROSCI.5048-07.2008","article-title":"Connexin 43 hemichannels are permeable to ATP","volume":"28","author":"Kang","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_509","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1126\/science.1169096","article-title":"Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice","volume":"323","author":"Kuchibhotla","year":"2009","journal-title":"Science"},{"key":"ref_510","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neuron.2008.06.008","article-title":"Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks","volume":"59","author":"Kuchibhotla","year":"2008","journal-title":"Neuron"},{"key":"ref_511","doi-asserted-by":"crossref","first-page":"17042","DOI":"10.1523\/JNEUROSCI.1836-13.2013","article-title":"Mitochondrial alterations near amyloid plaques in an Alzheimer\u2019s disease mouse model","volume":"33","author":"Xie","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_512","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1002\/glia.22886","article-title":"Dual pathways mediate \u03b2-amyloid stimulated glutathione release from astrocytes","volume":"63","author":"Ye","year":"2015","journal-title":"Glia"},{"key":"ref_513","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/NEN.0b013e3181cd44df","article-title":"The connexin43 C-terminal region mediates neuroprotection during stroke","volume":"69","author":"Kozoriz","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_514","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1074\/jbc.M113.508390","article-title":"Gap junction intercellular communication mediated by connexin43 in astrocytes is essential for their resistance to oxidative stress","volume":"289","author":"Le","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_515","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/cac.10.4-6.413.417","article-title":"Neuroprotective role of astrocytic gap junctions in ischemic stroke","volume":"10","author":"Nakase","year":"2003","journal-title":"Cell. Commun. Adhes."},{"key":"ref_516","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1016\/S0002-9440(10)63765-0","article-title":"Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes","volume":"164","author":"Nakase","year":"2004","journal-title":"Am. J. Pathol."},{"key":"ref_517","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1056\/NEJM200008173430701","article-title":"Patterns of brain activation in people at risk for Alzheimer\u2019s disease","volume":"343","author":"Bookheimer","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_518","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/ana.22105","article-title":"Hippocampal hyperactivation in presymptomatic familial Alzheimer\u2019s disease","volume":"68","author":"Quiroz","year":"2010","journal-title":"Ann. Neurol."},{"key":"ref_519","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s40478-018-0642-x","article-title":"GJA1 (connexin43) is a key regulator of Alzheimer\u2019s disease pathogenesis","volume":"6","author":"Kajiwara","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_520","doi-asserted-by":"crossref","unstructured":"Theodoric, N., Bechberger, J.F., Naus, C.C., and Sin, W.C. (2012). Role of gap junction protein connexin43 in astrogliosis induced by brain injury. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047311"},{"key":"ref_521","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.neuron.2012.03.023","article-title":"Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment","volume":"74","author":"Bakker","year":"2012","journal-title":"Neuron"},{"key":"ref_522","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/cns.12095","article-title":"Amyloid \u03b2, glutamate, excitotoxicity in Alzheimer\u2019s disease: Are we on the right track?","volume":"19","author":"Esposito","year":"2013","journal-title":"CNS Neurosci. Ther."},{"key":"ref_523","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.neuint.2004.03.007","article-title":"Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer\u2019s disease","volume":"45","author":"Hynd","year":"2004","journal-title":"Neurochem. Int."},{"key":"ref_524","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3389\/fnins.2015.00469","article-title":"Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?","volume":"9","author":"Lewerenz","year":"2015","journal-title":"Front. Neurosci."},{"key":"ref_525","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3233\/JAD-121990","article-title":"Slow excitotoxicity in Alzheimer\u2019s disease","volume":"35","author":"Ong","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"ref_526","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-4-431-56550-5_13","article-title":"Drebrins and Connexins: A Biomedical Perspective","volume":"1006","author":"Majoul","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_527","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.lfs.2018.07.033","article-title":"Specific deletion connexin43 in astrocyte ameliorates cognitive dysfunction in APP\/PS1 mice","volume":"208","author":"Ren","year":"2018","journal-title":"Life Sci."},{"key":"ref_528","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1007\/s12640-018-9975-2","article-title":"Carbenoxolone Reverses the Amyloid Beta 1\u201342 Oligomer-Induced Oxidative Damage and Anxiety-Related Behavior in Rats","volume":"35","author":"Sharma","year":"2019","journal-title":"Neurotox. Res."},{"key":"ref_529","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/glia.23080","article-title":"Cannabinoids prevent the amyloid \u03b2-induced activation of astroglial hemichannels: A neuroprotective mechanism","volume":"65","author":"Labra","year":"2017","journal-title":"Glia"},{"key":"ref_530","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nrneurol.2013.192","article-title":"Cortical spreading depression and migraine","volume":"9","author":"Charles","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"ref_531","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1129-2377-14-62","article-title":"Cortical spreading depression as a target for anti-migraine agents","volume":"14","author":"Costa","year":"2013","journal-title":"J. Headache Pain"},{"key":"ref_532","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fphys.2014.00078","article-title":"Involvement of gap junction channels in the pathophysiology of migraine with aura","volume":"5","author":"Sarrouilhe","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_533","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.2174\/0929867325666180327103530","article-title":"Targeting Gap Junctions: New Insights into the Treatment of Major Depressive Disorder","volume":"26","author":"Sarrouilhe","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"ref_534","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cobeha.2015.11.017","article-title":"Perinatal exposure to endocrine disruptors: Sex, timing and behavioral endpoints","volume":"7","author":"Palanza","year":"2016","journal-title":"Curr. Opin. Behav. Sci."},{"key":"ref_535","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.yhbeh.2018.05.010","article-title":"Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction","volume":"102","author":"Xin","year":"2018","journal-title":"Horm. Behav."},{"key":"ref_536","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00204-015-1485-x","article-title":"Prenatal exposure to bisphenol A impacts neuronal morphology in the hippocampal CA1 region in developing and aged mice","volume":"90","author":"Kimura","year":"2016","journal-title":"Arch. Toxicol."},{"key":"ref_537","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1002\/cam4.730","article-title":"Expression of a gap junction protein, connexin43, in a large panel of human gliomas: New insights","volume":"5","author":"Crespin","year":"2016","journal-title":"Cancer Med."},{"key":"ref_538","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/(SICI)1096-9098(199901)70:1<21::AID-JSO4>3.0.CO;2-0","article-title":"Reduced connexin43 expression in high-grade human brain glioma cells","volume":"70","author":"Huang","year":"1999","journal-title":"J. Surg. Oncol."},{"key":"ref_539","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/1098-1136(200102)33:2<107::AID-GLIA1010>3.0.CO;2-4","article-title":"Reduced expression of connexin-43 and functional gap junction coupling in human gliomas","volume":"33","author":"Soroceanu","year":"2001","journal-title":"Glia"},{"key":"ref_540","doi-asserted-by":"crossref","first-page":"5712","DOI":"10.1038\/onc.2010.299","article-title":"Connexin43 inhibits the oncogenic activity of c-Src in C6 glioma cells","volume":"29","author":"Gangoso","year":"2010","journal-title":"Oncogene"},{"key":"ref_541","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1038\/onc.2015.210","article-title":"Astrocytes promote glioma invasion via the gap junction protein connexin43","volume":"35","author":"Sin","year":"2016","journal-title":"Oncogene"},{"key":"ref_542","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/mc.20853","article-title":"Down-regulation of Connexin43 expression reveals the involvement of caveolin-1 containing lipid rafts in human U251 glioblastoma cell invasion","volume":"51","author":"Strale","year":"2012","journal-title":"Mol. Carcinog."},{"key":"ref_543","doi-asserted-by":"crossref","first-page":"11447","DOI":"10.18632\/oncotarget.3407","article-title":"Reduction in gap junction intercellular communication promotes glioma migration","volume":"6","author":"Aftab","year":"2015","journal-title":"Oncotarget"},{"key":"ref_544","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1002\/glia.20569","article-title":"Connexin43 enhances glioma invasion by a mechanism involving the carboxy terminus","volume":"55","author":"Bates","year":"2007","journal-title":"Glia"},{"key":"ref_545","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jcb.22554","article-title":"The carboxy-terminal tail of connexin43 gap junction protein is sufficient to mediate cytoskeleton changes in human glioma cells","volume":"110","author":"Crespin","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"ref_546","doi-asserted-by":"crossref","unstructured":"Chepied, A., Daoud-Omar, Z., Meunier-Balandre, A.C., Laird, D.W., Mesnil, M., and Defamie, N. (2020). Involvement of the Gap Junction Protein, Connexin43, in the Formation and Function of Invadopodia in the Human U251 Glioblastoma Cell Line. Cells, 9.","DOI":"10.3390\/cells9010117"},{"key":"ref_547","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.celrep.2015.04.021","article-title":"Differential connexin function enhances self-renewal in glioblastoma","volume":"11","author":"Hitomi","year":"2015","journal-title":"Cell Rep."},{"key":"ref_548","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1016\/j.bbamem.2011.10.022","article-title":"Opposing roles of connexin43 in glioma progression","volume":"1818","author":"Sin","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_549","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrc.2016.105","article-title":"Gap junctions and cancer: Communicating for 50 years","volume":"16","author":"Aasen","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"ref_550","doi-asserted-by":"crossref","first-page":"e672","DOI":"10.1097\/SCS.0000000000001707","article-title":"A Meta-Analysis of Association Between Pesticides Exposure and Glioma Risk in Adults","volume":"26","author":"Li","year":"2015","journal-title":"J. Craniofac. Surg."},{"key":"ref_551","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.intell.2013.04.006","article-title":"Were the Victorians cleverer than us? The decline in general intelligence estimated from a meta-analysis of the slowing of simple reaction time","volume":"41","author":"Woodley","year":"2013","journal-title":"Intelligence"},{"key":"ref_552","doi-asserted-by":"crossref","first-page":"A703","DOI":"10.1289\/ehp.021100703","article-title":"Parent bisphenol a accumulation in the human maternal-fetal-placental unit","volume":"110","author":"Wittfoht","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"ref_553","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.reprotox.2007.06.007","article-title":"Bisphenol-A and chlorinated derivatives in adipose tissue of women","volume":"24","author":"Fernandez","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"ref_554","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/jes.2012.39","article-title":"Bisphenol A in 24\u2009h urine and plasma samples of the German Environmental Specimen Bank from 1995 to 2009: A retrospective exposure evaluation","volume":"22","author":"Koch","year":"2012","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"ref_555","doi-asserted-by":"crossref","first-page":"615068","DOI":"10.1100\/2012\/615068","article-title":"Human elimination of phthalate compounds: Blood, urine, and sweat (BUS) study","volume":"2012","author":"Genuis","year":"2012","journal-title":"Sci. World J."},{"key":"ref_556","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1093\/humrep\/17.11.2839","article-title":"Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure","volume":"17","author":"Ikezuki","year":"2002","journal-title":"Hum. Reprod."},{"key":"ref_557","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ijheh.2009.03.004","article-title":"Levels of metabolites of organophosphate pesticides, phthalates, and bisphenol A in pooled urine specimens from pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa)","volume":"212","author":"Ye","year":"2009","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_558","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.envint.2012.07.003","article-title":"Urinary levels of bisphenol A, triclosan and 4-nonylphenol in a general Belgian population","volume":"48","author":"Pirard","year":"2012","journal-title":"Environ. Int."},{"key":"ref_559","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1289\/ehp.10753","article-title":"Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003\u20132004","volume":"116","author":"Calafat","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"ref_560","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jchromb.2005.11.050","article-title":"Measuring environmental phenols and chlorinated organic chemicals in breast milk using automated on-line column-switching-high performance liquid chromatography-isotope dilution tandem mass spectrometry","volume":"831","author":"Ye","year":"2006","journal-title":"Analyt. Technol. Biomed. Life Sci."},{"key":"ref_561","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.chemosphere.2012.01.002","article-title":"Distribution of bisphenol-A, triclosan and n-nonylphenol in human adipose tissue, liver and brain","volume":"87","author":"Geens","year":"2012","journal-title":"Chemosphere"},{"key":"ref_562","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1289\/ehp.0800265","article-title":"Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infants","volume":"117","author":"Calafat","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"ref_563","doi-asserted-by":"crossref","first-page":"105692","DOI":"10.1016\/j.envint.2020.105692","article-title":"Prenatal exposure to mixture of heavy metals, pesticides and phenols and IQ in children at 7 years of age: The SMBCS study","volume":"139","author":"Guo","year":"2020","journal-title":"Environ. Int."},{"key":"ref_564","doi-asserted-by":"crossref","first-page":"109844","DOI":"10.1016\/j.envres.2020.109844","article-title":"Prenatal and postnatal lead exposures and intellectual development among 12-year-old Japanese children","volume":"189","author":"Tatsuta","year":"2020","journal-title":"Environ. Res."},{"key":"ref_565","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1289\/ehp.9270","article-title":"Arsenic and fluoride exposure in drinking water: children\u2019s IQ and growth in Shanyin county, Shanxi province, China","volume":"115","author":"Wang","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"ref_566","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.tiv.2015.09.024","article-title":"Models and methods for in vitro testing of hepatic gap junctional communication","volume":"30","author":"Maes","year":"2015","journal-title":"Toxicol In Vitro"},{"key":"ref_567","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/inthealth\/ihy006","article-title":"Developmental Origins of Health and Disease: The relevance to developing nations","volume":"10","author":"Mandy","year":"2018","journal-title":"Int. Health"},{"key":"ref_568","doi-asserted-by":"crossref","unstructured":"Martorell, R. (2017). Improved nutrition in the first 1000 days and adult human capital and health. Am. J. Hum. Biol., 29.","DOI":"10.1002\/ajhb.22952"},{"key":"ref_569","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.conb.2005.03.012","article-title":"Changes in cerebral functional organization during cognitive development","volume":"15","author":"Casey","year":"2005","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_570","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3389\/fimmu.2013.00398","article-title":"Mechanisms of sterile inflammation","volume":"4","author":"Rubartelli","year":"2013","journal-title":"Front. Immunol."},{"key":"ref_571","first-page":"182","article-title":"Extracellular vesicles as mediators of neuron-glia communication","volume":"7","author":"Kuo","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"ref_572","doi-asserted-by":"crossref","first-page":"7541","DOI":"10.1073\/pnas.96.13.7541","article-title":"Gap-junctional coupling between neurons and astrocytes in primary central nervous system cultures","volume":"96","author":"Correia","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_573","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1159\/000048729","article-title":"Gap junction-mediated bidirectional signaling between human fetal hippocampal neurons and astrocytes","volume":"23","author":"Rozental","year":"2001","journal-title":"Dev. Neurosci."},{"key":"ref_574","doi-asserted-by":"crossref","unstructured":"Wang, X., Bukoreshtliev, N.V., and Gerdes, H.H. (2012). Developing neurons form transient nanotubes facilitating electrical coupling and calcium signaling with distant astrocytes. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047429"},{"key":"ref_575","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1513\/AnnalsATS.201907-538CME","article-title":"Health Benefits of Air Pollution Reduction","volume":"16","author":"Schraufnagel","year":"2019","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_576","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijheh.2019.10.002","article-title":"Changes in urinary excretion of phthalates, phthalate substitutes, bisphenols and other polychlorinated and phenolic substances in young Danish men; 2009\u20132017","volume":"223","author":"Frederiksen","year":"2020","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_577","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.2174\/1381612826666200325110014","article-title":"The Blood-Brain Barrier Interface in Diabetes Mellitus: Dysfunctions, Mechanisms and Approaches to Treatment","volume":"26","author":"Banks","year":"2020","journal-title":"Curr. Pharm. Des."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/1\/51\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:48:46Z","timestamp":1760179726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/1\/51"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,31]]},"references-count":577,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["biom11010051"],"URL":"https:\/\/doi.org\/10.3390\/biom11010051","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,31]]}}}