{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:38:26Z","timestamp":1790501906905,"version":"4.1.0"},"reference-count":78,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T00:00:00Z","timestamp":1625875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660751, 81660151, 82060661"],"award-info":[{"award-number":["81660751, 81660151, 82060661"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Nitric oxide (NO), a free radical, plays a critical role in a wide range of physiological and pathological processes. Due to its pleiotropic function, it has been widely investigated in various types of cancers and is strongly associated with cancer development. Mounting pieces of evidence show that NO regulates various cancer-related events, which mainly depends on phosphorylating the key proteins in several signaling pathways. However, phosphorylation of proteins modulated by NO signaling pathway may lead to different effects in different types of cancer, which is complex and remains unclear. Therefore, in this review, we focus on the effect of protein phosphorylation modulated by NO signaling pathway in different types of cancers including breast cancer, lung cancer, prostate cancer, colon cancer, gastric cancer, pancreatic cancer, ovarian cancer, and neuroblastoma. Phosphorylation of key proteins, including p38 MAPK, ERK, PI3K, STAT3, and p53, modified by NO in various signaling pathways affects different cancer-related processes including cell apoptosis, proliferation, angiogenesis, metastasis, and several cancer therapies. Our review links the NO signaling pathway to protein phosphorylation in cancer development and provides new insight into potential targets and cancer therapy.<\/jats:p>","DOI":"10.3390\/biom11071009","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:23:36Z","timestamp":1626049416000},"page":"1009","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Protein Phosphorylation in Cancer: Role of Nitric Oxide Signaling Pathway"],"prefix":"10.3390","volume":"11","author":[{"given":"Xinran","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Medicine, Nanchang University, Nanchang 330006, China"},{"name":"Queen Mary School, Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, Nanchang University, Nanchang 330006, China"},{"name":"Queen Mary School, Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, Nanchang University, Nanchang 330006, China"},{"name":"Queen Mary School, Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiwen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Physiology, Fuzhou Medical College, Fuzhou 344000, China"},{"name":"Department of Nurse, Nanchang University Hospital, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenfang","family":"Hong","sequence":"additional","affiliation":[{"name":"Experimental Center of Pathogen Biology, Nanchang University, Nanchang 330031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1407-6255","authenticated-orcid":false,"given":"Shulong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, Nanchang University, Nanchang 330006, China"},{"name":"Department of Physiology, Fuzhou Medical College, Fuzhou 344000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cell.2016.03.014","article-title":"On the Dependency of Cellular Protein Levels on mRNA Abundance","volume":"165","author":"Liu","year":"2016","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jssc.201900804","article-title":"Enrichments of post-translational modifications in proteomic studies","volume":"43","author":"Pieroni","year":"2020","journal-title":"J. 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