{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T01:58:39Z","timestamp":1769306319550,"version":"3.49.0"},"reference-count":15,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The EndoBarrier\u2122 medical device is a duodenal-jejunal bypass liner designed to mimic the effects of gastric bypass surgery to induce weight loss and glycaemic improvement. In this study, 10 participants with type 2 diabetes mellitus (T2DM), a mean body mass index (BMI) of 43.3 \u00b1 5.0 (kg\/m2) and a mean glycated haemoglobin A1c (HbA1c) of 60.6 \u00b1 8.6 mmol\/mol were examined at baseline (before implantation of EndoBarrier\u2122), 4 weeks after implantation, at 36 weeks (right before explantation) and 24 weeks after the removal of the device to explore the short and long-term effects on glucose metabolism. Besides a significant reduction in body weight and fat mass, EndoBarrier\u2122 treatment significantly improved insulin sensitivity during Botnia clamp investigations after four weeks of implantation. The beneficial effects decreased over time but remained significant 24 weeks after removal of the device.<\/jats:p>","DOI":"10.3390\/biom11040574","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T15:30:39Z","timestamp":1618414239000},"page":"574","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["EndoBarrier\u2122 Implantation Rapidly Improves Insulin Sensitivity in Obese Individuals with Type 2 Diabetes Mellitus"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7663-0426","authenticated-orcid":false,"given":"Anna","family":"Obermayer","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert J.","family":"Tripolt","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and 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Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6704-0723","authenticated-orcid":false,"given":"Nandu","family":"Goswami","sequence":"additional","affiliation":[{"name":"Otto Loewi Research Centre, Physiology Division, Medical University of Graz, 8010 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Kojzar","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter N.","family":"Pferschy","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, Austria"},{"name":"CBmed\u2014Center for Biomarker Research in Medicine, 8010 Graz, 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