{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:18:24Z","timestamp":1790360304621,"version":"4.1.0"},"reference-count":142,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondazione Cariplo","award":["2018-0298"],"award-info":[{"award-number":["2018-0298"]}]},{"name":"AIRC Foundation","award":["22905"],"award-info":[{"award-number":["22905"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The vascular endothelium acts as a selective barrier to regulate macromolecule exchange between the blood and tissues. However, the integrity of the endothelium barrier is compromised in an array of pathological settings, including ischemic disease and cancer, which are the leading causes of death worldwide. The resulting vascular hyperpermeability to plasma molecules as well as leukocytes then leads to tissue damaging edema formation and inflammation. The vascular endothelial growth factor A (VEGFA) is a potent permeability factor, and therefore a desirable target for impeding vascular hyperpermeability. However, VEGFA also promotes angiogenesis, the growth of new blood vessels, which is required for reperfusion of ischemic tissues. Moreover, edema increases interstitial pressure in poorly perfused tumors, thereby affecting the delivery of therapeutics, which could be counteracted by stimulating the growth of new functional blood vessels. Thus, targets must be identified to accurately modulate the barrier function of blood vessels without affecting angiogenesis, as well as to develop more effective pro- or anti-angiogenic therapies. Recent studies have shown that the VEGFA co-receptor neuropilin 1 (NRP1) could be playing a fundamental role in steering VEGFA-induced responses of vascular endothelial cells towards angiogenesis or vascular permeability. Moreover, NRP1 is involved in mediating permeability signals induced by ligands other than VEGFA. This review therefore focuses on current knowledge on the role of NRP1 in the regulation of vascular permeability signaling in the endothelium to provide an up-to-date landscape of the current knowledge in this field.<\/jats:p>","DOI":"10.3390\/biom11050666","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T05:10:55Z","timestamp":1619759455000},"page":"666","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Neuropilin 1 Regulation of Vascular Permeability Signaling"],"prefix":"10.3390","volume":"11","author":[{"given":"Alison","family":"Domingues","sequence":"first","affiliation":[{"name":"Department of Biosciences, University of Milan, Via G. Celoria 26, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5517-6068","authenticated-orcid":false,"given":"Alessandro","family":"Fantin","sequence":"additional","affiliation":[{"name":"Department of Biosciences, University of Milan, Via G. Celoria 26, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-3-642-37078-6_252","article-title":"Integrated Vascular Anatomy","volume":"Volume 67","author":"Wilting","year":"2015","journal-title":"PanVascular Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0046-8177(87)80005-9","article-title":"Cell biology of endothelial cells","volume":"18","author":"Jaffe","year":"1987","journal-title":"Hum. Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1096\/fasebj.9.10.7615161","article-title":"Differentiation of endothelium","volume":"9","author":"Risau","year":"1995","journal-title":"FASEB J."},{"key":"ref_4","first-page":"671","article-title":"Mechanisms of angiogenesis","volume":"386","author":"Risau","year":"1997","journal-title":"Nat. Cell Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bcmd.2013.09.005","article-title":"A short history of hemogenic endothelium","volume":"51","author":"Swiers","year":"2013","journal-title":"Blood Cells Mol. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Canu, G., and Ruhrberg, C. (2021). First blood: The endothelial origins of hematopoietic progenitors. Angiogenesis, 1\u201313.","DOI":"10.1007\/s10456-021-09783-9"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.immuni.2014.10.008","article-title":"Leukocyte Migration into Inflamed Tissues","volume":"41","author":"Nourshargh","year":"2014","journal-title":"Immunity"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.molmed.2020.11.006","article-title":"Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies","volume":"27","author":"Dejana","year":"2021","journal-title":"Trends Mol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1165\/ajrcmb.22.6.3779","article-title":"Lung Overexpression of the Vascular Endothelial Growth Factor Gene Induces Pulmonary Edema","volume":"22","author":"Kaner","year":"2000","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"L460","DOI":"10.1152\/ajplung.2000.279.3.L460","article-title":"VEGF, fetal liver kinase-1, and permeability increase during unilateral lung ischemia","volume":"279","author":"Kazi","year":"2000","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1096\/fj.05-4829fje","article-title":"The phosphatidylinositol-3 kinase\/Akt pathway mediates VEGF\u2019s neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia","volume":"20","author":"Kilic","year":"2006","journal-title":"FASEB J."},{"key":"ref_12","first-page":"497","article-title":"Pathophysiological consequences of VEGF-induced vascular permeability","volume":"437","author":"Weis","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"ref_13","first-page":"445","article-title":"Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases","volume":"16","author":"Xu","year":"2000","journal-title":"Int. J. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1172\/JCI11317","article-title":"Control of hair growth and follicle size by VEGF-mediated angiogenesis","volume":"107","author":"Yano","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1023\/A:1006453428508","article-title":"Expression of vascular permeability factor in glioblastoma specimens: Correlation with tumor vascular endothelial surface and peritumoral edema","volume":"49","author":"Vaquero","year":"2000","journal-title":"J. Neuro-Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/07853890.2010.532150","article-title":"Vascular endothelial growth factors in retinal and choroidal neovascular diseases","volume":"44","author":"Kinnunen","year":"2011","journal-title":"Ann. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/86490","article-title":"Vascular endothelial growth factor enhances atherosclerotic plaque progression","volume":"7","author":"Celletti","year":"2001","journal-title":"Nat. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3389\/fphys.2020.00763","article-title":"Suppressed Vascular Leakage and Myocardial Edema Improve Outcome from Myocardial Infarction","volume":"11","author":"Li","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/cvr\/cvq105","article-title":"Vascular endothelial growth factors and vascular permeability","volume":"87","author":"Bates","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/03009734.2015.1064501","article-title":"Vascular permeability\u2014The essentials","volume":"120","year":"2015","journal-title":"Upsala J. Med Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1096\/fasebj.9.10.7615160","article-title":"Endothelial cell-to-cell junctions","volume":"9","author":"Dejana","year":"1995","journal-title":"FASEB J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.febslet.2008.11.032","article-title":"Breaking the VE-cadherin bonds","volume":"583","author":"Gavard","year":"2009","journal-title":"FEBS Lett."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/MOH.0000000000000137","article-title":"New insights in the control of vascular permeability: Vascular endothelial-cadherin and other players","volume":"22","author":"Trani","year":"2015","journal-title":"Curr. Opin. Hematol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"23463","DOI":"10.1074\/jbc.274.33.23463","article-title":"Vascular Endothelial Growth Factor Induces Rapid Phosphorylation of Tight Junction Proteins Occludin and Zonula Occluden 1: A potential mechanism for vascular permeability in diabetic retinopathy and tumors","volume":"274","author":"Antonetti","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"15099","DOI":"10.1074\/jbc.273.24.15099","article-title":"Vascular permeability factor\/vascular endothelial cell growth fac-tor-mediated permeability occurs through disorganization of endothelial junctional proteins","volume":"273","author":"Kevil","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1083\/jcb.140.4.947","article-title":"Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro","volume":"140","author":"Esser","year":"1998","journal-title":"J. Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/ncomms2199","article-title":"Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo","volume":"3","author":"Orsenigo","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/ncb1486","article-title":"VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin","volume":"8","author":"Gavard","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/002215540104900401","article-title":"The Vesiculo\u2013Vacuolar Organelle (VVO): A New Endothelial Cell Permeability Organelle","volume":"49","author":"Dvorak","year":"2001","journal-title":"J. Histochem. Cytochem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.2353\/ajpath.2009.090171","article-title":"Vascular Permeability and Pathological Angiogenesis in Caveolin-1-Null Mice","volume":"175","author":"Chang","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.devcel.2012.11.003","article-title":"The Diaphragms of Fenestrated Endothelia: Gatekeepers of Vascular Permeability and Blood Composition","volume":"23","author":"Stan","year":"2012","journal-title":"Dev. Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-1-4615-0119-0_5","article-title":"Structural and Functional Relation of Neuropilins","volume":"515","author":"Nakamural","year":"2002","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/dvdy.20048","article-title":"Zebrafish neuropilins are differentially expressed and interact with vascular endothelial growth factor during embryonic vascular development","volume":"231","author":"Martyn","year":"2004","journal-title":"Dev. Dyn."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"921","DOI":"10.18632\/oncotarget.626","article-title":"Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity","volume":"3","author":"Glinka","year":"2012","journal-title":"Oncotarget"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/BJ20071639","article-title":"Neuropilins: Structure, function and role in disease","volume":"411","author":"Frankel","year":"2008","journal-title":"Biochem. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.semcdb.2013.01.001","article-title":"Neuropilin signalling in vessels, neurons and tumours","volume":"24","author":"Raimondi","year":"2013","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.preteyeres.2016.02.003","article-title":"NRP1 function and targeting in neurovascular development and eye disease","volume":"52","author":"Raimondi","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1242\/dev.002402","article-title":"Selective requirements for NRP1 ligands during neurovascular patterning","volume":"134","author":"Vieira","year":"2007","journal-title":"Development"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1534-5807(03)00169-2","article-title":"Neuropilin-1 Conveys Semaphorin and VEGF Signaling during Neural and Cardiovascular Development","volume":"5","author":"Gu","year":"2003","journal-title":"Dev. Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"24818","DOI":"10.1074\/jbc.M200730200","article-title":"Neuropilin-1 Binds Vascular Endothelial Growth Factor 165, Placenta Growth Factor-2, and Heparin via Its b1b2 Domain","volume":"277","author":"Mamluk","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"18069","DOI":"10.1074\/jbc.M201681200","article-title":"Characterization of Neuropilin-1 Structural Features That Confer Binding to Semaphorin 3A and Vascular Endothelial Growth Factor 165","volume":"277","author":"Gu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/geno.2000.6381","article-title":"Genomic Organization of Human Neuropilin-1 and Neuropilin-2 Genes: Identification and Distribution of Splice Variants and Soluble Isoforms","volume":"70","author":"Rossignola","year":"2000","journal-title":"Genom."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1091\/mbc.e09-12-1061","article-title":"VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation","volume":"22","author":"Herzog","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1182\/blood-2012-05-424713","article-title":"NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis","volume":"121","author":"Fantin","year":"2013","journal-title":"Blood"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1084\/jem.20160311","article-title":"VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation","volume":"214","author":"Fantin","year":"2017","journal-title":"J. Exp. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1172\/JCI0215467","article-title":"Semaphorins as signals for cell repulsion and invasion","volume":"109","author":"Goshima","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1172\/JCI120879","article-title":"Angiopoietin-like 4 binds neuropilins and cooperates with VEGF to induce diabetic macular edema","volume":"129","author":"Sodhi","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"ra42","DOI":"10.1126\/scisignal.aad3812","article-title":"Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation","volume":"9","author":"Roth","year":"2016","journal-title":"Sci. Signal."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1096\/fj.05-5504fje","article-title":"C terminus of RGS-GAIP-interacting protein conveys neuropilin-1-mediated signaling during angiogenesis","volume":"20","author":"Wang","year":"2006","journal-title":"FASEB J."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Valdembri, D., Caswell, P.T., I Anderson, K., Schwarz, J.P., K\u00f6nig, I., Astanina, E., Caccavari, F., Norman, J.C., Humphries, M.J., and Bussolino, F. (2009). Neuropilin-1\/GIPC1 Signaling Regulates \u03b15\u03b21 Integrin Traffic and Function in Endothelial Cells. PLoS Biol., 7.","DOI":"10.1371\/journal.pbio.1000025"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"25110","DOI":"10.1074\/jbc.C800137200","article-title":"Neuropilin-1-VEGFR-2 Complexing Requires the PDZ-binding Domain of Neuropilin-1","volume":"283","author":"Prahst","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1182\/blood-2011-01-328773","article-title":"Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output","volume":"118","author":"Andersson","year":"2011","journal-title":"Blood"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.devcel.2013.03.019","article-title":"The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis","volume":"25","author":"Lanahan","year":"2013","journal-title":"Dev. Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1093>3.0.CO;2-D","article-title":"Differential expression of VEGF isoforms in mouse during development and in the adult","volume":"220","author":"Ng","year":"2001","journal-title":"Dev. Dyn."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1172\/jci.insight.130979","article-title":"VEGF188 promotes corneal reinnervation after injury","volume":"4","author":"Brash","year":"2019","journal-title":"JCI Insight"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1091\/mbc.4.12.1317","article-title":"The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF","volume":"4","author":"Park","year":"1993","journal-title":"Mol. Biol. Cell"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1101\/gad.242002","article-title":"Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis","volume":"16","author":"Ruhrberg","year":"2002","journal-title":"Genes Dev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"11082","DOI":"10.1074\/jbc.M111.331140","article-title":"Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1","volume":"287","author":"Parker","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"13493","DOI":"10.1074\/jbc.M512121200","article-title":"Characterization of a Bicyclic Peptide Neuropilin-1 (NP-1) Antagonist (EG3287) Reveals Importance of Vascular Endothelial Growth Factor Exon 8 for NP-1 Binding and Role of NP-1 in KDR Signaling","volume":"281","author":"Jia","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"24049","DOI":"10.1074\/jbc.M703554200","article-title":"Neuropilin-1 Binds to VEGF121 and Regulates Endothelial Cell Migration and Sprouting","volume":"282","author":"Pan","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1074\/jbc.271.10.5519","article-title":"Selective Binding of VEGF121 to One of the Three Vascular Endothelial Growth Factor Receptors of Vascular Endothelial Cells","volume":"271","author":"Cohen","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1006\/dbio.1995.1208","article-title":"Expression of a Cell Adhesion Molecule, Neuropilin, in the Developing Chick Nervous System","volume":"170","author":"Takagi","year":"1995","journal-title":"Dev. Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0092-8674(00)80535-8","article-title":"Neuropilin Is a Semaphorin III Receptor","volume":"90","author":"Kolodkin","year":"1997","journal-title":"Cell"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0092-8674(00)80534-6","article-title":"Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III","volume":"90","author":"He","year":"1997","journal-title":"Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/hmg\/ddq468","article-title":"Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: Implications for the aetiology of hypogonadotropic hypogonadism","volume":"20","author":"Cariboni","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4161\/cam.4.1.10207","article-title":"Neuropilin, you gotta let me know","volume":"4","author":"Schwarz","year":"2010","journal-title":"Cell Adhes. Migr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1042\/BST0371228","article-title":"Neuropilin ligands in vascular and neuronal patterning","volume":"37","author":"Fantin","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1242\/dev.014902","article-title":"Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos","volume":"135","author":"Jones","year":"2008","journal-title":"Development"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/dvdy.20148","article-title":"Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system","volume":"231","author":"Gerhardt","year":"2004","journal-title":"Dev. Dyn."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1242\/dev.126.21.4895","article-title":"A requirement for neuropilin-1 in embryonic vessel formation","volume":"126","author":"Kawasaki","year":"1999","journal-title":"Development"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1242\/dev.103028","article-title":"Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis","volume":"141","author":"Fantin","year":"2014","journal-title":"Development (Cambridge)"},{"key":"ref_72","first-page":"e03720","article-title":"Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding","volume":"3","author":"Gelfand","year":"2014","journal-title":"Abstract"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1084\/jem.20132330","article-title":"Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1\u2013dependent ABL1 activation in endothelial cells","volume":"211","author":"Raimondi","year":"2014","journal-title":"J. Exp. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.1038\/ncomms8264","article-title":"Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch","volume":"6","author":"Aspalter","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1172\/JCI79668","article-title":"Neural crest\u2013derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation","volume":"125","author":"Plein","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1126\/science.6823562","article-title":"Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid","volume":"219","author":"Senger","year":"1983","journal-title":"Science"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1167\/iovs.03-0106","article-title":"VEGF164(165)as the Pathological Isoform: Differential Leukocyte and Endothelial Responses through VEGFR1 and VEGFR2","volume":"45","author":"Usui","year":"2004","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"6023","DOI":"10.1073\/pnas.082110999","article-title":"A dynamic shift of VEGF isoforms with a transient and selective progesterone-induced expression of VEGF189 regulates angiogenesis and vascular permeability in human uterus","volume":"99","author":"Ancelin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0304-4165(94)00150-V","article-title":"The shortest isoform of human vascular endothelial growth factor\/vascular permeability factor (VEGF\/VPF121) produced by Saccharomyces cerevisiae promotes both angiogenesis and vascular permeability","volume":"1243","author":"Kondo","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1074\/jbc.M110.177006","article-title":"Heparan Sulfate Regulates VEGF165- and VEGF121-mediated Vascular Hyperpermeability","volume":"286","author":"Xu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/01.CIR.97.1.99","article-title":"Vascular endothelial growth factor\/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin","volume":"97","author":"Murohara","year":"1998","journal-title":"Circulation"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1172\/JCI200420702","article-title":"Src blockade stabilizes a Flk\/cadherin complex, reducing edema and tissue injury following myocardial infarction","volume":"113","author":"Weis","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1084\/jem.20111343","article-title":"VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd","volume":"209","author":"Sun","year":"2012","journal-title":"J. Exp. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.devcel.2014.06.027","article-title":"Differential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriers","volume":"30","author":"Hudson","year":"2014","journal-title":"Dev. Cell"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"11017","DOI":"10.1038\/ncomms11017","article-title":"VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread","volume":"7","author":"Li","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Brash, J.T., Ruhrberg, C., and Fantin, A. (2018). Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay. J. Vis. Exp., e57524.","DOI":"10.3791\/57524-v"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1161\/CIRCULATIONAHA.112.091603","article-title":"Elevated Vascular Endothelial Growth Factor Receptor-2 Abundance Contributes to Increased Angiogenesis in Vascular Endothelial Growth Factor Receptor-1\u2013Deficient Mice","volume":"126","author":"Ho","year":"2012","journal-title":"Circulation"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.mod.2015.07.001","article-title":"Vascularisation of the central nervous system","volume":"138","author":"Tata","year":"2015","journal-title":"Mech. Dev."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1161\/ATVBAHA.107.150433","article-title":"VEGFR1 Tyrosine Kinase Signaling Promotes Lymphangiogenesis as Well as Angiogenesis Indirectly via Macrophage Recruitment","volume":"28","author":"Murakami","year":"2008","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S1097-2765(00)80221-X","article-title":"Selective Requirement for Src Kinases during VEGF-Induced Angiogenesis and Vascular Permeability","volume":"4","author":"Eliceiri","year":"1999","journal-title":"Mol. Cell"},{"key":"ref_91","first-page":"2337","article-title":"Retinal vascular permeability suppression by topical application of a novel VEGFR2\/Src kinase inhibitor in mice and rabbits","volume":"118","author":"Scheppke","year":"2008","journal-title":"J. Clin. Investig."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"dev185405","DOI":"10.1242\/dev.185405","article-title":"c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly","volume":"147","author":"Schimmel","year":"2020","journal-title":"Development"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.1182\/blood-2013-03-491423","article-title":"A critical role for Lyn kinase in strengthening endothelial integrity and barrier function","volume":"122","author":"Han","year":"2013","journal-title":"Blood"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10456-012-9252-6","article-title":"c-ABL modulates MAP kinases activation downstream of VEGFR-2 signaling by direct phosphorylation of the adaptor proteins GRB2 and NCK1","volume":"15","author":"Anselmi","year":"2012","journal-title":"Angiogenesis"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1161\/CIRCULATIONAHA.112.134304","article-title":"Effective Treatment of Edema and Endothelial Barrier Dysfunction with Imatinib","volume":"126","author":"Aman","year":"2012","journal-title":"Circulation"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Chislock, E.M., and Pendergast, A.M. (2013). Abl Family Kinases Regulate Endothelial Barrier Function In Vitro and in Mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0085231"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.molcel.2010.07.013","article-title":"S-Nitrosylation of \u03b2-Catenin by eNOS-Derived NO Promotes VEGF-Induced Endothelial Cell Permeability","volume":"39","author":"Thibeault","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1073\/pnas.041359198","article-title":"Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability","volume":"98","author":"Fukumura","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1182\/blood-2007-08-110205","article-title":"Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor","volume":"111","author":"Acevedo","year":"2008","journal-title":"Blood"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Wang, J., Wang, S., Li, M., Wu, D., Liu, F., Yang, R., Ji, S., Ji, A., and Li, Y. (2015). The Neuropilin-1 Inhibitor, ATWLPPR Peptide, Prevents Experimental Diabetes-Induced Retinal Injury by Preserving Vascular Integrity and Decreasing Oxidative Stress. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0142571"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"16157","DOI":"10.1073\/pnas.0908201106","article-title":"C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration","volume":"106","author":"Teesalu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1161\/01.RES.0000171756.13554.49","article-title":"Neuropilin-1 Regulates Vascular Endothelial Growth Factor\u2013Mediated Endothelial Permeability","volume":"96","author":"Becker","year":"2005","journal-title":"Circ. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ccr.2006.10.018","article-title":"Blocking Neuropilin-1 Function Has an Additive Effect with Anti-VEGF to Inhibit Tumor Growth","volume":"11","author":"Pan","year":"2007","journal-title":"Cancer Cell"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.cmet.2013.09.003","article-title":"Neuron-Derived Semaphorin 3A Is an Early Inducer of Vascular Permeability in Diabetic Retinopathy via Neuropilin-1","volume":"18","author":"Cerani","year":"2013","journal-title":"Cell Metab."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1242\/dev.070037","article-title":"The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins","volume":"138","author":"Fantin","year":"2011","journal-title":"Development (Cambridge)"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/ng1383","article-title":"Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma\u2013associated herpesvirus","volume":"36","author":"Hong","year":"2004","journal-title":"Nat. Genet."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1549-8719.2010.00071.x","article-title":"MEK5 is Activated by Shear Stress, Activates ERK5 and Induces KLF4 to Modulate TNF Responses in Human Dermal Microvascular Endothelial Cells","volume":"18","author":"Clark","year":"2010","journal-title":"Microcirculation"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1161\/ATVBAHA.112.300893","article-title":"Claudin-5 Controls Intercellular Barriers of Human Dermal Microvascular but Not Human Umbilical Vein Endothelial Cells","volume":"33","author":"Kluger","year":"2013","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1016\/j.jmb.2013.07.017","article-title":"Effect of C-Terminal Sequence on Competitive Semaphorin Binding to Neuropilin-1","volume":"425","author":"Parker","year":"2013","journal-title":"J. Mol. Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms5904","article-title":"An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability","volume":"5","author":"Pang","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fncel.2019.00117","article-title":"Semaphorin 3A Contributes to Secondary Blood\u2013Brain Barrier Damage After Traumatic Brain Injury","volume":"13","author":"Yang","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1038\/sj.emboj.7601906","article-title":"Structural studies of neuropilin\/antibody complexes provide insights into semaphorin and VEGF binding","volume":"26","author":"Wu","year":"2007","journal-title":"EMBO J."},{"key":"ref_113","first-page":"4137","article-title":"Semaphorin 3A elevates endothelial cell permeability through PP2A inactivation","volume":"125","author":"Dwyer","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"7890","DOI":"10.1038\/srep07890","article-title":"Semaphorin3A elevates vascular permeability and contributes to cerebral ischemia-induced brain damage","volume":"5","author":"Hou","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1016\/j.ajpath.2016.07.022","article-title":"Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency","volume":"186","author":"Mucka","year":"2016","journal-title":"Am. J. Pathol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"E3425","DOI":"10.1073\/pnas.1217091110","article-title":"Hypoxic retinal M\u00fcller cells promote vascular permeability by HIF-1\u2013dependent up-regulation of angiopoietin-like 4","volume":"110","author":"Xin","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1182\/blood-2011-01-328716","article-title":"ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters","volume":"118","author":"Huang","year":"2011","journal-title":"Blood"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cell.2008.01.046","article-title":"TGF\u03b2 Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4","volume":"133","author":"Padua","year":"2008","journal-title":"Cell"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"14363","DOI":"10.1073\/pnas.1001065107","article-title":"Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi\u2019s sarcoma","volume":"107","author":"Ma","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/BSR20110102","article-title":"Angiopoietin-like 4: A decade of research","volume":"32","author":"Zhu","year":"2011","journal-title":"Biosci. Rep."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"26523","DOI":"10.1074\/jbc.274.37.26523","article-title":"Molecular Cloning, Expression, and Characterization of Angiopoietin-related Protein","volume":"274","author":"Kim","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"945","DOI":"10.7326\/0003-4819-140-11-200406010-00035","article-title":"The Evolving Diabetes Burden in the United States","volume":"140","author":"Engelgau","year":"2004","journal-title":"Ann. Intern. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.preteyeres.2015.06.002","article-title":"Molecular pathogenesis of retinal and choroidal vascular diseases","volume":"49","author":"Campochiaro","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1172\/JCI65157","article-title":"Targeted deletion of Vegfa in adult mice induces vision loss","volume":"122","author":"Kurihara","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/sj.gt.3302769","article-title":"EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV","volume":"13","author":"Balaggan","year":"2006","journal-title":"Gene Ther."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"18751","DOI":"10.1073\/pnas.0905010106","article-title":"An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris","volume":"106","author":"Kurihara","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1038\/onc.2015.317","article-title":"Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in glioblastoma","volume":"35","author":"Treps","year":"2016","journal-title":"Oncogene"},{"key":"ref_128","first-page":"3356","article-title":"Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models","volume":"119","author":"Maione","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/joim.12017","article-title":"Class 3 semaphorins: Physiological vascular normalizing agents for anti-cancer therapy","volume":"273","author":"Serini","year":"2013","journal-title":"J. Intern. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"eaah4807","DOI":"10.1126\/scitranslmed.aah4807","article-title":"A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent","volume":"10","author":"Gioelli","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jconrel.2015.08.016","article-title":"Immunoglobulin Fc-fused, neuropilin-1-specific peptide shows efficient tumor tissue penetration and inhibits tumor growth via anti-angiogenesis","volume":"216","author":"Kim","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jconrel.2015.01.011","article-title":"Cell penetrating peptides improve tumor delivery of cargos through neuropilin-1-dependent extravasation","volume":"201","author":"Kadonosono","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1126\/science.1183057","article-title":"Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs","volume":"328","author":"Sugahara","year":"2010","journal-title":"Science"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.ccr.2009.10.013","article-title":"Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors","volume":"16","author":"Sugahara","year":"2009","journal-title":"Cancer Cell"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Xiang, Z., Jiang, G., Yang, X., Fan, D., Nan, X., Li, D., Hu, Z., and Fang, Q. (2019). Peptosome Coadministration Improves Nanoparticle Delivery to Tumors through NRP1-Mediated Co-Endocytosis. Biomolecules, 9.","DOI":"10.3390\/biom9050172"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"8739","DOI":"10.2147\/IJN.S261352","article-title":"Multiscale Selectivity and in vivo Biodistribution of NRP-1-Targeted Theranostic AGuIX Nanoparticles for PDT of Glioblastoma","volume":"15","author":"Gries","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.apsb.2018.06.006","article-title":"Efficacy of inverso isomer of CendR peptide on tumor tissue penetration","volume":"8","author":"Wang","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1021\/acs.molpharmaceut.8b00854","article-title":"Targeted Modification of the Cationic Anticancer Peptide HPRP-A1 with iRGD To Improve Specificity, Penetration, and Tumor-Tissue Accumulation","volume":"16","author":"Hu","year":"2018","journal-title":"Mol. Pharm."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"8875","DOI":"10.2147\/IJN.S270208","article-title":"A Dual Receptor Targeting- and BBB Penetrating- Peptide Functionalized Polyethyleneimine Nanocomplex for Secretory Endostatin Gene Delivery to Malignant Glioma","volume":"15","author":"Lu","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.bbrc.2019.03.190","article-title":"Enhanced tumor uptake and activity of nanoplex-loaded doxorubicin","volume":"513","author":"Zhao","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1126\/science.abd2985","article-title":"Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity","volume":"370","author":"Ojha","year":"2020","journal-title":"Science"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Mayi, B.S., Leibowitz, J.A., Woods, A.T., Ammon, K.A., Liu, A.E., and Raja, A. (2021). The role of Neuropilin-1 in COVID-19. 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