{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:37:50Z","timestamp":1784860670894,"version":"3.55.0"},"reference-count":147,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FO 315 51"],"award-info":[{"award-number":["FO 315 51"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD), the most common cause of dementia in the elderly, is a neurodegenerative disorder associated with neurovascular dysfunction and cognitive decline. While the deposition of amyloid \u03b2 peptide (A\u03b2) and the formation of neurofibrillary tangles (NFTs) are the pathological hallmarks of AD-affected brains, the majority of cases exhibits a combination of comorbidities that ultimately lead to multi-organ failure. Of particular interest, it can be demonstrated that A\u03b2 pathology is present in the hearts of patients with AD, while the formation of NFT in the auditory system can be detected much earlier than the onset of symptoms. Progressive hearing impairment may beget social isolation and accelerate cognitive decline and increase the risk of developing dementia. The current review discusses the concept of a brain\u2013ear\u2013heart axis by which A\u03b2 and NFT inhibition could be achieved through targeted supplementation of neurotrophic factors to the cochlea and the brain. Such amyloid inhibition might also indirectly affect amyloid accumulation in the heart, thus reducing the risk of developing AD-associated amyloid cardiomyopathy and cardiovascular disease.<\/jats:p>","DOI":"10.3390\/biom11060900","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T11:20:26Z","timestamp":1623928826000},"page":"900","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Conspicuous Link between Ear, Brain and Heart\u2013Could Neurotrophin-Treatment of Age-Related Hearing Loss Help Prevent Alzheimer\u2019s Disease and Associated Amyloid Cardiomyopathy?"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6953-9771","authenticated-orcid":false,"given":"Sergey","family":"Shityakov","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital W\u00fcrzburg, D-97080 W\u00fcrzburg, Germany"},{"name":"Infochemistry Scientific Center, Laboratory of Chemoinformatics, ITMO University, 191002 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Advanced Stroke Center, Shimane University Hospital, 89-1 Enya, Shimane, Izumo 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1771-7249","authenticated-orcid":false,"given":"Stefan","family":"St\u00f6rk","sequence":"additional","affiliation":[{"name":"Comprehensive Heart Failure Q9 Center, University of W\u00fcrzburg, D-97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8618-8793","authenticated-orcid":false,"given":"Verena","family":"Scheper","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Hannover Medical School and Cluster of Excellence \u201cHearing4All\u201d, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9307-5989","authenticated-orcid":false,"given":"Thomas","family":"Lenarz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Hannover Medical School and Cluster of Excellence \u201cHearing4All\u201d, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola Y.","family":"F\u00f6rster","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital W\u00fcrzburg, D-97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"a011452","DOI":"10.1101\/cshperspect.a011452","article-title":"Neurovascular dysfunction and faulty amyloid beta-peptide clearance in Alzheimer disease","volume":"2","author":"Sagare","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1001\/archneur.61.4.556","article-title":"Executive Dysfunction in Alzheimer Disease","volume":"61","author":"Swanberg","year":"2004","journal-title":"Arch. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer\u2019s disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nrn2194","article-title":"Tau-mediated neurodegeneration in Alzheimer\u2019s disease and related disorders","volume":"8","author":"Ballatore","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_5","first-page":"391","article-title":"Alzheimer\u2019s disease facts and figures","volume":"16","author":"Zhao","year":"2020","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40035-018-0107-y","article-title":"Alzheimer\u2019s disease hypothesis and related therapies","volume":"7","author":"Du","year":"2018","journal-title":"Transl. Neurodegener."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1056\/NEJMra040223","article-title":"Alzheimer\u2019s disease","volume":"351","author":"Cummings","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: Progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00401-009-0522-3","article-title":"Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer\u2019s disease","volume":"118","author":"Bell","year":"2009","journal-title":"Acta Neuropathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/nm890","article-title":"RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain","volume":"9","author":"Deane","year":"2003","journal-title":"Nat. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"20021","DOI":"10.1073\/pnas.0905686106","article-title":"RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction","volume":"106","author":"Takuma","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1126\/science.1131864","article-title":"Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host","volume":"313","author":"Coomaraswamy","year":"2006","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nature06616","article-title":"Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer\u2019s disease","volume":"451","author":"Prada","year":"2008","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1126\/science.1194516","article-title":"Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis","volume":"330","author":"Eisele","year":"2010","journal-title":"Science"},{"key":"ref_15","first-page":"1","article-title":"Human prion diseases and neurodegeneration","volume":"207","author":"Prusiner","year":"1996","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_16","first-page":"409","article-title":"New therapeutic targets in the neurovascular pathway in Alzheimer\u2019s disease","volume":"5","author":"Zlokovic","year":"2008","journal-title":"Neurother. J. Am. Soc. Exp. Neurother."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in Alzheimer\u2019s disease and other disorders","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000285520","article-title":"The vascular hypothesis of Alzheimer\u2019s disease: Bench to bedside and beyond","volume":"7","year":"2010","journal-title":"Neuro-Degener. Dis."},{"key":"ref_19","first-page":"5","article-title":"Alzheimer\u2019s dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: Implications for early detection and therapy","volume":"25","author":"Marchesi","year":"2011","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.tins.2005.02.001","article-title":"Neurovascular mechanisms of Alzheimer\u2019s neurodegeneration","volume":"28","author":"Zlokovic","year":"2005","journal-title":"Trends Neurosci."},{"key":"ref_21","first-page":"1","article-title":"Therapeutic Potential of Multifunctional Derivatives of Cholinesterase Inhibitors","volume":"19","author":"Dzierzbicka","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/jnnp.66.2.137","article-title":"The cholinergic hypothesis of Alzheimer\u2019s disease: A review of progress","volume":"66","author":"Francis","year":"1999","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: Where do we go from here?","volume":"17","author":"Leng","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fnins.2018.00025","article-title":"Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer\u2019s Disease","volume":"12","author":"Kametani","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrd.2015.21","article-title":"From blood-brain barrier to blood-brain interface: New opportunities for CNS drug delivery","volume":"15","author":"Banks","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nm.3407","article-title":"Development, maintenance and disruption of the blood-brain barrier","volume":"19","author":"Obermeier","year":"2013","journal-title":"Nat. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10545-013-9608-0","article-title":"Blood-brain barrier structure and function and the challenges for CNS drug delivery","volume":"36","author":"Abbott","year":"2013","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.2147\/IJN.S68429","article-title":"Blood-brain barrier transport studies, aggregation, and molecular dynamics simulation of multiwalled carbon nanotube functionalized with fluorescein isothiocyanate","volume":"10","author":"Shityakov","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_29","first-page":"862","article-title":"In vitro models of the blood\u2013brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use","volume":"36","author":"Helms","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuint.2019.04.005","article-title":"Astrocyte dysfunction and neurovascular impairment in neurological disorders: Correlation or causation?","volume":"128","author":"McConnell","year":"2019","journal-title":"Neurochem. Int."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1161\/01.STR.0000143224.36527.44","article-title":"Amyloid Angiopathy-Related Vascular Cognitive Impairment","volume":"35","author":"Greenberg","year":"2004","journal-title":"Stroke"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0140-6736(17)31326-0","article-title":"Cerebral amyloid angiopathy and implications for atrial fibrillation management","volume":"390","author":"DeSimone","year":"2017","journal-title":"Lancet"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00418-008-0424-9","article-title":"Tight junctions and the modulation of barrier function in disease","volume":"130","author":"Forster","year":"2008","journal-title":"Histochem. Cell Biol."},{"key":"ref_34","first-page":"575","article-title":"Inflammation as a central mechanism in Alzheimer\u2019s disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimer\u2019s Dementia: Transl. Res. Clin. Interv."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.it.2012.07.004","article-title":"Capture, crawl, cross: The T cell code to breach the blood-brain barriers","volume":"33","author":"Engelhardt","year":"2012","journal-title":"Trends Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s40139-016-0106-6","article-title":"Tight Junctions and the Tumor Microenvironment","volume":"4","author":"Salvador","year":"2016","journal-title":"Curr. Pathobiol. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1161\/STROKEAHA.110.592238","article-title":"Glucocorticoid Insensitivity at the Hypoxic Blood\u2013Brain Barrier Can Be Reversed by Inhibition of the Proteasome","volume":"42","author":"Kleinschnitz","year":"2011","journal-title":"Stroke"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Yamazaki, Y., and Kanekiyo, T. (2017). Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer\u2019s Disease. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18091965"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1161\/STROKEAHA.111.627562","article-title":"Amyloid-beta contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy","volume":"43","author":"Hartz","year":"2012","journal-title":"Stroke"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0196-9781(02)00070-0","article-title":"Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins","volume":"23","author":"Atwood","year":"2002","journal-title":"Peptides"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0002-9440(10)62995-1","article-title":"Dense-Core Plaques in Tg2576 and PSAPP Mouse Models of Alzheimer\u2019s Disease Are Centered on Vessel Walls","volume":"167","author":"Pirici","year":"2005","journal-title":"Am. J. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Hellberg, S., Silvola, J.M., Liljenb\u00e4ck, H., Kiugel, M., Eskola, O., Hakovirta, H., H\u00f6rkk\u00f6, S., Morisson-Iveson, V., Hirani, E., and Saukko, P. (2019). Amyloid-Targeting PET Tracer [18F]Flutemetamol Accumulates in Atherosclerotic Plaques. Molecules, 24.","DOI":"10.3390\/molecules24061072"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/2191-219X-2-57","article-title":"Blood\u2013brain barrier P-glycoprotein function in healthy subjects and Alzheimer\u2019s disease patients: Effect of polymorphisms in the ABCB1 gene","volume":"2","author":"Lubberink","year":"2012","journal-title":"EJNMMI Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fpsyt.2012.00054","article-title":"ABC Transporters and the Alzheimer\u2019s Disease Enigma","volume":"3","author":"Wolf","year":"2012","journal-title":"Front. Psychiatry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1089\/ars.2011.3895","article-title":"Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy","volume":"15","author":"Carrano","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3233\/JAD-2006-9105","article-title":"Thrombin and inflammatory proteins are elevated in Alzheimer\u2019s disease microvessels: Implications for disease pathogenesis","volume":"9","author":"Grammas","year":"2006","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1161\/STROKEAHA.109.558197","article-title":"Patients with Alzheimer disease with multiple microbleeds: Relation with cerebrospinal fluid biomarkers and cognition","volume":"40","author":"Goos","year":"2009","journal-title":"Stroke"},{"key":"ref_48","first-page":"11","article-title":"Genetics of cerebral hemorrhage and microbleeds","volume":"55","author":"Lanfranconi","year":"2013","journal-title":"Panminerva Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/ana.410190306","article-title":"A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study","volume":"19","author":"Brun","year":"1986","journal-title":"Ann. Neurol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuron.2004.07.017","article-title":"LRP\/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms","volume":"43","author":"Deane","year":"2004","journal-title":"Neuron"},{"key":"ref_51","first-page":"G746","article-title":"Serum proteomic analysis of diet-induced steatohepatitis and metabolic syndrome in the Ossabaw miniature swine","volume":"298","author":"Bell","year":"2010","journal-title":"Am. J. Physiol. Liver Physiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000285518","article-title":"Prevalence and impact of cerebrovascular lesions in Alzheimer and lewy body diseases","volume":"7","author":"Jellinger","year":"2010","journal-title":"Neuro-Degener. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/ana.20493","article-title":"Cerebral hypoperfusion and clinical onset of dementia: The Rotterdam study","volume":"57","author":"Ruitenberg","year":"2005","journal-title":"Ann. Neurol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1056\/NEJMoa022066","article-title":"Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline","volume":"348","author":"Vermeer","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.1997.03540340047031","article-title":"Brain Infarction and the Clinical Expression of Alzheimer DiseaseThe Nun Study","volume":"277","author":"Snowdon","year":"1997","journal-title":"JAMA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/mds.23045","article-title":"Cerebellar involvement in progressive supranuclear palsy","volume":"25","author":"Jellinger","year":"2010","journal-title":"Mov. Disord. Off. J. Mov. Disord. Soc."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1161\/STROKEAHA.112.672527","article-title":"Carotid atherosclerosis and prospective risk of dementia","volume":"43","author":"Wendell","year":"2012","journal-title":"Stroke"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.nbd.2015.08.014","article-title":"Vascular dysfunction in the pathogenesis of Alzheimer\u2019s disease\u2014A review of endothelium-mediated mechanisms and ensuing vicious circles","volume":"82","author":"Venneri","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nbd.2016.07.007","article-title":"The blood-brain barrier in Alzheimer\u2019s disease","volume":"107","author":"Zenaro","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2174\/187152709787601867","article-title":"Clearance of amyloid-beta peptide across the blood-brain barrier: Implication for therapies in Alzheimer\u2019s disease","volume":"8","author":"Deane","year":"2009","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/j.jacc.2016.08.073","article-title":"Abeta Amyloid Pathology Affects the Hearts of Patients With Alzheimer\u2019s Disease: Mind the Heart","volume":"68","author":"Troncone","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_62","first-page":"57","article-title":"Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: The HAAS\u2606","volume":"21","author":"Petrovitch","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"61","DOI":"10.31887\/DCNS.2007.9.1\/ctzourio","article-title":"Hypertension, cognitive decline, and dementia: An epidemiological perspective","volume":"9","author":"Tzourio","year":"2007","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.vph.2016.11.008","article-title":"The blood brain barrier in Alzheimer\u2019s disease","volume":"89","author":"Chakraborty","year":"2017","journal-title":"Vasc. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s11906-000-0066-3","article-title":"Oxidative stress and vascular damage in hypertension","volume":"2","author":"Touyz","year":"2000","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/WAD.0b013e3181a4485c","article-title":"Metabolic syndrome, inflammation, and nonamnestic mild cognitive impairment in older persons: A population-based study","volume":"24","author":"Roberts","year":"2010","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2174\/18715273113126660135","article-title":"Molecular Linkages Between Diabetes and Alzheimer\u2019s Disease: Current Scenario and Future Prospects","volume":"13","author":"Dar","year":"2014","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1212\/WNL.53.9.1937","article-title":"Diabetes mellitus and the risk of dementia: The Rotterdam Study","volume":"53","author":"Ott","year":"1999","journal-title":"Neurology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3233\/JAD-2009-0982","article-title":"Reactive oxygen species in diabetes-induced vascular damage, stroke, and Alzheimer\u2019s disease","volume":"16","author":"Muhammad","year":"2009","journal-title":"J. Alzheimer\u2019s Dis. JAD"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1212\/01.wnl.0000306313.89165.ef","article-title":"Central obesity and increased risk of dementia more than three decades later","volume":"71","author":"Whitmer","year":"2008","journal-title":"Neurology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tcm.2015.10.004","article-title":"Metabolic syndrome update","volume":"26","author":"Grundy","year":"2016","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3389\/fnins.2014.00375","article-title":"Obesity and cognitive decline: Role of inflammation and vascular changes","volume":"8","author":"Nguyen","year":"2014","journal-title":"Front. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mehy.2003.12.045","article-title":"A \u201cmitochondrial cascade hypothesis\u201d for sporadic Alzheimer\u2019s disease","volume":"63","author":"Swerdlow","year":"2004","journal-title":"Med. Hypotheses"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0005-2736(03)00025-7","article-title":"Amyloid beta-protein interactions with membranes and cholesterol: Causes or casualties of Alzheimer\u2019s disease","volume":"1610","author":"Wood","year":"2003","journal-title":"Biochim. Biophys. Acta (BBA) Biomembr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1227\/01.NEU.0000371730.11404.36","article-title":"A review of carotid atherosclerosis and vascular cognitive decline: A new understanding of the keys to symptomology","volume":"67","author":"Dempsey","year":"2010","journal-title":"Neurosurgery"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.cardfail.2004.01.009","article-title":"Age, functional capacity, and health-related quality of life in patients with heart failure","volume":"10","author":"Masoudi","year":"2004","journal-title":"J. Card. Fail."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cardfail.2020.02.004","article-title":"Age and Heart Failure Trials\u2014Lessons from DAPA-HF","volume":"26","author":"Rich","year":"2020","journal-title":"J. Card. Fail."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s11897-019-00446-x","article-title":"Amyloidosis in Heart Failure","volume":"16","author":"Ihne","year":"2019","journal-title":"Curr. Hear. Fail. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1527-5299.2007.06612.x","article-title":"Prevalence and Determinants of Cognitive Impairment in Chronic Heart Failure Patients","volume":"13","author":"Debette","year":"2007","journal-title":"Congest. Hear. Fail."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1196\/annals.1333.062","article-title":"Oxidative Stress and Neurodegeneration","volume":"1043","author":"Moreira","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/msj.21352","article-title":"Amyloid Neuropathies","volume":"79","author":"Shin","year":"2012","journal-title":"Mt. Sinai J. Med. A J. Transl. Pers. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1161\/CIRCRESAHA.117.310643","article-title":"Amyloid Cardiomyopathy","volume":"120","author":"Liao","year":"2017","journal-title":"Circ. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3233\/JAD-150169","article-title":"Autonomic Dysfunction in Patients with Mild to Moderate Alzheimer\u2019s Disease","volume":"47","author":"Waldemar","year":"2015","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4239\/wjd.v9.i1.1","article-title":"Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment","volume":"9","author":"Serhiyenko","year":"2018","journal-title":"World J. Diabetes"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1080\/13506129.2019.1625322","article-title":"Prevalence of cardiac amyloidosis among elderly patients with systolic heart failure or conduction disorders","volume":"26","author":"Sainz","year":"2019","journal-title":"Amyloid"},{"key":"ref_86","first-page":"483","article-title":"Cardiovascular risk factors, cortisol, and amyloid-beta deposition in Alzheimer\u2019s Disease Neuroimaging Initiative. Alzheimer\u2019s Dement","volume":"8","author":"Toledo","year":"2012","journal-title":"J. Alzheimer\u2019s Assoc."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jchf.2018.10.022","article-title":"Cardiac Abnormalities in Alzheimer Disease: Clinical Relevance Beyond Pathophysiological Rationale and Instrumental Findings?","volume":"7","author":"Sanna","year":"2019","journal-title":"JACC Heart Fail."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1161\/CIRCULATIONAHA.109.879510","article-title":"Protein Aggregates and Novel Presenilin Gene Variants in Idiopathic Dilated Cardiomyopathy","volume":"121","author":"Gianni","year":"2010","journal-title":"Circulation"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.jacc.2015.01.031","article-title":"Cofilin-2 phosphorylation and sequestration in myocardial aggregates: Novel pathogenetic mechanisms for idiopathic dilated cardiomyopathy","volume":"65","author":"Subramanian","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1086\/509900","article-title":"Mutations of Presenilin Genes in Dilated Cardiomyopathy and Heart Failure","volume":"79","author":"Li","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.18632\/oncotarget.26872","article-title":"Prevalence of cardiovascular risk factors and diseases in patients with multiple myeloma undergoing autologous peripheral blood stem cell transplantation","volume":"10","author":"Backs","year":"2019","journal-title":"Oncotarget"},{"key":"ref_92","first-page":"e178","article-title":"Cardiac amyloidosis","volume":"126","author":"CQuarta","year":"2012","journal-title":"Circulation"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jalz.2012.09.011","article-title":"Alzheimer\u2019s Association recommendations for operationalizing the detection of cognitive impairment during the Medicare Annual Wellness Visit in a primary care setting","volume":"9","author":"Cordell","year":"2013","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jalz.2013.02.003","article-title":"Alzheimer\u2019s Association. 2013 Alzheimer\u2019s disease facts and figures","volume":"9","author":"Thies","year":"2013","journal-title":"Alzheimers Dement."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1039\/C6CS00731G","article-title":"Towards an understanding of amyloid-beta oligomers: Characterization, toxicity mechanisms, and inhibitors","volume":"46","author":"Lee","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1007\/s12035-019-01819-y","article-title":"Alterations of Transcription of Genes Coding Anti-oxidative and Mitochondria-Related Proteins in Amyloid beta Toxicity: Relevance to Alzheimer\u2019s Disease","volume":"57","author":"Cieslik","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/sj.bjp.0704911","article-title":"A novel beta-sheet breaker, RS-0406, reverses amyloid beta-induced cytotoxicity and impairment of long-term potentiation in vitro","volume":"137","author":"Nakagami","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.bbapap.2017.07.022","article-title":"Pseudo-peptide amyloid-beta blocking inhibitors: Molecular dynamics and single molecule force spectroscopy study. Biochim. Biophys","volume":"1865","author":"Mehrazma","year":"2017","journal-title":"Acta Proteins Proteom."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1021\/acs.langmuir.7b03617","article-title":"Inhibition of beta-Amyloid Aggregation through a Designed beta-Hairpin Peptide","volume":"34","author":"Jha","year":"2018","journal-title":"Langmuir"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1039\/C6MD00716C","article-title":"Neuroprotective effect of single-wall carbon nanotubes with built-in peroxidase-like activity against beta-amyloid-induced neurotoxicity","volume":"8","author":"Shin","year":"2017","journal-title":"Medchemcomm"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"16861","DOI":"10.3390\/molecules191016861","article-title":"Ionization states, cellular toxicity and molecular modeling studies of midazolam complexed with trimethyl-beta-cyclodextrin","volume":"19","author":"Shityakov","year":"2014","journal-title":"Molecules"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.2147\/IJN.S31373","article-title":"Alpha-Cyclodextrin dimer complexes of dopamine and levodopa derivatives to assess drug delivery to the central nervous system: ADME and molecular docking studies","volume":"7","author":"Shityakov","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1084\/jem.20121239","article-title":"Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease","volume":"209","author":"Yao","year":"2012","journal-title":"J. Exp. Med."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Stefanescu, R., Stanciu, G.D., Luca, A., Caba, I.C., Tamba, B.I., and Mihai, C.T. (2019). Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-beta Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer\u2019s Disease. Molecules, 24.","DOI":"10.3390\/molecules24061167"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature19323","article-title":"The antibody aducanumab reduces Abeta plaques in Alzheimer\u2019s disease","volume":"537","author":"Sevigny","year":"2016","journal-title":"Nature"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.3233\/JAD-200620","article-title":"Low Doses of Ionizing Radiation as a Treatment for Alzheimer\u2019s Disease: A Pilot Study","volume":"80","author":"Cuttler","year":"2021","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1001\/jamaoto.2017.2513","article-title":"Association of Age-Related Hearing Loss With Cognitive Function, Cognitive Impairment, and Dementia","volume":"144","author":"Loughrey","year":"2018","journal-title":"JAMA Otolaryngol. Neck Surg."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S1474-4422(11)70072-2","article-title":"The projected effect of risk factor reduction on Alzheimer\u2019s disease prevalence","volume":"10","author":"Barnes","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1377\/hlthaff.2013.1276","article-title":"Unintended Benefits: The Potential Economic Impact Of Addressing Risk Factors To Prevent Alzheimer\u2019s Disease","volume":"33","author":"Lin","year":"2014","journal-title":"Health Aff."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fnagi.2019.00146","article-title":"Modifiable Risk Factors for Alzheimer\u2019s Disease","volume":"11","author":"Edwards","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2040622318811000","DOI":"10.1177\/2040622318811000","article-title":"Sensorial frailty: Age-related hearing loss and the risk of cognitive impairment and dementia in later life","volume":"10","author":"Panza","year":"2019","journal-title":"Ther. Adv. Chronic Dis."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.neuroscience.2018.07.053","article-title":"Primary Neural Degeneration in the Human Cochlea: Evidence for Hidden Hearing Loss in the Aging Ear","volume":"407","author":"Wu","year":"2019","journal-title":"Neuroscience"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.heares.2009.10.009","article-title":"Age-related loss of spiral ganglion neurons","volume":"264","author":"Bao","year":"2010","journal-title":"Hear. Res."},{"key":"ref_115","unstructured":"F\u00f6rster, C.Y., Scheper, V., and Lenarz, T. (2019). Hearing loss and strial microvascular pathology towards unravelling the functional contribution of the bloodlabyrinth.barrier. Otorhinolaryngol. Head. Neck. Surg."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"eaao0935","DOI":"10.1126\/scitranslmed.aao0935","article-title":"Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier","volume":"11","author":"Nyberg","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1212\/WNL.43.4.779","article-title":"Auditory system degeneration in Alzheimer\u2019s disease","volume":"43","author":"Sinha","year":"1993","journal-title":"Neurology"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1113\/JP281014","article-title":"Biased auditory nerve central synaptopathy is associated with age-related hearing loss","volume":"599","author":"Wang","year":"2021","journal-title":"J. Physiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0378-5955(90)90103-V","article-title":"Spiral ganglion cell endings in the cochlear nucleus of young and old rats","volume":"49","author":"Keithley","year":"1990","journal-title":"Hear. Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/00007611-196410000-00008","article-title":"The Pathology of Several Disorders of the Inner Ear Which Cause Vertigo","volume":"57","author":"Schuknecht","year":"1964","journal-title":"South. Med. J."},{"key":"ref_121","first-page":"799","article-title":"Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice","volume":"39","author":"Ernfors","year":"1995","journal-title":"Int. J. Dev. Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s10162-019-00723-5","article-title":"AAV-Mediated Neurotrophin Gene Therapy Promotes Improved Survival of Cochlear Spiral Ganglion Neurons in Neonatally Deafened Cats: Comparison of AAV2-hBDNF and AAV5-hGDNF","volume":"20","author":"Leake","year":"2019","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4103\/1673-5374.205084","article-title":"Neurotrophic factors in Alzheimer\u2019s and Parkinson\u2019s diseases: Implications for pathogenesis and therapy","volume":"12","author":"Pinton","year":"2017","journal-title":"Neural Regen. Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.neurobiolaging.2006.02.008","article-title":"BDNF mRNA expression and protein localization are changed in age-related hearing loss","volume":"28","author":"Schimmang","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"107955","DOI":"10.1016\/j.heares.2020.107955","article-title":"Neurotrophin gene therapy to promote survival of spiral ganglion neurons after deafness","volume":"394","author":"Leake","year":"2020","journal-title":"Hear. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.nbd.2016.01.021","article-title":"Biology of GDNF and its receptors\u2014Relevance for disorders of the central nervous system","volume":"97","author":"Ibanez","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Bothwell, M. (2016). Recent advances in understanding neurotrophin signaling. F1000Research, 5.","DOI":"10.12688\/f1000research.8434.1"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1749-6632.1999.tb08650.x","article-title":"Rescue and Regrowth of Sensory Nerves Following Deafferentation by Neurotrophic Factors","volume":"884","author":"Altschuler","year":"1999","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1523\/JNEUROSCI.15-09-06213.1995","article-title":"Nerve growth factor in Alzheimer\u2019s disease: Increased levels throughout the brain coupled with declines in nucleus basalis","volume":"15","author":"Scott","year":"1995","journal-title":"J. Neurosci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3389\/fncel.2019.00363","article-title":"Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain","volume":"13","author":"Miranda","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.3892\/etm.2014.2033","article-title":"Brain-derived neurotrophic factor exerts neuroprotective actions against amyloid beta-induced apoptosis in neuroblastoma cells","volume":"8","author":"Kim","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn812","article-title":"The GDNF family: Signalling, biological functions and therapeutic value","volume":"3","author":"Airaksinen","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"331","DOI":"10.14336\/AD.2015.0825","article-title":"The involvement of BDNF, NGF and GDNF in aging and Alzheimer\u2019s disease","volume":"6","author":"Budni","year":"2015","journal-title":"Aging Dis."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"853","DOI":"10.2174\/156720511798192754","article-title":"Influence of Lithium Treatment on GDNF Serum and CSF Concentrations in Patients with Early Alzheimers Disease","volume":"8","author":"Straten","year":"2011","journal-title":"Curr. Alzheimer Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.neurobiolaging.2009.03.011","article-title":"Five out of 16 plasma signaling proteins are enhanced in plasma of patients with mild cognitive impairment and Alzheimer\u2019s disease","volume":"32","author":"Marksteiner","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jpsychires.2014.01.019","article-title":"Increased plasma levels of BDNF and inflammatory markers in Alzheimer\u2019s disease","volume":"53","author":"Faria","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Sharif, M., Noroozian, M., and Hashemian, F. (2020). Do serum GDNF levels correlate with severity of Alzheimer\u2019s disease?. Neurol. Sci.","DOI":"10.1007\/s10072-020-04909-1"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1242\/dev.113.2.455","article-title":"Expression of nerve growth factor (NGF) receptors in the developing inner ear of chick and rat","volume":"113","author":"Patterson","year":"1991","journal-title":"Development"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(03)00277-6","article-title":"Expression of Trk A receptors in the mammalian inner ear","volume":"187","author":"Dai","year":"2004","journal-title":"Hear. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"303","DOI":"10.21053\/ceo.2016.01354","article-title":"Hearing Improvement in A\/J Mice via the Mouse Nerve Growth Factor","volume":"10","author":"Gao","year":"2017","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00441-017-2686-9","article-title":"Role of BDNF and neurotrophic receptors in human inner ear development","volume":"370","author":"Chacko","year":"2017","journal-title":"Cell Tissue Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1006\/exnr.2000.7353","article-title":"Analysis of BDNF production in the aging gerbil cochlea","volume":"162","author":"Medd","year":"2000","journal-title":"Exp. Neurol."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Szobota, S., Mathur, P.D., Siegel, S., Black, K., Saragovi, H.U., and Foster, A.C. (2019). BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0224022"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1097\/00001756-200512190-00008","article-title":"Brain-derived neurotrophic factor\/glial cell line-derived neurotrophic factor survival effects on auditory neurons are not limited by dexamethasone","volume":"16","author":"Wefstaedt","year":"2005","journal-title":"NeuroReport"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Schwieger, J., Warnecke, A., Lenarz, T., Esser, K.-H., and Scheper, V. (2015). Neuronal Survival, Morphology and Outgrowth of Spiral Ganglion Neurons Using a Defined Growth Factor Combination. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0133680"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0006-8993(00)03217-0","article-title":"Differential expression of GDNF, BDNF, and NT-3 in the aging nigrostriatal system following a neurotoxic lesion","volume":"891","author":"Yurek","year":"2001","journal-title":"Brain Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s101620010011","article-title":"Spiral Ganglion Neurons Are Protected from Degeneration by GDNF Gene Therapy","volume":"1","author":"Yagi","year":"2000","journal-title":"J. Assoc. Res. Otolaryngol."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/6\/900\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:17:27Z","timestamp":1760163447000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/6\/900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,17]]},"references-count":147,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["biom11060900"],"URL":"https:\/\/doi.org\/10.3390\/biom11060900","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,17]]}}}