{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:01:41Z","timestamp":1790564501227,"version":"4.1.0"},"reference-count":203,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019M3A9H1103495"],"award-info":[{"award-number":["2019M3A9H1103495"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>A cellular prion protein (PrPC) is a ubiquitous cell surface glycoprotein, and its physiological functions have been receiving increased attention. Endogenous PrPC is present in various kidney tissues and undergoes glomerular filtration. In prion diseases, abnormal prion proteins are found to accumulate in renal tissues and filtered into urine. Urinary prion protein could serve as a diagnostic biomarker. PrPC plays a role in cellular signaling pathways, reno-protective effects, and kidney iron uptake. PrPC signaling affects mitochondrial function via the ERK pathway and is affected by the regulatory influence of microRNAs, small molecules, and signaling proteins. Targeting PrPC in acute and chronic kidney disease could help improve iron homeostasis, ameliorate damage from ischemia\/reperfusion injury, and enhance the efficacy of mesenchymal stem\/stromal cell or extracellular vesicle-based therapeutic strategies. PrPC may also be under the influence of BMP\/Smad signaling and affect the progression of TGF-\u03b2-related renal fibrosis. PrPC conveys TNF-\u03b1 resistance in some renal cancers, and therefore, the coadministration of anti-PrPC antibodies improves chemotherapy. PrPC can be used to design antibody\u2013drug conjugates, aptamer\u2013drug conjugates, and customized tissue inhibitors of metalloproteinases to suppress cancer. With preclinical studies demonstrating promising results, further research on PrPC in the kidney may lead to innovative PrPC-based therapeutic strategies for renal disease.<\/jats:p>","DOI":"10.3390\/biom11060784","type":"journal-article","created":{"date-parts":[[2021,5,23]],"date-time":"2021-05-23T23:59:03Z","timestamp":1621814343000},"page":"784","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Harnessing the Physiological Functions of Cellular Prion Protein in the Kidneys: Applications for Treating Renal Diseases"],"prefix":"10.3390","volume":"11","author":[{"given":"Sungtae","family":"Yoon","sequence":"first","affiliation":[{"name":"Stembio, Ltd., Entrepreneur 306, Soonchunhyang-ro 22, Sinchang-myeon, Asan 31538, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeongyun","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Soonchunhyang University College of Medicine, Cheonan 31151, Korea"},{"name":"Department of Biochemistry, BK21FOUR Project2, College of Medicine, Soonchunhyang, Cheonan 31151, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeomin","family":"Yoon","sequence":"additional","affiliation":[{"name":"Medical Science Research Institute, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiho","family":"Lim","sequence":"additional","affiliation":[{"name":"Medical Science Research Institute, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaeun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Soonchunhyang University College of Medicine, Cheonan 31151, Korea"},{"name":"Department of Biochemistry, BK21FOUR Project2, College of Medicine, Soonchunhyang, Cheonan 31151, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghun","family":"Lee","sequence":"additional","affiliation":[{"name":"Stembio, Ltd., Entrepreneur 306, Soonchunhyang-ro 22, Sinchang-myeon, Asan 31538, Korea"},{"name":"Department of Biochemistry, Soonchunhyang University College of Medicine, Cheonan 31151, Korea"},{"name":"Department of Biochemistry, BK21FOUR Project2, College of Medicine, Soonchunhyang, Cheonan 31151, Korea"},{"name":"Medical Science Research Institute, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1126\/science.6801762","article-title":"Novel proteinaceous infectious particles cause scrapie","volume":"216","author":"Prusiner","year":"1982","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/bs.pmbts.2017.06.018","article-title":"Cell Biology of Prion Protein","volume":"150","author":"Sarnataro","year":"2017","journal-title":"Prog. 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