{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:20:57Z","timestamp":1791649257547,"version":"4.3.4"},"reference-count":179,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011773","name":"Conseil r\u00e9gional de Bourgogne-Franche-Comt\u00e9","doi-asserted-by":"publisher","award":["(PARI grant)"],"award-info":[{"award-number":["(PARI grant)"]}],"id":[{"id":"10.13039\/501100011773","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Funding for Regional Economic Development","award":["FEDER"],"award-info":[{"award-number":["FEDER"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The survival of insects depends on their ability to detect molecules present in their environment. Odorant-binding proteins (OBPs) form a family of proteins involved in chemoreception. While OBPs were initially found in olfactory appendages, recently these proteins were discovered in other chemosensory and non-chemosensory organs. OBPs can bind, solubilize and transport hydrophobic stimuli to chemoreceptors across the aqueous sensilla lymph. In addition to this broadly accepted \u201ctransporter role\u201d, OBPs can also buffer sudden changes in odorant levels and are involved in hygro-reception. The physiological roles of OBPs expressed in other body tissues, such as mouthparts, pheromone glands, reproductive organs, digestive tract and venom glands, remain to be investigated. This review provides an updated panorama on the varied structural aspects, binding properties, tissue expression and functional roles of insect OBPs.<\/jats:p>","DOI":"10.3390\/biom11040509","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T09:57:04Z","timestamp":1617098224000},"page":"509","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":223,"title":["The 40-Year Mystery of Insect Odorant-Binding Proteins"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7407-9311","authenticated-orcid":false,"given":"Karen","family":"Rihani","sequence":"first","affiliation":[{"name":"Dijon, CNRS, INRAE, Universit\u00e9 de Bourgogne Franche-Comt\u00e9, Centre des Sciences du Go\u00fbt et de l\u2019Alimentation, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4022-686X","authenticated-orcid":false,"given":"Jean-Fran\u00e7ois","family":"Ferveur","sequence":"additional","affiliation":[{"name":"Dijon, CNRS, INRAE, Universit\u00e9 de Bourgogne Franche-Comt\u00e9, Centre des Sciences du Go\u00fbt et de l\u2019Alimentation, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Briand","sequence":"additional","affiliation":[{"name":"Dijon, CNRS, INRAE, Universit\u00e9 de Bourgogne Franche-Comt\u00e9, Centre des Sciences du Go\u00fbt et de l\u2019Alimentation, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0301-0082(84)90008-X","article-title":"Perireceptor and receptor events in vertebrate olfaction","volume":"23","author":"Getchell","year":"1984","journal-title":"Prog. Neurobiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev-ento-120811-153635","article-title":"Odorant Reception in Insects: Roles of Receptors, Binding Proteins, and Degrading Enzymes","volume":"58","author":"Leal","year":"2013","journal-title":"Annu. Rev. Entomol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1007\/s00018-005-5607-0","article-title":"Soluble proteins in insect chemical communication","volume":"63","author":"Pelosi","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0305-0491(95)00019-5","article-title":"Odorant-binding proteins in insects","volume":"111","author":"Pelosi","year":"1995","journal-title":"Comp. Biochem. Physiol. Part B Biochem. Mol. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1749-6632.1998.tb10591.x","article-title":"Odorant-Binding Proteins: Expression and Function","volume":"855","author":"Steinbrecht","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0167-4838(00)00167-9","article-title":"Mammalian odorant binding proteins","volume":"1482","author":"Tegonia","year":"2000","journal-title":"Biochim. Biophys. Acta (BBA) Protein Struct. Mol. Enzym."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/B0-44-451924-6\/00047-8","article-title":"Molecular Basis of Pheromone Detection in Insects","volume":"3","author":"Vogt","year":"2005","journal-title":"Compr. Mol. Insect Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1042\/bj2010245","article-title":"Identification of a specific olfactory receptor for 2-isobutyl-3-methoxypyrazine","volume":"201","author":"Pelosi","year":"1982","journal-title":"Biochem. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/chemse\/6.2.77","article-title":"Binding of [3H]-2-isobutyl-3-methoxypyrazine to cow olfactory mucosa","volume":"6","author":"Pelosi","year":"1981","journal-title":"Chem. Senses"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1016\/S0021-9258(19)39300-7","article-title":"Odorant-binding protein. Characterization of ligand binding","volume":"265","author":"Pevsner","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_11","first-page":"161","article-title":"Pheromone binding and inactivation by moth antennae","volume":"293","author":"Vogt","year":"1981","journal-title":"Nat. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1073\/pnas.83.13.4942","article-title":"Odorant-binding protein: Localization to nasal glands and secretions","volume":"83","author":"Pevsner","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/jmbi.2000.3820","article-title":"Complexes of porcine odorant binding protein with odorant molecules belonging to different chemical classes","volume":"300","author":"Vincent","year":"2000","journal-title":"J. Mol. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7913","DOI":"10.1021\/bi980179e","article-title":"The Structure of the Monomeric Porcine Odorant Binding Protein Sheds Light on the Domain Swapping Mechanism","volume":"37","author":"Spinelli","year":"1998","journal-title":"Biochemistry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1111\/j.1460-9568.2005.04337.x","article-title":"Specific expression of olfactory binding protein in the aerial olfactory cavity of adult and developing Xenopus","volume":"22","author":"Millery","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/hmg\/9.2.289","article-title":"A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: Differential expression in the oral and genital spheres","volume":"9","author":"Lacazette","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7241","DOI":"10.1021\/bi015916c","article-title":"Evidence of an Odorant-Binding Protein in the Human Olfactory Mucus: Location, Structural Characterization, and Odorant-Binding Properties","volume":"41","author":"Briand","year":"2002","journal-title":"Biochemistry"},{"key":"ref_18","first-page":"211A","article-title":"Identification and partial purification of a pheromone-binding protein in Bombyx mori","volume":"38","author":"Maida","year":"1989","journal-title":"Ital. J. Biochem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-31978-2","article-title":"In vivo functional characterisation of pheromone binding protein-1 in the silkmoth, Bombyx mori","volume":"8","author":"Shiota","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1523\/JNEUROSCI.09-09-03332.1989","article-title":"Expression of pheromone binding proteins during antennal development in the gypsy moth Lymantria dispar","volume":"9","author":"Vogt","year":"1989","journal-title":"J. Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/chemse\/20.4.461","article-title":"How is Pheromone Specificity Encoded in Proteins?","volume":"20","author":"Prestwich","year":"1995","journal-title":"Chem. Senses"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.ibmb.2009.04.002","article-title":"Global transcriptional analysis of pheromone biosynthesis-related genes in the female turnip moth, Agrotis segetum (Noctuidae) using a custom-made cDNA microarray","volume":"39","author":"Strandh","year":"2009","journal-title":"Insect Biochem. Mol. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.7150\/ijbs.6109","article-title":"Candidate Chemosensory Genes in the Stemborer Sesamia nonagrioides","volume":"9","author":"Glaser","year":"2013","journal-title":"Int. J. Biol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Sun, Y.-L., Huang, L.-Q., Pelosi, P., and Wang, C.-Z. (2012). Expression in Antennae and Reproductive Organs Suggests a Dual Role of an Odorant-Binding Protein in Two Sibling Helicoverpa Species. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030040"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-15-718","article-title":"Comparative genomics and transcriptomics in ants provide new insights into the evolution and function of odorant binding and chemosensory proteins","volume":"15","author":"McKenzie","year":"2014","journal-title":"BMC Genom."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/gbe\/evs131","article-title":"Comparative Genomics of Odorant Binding Proteins in Anopheles gambiae, Aedes aegypti, and Culex quinquefasciatus","volume":"5","author":"Manoharan","year":"2013","journal-title":"Genome Biol. Evol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/hdy.2009.55","article-title":"Molecular evolution of the major chemosensory gene families in insects","volume":"103","author":"Vieira","year":"2009","journal-title":"Heredity"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"180208","DOI":"10.1098\/rsob.180208","article-title":"The diverse small proteins called odorant-binding proteins","volume":"8","author":"Sun","year":"2018","journal-title":"R. Soc. Open Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/brv.12339","article-title":"Beyond chemoreception: Diverse tasks of soluble olfactory proteins in insects","volume":"93","author":"Pelosi","year":"2017","journal-title":"Biol. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/gbe\/evr033","article-title":"Comparative Genomics of the Odorant-Binding and Chemosensory Protein Gene Families across the Arthropoda: Origin and Evolutionary History of the Chemosensory System","volume":"3","author":"Vieira","year":"2011","journal-title":"Genome Biol. Evol."},{"key":"ref_31","first-page":"1838","article-title":"Evolutionary History of Chemosensory-Related Gene Families across the Arthropoda","volume":"34","author":"Eyun","year":"2017","journal-title":"Mol. Cell Proteom."},{"key":"ref_32","first-page":"320","article-title":"Soluble proteins of chemical communication: An overview across arthropods","volume":"5","author":"Epelosi","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF00328015","article-title":"Immunocytochemical localization of pheromone-binding protein in moth antennae","volume":"270","author":"Steinbrecht","year":"1992","journal-title":"Cell Tissue Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Larter, N.K., Sun, J.S., and Carlson, J.R. (2016). Organization and function of Drosophila odorant binding proteins. eLife, 5.","DOI":"10.7554\/eLife.20242"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.gene.2010.07.006","article-title":"Evolution of expression patterns of two odorant-binding protein genes, Obp57d and Obp57e, in Drosophila","volume":"467","author":"Yasukawa","year":"2010","journal-title":"Gene"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.neuron.2013.06.025","article-title":"An Odorant-Binding Protein Required for Suppression of Sweet Taste by Bitter Chemicals","volume":"79","author":"Jeong","year":"2013","journal-title":"Neuron"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-019-0673-2","article-title":"A conserved odorant binding protein is required for essential amino acid detection in Drosophila","volume":"2","author":"Rihani","year":"2019","journal-title":"Commun. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0896-6273(94)90150-3","article-title":"Members of a family of drosophila putative odorant-binding proteins are expressed in different subsets of olfactory hairs","volume":"12","author":"Pikielny","year":"1994","journal-title":"Neuron"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/jemt.1179","article-title":"Expression mosaic of odorant-binding proteins inDrosophila olfactory organs","volume":"55","author":"Shanbhag","year":"2001","journal-title":"Microsc. Res. Tech."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.7150\/ijbs.16517","article-title":"Conserved chemosensory proteins in the proboscis and eyes of Lepidoptera","volume":"12","author":"Zhu","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"ref_41","first-page":"100605","article-title":"Genome-wide identification and expression profiling of odorant-binding proteins in the oriental fruit fly, Bactrocera dorsalis","volume":"31","author":"Chen","year":"2019","journal-title":"Comp. Biochem. Physiol. Part D Genom. Proteom."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Pelletier, J., and Leal, W.S. (2009). Genome Analysis and Expression Patterns of Odorant-Binding Proteins from the Southern House Mosquito Culex pipiens quinquefasciatus. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0006237"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ibmb.2014.02.004","article-title":"The genetics of chemoreception in the labella and tarsi of Aedes aegypti","volume":"48","author":"Sparks","year":"2014","journal-title":"Insect Biochem. Mol. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-15-1141","article-title":"Tissue-specific transcriptomics, chromosomal localization, and phylogeny of chemosensory and odorant binding proteins from the red flour beetle Tribolium castaneum reveal subgroup specificities for olfaction or more general functions","volume":"15","author":"Dippel","year":"2014","journal-title":"BMC Genom."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/imb.12548","article-title":"Expression of odorant-binding proteins in mouthpart palps of the desert locustSchistocerca gregaria","volume":"28","author":"Pregitzer","year":"2019","journal-title":"Insect Mol. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/chemse\/27.4.319","article-title":"Novel odorant-binding proteins expressed in the taste tissue of the fly","volume":"27","author":"Koganezawa","year":"2002","journal-title":"Chem. Senses"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/genetics\/159.3.1059","article-title":"A large family of divergent Drosophila odorant-binding proteins expressed in gustatory and olfactory sensilla","volume":"159","author":"Galindo","year":"2001","journal-title":"Genetics"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/arch.20047","article-title":"Identification and expression of odorant-binding proteins of the malaria-carrying mosquitoesAnopheles gambiae andAnopheles arabiensis","volume":"58","author":"Li","year":"2005","journal-title":"Arch. Insect Biochem. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/s11033-010-0293-x","article-title":"Identification of odorant-binding protein genes from antennal expressed sequence tags of the onion fly, Delia antiqua","volume":"38","author":"Mitaka","year":"2010","journal-title":"Mol. Biol. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"14936","DOI":"10.3390\/ijms140714936","article-title":"Identification and Expression Profile Analysis of Odorant Binding Proteins in the Oriental Fruit Fly Bactrocera dorsalis","volume":"14","author":"Zheng","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_51","first-page":"211","article-title":"Antennal transcriptome analysis and expression profiles of odorant binding proteins in Clostera restitura","volume":"29","author":"Gu","year":"2019","journal-title":"Comp. Biochem. Physiol. Part D Genom. Proteom."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ibmb.2011.01.002","article-title":"Identification and tissue distribution of odorant binding protein genes in the lucerne plant bug Adelphocoris lineolatus (Goeze)","volume":"41","author":"Gu","year":"2011","journal-title":"Insect Biochem. Mol. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ibmb.2005.01.002","article-title":"Expression of odorant-binding proteins and chemosensory proteins in some Hymenoptera","volume":"35","author":"Calvello","year":"2005","journal-title":"Insect Biochem. Mol. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ng2049","article-title":"Using FlyAtlas to identify better Drosophila melanogaster models of human disease","volume":"39","author":"Chintapalli","year":"2007","journal-title":"Nat. Genet."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1002\/pmic.200800795","article-title":"Proteome mapping of the Drosophila melanogaster male reproductive system","volume":"9","author":"Takemori","year":"2009","journal-title":"Proteomics"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1111\/j.1420-9101.2010.01998.x","article-title":"Molecular evolutionary analysis of seminal receptacle sperm storage organ genes of Drosophila melanogaster","volume":"23","author":"Prokupek","year":"2010","journal-title":"J. Evol. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Sun, J.S., Larter, N.K., Chahda, J.S., Rioux, D., Gumaste, A., and Carlson, J.R. (2018). Humidity response depends on the small soluble protein Obp59a in Drosophila. eLife, 7.","DOI":"10.7554\/eLife.39249"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/neu.10057","article-title":"Inactivation of olfactory sensilla of a single morphological type differentially affects the response ofDrosophila to odors","volume":"51","author":"Park","year":"2002","journal-title":"J. Neurobiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.celrep.2013.04.001","article-title":"Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila","volume":"3","author":"Buchon","year":"2013","journal-title":"Cell Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1021\/pr2000754","article-title":"Differential Expression of Odorant-Binding Proteins in the Mandibular Glands of the Honey Bee According to Caste and Age","volume":"10","author":"Iovinella","year":"2011","journal-title":"J. Proteome Res."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Findlay, G.D., Yi, X., Maccoss, M.J., and Swanson, W.J. (2008). Proteomics reveals novel Drosophila seminal fluid proteins transferred at mating. PLoS Biol., 6.","DOI":"10.1371\/annotation\/2177fe97-a5bc-45d5-8fa9-5c3639dda4f3"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Chapman, T. (2008). The Soup in My Fly: Evolution, Form and Function of Seminal Fluid Proteins. PLoS Biol., 6.","DOI":"10.1371\/journal.pbio.0060179"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1074\/mcp.RA118.000831","article-title":"Quantitative Proteomics Identification of Seminal Fluid Proteins in Male Drosophila melanogaster","volume":"18","author":"Sepil","year":"2019","journal-title":"Mol. Cell. Proteom."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.bbrc.2008.05.064","article-title":"Multiple functions of an odorant-binding protein in the mosquito Aedes aegypti","volume":"372","author":"Li","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ibmb.2007.10.007","article-title":"Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: Potential tools for control of female feeding and reproduction","volume":"38","author":"Sirot","year":"2008","journal-title":"Insect Biochem. Mol. Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5646","DOI":"10.1016\/j.jprot.2012.08.002","article-title":"Seminal fluid proteins differ in abundance between genetic lineages of honeybees","volume":"75","author":"Baer","year":"2012","journal-title":"J. Proteom."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jprot.2012.11.011","article-title":"Proteomics of Tribolium castaneum seminal fluid proteins: Identification of an angiotensin-converting enzyme as a key player in regulation of reproduction","volume":"78","author":"Xu","year":"2013","journal-title":"J. Proteom."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1186\/1756-3305-6-364","article-title":"Expression and accumulation of the two-domain odorant-binding protein AaegOBP45 in the ovaries of blood-fed Aedes aegypti","volume":"6","author":"Kojin","year":"2013","journal-title":"Parasites Vectors"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Marinotti, O., Ngo, T., Kojin, B.B., Chou, S.-P., Nguyen, B., Juhn, J., Carballar-Lejaraz\u00fa, R., Marinotti, P.N., Jiang, X., and Walter, M.F. (2014). Integrated proteomic and transcriptomic analysis of the Aedes aegypti eggshell. BMC Dev. Biol., 14.","DOI":"10.1186\/1471-213X-14-15"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.jinsphys.2010.04.013","article-title":"Proteomics reveals novel components of the Anopheles gambiae eggshell","volume":"56","author":"Amenya","year":"2010","journal-title":"J. Insect Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Andersson, M.N., Videvall, E., Walden, K.K.O., Harris, M.O., Robertson, H.M., and L\u00f6fstedt, C. (2014). Sex- and tissue-specific profiles of chemosensory gene expression in a herbivorous gall-inducing fly (Diptera: Cecidomyiidae). BMC Genom., 15.","DOI":"10.1186\/1471-2164-15-501"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Xu, W., Cornel, A.J., and Leal, W.S. (2010). Odorant-Binding Proteins of the Malaria Mosquito Anopheles funestus sensu stricto. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0015403"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.gene.2013.04.080","article-title":"Partial venom gland transcriptome of a Drosophila parasitoid wasp, Leptopilina heterotoma, reveals novel and shared bioactive profiles with stinging Hymenoptera","volume":"526","author":"Heavner","year":"2013","journal-title":"Gene"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/arch.21206","article-title":"VENOM OF THE PARASITOID WASPPteromalus puparumCONTAINS AN ODORANT BINDING PROTEIN","volume":"88","author":"Wang","year":"2015","journal-title":"Arch. Insect Biochem. Physiol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Li, R., Zhang, L., Fang, Y., Han, B., Lu, X., Zhou, T., Feng, M., and Li, J. (2013). Proteome and phosphoproteome analysis of honeybee (Apis mellifera) venom collected from electrical stimulation and manual extraction of the venom gland. BMC Genom., 14.","DOI":"10.1186\/1471-2164-14-766"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Ishida, Y., Ishibashi, J., and Leal, W.S. (2013). Fatty Acid Solubilizer from the Oral Disk of the Blowfly. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0051779"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Ribeiro, S.P., Genta, F.A., Sorgine, M.H.F., Logullo, R., Mesquita, R.D., Paiva-Silva, G.O., Majerowicz, D., Medeiros, M., Koerich, L., and Terra, W.R. (2014). An Insight into the Transcriptome of the Digestive Tract of the Bloodsucking Bug, Rhodnius prolixus. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0002594"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1093\/jmedent\/45.2.326","article-title":"Bloodmeal-induced differential gene expression in the disease vector culex nigripalpus (Diptera: Culicidae)","volume":"45","author":"Smartt","year":"2008","journal-title":"J. Med. Entomol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1603\/033.046.0617","article-title":"Expression of a Novel Member of the Odorant-Binding Protein Gene Family in Culex nigripalpus (Diptera: Culicidae)","volume":"46","author":"Smartt","year":"2009","journal-title":"J. Med. Entomol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-27476-0","article-title":"Host-plant induced changes in microbial community structure and midgut gene expression in an invasive polyphage (Anoplophora glabripennis)","volume":"8","author":"Scully","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Benoit, J.B., Vigneron, A., Broderick, N.A., Wu, Y., Sun, J.S., Carlson, J.R., Aksoy, S., and Weiss, B.L. (2017). Symbiont-induced odorant binding proteins mediate insect host hematopoiesis. eLife, 6.","DOI":"10.7554\/eLife.19535"},{"key":"ref_82","first-page":"65","article-title":"Rapid kinetics of second messenger formation in olfactory transduction","volume":"345","author":"Breer","year":"1990","journal-title":"Nat. Cell Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/BF00258977","article-title":"Primary structure of a pheromone-binding protein from Antheraea pernyi: Homologies with other ligand-carrying proteins","volume":"160","author":"Raming","year":"1990","journal-title":"J. Comp. Physiol. B"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"9851","DOI":"10.1073\/pnas.85.24.9851","article-title":"Characterization and cDNA cloning of the pheromone-binding protein from the tobacco hornworm, Manduca sexta: A tissue-specific developmentally regulated protein","volume":"85","author":"Gyorgyi","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0014-5793(89)81751-X","article-title":"Molecular cloning of an insect pheromone-binding protein","volume":"256","author":"Raming","year":"1989","journal-title":"FEBS Lett."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1523\/JNEUROSCI.11-10-02972.1991","article-title":"Molecular cloning and sequencing of general odorant-binding proteins GOBP1 and GOBP2 from the tobacco hawk moth Manduca sexta: Comparisons with other insect OBPs and their signal peptides","volume":"11","author":"Vogt","year":"1991","journal-title":"J. Neurosci."},{"key":"ref_87","first-page":"178","article-title":"Immunocytochemical Localization of General Odorant-Binding Protein in Olfactory Sensilla of the Silkmoth Antheraea polyphemus","volume":"81","author":"Laue","year":"1994","journal-title":"Naturwissenschaften"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0965-1748(95)00096-8","article-title":"Binding proteins from the antennae of Bombyx mori","volume":"26","author":"Krieger","year":"1996","journal-title":"Insect Biochem. Mol. Biol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Gong, D.-P., Zhang, H.-J., Zhao, P., Xia, Q.-Y., and Xiang, Z.-H. (2009). The Odorant Binding Protein Gene Family from the Genome of Silkworm, Bombyx mori. BMC Genom., 10.","DOI":"10.1186\/1471-2164-10-332"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1101\/gr.239402","article-title":"Genome-Wide Analysis of the Odorant-Binding Protein Gene Family in Drosophila melanogaster","volume":"12","author":"Scafe","year":"2002","journal-title":"Genome Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1046\/j.1365-2583.2003.00440.x","article-title":"Identification of a distinct family of genes encoding atypical odorant-binding proteins in the malaria vector mosquito, Anopheles gambiae","volume":"12","author":"Xu","year":"2003","journal-title":"Insect Mol. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.gene.2003.11.007","article-title":"\u201cPlus-C\u201d odorant-binding protein genes in two Drosophila species and the malaria mosquito Anopheles gambiae","volume":"327","author":"Zhou","year":"2004","journal-title":"Gene"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-5793(03)01521-7","article-title":"Revisiting the odorant-binding protein LUSH ofDrosophila melanogaster: Evidence for odour recognition and discrimination","volume":"558","author":"Zhou","year":"2004","journal-title":"FEBS Lett."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1007\/s00018-019-03300-4","article-title":"The Drosophila odorant-binding protein 28a is involved in the detection of the floral odour \u00df-ionone","volume":"77","author":"Gonzalez","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0014-5793(99)01683-X","article-title":"Disulfide structure of the pheromone binding protein from the silkworm moth, Bombyx mori","volume":"464","author":"Leal","year":"1999","journal-title":"FEBS Lett."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1006\/bbrc.1999.1791","article-title":"Structural Analysis and Disulfide-Bridge Pairing of Two Odorant-Binding Proteins from Bombyx mori","volume":"266","author":"Scaloni","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1046\/j.1432-1327.2001.01927.x","article-title":"Ligand binding and physico-chemical properties of ASP2, a recombinant odorant-binding protein from honeybee (Apis mellifera L.)","volume":"268","author":"Briand","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jinsphys.2016.09.008","article-title":"A look inside odorant-binding proteins in insect chemoreception","volume":"95","author":"Brito","year":"2016","journal-title":"J. Insect Physiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"30213","DOI":"10.1074\/jbc.M304688200","article-title":"The Crystal Structure of a Cockroach Pheromone-binding Protein Suggests a New Ligand Binding and Release Mechanism","volume":"278","author":"Lartigue","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1074\/jbc.M311212200","article-title":"Sulfur Single-wavelength Anomalous Diffraction Crystal Structure of a Pheromone-Binding Protein from the Honeybee Apis mellifera L","volume":"279","author":"Lartigue","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1021\/bi802300k","article-title":"Structural Basis of the Broad Specificity of a General Odorant-Binding Protein from Honeybee","volume":"48","author":"Lescop","year":"2009","journal-title":"Biochemistry"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Pelosi, P., Zhu, J., and Knoll, W. (2018). Odorant-Binding Proteins as Sensing Elements for Odour Monitoring. Sensors, 18.","DOI":"10.3390\/s18103248"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jmb.2008.04.048","article-title":"Structural Basis of the Honey Bee PBP Pheromone and pH-induced Conformational Change","volume":"380","author":"Pesenti","year":"2008","journal-title":"J. Mol. Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.jmb.2009.05.067","article-title":"Queen Bee Pheromone Binding Protein pH-Induced Domain Swapping Favors Pheromone Release","volume":"390","author":"Pesenti","year":"2009","journal-title":"J. Mol. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ibmb.2011.10.005","article-title":"Crystal structure of Apis mellifera OBP14, a C-minus odorant-binding protein, and its complexes with odorant molecules","volume":"42","author":"Spinelli","year":"2012","journal-title":"Insect Biochem. Mol. Biol."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Leite, N.R., Krogh, R., Xu, W., Ishida, Y., Iulek, J., Leal, W.S., and Oliva, G. (2009). Structure of an Odorant-Binding Protein from the Mosquito Aedes aegypti Suggests a Binding Pocket Covered by a pH-Sensitive \u201cLid\u201d. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0008006"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bbrc.2005.10.191","article-title":"The crystal structure of an odorant binding protein from Anopheles gambiae: Evidence for a common ligand release mechanism","volume":"339","author":"Wogulis","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"20078","DOI":"10.1074\/jbc.M100713200","article-title":"Revisiting the Specificity of Mamestra brassicaeand Antheraea polyphemus Pheromone-binding Proteins with a Fluorescence Binding Assay","volume":"276","author":"Campanacci","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00018-016-2335-6","article-title":"The crystal structure of the AgamOBP1\u2022Icaridin complex reveals alternative binding modes and stereo-selective repellent recognition","volume":"74","author":"Drakou","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2583.2012.01167.x","article-title":"Quantitative analysis of pheromone-binding protein specificity","volume":"22","author":"Katti","year":"2013","journal-title":"Insect. Mol. Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.cell.2008.04.046","article-title":"Activation of Pheromone-Sensitive Neurons Is Mediated by Conformational Activation of Pheromone-Binding Protein","volume":"133","author":"Laughlin","year":"2008","journal-title":"Cell"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.tibs.2004.03.003","article-title":"Structural aspects of sexual attraction and chemical communication in insects","volume":"29","author":"Tegoni","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1074-5521(00)00078-8","article-title":"Sexual attraction in the silkworm moth: Structure of the pheromone-binding-protein\u2013bombykol complex","volume":"7","author":"Sandler","year":"2000","journal-title":"Chem. Biol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1042\/bj20021877","article-title":"A pheromone-binding protein from the cockroach Leucophaea maderae: Cloning, expression and pheromone binding","volume":"371","author":"Lartigue","year":"2003","journal-title":"Biochem. J."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"14374","DOI":"10.1073\/pnas.251532998","article-title":"NMR structure reveals intramolecular regulation mechanism for pheromone binding and release","volume":"98","author":"Horst","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1073\/pnas.0501447102","article-title":"Kinetics and molecular properties of pheromone binding and release","volume":"102","author":"Leal","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"30950","DOI":"10.1074\/jbc.274.43.30950","article-title":"Conformational Change in the Pheromone-binding Protein fromBombyx mori Induced by pH and by Interaction with Membranes","volume":"274","author":"Wojtasek","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Han, L., Zhang, Y.-J., Zhang, L., Cui, X., Yu, J., Zhang, Z., and Liu, M.S. (2014). Operating Mechanism and Molecular Dynamics of Pheromone-Binding Protein ASP1 as Influenced by pH. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0110565"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1021\/bi9020132","article-title":"NMR Structure of Navel Orangeworm Moth Pheromone-Binding Protein (AtraPBP1): Implications for pH-Sensitive Pheromone Detection","volume":"49","author":"Xu","year":"2010","journal-title":"Biochemistry"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jmb.2005.10.015","article-title":"Structural Consequences of the pH-induced Conformational Switch in A.polyphemus Pheromone-binding Protein: Mechanisms of Ligand Release","volume":"354","author":"Zubkov","year":"2005","journal-title":"J. Mol. Biol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"19102","DOI":"10.1073\/pnas.1012274107","article-title":"Crystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone","volume":"107","author":"Mao","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"11866","DOI":"10.1038\/ncomms11866","article-title":"A CD36 ectodomain mediates insect pheromone detection via a putative tunnelling mechanism","volume":"7","author":"Bargeton","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.neuron.2013.07.038","article-title":"A spoonful of bitter helps the sugar response go down","volume":"79","author":"Lvovskaya","year":"2013","journal-title":"Neuron"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"10996","DOI":"10.1073\/pnas.0803309105","article-title":"SNMP is a signaling component required for pheromone sensitivity in Drosophila","volume":"105","author":"Jin","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"18680","DOI":"10.1073\/pnas.1317706110","article-title":"Pheromone discrimination by a pH-tuned polymorphism of the Bombyx mori pheromone-binding protein","volume":"110","author":"Damberger","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3109\/10409239409086801","article-title":"Odorant-Binding Proteins","volume":"29","author":"Pelosi","year":"1994","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Biessmann, H., Andronopoulou, E., Biessmann, M.R., Douris, V., Dimitratos, S.D., Eliopoulos, E., Guerin, P.M., Iatrou, K., Justice, R.W., and Kr\u00f6ber, T. (2010). The Anopheles gambiae Odorant Binding Protein 1 (AgamOBP1) Mediates Indole Recognition in the Antennae of Female Mosquitoes. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0009471"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10886-010-9762-x","article-title":"Knockdown of a Mosquito Odorant-binding Protein Involved in the Sensitive Detection of Oviposition Attractants","volume":"36","author":"Pelletier","year":"2010","journal-title":"J. Chem. Ecol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Deng, Y., Yan, H., Gu, J., Xu, J., Wu, K., Tu, Z., James, A.A., and Chen, X. (2013). Molecular and Functional Characterization of Odorant-Binding Protein Genes in an Invasive Vector Mosquito, Aedes albopictus. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068836"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"13093","DOI":"10.1038\/srep13093","article-title":"Pheromone binding proteins enhance the sensitivity of olfactory receptors to sex pheromones in Chilo suppressalis","volume":"5","author":"Chang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"745","DOI":"10.7150\/ijbs.5.745","article-title":"A receptor and binding protein interplay in the detection of a distinct pheromone component in the silkmoth Antheraea polyphemus","volume":"5","author":"Forstner","year":"2009","journal-title":"Int. J. Biol. Sci."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Sun, M., Liu, Y., Walker, W.B., Liu, C., Lin, K., Gu, S., Zhang, Y., Zhou, J., and Wang, G. (2013). Identification and Characterization of Pheromone Receptors and Interplay between Receptors and Pheromone Binding Proteins in the Diamondback Moth, Plutella xyllostella. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062098"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/chemse\/bjj059","article-title":"A Pheromone-Binding Protein Mediates the Bombykol-Induced Activation of a Pheromone Receptor In Vitro","volume":"31","author":"Krieger","year":"2006","journal-title":"Chem. Senses"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Gomez-Diaz, C., Reina, J.H., Cambillau, C., and Benton, R. (2013). Ligands for Pheromone-Sensing Neurons Are Not Conformationally Activated Odorant Binding Proteins. PLoS Biol., 11.","DOI":"10.1371\/journal.pbio.1001546"},{"key":"ref_135","first-page":"289","article-title":"An essential role for a CD36-related receptor in pheromone detection in Drosophila","volume":"450","author":"Benton","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_136","first-page":"542","article-title":"A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone","volume":"446","author":"Kurtovic","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.cub.2007.02.043","article-title":"Receptors and Neurons for Fly Odors in Drosophila","volume":"17","author":"Naters","year":"2007","journal-title":"Curr. Biol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1126\/science.1106267","article-title":"Insect Sex-Pheromone Signals Mediated by Specific Combinations of Olfactory Receptors","volume":"307","author":"Nakagawa","year":"2005","journal-title":"Science"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms7077","article-title":"Amino acid coevolution reveals three-dimensional structure and functional domains of insect odorant receptors","volume":"6","author":"Hopf","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Bentzur, A., Shmueli, A., Omesi, L., Ryvkin, J., Knapp, J.-M., Parnas, M., Davis, F.P., and Shohat-Ophir, G. (2018). Odorant binding protein 69a connects social interaction to modulation of social responsiveness in Drosophila. PLoS Genet., 14.","DOI":"10.1371\/journal.pgen.1007328"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1601-183X.2011.00704.x","article-title":"Functional dissection of Odorant binding protein genes in Drosophila melanogaster","volume":"10","author":"Swarup","year":"2011","journal-title":"Genes, Brain Behav."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1534\/g3.116.034595","article-title":"Obp56hModulates Mating Behavior inDrosophila melanogaster","volume":"6","author":"Shorter","year":"2016","journal-title":"G3 Genes|Genomes|Genetics"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev.ento.50.071803.130359","article-title":"ECOLOGICAL, BEHAVIORAL, AND BIOCHEMICAL ASPECTS OF INSECT HYDROCARBONS","volume":"50","author":"Howard","year":"2005","journal-title":"Annu. Rev. Entomol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1098\/rspb.1996.0143","article-title":"Simultaneous influence on male courtship of stimulatory and inhibitory pheromones produced by live sex-mosaic Drosophila melanogaster","volume":"263","author":"Ferveur","year":"1996","journal-title":"Proc. R. Soc. B Boil. Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/bies.950190413","article-title":"The pheromonal role of cuticular hydrocarbons inDrosophila melanogaster","volume":"19","author":"Ferveur","year":"1997","journal-title":"BioEssays"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/genetics\/152.4.1653","article-title":"Analysis of the doublesex female protein in Drosophila melanogaster: Role on sexual differentiation and behavior and dependence on intersex","volume":"152","author":"Waterbury","year":"1999","journal-title":"Genetics"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.51040","article-title":"Robust olfactory responses in the absence of odorant binding proteins","volume":"8","author":"Xiao","year":"2019","journal-title":"eLife"},{"key":"ref_148","first-page":"706","article-title":"Redox-Shift of the Pheromone-Binding Protein in the Silkmoth Antheraea Polyphemus","volume":"232","author":"Ziegelberger","year":"2008","journal-title":"Eur. J. Biochem."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"16340","DOI":"10.1016\/S0021-9258(17)34013-9","article-title":"Putative Drosophila pheromone-binding proteins expressed in a subregion of the olfactory system","volume":"269","author":"McKenna","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1534\/genetics.119.302629","article-title":"Odor-Specific Deactivation Defects in aDrosophilaOdorant-Binding Protein Mutant","volume":"213","author":"Scheuermann","year":"2019","journal-title":"Genet."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1266\/ggs.83.257","article-title":"Behavioral analyses of mutants for two odorant-binding protein genes, Obp57d and Obp57e, in Drosophila melanogaster","volume":"83","author":"Harada","year":"2008","journal-title":"Genes Genet. Syst."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Matsuo, T., Sugaya, S., Yasukawa, J., Aigaki, T., and Fuyama, Y. (2007). Odorant-Binding Proteins OBP57d and OBP57e Affect Taste Perception and Host-Plant Preference in Drosophila sechellia. PLoS Biol., 5.","DOI":"10.1371\/journal.pbio.0050118"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/chemse\/bjt061","article-title":"Modulation of Feeding Behavior by Odorant-Binding Proteins in Drosophila melanogaster","volume":"39","author":"Swarup","year":"2014","journal-title":"Chem. Senses"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"103915","DOI":"10.1016\/j.jinsphys.2019.103915","article-title":"Mouthparts enriched odorant binding protein AfasOBP11 plays a role in the gustatory perception of Adelphocoris fasciaticollis","volume":"117","author":"Li","year":"2019","journal-title":"J. Insect Physiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"e31625","DOI":"10.7554\/eLife.31625","article-title":"Internal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila","volume":"7","author":"Steck","year":"2018","journal-title":"eLife"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1126\/science.aal3245","article-title":"Branch-specific plasticity of a bifunctional dopamine circuit encodes protein hunger","volume":"356","author":"Liu","year":"2017","journal-title":"Sci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"14161","DOI":"10.1038\/ncomms14161","article-title":"Drosophila FIT is a protein-specific satiety hormone essential for feeding control","volume":"8","author":"Sun","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"103554","DOI":"10.1016\/j.ibmb.2021.103554","article-title":"Contribution of odorant binding proteins to olfactory detection of (Z)-11-hexadecenal in Helicoverpa armigera","volume":"131","author":"Guo","year":"2021","journal-title":"Insect Biochem. Mol. Biol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1111\/j.1742-4658.2006.05510.x","article-title":"Odorant binding protein has the biochemical properties of a scavenger for 4-hydroxy-2-nonenal in mammalian nasal mucosa","volume":"273","author":"Grolli","year":"2006","journal-title":"FEBS J."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"814","DOI":"10.3109\/10715762.2014.910867","article-title":"Overexpression of a monomeric form of the bovine odorant-binding protein protectsEscherichia colifrom chemical-induced oxidative stress","volume":"48","author":"Grolli","year":"2014","journal-title":"Free. Radic. Res."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Bianchi, F., Flisi, S., Careri, M., Riboni, N., Resimini, S., Sala, A., Conti, V., Mattarozzi, M., Taddei, S., and Spadini, C. (2019). Vertebrate odorant binding proteins as antimicrobial humoral components of innate immunity for pathogenic microorganisms. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0213545"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0167-4838(00)00149-7","article-title":"Major urinary proteins, \u03b12U-globulins and aphrodisin","volume":"1482","author":"Cavaggioni","year":"2000","journal-title":"Biochim. Biophys. Acta Protein Struct. Mol. Enzym."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1002\/bies.20147","article-title":"Scent wars: The chemobiology of competitive signalling in mice","volume":"26","author":"Hurst","year":"2004","journal-title":"BioEssays"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1002\/rcm.4766","article-title":"Using mass spectrometry to detect buffalo salivary odorant-binding protein and its post-translational modifications","volume":"24","author":"Rajkumar","year":"2010","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1038\/srep05201","article-title":"Evaluating the binding efficiency of pheromone binding protein with its natural ligand using molecular docking and fluorescence analysis","volume":"4","author":"Ilayaraja","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1046\/j.1432-1033.2002.02901.x","article-title":"Boar salivary lipocalin","volume":"269","author":"Spinelli","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"E9802","DOI":"10.1073\/pnas.1711437114","article-title":"Reverse chemical ecology: Olfactory proteins from the giant panda and their interactions with putative pheromones and bamboo volatiles","volume":"114","author":"Zhu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"9323","DOI":"10.1038\/s41598-018-27550-7","article-title":"Buffalo nasal odorant-binding protein (bunOBP) and its structural evaluation with putative pheromones","volume":"8","author":"Muthukumar","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1042\/bj3500369","article-title":"Cloning, post-translational modifications, heterologous expression and ligand-binding of boar salivary lipocalin","volume":"350","author":"Loebel","year":"2000","journal-title":"Biochem. J."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Manikkaraja, C., Bhavika, M., Singh, R., Nagarathnam, B., George, G., Gulyani, A., Archunan, G., and Sowdhamini, R. (2020). Molecular and functional characterization of buffalo nasal epithelial odorant binding proteins and their structural insights by in silico and biochemical approaches. J. Biomol. Struct. Dyn., 1\u201324.","DOI":"10.1101\/2020.09.17.301234"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.sbi.2004.07.004","article-title":"Periplasmic binding proteins: A versatile superfamily for protein engineering","volume":"14","author":"Dwyer","year":"2004","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0167-7799(98)01174-3","article-title":"Protein engineering and the development of generic biosensors","volume":"16","author":"Hellinga","year":"1998","journal-title":"Trends Biotechnol."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Jeffery, C.J. (2011). Engineering periplasmic ligand binding proteins as glucose nanosensors. Nano Rev., 2.","DOI":"10.3402\/nano.v2i0.5743"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"78661","DOI":"10.1039\/C6RA17375F","article-title":"Genetically encoded FRET sensors using a fluorescent unnatural amino acid as a FRET donor","volume":"6","author":"Ko","year":"2016","journal-title":"RSC Adv."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"8761","DOI":"10.1039\/C7OB02165H","article-title":"Engineering a periplasmic binding protein for amino acid sensors with improved binding properties","volume":"15","author":"Ko","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"ref_176","first-page":"1","article-title":"The complete European guidelines on phenylketonuria: Diagnosis and treatment","volume":"12","author":"Macdonald","year":"2017","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_177","first-page":"1","article-title":"Biotechnological applications of mammalian odorant-binding proteins","volume":"2021","author":"Ribeiro","year":"2021","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s00216-012-6499-0","article-title":"An innovative bovine odorant binding protein-based filtering cartridge for the removal of triazine herbicides from water","volume":"405","author":"Bianchi","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_179","first-page":"3629","article-title":"Odorant binding proteins: A biotechnological tool for odour control","volume":"98","author":"Azoia","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/4\/509\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:10:27Z","timestamp":1760364627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/4\/509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,30]]},"references-count":179,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["biom11040509"],"URL":"https:\/\/doi.org\/10.3390\/biom11040509","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,30]]}}}