{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:30:55Z","timestamp":1790238655567,"version":"4.1.0"},"reference-count":62,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Nutrition","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"name":"CNRS","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"name":"Universit\u00e9 de Paris","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The impact of maternal nutrition on offspring is well documented. However, the implication of pre-conceptional paternal nutrition on the metabolic health of the progeny remains underexplored. Here, we investigated the impact of paternal high-protein diet (HPD, 43.2% protein) consumption on the endocrine pancreas and the metabolic phenotype of offspring. Male Wistar rats were given HPD or standard diet (SD, 18.9% protein) for two months. The progenies (F1) were studied at fetal stage and in adulthood. Body weight, glycemia, glucose tolerance (GT), glucose-induced insulin secretion in vivo (GIIS) and whole-body insulin sensitivity were assessed in male and female F1 offspring. Insulin sensitivity, GT and GIIS were similar between F1 females from HPD (HPD\/F1) and SD fathers (SD\/F1). Conversely, male HPD\/F1 exhibited increased insulin sensitivity (p &lt; 0.05) and decreased GIIS (p &lt; 0.05) compared to male SD\/F1. The improvement of insulin sensitivity in HPD\/F1 was sustained even after 2 months of high-fat feeding. In male HPD\/F1, the \u03b2 cell mass was preserved and the \u03b2 cell plasticity, following metabolic challenge, was enhanced compared to SD\/F1. In conclusion, we provide the first evidence of a sex-specific impact of paternal HPD on the insulin sensitivity and GIIS of their descendants, demonstrating that changes in paternal nutrition alter the metabolic status of their progeny in adulthood.<\/jats:p>","DOI":"10.3390\/biom11050751","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T06:01:33Z","timestamp":1621317693000},"page":"751","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Paternal High-Protein Diet Programs Offspring Insulin Sensitivity in a Sex-Specific Manner"],"prefix":"10.3390","volume":"11","author":[{"given":"Pengfei","family":"Gong","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, BFA, UMR 8251, CNRS, Team \u201cBiologie et Pathologie du Pancr\u00e9as Endocrine\u201d, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Bailb\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, BFA, UMR 8251, CNRS, Team \u201cBiologie et Pathologie du Pancr\u00e9as Endocrine\u201d, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lola","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, BFA, UMR 8251, CNRS, Team \u201cBiologie et Pathologie du Pancr\u00e9as Endocrine\u201d, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Pommier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, BFA, UMR 8251, CNRS, Team \u201cBiologie et Pathologie du Pancr\u00e9as Endocrine\u201d, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3763-730X","authenticated-orcid":false,"given":"Junjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Shandong Institute of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0928-5810","authenticated-orcid":false,"given":"Stefania","family":"Tolu","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, BFA, UMR 8251, CNRS, Team \u201cBiologie et Pathologie du Pancr\u00e9as Endocrine\u201d, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Stathopoulou","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te d\u2019Azur, Inserm, C3M, Team Control of Gene Expression (10), 06103 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Portha","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, BFA, UMR 8251, CNRS, Team \u201cBiologie et Pathologie du Pancr\u00e9as Endocrine\u201d, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1661-7411","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Grandjean","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te d\u2019Azur, Inserm, C3M, Team Control of Gene Expression (10), 06103 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamileh","family":"Movassat","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, BFA, UMR 8251, CNRS, Team \u201cBiologie et Pathologie du Pancr\u00e9as Endocrine\u201d, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/jech.58.2.114","article-title":"Developmental Origins of Adult Health and Disease","volume":"58","author":"Barker","year":"2004","journal-title":"J. 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