{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:34:43Z","timestamp":1790739283496,"version":"4.1.0"},"reference-count":146,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T00:00:00Z","timestamp":1619913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The extracellular matrix (ECM) plays an important role in the evolution of early metazoans, as it provides structural and biochemical support to the surrounding cells through the cell\u2013cell and cell\u2013matrix interactions. In multi-cellular organisms, ECM plays a pivotal role in the differentiation of tissues and in the development of organs. Fibulins are ECM glycoproteins, found in a variety of tissues associated with basement membranes, elastic fibers, proteoglycan aggregates, and fibronectin microfibrils. The expression profile of fibulins reveals their role in various developmental processes such as elastogenesis, development of organs during the embryonic stage, tissue remodeling, maintenance of the structural integrity of basement membrane, and elastic fibers, as well as other cellular processes. Apart from this, fibulins are also involved in the progression of human diseases such as cancer, cardiac diseases, congenital disorders, and chronic fibrotic disorders. Different isoforms of fibulins show a dual role of tumor-suppressive and tumor-promoting activities, depending on the cell type and cellular microenvironment in the body. Knockout animal models have provided deep insight into their role in development and diseases. The present review covers details of the structural and expression patterns, along with the role of fibulins in embryonic development and disease progression, with more emphasis on their involvement in the modulation of cancer diseases.<\/jats:p>","DOI":"10.3390\/biom11050685","type":"journal-article","created":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T08:05:21Z","timestamp":1619942721000},"page":"685","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Role of Fibulins in Embryonic Stage Development and Their Involvement in Various Diseases"],"prefix":"10.3390","volume":"11","author":[{"given":"Deviyani","family":"Mahajan","sequence":"first","affiliation":[{"name":"Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab 144411, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhakar","family":"Kancharla","sequence":"additional","affiliation":[{"name":"Devansh Lab Werks, 234 Aquarius Drive, Homewood, AL 35209, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachetha","family":"Kolli","sequence":"additional","affiliation":[{"name":"Microgen Health Inc., 14225 Sullyfield Cir Suite E, Chantilly, VA 20151, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarish Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab 144411, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab 144411, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudarshan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Animal Biotechnology Centre, National Dairy Research Institute, Karnal, Haryana 132001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Animal Biotechnology Centre, National Dairy Research Institute, Karnal, Haryana 132001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-8539","authenticated-orcid":false,"given":"Manoj Kumar","family":"Jena","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab 144411, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,2]]},"reference":[{"key":"ref_1","unstructured":"Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raff, M., Roberts, K., and Walter, P. (2015). The Extracellular Matrix of Animals. Molecular Biol. of the Cell, Garland Science. [6th ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0945-053X(99)00038-4","article-title":"Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4","volume":"18","author":"Giltay","year":"1999","journal-title":"Matrix Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1007\/s00018-009-8632-6","article-title":"Fibulins: Multiple roles in matrix structures and tissue functions","volume":"66","author":"Iwamoto","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1093\/emboj\/16.11.3035","article-title":"Dimer model for the microfibrillar protein fibulin-2 and identification of the connecting disulfide bridge","volume":"16","author":"Sasaki","year":"1997","journal-title":"EMBO J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0945-053X(98)90114-7","article-title":"Identification of chicken and C. elegans fibulin-1 homologs and characterization of the C. elegans fibulin-1 gene","volume":"17","author":"Barth","year":"1998","journal-title":"Matrix Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1083\/jcb.111.6.3155","article-title":"Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure","volume":"111","author":"Argraves","year":"1990","journal-title":"J. Cell Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"11805","DOI":"10.1074\/jbc.M611029200","article-title":"A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization","volume":"282","author":"Kobayashi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1128\/MCB.15.1.120","article-title":"An overexpressed gene transcript in senescent and quiescent human fibroblasts encoding a novel protein in the epidermal growth factor-like repeat family stimulates DNA synthesis","volume":"15","author":"Lumpkin","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s12079-009-0065-3","article-title":"Fibulin-5, an integrin-binding matricellular protein: Its function in development and disease","volume":"3","author":"Yanagisawa","year":"2009","journal-title":"J. Cell Commun. Signal."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"30878","DOI":"10.1074\/jbc.M705847200","article-title":"TM14 is a new member of the fibulin family (fibulin-7) that interacts with extracellular matrix molecules and is active for cell binding","volume":"282","author":"Iwamoto","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1242\/dev.128.6.883","article-title":"Hemicentin, a conserved extracellular member of the immunoglobulin superfamily, organizes epithelial and other cell attachments into oriented line-shaped junctions","volume":"128","author":"Vogel","year":"2001","journal-title":"Development"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"23606","DOI":"10.1074\/jbc.M513589200","article-title":"Hemicentin assembly in the extracellular matrix is mediated by distinct structural modules","volume":"281","author":"Dong","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/2045-3701-3-27","article-title":"Specific structure and unique function define the hemicentin","volume":"3","author":"Xu","year":"2013","journal-title":"Cell Biosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/CS20120636","article-title":"Fibulin-2 deficiency attenuates angiotensin II-induced cardiac hypertrophy by reducing transforming growth factor-\u03b2 signalling","volume":"126","author":"Zhang","year":"2014","journal-title":"Clin. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"27367","DOI":"10.1074\/jbc.M200148200","article-title":"Context-specific effects of fibulin-5 (DANCE\/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades","volume":"277","author":"Schiemann","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"C1412","DOI":"10.1152\/ajpcell.00087.2006","article-title":"Fibulin-5 gene expression in human lung fibroblasts is regulated by TGF-beta and phosphatidylinositol 3-kinase activity","volume":"291","author":"Kuang","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"22244","DOI":"10.1074\/jbc.M116.730945","article-title":"Hypoxia and Transforming Growth Factor \u03b2 Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer","volume":"291","author":"Topalovski","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1210\/en.2004-1239","article-title":"Transcriptional and Posttranscriptional Regulation of Fibulin-1 by Estrogens Leads to Differential Induction of Messenger Ribonucleic Acid Variants in Ovarian and Breast Cancer Cells","volume":"146","author":"Bardin","year":"2005","journal-title":"Endocrinology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1038\/jid.2014.166","article-title":"Regulation of fibulin-2 gene expression by integrin \u03b13\u03b21 contributes to the invasive phenotype of transformed keratinocytes","volume":"134","author":"Missan","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0092-8674(89)90097-4","article-title":"Fibulin, a novel protein that interacts with the fibronectin receptor beta subunit cytoplasmic domain","volume":"58","author":"Argraves","year":"1989","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1432-1033.1990.tb19383.x","article-title":"Characterization of a novel calcium-binding 90-kDa glycoprotein (BM-90) shared by basement membranes and serum","volume":"193","author":"Kluge","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/43.4.7534784","article-title":"The association of human fibulin-1 with elastic fibers: An immunohistological, ultrastructural, and RNA study","volume":"43","author":"Roark","year":"1995","journal-title":"J. Histochem. Cytochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0945-053X(03)00014-3","article-title":"Codistribution analysis of elastin and related fibrillar proteins in early vertebrate development","volume":"22","author":"Visconti","year":"2003","journal-title":"Matrix Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0012-1606(92)90186-K","article-title":"Fibulin is localized at sites of epithelial-mesenchymal transitions in the early avian embryo","volume":"151","author":"Spence","year":"1992","journal-title":"Dev. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/(SICI)1097-0185(199604)244:4<540::AID-AR12>3.0.CO;2-P","article-title":"Fibulin-1, vitronectin, and fibronectin expression during avian cardiac valve and septa development","volume":"244","author":"Bouchey","year":"1996","journal-title":"Anatom. Rec."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/(SICI)1097-0177(199603)205:3<348::AID-AJA13>3.0.CO;2-0","article-title":"Fibulin-1 and fibulin-2 expression during organogenesis in the developing mouse embryo","volume":"205","author":"Zhang","year":"1996","journal-title":"Dev. Dynam."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1093\/humrep\/deh841","article-title":"Progesterone induces the fibulin-1 expression in human endometrial stromal cells","volume":"20","author":"Nakamoto","year":"2005","journal-title":"Hum. Reprod."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mod.2014.12.005","article-title":"Fibulin-1 suppresses endothelial to mesenchymal transition in the proximal outflow tract","volume":"136","author":"Harikrishnan","year":"2015","journal-title":"Mech. Dev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"18730","DOI":"10.1074\/jbc.M115.702761","article-title":"Fibulin-1 Binds to Fibroblast Growth Factor 8 with High Affinity: Effects on embryo survival","volume":"291","author":"Fresco","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/02713680701411269","article-title":"Expression of extracellular matrix proteins fibulin-1 and fibulin-2 by human corneal fibroblasts","volume":"32","author":"Ducros","year":"2007","journal-title":"Curr. Eye Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/jmbi.1997.1244","article-title":"Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules","volume":"272","author":"Adam","year":"1997","journal-title":"J. Mol. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ydbio.2008.04.029","article-title":"Fibulin-1 is required for morphogenesis of neural crest-derived structures","volume":"319","author":"Cooley","year":"2008","journal-title":"Dev. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/dvdy.23716","article-title":"Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1\/2 activation, and to attenuate trabecular cardiomyocyte proliferation","volume":"241","author":"Cooley","year":"2012","journal-title":"Dev. Dynam."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"34796","DOI":"10.1074\/jbc.M506980200","article-title":"Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1","volume":"280","author":"Lee","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1128\/MCB.21.20.7025-7034.2001","article-title":"Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice","volume":"21","author":"Kostka","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1083\/jcb.123.5.1269","article-title":"Structure and expression of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium binding","volume":"123","author":"Pan","year":"1993","journal-title":"J. Cell Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/bs.acc.2014.09.008","article-title":"Fibulins and their role in cardiovascular biology and disease","volume":"67","author":"Cangemi","year":"2014","journal-title":"Adv. Clin. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nrm1130","article-title":"Fibulins: A versatile family of extracellular matrix proteins","volume":"4","author":"Timpl","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Tsuda, T. (2018). Extracellular Interactions between Fibulins and Transforming Growth Factor (TGF)-\u03b2 in Physiological and Pathological Conditions. IJMS, 19.","DOI":"10.3390\/ijms19092787"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1006\/dbio.1995.1003","article-title":"Extracellular matrix protein fibulin-2 is expressed in the embryonic endocardial cushion tissue and is a prominent component of valves in adult heart","volume":"167","author":"Zhang","year":"1995","journal-title":"Dev. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1007\/s00018-014-1577-4","article-title":"Fibulin-2 is involved in early extracellular matrix development of the outgrowing mouse mammary epithelium","volume":"71","author":"Olijnyk","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/dvdy.1172","article-title":"Fibulin-2 expression marks transformed mesenchymal cells in developing cardiac valves, aortic arch vessels, and coronary vessels","volume":"222","author":"Tsuda","year":"2001","journal-title":"Dev. Dynam."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ydbio.2018.06.014","article-title":"Identification of the extracellular matrix protein Fibulin-2 as a regulator of spinal nerve organization","volume":"442","author":"Schaeffer","year":"2018","journal-title":"Dev. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF02331415","article-title":"The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo","volume":"28","author":"Miosge","year":"1996","journal-title":"Histochem. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1006\/excr.1996.0014","article-title":"Differential regulation of fibulin, tenascin-C, and nidogen expression during wound healing of normal and glucocorticoid-treated mice","volume":"222","author":"Sasaki","year":"1996","journal-title":"Exp. Cell Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0016-5085(99)70407-5","article-title":"Rat liver myofibroblasts and hepatic stellate cells: Different cell populations of the fibroblast lineage with fibrogenic potential","volume":"117","author":"Knittel","year":"1999","journal-title":"Gastroenterology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1046\/j.1365-2133.2001.04337.x","article-title":"Increased deposition of fibulin-2 in solar elastosis and its colocalization with elastic fibres","volume":"145","author":"Hunzelmann","year":"2001","journal-title":"Br. J. Dermatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1128\/MCB.01876-07","article-title":"Fibulin-2 is dispensable for mouse development and elastic fiber formation","volume":"28","author":"Sicot","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/jid.2014.10","article-title":"Reduced fibulin-2 contributes to loss of basement membrane integrity and skin blistering in mice lacking integrin \u03b13\u03b21 in the epidermis","volume":"134","author":"Longmate","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S1567-133X(03)00084-X","article-title":"Cloning, expression and characterization of the murine Efemp1, a gene mutated in Doyne-Honeycomb retinal dystrophy","volume":"3","author":"Ehlermann","year":"2003","journal-title":"Gene Expr. Patterns"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/9722","article-title":"A single EFEMP1 mutation associated with both MalattiaLeventinese and Doyne honeycomb retinal dystrophy","volume":"22","author":"Stone","year":"1999","journal-title":"Nat. Genet."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1093\/hmg\/ddm264","article-title":"Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice","volume":"16","author":"McLaughlin","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1093\/hmg\/ddm199","article-title":"Formation and progression of sub-retinal pigment epithelium deposits in Efemp1 mutation knock-in mice: A model for the early pathogenic course of macular degeneration","volume":"16","author":"Marmorstein","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s004399900224","article-title":"Isolation of a paralog of the Doyne honeycomb retinal dystrophy gene from the multiple retinopathy critical region on 11q13","volume":"106","author":"Katsanis","year":"2000","journal-title":"Hum. Genet."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"eabc1404","DOI":"10.1126\/sciadv.abc1404","article-title":"A matricellular protein fibulin-4 is essential for the activation of lysyl oxidase","volume":"6","author":"Noda","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0014-5793(00)02389-9","article-title":"Human fibulin-4: Analysis of its biosynthetic processing and mRNA expression in normal and tumour tissues","volume":"489","author":"Gallagher","year":"2001","journal-title":"FEBS Lett."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.4049\/jimmunol.176.5.3196","article-title":"Fibulin-4 is a target of autoimmunity predominantly in patients with osteoarthritis","volume":"176","author":"Xiang","year":"2006","journal-title":"J. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1161\/CIRCRESAHA.109.207852","article-title":"Fibulin-4 deficiency results in ascending aortic aneurysms: A potential link between abnormal smooth muscle cell phenotype and aneurysm progression","volume":"106","author":"Huang","year":"2010","journal-title":"Circul. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1128\/MCB.26.5.1700-1709.2006","article-title":"Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice","volume":"26","author":"McLaughlin","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1161\/01.RES.0000260181.19449.95","article-title":"Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice","volume":"100","author":"Hanada","year":"2007","journal-title":"Circul. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1161\/CIRCIMAGING.109.933093","article-title":"Multimodality imaging reveals a gradual increase in matrix metalloproteinase activity at aneurysmal lesions in live fibulin-4 mice","volume":"3","author":"Kaijzel","year":"2010","journal-title":"Circul. Cardiovasc. Imaging"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1042\/BJ20090993","article-title":"Fibulin-4 regulates expression of the tropoelastin gene and consequent elastic-fibre formation by human fibroblasts","volume":"423","author":"Chen","year":"2009","journal-title":"Biochem. J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e23411","DOI":"10.1371\/journal.pone.0023411","article-title":"Impaired vascular contractility and aortic wall degeneration in fibulin-4 deficient mice: Effect of angiotensin II type 1 (AT1) receptor blockade","volume":"6","author":"Moltzer","year":"2011","journal-title":"PLoS ONE"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e1602532","DOI":"10.1126\/sciadv.1602532","article-title":"Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries","volume":"3","author":"Halabi","year":"2017","journal-title":"Sci. Adv."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"22476","DOI":"10.1074\/jbc.274.32.22476","article-title":"DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries","volume":"274","author":"Nakamura","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1161\/01.RES.84.10.1166","article-title":"EVEC, a novel epidermal growth factor-like repeat-containing protein upregulated in embryonic and diseased adult vasculature","volume":"84","author":"Kowal","year":"1999","journal-title":"Circul. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.placenta.2015.10.008","article-title":"Fibulin-5 is upregulated in decidualized human endometrial stromal cells and promotes primary human extravillous trophoblast outgrowth","volume":"36","author":"Winship","year":"2015","journal-title":"Placenta"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1071\/RD18218","article-title":"Morphometric and gene expression analyses of stromal expansion during development of the bovine fetal ovary","volume":"31","author":"Hartanti","year":"2019","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.matbio.2018.02.003","article-title":"Roles of short fibulins, a family of matricellular proteins, in lung matrix assembly and disease","volume":"73","author":"Nakamura","year":"2018","journal-title":"J. Int. Soc. Matrix Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.bbrc.2015.09.089","article-title":"Fibulin-5 deficiency causes developmental defect of premaxillary bone in mice","volume":"466","author":"Noda","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/415168a","article-title":"Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo","volume":"415","author":"Yanagisawa","year":"2002","journal-title":"Nature"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.matbio.2009.03.004","article-title":"Analysis of dermal elastic fibers in the absence of fibulin-5 reveals potential roles for fibulin-5 in elastic fiber assembly","volume":"28","author":"Choi","year":"2009","journal-title":"J. Int. Soc. Matrix Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1073\/pnas.0500058102","article-title":"Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration","volume":"102","author":"Spencer","year":"2005","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20050368","article-title":"Fibulin-5 interacts with fibrillin-1 molecules and microfibrils","volume":"38","author":"Freeman","year":"2005","journal-title":"Biochem. J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1161\/01.RES.0000149568.85071.FB","article-title":"Fibulin-5 is a novel binding protein for extracellular superoxide dismutase","volume":"95","author":"Nguyen","year":"2004","journal-title":"Circul. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1038\/sj.emboj.7601768","article-title":"Latent TGF-beta-binding protein 2 binds to DANCE\/fibulin-5 and regulates elastic fiber assembly","volume":"26","author":"Hirai","year":"2007","journal-title":"EMBO J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1073\/pnas.1215779110","article-title":"Latent TGF-\u03b2 binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5","volume":"110","author":"Noda","year":"2013","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/ng1297","article-title":"Elastic fiber homeostasis requires lysyl oxidase-like 1 protein","volume":"36","author":"Liu","year":"2004","journal-title":"Nat. Genet."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1089\/104454904323145254","article-title":"Fibulin-5 antagonizes vascular endothelial growth factor (VEGF) signaling and angiogenic sprouting by endothelial cells","volume":"23","author":"Albig","year":"2004","journal-title":"DNA Cell Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.abb.2014.01.013","article-title":"A C-terminal fragment of fibulin-7 interacts with endothelial cells and inhibits their tube formation in culture","volume":"545","author":"Suzuki","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s10020-020-00169-z","article-title":"The role of adhesion protein Fibulin7 in development and diseases","volume":"26","author":"Chakraborty","year":"2020","journal-title":"Mol. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.matbio.2018.04.014","article-title":"Fibulin-7, a heparin binding matricellular protein, promotes renal tubular calcification in mice","volume":"74","author":"Tsunezumi","year":"2018","journal-title":"J. Int. Soc. Matrix Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1093\/hmg\/ddu144","article-title":"Functional analysis of candidate genes in 2q13 deletion syndrome implicates FBLN7 and TMEM87B deficiency in congenital heart defects and FBLN7 in craniofacial malformations","volume":"23","author":"Russell","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/bip.22754","article-title":"Identification of peptides derived from the C-terminal domain of fibulin-7 active for endothelial cell adhesion and tube formation disruption","volume":"106","author":"Hozumi","year":"2016","journal-title":"Biopolymers"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1096\/fj.201700686RRR","article-title":"Cell adhesion protein fibulin-7 and its C-terminal fragment negatively regulate monocyte and macrophage migration and functions in vitro and in vivo","volume":"32","author":"Sarangi","year":"2018","journal-title":"FASEB J."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1093\/hmg\/ddg348","article-title":"Analysis of the ARMD1 locus: Evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family","volume":"12","author":"Schultz","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.devcel.2014.08.024","article-title":"B-LINK: A hemicentin, plakin, and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes","volume":"31","author":"Morrissey","year":"2014","journal-title":"Dev. Cell"},{"key":"ref_88","unstructured":"Riddle, D.L., Blumenthal, T., Meyer, B.J., and Priess, J.R. (1997). C. Elegans II, Cold Spring Harbor Laboratory Press. [2nd ed.]."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e1000907","DOI":"10.1371\/journal.pgen.1000907","article-title":"Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes","volume":"6","author":"Carney","year":"2010","journal-title":"PLoS Genet."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ydbio.2012.06.023","article-title":"Hemicentin 2 and Fibulin 1 are required for epidermal-dermal junction formation and fin mesenchymal cell migration during zebrafish development","volume":"369","author":"Feitosa","year":"2012","journal-title":"Dev. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/bdrc.20003","article-title":"Fibulins in development and heritable disease","volume":"72","author":"Chu","year":"2004","journal-title":"Birth Defects Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1038\/sj.onc.1201385","article-title":"Suppression of anchorage-independent growth and matrigel invasion and delayed tumor formation by elevated expression of fibulin-1D in human fibrosarcoma-derived cell lines","volume":"15","author":"Qing","year":"1997","journal-title":"Oncogene"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1242\/jcs.114.24.4587","article-title":"Fibulin-1 suppression of fibronectin-regulated cell adhesion and motility","volume":"114","author":"Twal","year":"2001","journal-title":"J. Cell Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1023\/A:1015854415746","article-title":"Identification of breast cancer-restricted antigens by antibody screening of SKBR3 cDNA library using a preselected patient\u2019s serum","volume":"73","author":"Forti","year":"2002","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1182\/blood-2019-130560","article-title":"Highly Deregulated Fibulins in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms","volume":"134","author":"Skov","year":"2019","journal-title":"Blood"},{"key":"ref_96","first-page":"37","article-title":"The molecular interaction of ADAMTS-1 and fibulin-1 and its potential contribution to breast cancer biology","volume":"5","author":"Mohamedi","year":"2019","journal-title":"J. Cancer Met. Treat."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/sj.onc.1205171","article-title":"Estrogen induction and overexpression of fibulin-1C mRNA in ovarian cancer cells","volume":"21","author":"Moll","year":"2002","journal-title":"Oncogene"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ng1060","article-title":"A molecular signature of metastasis in primary solid tumors","volume":"33","author":"Ramaswamy","year":"2003","journal-title":"Nat. Genet."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e67054","DOI":"10.1371\/journal.pone.0067054","article-title":"Fibulin-2 is a driver of malignant progression in lung adenocarcinoma","volume":"8","author":"Baird","year":"2013","journal-title":"PLoS ONE"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1038\/onc.2011.505","article-title":"Role of MUC4-NIDO domain in the MUC4-mediated metastasis of pancreatic cancer cells","volume":"31","author":"Senapati","year":"2012","journal-title":"Oncogene"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/onc.2011.272","article-title":"Anti-angiogenic and tumor-suppressive roles of candidate tumor-suppressor gene, Fibulin-2, in nasopharyngeal carcinoma","volume":"31","author":"Law","year":"2012","journal-title":"Oncogene"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.ajpath.2011.05.024","article-title":"KSHV regulation of fibulin-2 in Kaposi\u2019s sarcoma: Implications for tumorigenesis","volume":"179","author":"Alcendor","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_103","first-page":"e918099","article-title":"Roles of Fibulin-2 in Carcinogenesis","volume":"26","author":"Zhang","year":"2020","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.2353\/ajpath.2007.060478","article-title":"Loss of fibulin-2 expression is associated with breast cancer progression","volume":"170","author":"Yi","year":"2007","journal-title":"Am. J. Pathol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.18632\/oncotarget.1690","article-title":"Interaction between the ADAMTS-12 metalloprotease and fibulin-2 induces tumor-suppressive effects in breast cancer cells","volume":"5","author":"Fontanil","year":"2014","journal-title":"Oncotarget"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"796","DOI":"10.3389\/fonc.2019.00796","article-title":"Novel Associations within the Tumor Microenvironment: Fibulins Meet ADAMTSs","volume":"9","author":"Fontanil","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_107","first-page":"15222","article-title":"EFEMP1 rs3791679 polymorphism was associated with susceptibility to glioma","volume":"8","author":"Qin","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.bbrc.2016.05.018","article-title":"Fibulin-4 is a novel Wnt\/\u03b2-Catenin pathway activator in human osteosarcoma","volume":"474","author":"Li","year":"2016","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.ygyno.2009.12.016","article-title":"The expression of EFEMP1 in cervical carcinoma and its relationship with prognosis","volume":"117","year":"2010","journal-title":"Gynecol. Oncol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"6215","DOI":"10.1038\/s41598-017-06353-2","article-title":"Fibulin-3 promotes osteosarcoma invasion and metastasis by inducing epithelial to mesenchymal transition and activating the Wnt\/\u03b2-catenin signaling pathway","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1158\/1541-7786.MCR-09-0207","article-title":"Fibulin-3 is uniquely upregulated in malignant gliomas and promotes tumor cell motility and invasion","volume":"7","author":"Hu","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.biopha.2017.01.137","article-title":"MiR-338-5p suppresses proliferation, migration, invasion, and promote apoptosis of glioblastoma cells by directly targeting EFEMP1","volume":"89","author":"Lei","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1158\/1078-0432.CCR-10-2817","article-title":"EFEMP1 as a novel DNA methylation marker for prostate cancer: Array-based DNA methylation and expression profiling","volume":"17","author":"Kim","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"336","DOI":"10.4149\/neo_2018_180703N441","article-title":"FBLN3 inhibited the invasion and metastasis of colorectal cancer through the AKT\/mTOR pathway","volume":"66","author":"Mao","year":"2019","journal-title":"Neoplasma"},{"key":"ref_115","first-page":"4076","article-title":"Decreased preoperative serum fibulin-3 levels in colon cancer patients","volume":"19","author":"Simsek","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1158\/1078-0432.CCR-07-0015","article-title":"Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation","volume":"13","author":"Yue","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Luo, R., Zhang, M., Liu, L., Lu, S., Zhang, C.Z., and Yun, J. (2013). Decrease of fibulin-3 in hepatocellular carcinoma indicates poor prognosis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0070511"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1055\/s-0035-1569289","article-title":"Identification of Genes Associated with Papillary Thyroid Carcinoma (PTC) for Diagnosis by Integrated Analysis","volume":"48","author":"Li","year":"2016","journal-title":"Horm. Metab. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1002\/ijc.24108","article-title":"Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker","volume":"124","author":"Ramser","year":"2009","journal-title":"Int. J. Cancer"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/path.2776","article-title":"Fibulin-3 is associated with tumour progression and a poor prognosis in nasopharyngeal carcinomas and inhibits cell migration and invasion via suppressed AKT activity","volume":"222","author":"Hwang","year":"2010","journal-title":"J. Pathol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Yang, T., Qiu, H., Bao, W., Li, B., Lu, C., Du, G., Luo, X., Wang, L., and Wan, X. (2013). Epigenetic inactivation of EFEMP1 is associated with tumor suppressive function in endometrial carcinoma. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0067458"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1038\/onc.2013.373","article-title":"Fibulin-3-mediated inhibition of epithelial-to-mesenchymal transition and self-renewal of ALDH+ lung cancer stem cells through IGF1R signaling","volume":"33","author":"Kim","year":"2014","journal-title":"Oncogene"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.1038\/onc.2015.13","article-title":"Fibulin-3 is a novel TGF-\u03b2 pathway inhibitor in the breast cancer microenvironment","volume":"34","author":"Tian","year":"2015","journal-title":"Oncogene"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1158\/1541-7786.MCR-08-0132","article-title":"EFEMP1 expression promotes in vivo tumor growth in human pancreatic adenocarcinoma","volume":"7","author":"Seeliger","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.3892\/ijo.2017.3921","article-title":"Fibulin-4 promotes osteosarcoma invasion and metastasis by inducing epithelial to mesenchymal transition via the PI3K\/Akt\/mTOR pathway","volume":"50","author":"Zhang","year":"2017","journal-title":"Int. J. Oncol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"18991","DOI":"10.18632\/oncotarget.15086","article-title":"Fibulin-4 is associated with prognosis of endometrial cancer patients and inhibits cancer cell invasion and metastasis via Wnt\/\u03b2-catenin signaling pathway","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"14251","DOI":"10.18632\/oncotarget.24484","article-title":"Dysregulation of fibulin-5 and matrix metalloproteases in epithelial ovarian cancer","volume":"9","author":"Manders","year":"2018","journal-title":"Oncotarget"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3892\/ol.2016.4650","article-title":"Fibulin-5 localisation in human endometrial cancer shifts from epithelial to stromal with increasing tumour grade, and silencing promotes endometrial epithelial cancer cell proliferation","volume":"12","author":"Winship","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1136\/jclinpath-2015-203129","article-title":"Fibulin-5 is a tumour suppressor inhibiting cell migration and invasion in ovarian cancer","volume":"69","author":"Heo","year":"2016","journal-title":"J. Clin. Pathol."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Tu, K., Dou, C., Zheng, X., Li, C., Yang, W., Yao, Y., and Liu, Q. (2014). Fibulin-5 inhibits hepatocellular carcinoma cell migration and invasion by down-regulating matrix metalloproteinase-7 expression. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-938"},{"key":"ref_131","first-page":"2143","article-title":"FBLN5 is targeted by microRNA-27a-3p and suppresses tumorigenesis and progression in high-grade serous ovarian carcinoma","volume":"44","author":"Li","year":"2020","journal-title":"Oncol. Rep."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"5058","DOI":"10.1158\/0008-5472.CAN-15-0744","article-title":"Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer","volume":"75","author":"Wang","year":"2015","journal-title":"Cancer Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/febs.15333","article-title":"AC-terminal fragment of adhesion protein fibulin-7 inhibits growth of murine breast tumor by regulating macrophage reprogramming","volume":"288","author":"Chakraborty","year":"2021","journal-title":"FEBS J."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/ijc.32306","article-title":"Fibulin-7 is overexpressed in glioblastomas and modulates glioblastoma neovascularization through interaction with angiopoietin-1","volume":"145","author":"Kondo","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/ajh.10425","article-title":"MYH9 spectrum of autosomal-dominant giant platelet syndromes: Unexpected association with fibulin-1 variant-D inactivation","volume":"74","author":"Toren","year":"2003","journal-title":"Am. J. Hematol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1136\/jmg.39.2.98","article-title":"The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex type of synpolydactyly","volume":"39","author":"Debeer","year":"2002","journal-title":"J. Med. Genet."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1167\/iovs.03-0112","article-title":"Transcriptional regulation and expression of the dominant drusen gene FBLN3 (EFEMP1) in mammalian retina","volume":"44","author":"Blackburn","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.matbio.2016.06.003","article-title":"Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa","volume":"56","author":"Sasaki","year":"2016","journal-title":"J. Int. Soc. Matrix Biol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1086\/504304","article-title":"Fibulin-4: A novel gene for an autosomal recessive cutis laxa syndrome","volume":"78","author":"Hucthagowder","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"21443","DOI":"10.1074\/jbc.M115.640425","article-title":"Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities","volume":"290","author":"Igoucheva","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1093\/hmg\/11.18.2113","article-title":"Homozygosity for a missense mutation in fibulin-5 (FBLN5) results in a severe form of cutis laxa","volume":"11","author":"Loeys","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/intimm\/dxp001","article-title":"Fibulin-6 expression and anoikis in human salivary gland epithelial cells: Implications in Sjogren\u2019s syndrome","volume":"21","author":"Sisto","year":"2009","journal-title":"Int. Immunol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"15853","DOI":"10.1074\/jbc.M512370200","article-title":"Evidence that fibulin family members contribute to the steroid-dependent extravascular sequestration of sex hormone-binding globulin","volume":"281","author":"Ng","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"151-1","DOI":"10.1095\/biolreprod.111.095653","article-title":"Elastic fiber assembly in the adult mouse pubic symphysis during pregnancy and postpartum","volume":"86","author":"Consonni","year":"2012","journal-title":"Biol. Reprod."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/pmic.200700465","article-title":"Proteomic analysis of bovine conceptus fluids during early pregnancy","volume":"8","author":"Riding","year":"2008","journal-title":"Proteomics"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12014-016-9116-y","article-title":"Identification of potential protein biomarkers for early detection of pregnancy in cow urine using 2D DIGE and label free quantitation","volume":"13","author":"Rawat","year":"2016","journal-title":"Clin. Proteom."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/5\/685\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:56:47Z","timestamp":1760162207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/5\/685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,2]]},"references-count":146,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["biom11050685"],"URL":"https:\/\/doi.org\/10.3390\/biom11050685","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,2]]}}}