{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:55:08Z","timestamp":1760234108726,"version":"build-2065373602"},"reference-count":194,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIDDK R01DK110292 and DK079626; NIH\/NIAID 1 R21 AI 146743"],"award-info":[{"award-number":["NIDDK R01DK110292 and DK079626; NIH\/NIAID 1 R21 AI 146743"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The Ca2+-independent phospholipase A2\u03b2 (iPLA2\u03b2) is a member of the PLA2 family that has been proposed to have roles in multiple biological processes including membrane remodeling, cell proliferation, bone formation, male fertility, cell death, and signaling. Such involvement has led to the identification of iPLA2\u03b2 activation in several diseases such as cancer, cardiovascular abnormalities, glaucoma, periodontitis, neurological disorders, diabetes, and other metabolic disorders. More recently, there has been heightened interest in the role that iPLA2\u03b2 plays in promoting inflammation. Recognizing the potential contribution of iPLA2\u03b2 in the development of autoimmune diseases, we review this issue in the context of an iPLA2\u03b2 link with macrophages and T-cells.<\/jats:p>","DOI":"10.3390\/biom11040577","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T12:11:00Z","timestamp":1618488660000},"page":"577","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of the Ca2+-Independent Phospholipase A2\u03b2 (iPLA2\u03b2) on Immune Cells"],"prefix":"10.3390","volume":"11","author":[{"given":"Tayleur D.","family":"White","sequence":"first","affiliation":[{"name":"Department of Cell, Developmental and Integrative Biology, Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulaziz","family":"Almutairi","sequence":"additional","affiliation":[{"name":"Department of Cell, Developmental and Integrative Biology, Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying Gai","family":"Tusing","sequence":"additional","affiliation":[{"name":"Department of Cell, Developmental and Integrative Biology, Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyong","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Cell, Developmental and Integrative Biology, Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1664-0657","authenticated-orcid":false,"given":"Sasanka","family":"Ramanadham","sequence":"additional","affiliation":[{"name":"Department of Cell, Developmental and Integrative Biology, Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1006\/scdb.1997.0151","article-title":"Phospholipases A2","volume":"8","author":"Gijon","year":"1997","journal-title":"Semin. 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