{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:52:39Z","timestamp":1789735959514,"version":"4.0.1"},"reference-count":81,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan","award":["19K09781"],"award-info":[{"award-number":["19K09781"]}]},{"name":"a grant from the smoking research foundation","award":["2018G024"],"award-info":[{"award-number":["2018G024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Preeclampsia (PE) is a serious disease that can be fatal for the mother and fetus. The two-stage theory has been proposed as its cause, with the first stage comprising poor placentation associated with the failure of fertilized egg implantation. Successful implantation and placentation require maternal immunotolerance of the fertilized egg as a semi-allograft and appropriate extravillous trophoblast (EVT) invasion of the decidua and myometrium. The disturbance of EVT invasion during implantation in PE results in impaired spiral artery remodeling. PE is thought to be caused by hypoxia during remodeling failure\u2013derived poor placentation, which results in chronic inflammation. High-mobility group protein A (HMGA) is involved in the growth and invasion of cancer cells and likely in the growth and invasion of trophoblasts. Its mechanism of action is associated with immunotolerance. Thus, HMGA is thought to play a pivotal role in successful pregnancy, and its dysfunction may be related to the pathogenesis of PE. The evaluation of HMGA function and its changes in PE might confirm that it is a reliable biomarker of PE and provide prospects for PE treatment through the induction of EVT proliferation and invasion during the implantation.<\/jats:p>","DOI":"10.3390\/biom11060822","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T21:42:06Z","timestamp":1622497326000},"page":"822","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["HMGA1 Is a Potential Driver of Preeclampsia Pathogenesis by Interference with Extravillous Trophoblasts Invasion"],"prefix":"10.3390","volume":"11","author":[{"given":"Keiichi","family":"Matsubara","sequence":"first","affiliation":[{"name":"Department of Regional Pediatrics and Perinatology, Graduate School of Medicine, Ehime University, Ehime, Toon-shi 791-0295, Shitsukawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Ehime University, Ehime, Toon-shi 791-0295, Shitsukawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Uchikura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Ehime University, Ehime, Toon-shi 791-0295, Shitsukawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuko","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Ehime University, Ehime, Toon-shi 791-0295, Shitsukawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Ehime University, Ehime, Toon-shi 791-0295, Shitsukawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Ehime University, Ehime, Toon-shi 791-0295, Shitsukawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1432-1033.1973.tb03026.x","article-title":"A new group of chromatin-associated proteins with a high content of acidic and basic amino acids","volume":"38","author":"Goodwin","year":"1973","journal-title":"Eur. J. Biochem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0959-437X(00)00180-5","article-title":"Enhanceosomes","volume":"11","author":"Merika","year":"2001","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Vignali, R., and Marracci, S. (2020). HMGA Genes and Proteins in Development and Evolution. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21020654"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrrheum.2011.222","article-title":"HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease","volume":"8","author":"Harris","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/art.1780360712","article-title":"Autoantibodies to HMG-17 nucleosomal protein in autoimmune rheumatic diseases. Correlation with systemic lupus erythematosus clinical activity and with antibodies to double-stranded DNA","volume":"36","author":"Tzioufas","year":"1993","journal-title":"Arthritis Rheum."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1210\/me.2011-1379","article-title":"The HMGA1-IGF-I\/IGFBP system: A novel pathway for modulating glucose uptake","volume":"26","author":"Iiritano","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1210\/endo.138.10.5268","article-title":"Hepatic nuclear factor 3 and high mobility group I\/Y proteins bind the insulin response element of the insulin-like growth factor-binding protein-1 promoter","volume":"138","author":"Allander","year":"1997","journal-title":"Endocrinology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1111\/jcmm.14082","article-title":"HMGA1 in cancer: Cancer classification by location","volume":"23","author":"Wang","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1471-0528.1997.tb11977.x","article-title":"Transvaginal Doppler ultrasound of the uteroplacental circulation in the early prediction of pre-eclampsia and intrauterine growth retardation","volume":"104","author":"Harrington","year":"1997","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.placenta.2020.09.009","article-title":"Severe early-onset PE with or without FGR in Chinese women","volume":"101","author":"Shen","year":"2020","journal-title":"Placenta"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/S0140-6736(05)78873-5","article-title":"Ca++ oscillation in endothelial cells and pre-eclampsia","volume":"351","author":"Matsubara","year":"1998","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1447-0756.2009.01128.x","article-title":"Role of nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia","volume":"36","author":"Matsubara","year":"2010","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1341-8076.2003.00141.x","article-title":"Changes in serum concentrations of tumor necrosis factor alpha and adhesion molecules in normal pregnant women and those with pregnancy-induced hypertension","volume":"29","author":"Matsubara","year":"2003","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1136\/bmj.38555.462685.8F","article-title":"Recurrence of pre-eclampsia across generations: Exploring fetal and maternal genetic components in a population based cohort","volume":"331","author":"Skjaerven","year":"2005","journal-title":"BMJ"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1053\/plac.2000.0560","article-title":"Placental debris, oxidative stress and pre-eclampsia","volume":"21","author":"Redman","year":"2000","journal-title":"Placenta"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0378-1119(01)00689-8","article-title":"Molecular biology of HMGA proteins: Hubs of nuclear function","volume":"277","author":"Reeves","year":"2001","journal-title":"Gene"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1139\/o03-044","article-title":"HMGA proteins: Flexibility finds a nuclear niche?","volume":"81","author":"Reeves","year":"2003","journal-title":"Biochem. Cell Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0079-6603(08)60360-8","article-title":"High-mobility-group chromosomal proteins: Architectural components that facilitate chromatin function","volume":"54","author":"Bustin","year":"1996","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"ref_19","first-page":"2439","article-title":"High level expression of the HMGI (Y) gene during embryonic development","volume":"13","author":"Chiappetta","year":"1996","journal-title":"Oncogene"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1080\/15384101.2016.1146835","article-title":"Hmga1 null mouse embryonic fibroblasts display downregulation of spindle assembly checkpoint gene expression associated to nuclear and karyotypic abnormalities","volume":"15","author":"Pierantoni","year":"2016","journal-title":"Cell Cycle"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1158\/0008-5472.CAN-05-1889","article-title":"Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice","volume":"66","author":"Fedele","year":"2006","journal-title":"Cancer Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1038\/sj.onc.1208501","article-title":"Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone\/prolactin cell pituitary adenomas and natural killer cell lymphomas","volume":"24","author":"Fedele","year":"2005","journal-title":"Oncogene"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1111\/j.1349-7006.2007.00608.x","article-title":"High mobility group protein HMGA1 inhibits retinoblastoma protein-mediated cellular G0 arrest","volume":"98","author":"Ueda","year":"2007","journal-title":"Cancer Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/nrc2271","article-title":"Roles of HMGA proteins in cancer","volume":"7","author":"Fusco","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"ref_25","first-page":"4583","article-title":"Overexpression of proteins HMGA1 induces cell cycle deregulation and apoptosis in normal rat thyroid cells","volume":"61","author":"Fedele","year":"2001","journal-title":"Cancer Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4176","DOI":"10.1021\/acs.jproteome.6b00035","article-title":"Fecal Metabolome in Hmga1 Transgenic Mice with Polyposis: Evidence for Potential Screen for Early Detection of Precursor Lesions in Colorectal Cancer","volume":"15","author":"Williams","year":"2016","journal-title":"J. Proteome Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1021\/pr501084s","article-title":"HMGA1 drives metabolic reprogramming of intestinal epithelium during hyperproliferation, polyposis, and colorectal carcinogenesis","volume":"14","author":"Williams","year":"2015","journal-title":"J. Proteome Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1158\/1541-7786.MCR-08-0336","article-title":"Upregulation of MMP-2 by HMGA1 promotes transformation in undifferentiated, large-cell lung cancer","volume":"7","author":"Hillion","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Shah, S.N., Cope, L., Poh, W., Belton, A., Roy, S., Talbot, C.C., Sukumar, S., Huso, D.L., and Resar, L.M. (2013). HMGA1: A master regulator of tumor progression in triple-negative breast cancer cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0063419"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/modpathol.2009.139","article-title":"HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma","volume":"23","author":"Hristov","year":"2010","journal-title":"Mod. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Belton, A., Gabrovsky, A., Bae, Y.K., Reeves, R., Iacobuzio-Donahue, C., Huso, D.L., and Resar, L.M. (2012). HMGA1 induces intestinal polyposis in transgenic mice and drives tumor progression and stem cell properties in colon cancer cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030034"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","article-title":"The epithelial-mesenchymal transition generates cells with properties of stem cells","volume":"133","author":"Mani","year":"2008","journal-title":"Cell"},{"key":"ref_33","first-page":"775","article-title":"Oncological role of HMGA2 (Review)","volume":"55","author":"Zhang","year":"2019","journal-title":"Int. J. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/00125480-199909000-00001","article-title":"HMGI(Y) and HMGI-C dysregulation: A common occurrence in human tumors","volume":"6","author":"Tallini","year":"1999","journal-title":"Adv. Anat. Pathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/376771a0","article-title":"Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C","volume":"376","author":"Zhou","year":"1995","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/ng2121","article-title":"A common variant of HMGA2 is associated with adult and childhood height in the general population","volume":"39","author":"Weedon","year":"2007","journal-title":"Nat. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/gim.2017.105","article-title":"Genetic disruption of the oncogenic HMGA2\u2013PLAG1\u2013IGF2 pathway causes fetal growth restriction","volume":"20","author":"Brioude","year":"2018","journal-title":"Genet. Med."},{"key":"ref_38","first-page":"4256","article-title":"The oncogenic properties of the HMG-I gene family","volume":"60","author":"Wood","year":"2000","journal-title":"Cancer Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1158\/1078-0432.CCR-10-2542","article-title":"Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers","volume":"17","author":"Wang","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"ref_40","first-page":"1","article-title":"Downregulation of lysyl oxidase and lysyl oxidase-like protein 2 suppressed the migration and invasion of trophoblasts by activating the TGF-\u03b2\/collagen pathway in preeclampsia","volume":"51","author":"Xu","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1083\/jcb.200512110","article-title":"Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition","volume":"174","author":"Thuault","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.scr.2012.11.002","article-title":"HMGA2 regulates the in vitro aging and proliferation of human umbilical cord blood-derived stromal cells through the mTOR\/p70S6K signaling pathway","volume":"10","author":"Yu","year":"2013","journal-title":"Stem Cell Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1128\/MCB.00400-15","article-title":"Histone Deacetylase 10 Regulates the Cell Cycle G2\/M Phase Transition via a Novel Let-7-HMGA2-Cyclin A2 Pathway","volume":"35","author":"Li","year":"2015","journal-title":"Mol. Cell Biol."},{"key":"ref_44","first-page":"58","article-title":"Gene Expression Profiling of Muscle Stem Cells Identifies Novel Regulators of Postnatal Myogenesis","volume":"4","author":"Rochat","year":"2016","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1089\/scd.2012.0647","article-title":"Role of pericytes in skeletal muscle regeneration and fat accumulation","volume":"22","author":"Birbrair","year":"2013","journal-title":"Stem Cells Dev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/2044-5040-1-7","article-title":"Muscle satellite cell proliferation and association: New insights from myofiber time-lapse imaging","volume":"1","author":"Siegel","year":"2011","journal-title":"Skelet. Muscle"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.devcel.2012.10.019","article-title":"An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis","volume":"23","author":"Li","year":"2012","journal-title":"Dev. Cell."},{"key":"ref_48","first-page":"775","article-title":"HMGI-C expression patterns in human tissues","volume":"149","author":"Rogalla","year":"1996","journal-title":"Implications for the genesis of frequent mesenchymal tumors. Am. J. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00428-003-0892-1","article-title":"Expression of the high-mobility group protein HMGI(Y) in human trophoblast: Potential role in trophoblast invasion of maternal tissue","volume":"443","author":"Bamberger","year":"2003","journal-title":"Virchows Arch."},{"key":"ref_50","first-page":"5695","article-title":"HMG-I(Y) recognizes base-unpairing regions of matrix attachment sequences and its increased expression is directly linked to metastatic breast cancer phenotype","volume":"59","author":"Liu","year":"1999","journal-title":"Cancer Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/01.pgp.0000177995.30427.f0","article-title":"Expression of the high-mobility group protein HMGI(Y) in gestational trophoblastic diseases","volume":"25","author":"Briese","year":"2006","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/biolre\/ioy183","article-title":"HMGA2 is regulated by LIN28 and BRCA1 in human placental cells","volume":"100","author":"West","year":"2019","journal-title":"Biol. Reprod."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jri.2012.11.001","article-title":"Pregnancy-associated miRNA-clusters","volume":"97","author":"Chaiwangyen","year":"2013","journal-title":"J. Reprod. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"12348","DOI":"10.1096\/fj.201900718RR","article-title":"LIN28-let-7 axis regulates genes in immortalized human trophoblast cells by targeting the ARID3B-complex","volume":"33","author":"Ali","year":"2019","journal-title":"FASEB J."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Ali, A., Stenglein, M.D., Spencer, T.E., Bouma, G.J., Anthony, R.V., and Winger, Q.A. (2020). Trophectoderm-Specific Knockdown of LIN28 Decreases Expression of Genes Necessary for Cell Proliferation and Reduces Elongation of Sheep Conceptus. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072549"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1073\/pnas.1721630115","article-title":"High mobility group A2 (HMGA2) deficiency in pigs leads to dwarfism, abnormal fetal resource allocation, and cryptorchidism","volume":"115","author":"Chung","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Pillas, D., Hoggart, C.J., Evans, D.M., O\u2019Reilly, P.F., Sipil\u00e4, K., L\u00e4hdesm\u00e4ki, R., Millwood, I.Y., Kaakinen, M., Netuveli, G., and Blane, D. (2010). Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. PLoS Genet., 6.","DOI":"10.1371\/annotation\/e2a4252d-f903-4d2a-8acf-95d30a32a76c"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zhang, L.C., Liang, J., Pu, L., Zhang, Y.B., Wang, L.G., Liu, X., Yan, H., and Wang, L.X. (2017). mRNA and protein expression levels of four candidate genes for ear size in Erhualian and Large White pigs. Genet. Mol. Res., 16.","DOI":"10.4238\/gmr16029252"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/pros.20049","article-title":"High mobility group protein HMGI(Y) enhances tumor cell growth, invasion, and matrix metalloproteinase-2 expression in prostate cancer cells","volume":"60","author":"Takaha","year":"2004","journal-title":"Prostate"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1093\/jnci\/85.21.1758","article-title":"Association of MMP-2 activation potential with metastatic progression in human breast cancer cell lines independent of MMP-2 production","volume":"85","author":"Azzam","year":"1993","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_61","first-page":"140","article-title":"M(r) 92,000 type IV collagenase is increased in plasma of patients with colon cancer and breast cancer","volume":"53","author":"Zucker","year":"1993","journal-title":"Cancer Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/molehr\/gav070","article-title":"GnRH regulates trophoblast invasion via RUNX2-mediated MMP2\/9 expression","volume":"22","author":"Peng","year":"2016","journal-title":"Mol. Hum. Reprod."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Burchardt, L., Gottlieb, A., Helmke, B.M., Wosniok, W., Kuepker, W., and Bullerdiek, J. (2020). Expression patterns of HMGA2 in the placenta during pregnancy. medRxiv.","DOI":"10.1101\/2020.12.07.20245092"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"15008","DOI":"10.1038\/ncomms15008","article-title":"HMGA1 amplifies Wnt signaling and expands the intestinal stem cell compartment and Paneth cell niche","volume":"8","author":"Xian","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.biopha.2016.05.004","article-title":"HMGA1 facilitates tumor progression through regulating Wnt\/\u03b2-catenin pathway in endometrial cancer","volume":"82","author":"Han","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/cbf.2876","article-title":"The Wnt\/\u03b2-catenin\/T-cell factor 4 pathway up-regulates high-mobility group A1 expression in colon cancer","volume":"31","author":"Bush","year":"2013","journal-title":"Cell Biochem. Funct."},{"key":"ref_67","first-page":"36","article-title":"microRNA-758 inhibits the malignant phenotype of osteosarcoma cells by directly targeting HMGA1 and deactivating the Wnt\/\u03b2-catenin pathway","volume":"9","author":"Ren","year":"2019","journal-title":"Am. J. Cancer Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri3581","article-title":"Regulation of type I interferon responses","volume":"14","author":"Ivashkiv","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.febslet.2004.08.013","article-title":"Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer","volume":"574","author":"Sgarra","year":"2004","journal-title":"FEBS Lett."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1177\/1933719115585148","article-title":"Expression of Interferon \u03b3 by Decidual Cells and Natural Killer Cells at the Human Implantation Site: Implications for Preeclampsia, Spontaneous Abortion, and Intrauterine Growth Restriction","volume":"22","author":"Chen","year":"2015","journal-title":"Reprod. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3892\/etm.2020.9544","article-title":"Increased expression of IFN-\u03b3 in preeclampsia impairs human trophoblast invasion via a SOCS1\/JAK\/STAT1 feedback loop","volume":"21","author":"Liu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/intimm\/dxh209","article-title":"IFN-\u03b3 gene expression is controlled by the architectural transcription factor HMGA1","volume":"17","author":"Chau","year":"2005","journal-title":"Int. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1046\/j.1440-1711.1998.00770.x","article-title":"A role for the architectural transcription factors HMGI(Y) in cytokine gene transcription in T cells","volume":"76","author":"Shannon","year":"1998","journal-title":"Immunol. Cell Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/CIRCULATIONAHA.115.020617","article-title":"In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug","volume":"133","author":"Hopper","year":"2016","journal-title":"Circulation"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1177\/1933719117697254","article-title":"Extranuclear Translocation of High-Mobility Group A1 Reduces the Invasion of Extravillous Trophoblasts Involved in the Pathogenesis of Preeclampsia: New Aspect of High-Mobility Group A1","volume":"24","author":"Uchikura","year":"2017","journal-title":"Reprod. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3389\/fimmu.2018.00526","article-title":"High-Mobility Group Nucleosome-Binding Protein 1 as Endogenous Ligand Induces Innate Immune Tolerance in a TLR4-Sirtuin-1 Dependent Manner in Human Blood Peripheral Mononuclear Cells","volume":"9","author":"Arts","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1080\/15384101.2015.1093704","article-title":"Hmgn1 acts downstream of C\/EBP\u03b2 to regulate the decidualization of uterine stromal cells in mice","volume":"14","author":"Li","year":"2015","journal-title":"Cell Cycle."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"101086","DOI":"10.1016\/j.isci.2020.101086","article-title":"Molecular Mechanisms of Trophoblast Dysfunction Mediated by Imbalance between STOX1 Isoforms","volume":"23","author":"Ducat","year":"2020","journal-title":"iScience"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Rigourd, V., Chauvet, C., Chelbi, S.T., Rebourcet, R., Mondon, F., Letourneur, F., Mignot, T.M., Barbaux, S., and Vaiman, D. (2008). STOX1 overexpression in choriocarcinoma cells mimics transcriptional alterations observed in preeclamptic placentas. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003905"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.285.5425.248","article-title":"HMG-1 as a late mediator of endotoxin lethality in mice","volume":"285","author":"Wang","year":"1999","journal-title":"Science"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/ijgo.12491","article-title":"Increased serum levels of high mobility group protein B1 and calprotectin in pre-eclampsia","volume":"142","author":"Li","year":"2018","journal-title":"Int. J. Gynaecol. Obstet."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/6\/822\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:09:30Z","timestamp":1760162970000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/6\/822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,31]]},"references-count":81,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["biom11060822"],"URL":"https:\/\/doi.org\/10.3390\/biom11060822","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,31]]}}}