{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T14:08:19Z","timestamp":1764079699111,"version":"build-2065373602"},"reference-count":208,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Schwann cell development and peripheral nerve myelination are finely orchestrated multistep processes; some of the underlying mechanisms are well described and others remain unknown. Many posttranslational modifications (PTMs) like phosphorylation and ubiquitination have been reported to play a role during the normal development of the peripheral nervous system (PNS) and in demyelinating neuropathies. However, a relatively novel PTM, SUMOylation, has not been studied in these contexts. SUMOylation involves the covalent attachment of one or more small ubiquitin-like modifier (SUMO) proteins to a substrate, which affects the function, cellular localization, and further PTMs of the conjugated protein. SUMOylation also regulates other proteins indirectly by facilitating non-covalent protein\u2013protein interaction via SUMO interaction motifs (SIM). This pathway has important consequences on diverse cellular processes, and dysregulation of this pathway has been reported in several diseases including neurological and degenerative conditions. In this article, we revise the scarce literature on SUMOylation in Schwann cells and the PNS, we propose putative substrate proteins, and we speculate on potential mechanisms underlying the possible involvement of this PTM in peripheral myelination and neuropathies.<\/jats:p>","DOI":"10.3390\/biom11071055","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T04:55:40Z","timestamp":1626670540000},"page":"1055","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Wrestling and Wrapping: A Perspective on SUMO Proteins in Schwann Cells"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1440-3519","authenticated-orcid":false,"given":"Iman F.","family":"Fergani","sequence":"first","affiliation":[{"name":"Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana R.","family":"Frick","sequence":"additional","affiliation":[{"name":"Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA"},{"name":"Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wilson, E.R., Della-Flora Nunes, G., Weaver, M.R., Frick, L.R., and Feltri, M.L. (2020). Schwann cell interactions during the development of the peripheral nervous system. Dev. Neurobiol.","DOI":"10.1002\/dneu.22744"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Musner, N., Sidoli, M., Zambroni, D., Del Carro, U., Ungaro, D., D\u2019Antonio, M., Feltri, M.L., and Wrabetz, L. (2016). Perk Ablation Ameliorates Myelination in S63del-Charcot\u2013Marie\u2013Tooth 1B Neuropathy. ASN Neuro, 8.","DOI":"10.1177\/1759091416642351"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ghidinelli, M., Poitelon, Y., Shin, Y.K., Ameroso, D., Williamson, C., Ferri, C., Pellegatta, M., Espino, K., Mogha, A., and Monk, K. (2017). Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination. PLoS Biol., 15.","DOI":"10.1371\/journal.pbio.2001408"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nn.4316","article-title":"YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells","volume":"19","author":"Poitelon","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/glia.23251","article-title":"Impairment of protein degradation and proteasome function in hereditary neuropathies","volume":"66","author":"VerPlank","year":"2018","journal-title":"Glia"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"9633","DOI":"10.1523\/JNEUROSCI.1235-16.2016","article-title":"Schwann Cell O-GlcNAc Glycosylation Is Required for Myelin Maintenance and Axon Integrity","volume":"36","author":"Kim","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4249","DOI":"10.1242\/jcs.050542","article-title":"SUMOylation and deSUMOylation at a glance","volume":"122","author":"Wang","year":"2009","journal-title":"J. Cell Sci."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Xu, J., He, Y., Qiang, B., Yuan, J., Peng, X., and Pan, X.M. (2008). A novel method for high accuracy sumoylation site prediction from protein sequences. BMC Bioinform., 9.","DOI":"10.1186\/1471-2105-9-8"},{"key":"ref_9","first-page":"671269","article-title":"SUMOhunt: Combining Spatial Staging between Lysine and SUMO with Random Forests to Predict SUMOylation","volume":"2013","author":"Ijaz","year":"2013","journal-title":"Int. Sch. Res. Not."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1186\/s13059-014-0422-2","article-title":"SUMO-specific proteases\/isopeptidases: SENPs and beyond","volume":"15","author":"Nayak","year":"2014","journal-title":"Genome Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/nrm2293","article-title":"Concepts in sumoylation: A decade on","volume":"8","author":"Melchior","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.1091\/mbc.e04-07-0589","article-title":"Distinct in vivo dynamics of vertebrate SUMO paralogues","volume":"15","author":"Ayaydin","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.1074\/jbc.275.9.6252","article-title":"Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2\/3","volume":"275","author":"Saitoh","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Loriol, C., Parisot, J., Poupon, G., Gwizdek, C., and Martin, S. (2012). Developmental regulation and spatiotemporal redistribution of the sumoylation machinery in the rat central nervous system. PLoS One, 7.","DOI":"10.1371\/journal.pone.0033757"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.devcel.2005.10.007","article-title":"The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice","volume":"9","author":"Nacerddine","year":"2005","journal-title":"Dev. Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1128\/MCB.00651-08","article-title":"Sumo-1 function is dispensable in normal mouse development","volume":"28","author":"Zhang","year":"2008","journal-title":"Mol. Cell Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"878","DOI":"10.15252\/embr.201438534","article-title":"Sumo2 is essential while Sumo3 is dispensable for mouse embryonic development","volume":"15","author":"Wang","year":"2014","journal-title":"EMBO Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.biocel.2009.11.014","article-title":"SoxE factors as multifunctional neural crest regulatory factors","volume":"42","author":"Haldin","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6449","DOI":"10.1093\/nar\/gks313","article-title":"Genome-wide analysis of EGR2\/SOX10 binding in myelinating peripheral nerve","volume":"40","author":"Srinivasan","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1101\/gad.186601","article-title":"The transcription factor Sox10 is a key regulator of peripheral glial development","volume":"15","author":"Britsch","year":"2001","journal-title":"Genes Dev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.devcel.2005.09.016","article-title":"SoxE factors function equivalently during neural crest and inner ear development and their activity is regulated by SUMOylation","volume":"9","author":"Taylor","year":"2005","journal-title":"Dev. Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.febslet.2006.02.011","article-title":"Sumoylation of the SOX10 transcription factor regulates its transcriptional activity","volume":"580","author":"Girard","year":"2006","journal-title":"FEBS Lett."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1093\/hmg\/10.24.2783","article-title":"Human Connexin 32, a gap junction protein altered in the X-linked form of Charcot-Marie-Tooth disease, is directly regulated by the transcription factor SOX10","volume":"10","author":"Bondurand","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.1523\/JNEUROSCI.0325-09.2009","article-title":"Connexin32 mutations cause loss of function in Schwann cells and oligodendrocytes leading to PNS and CNS myelination defects","volume":"29","author":"Sargiannidou","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/0896-6273(95)90144-2","article-title":"Pax3: A paired domain gene as a regulator in PNS myelination","volume":"15","author":"Kioussi","year":"1995","journal-title":"Neuron"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/glia.22346","article-title":"Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor","volume":"60","author":"Doddrell","year":"2012","journal-title":"Glia"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41467-017-02354-x","article-title":"ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma","volume":"9","author":"Han","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/371796a0","article-title":"Krox-20 controls myelination in the peripheral nervous system","volume":"371","author":"Topilko","year":"1994","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1111\/j.1471-4159.2006.04069.x","article-title":"In vivo detection of Egr2 binding to target genes during peripheral nerve myelination","volume":"98","author":"Jang","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1111\/j.1471-4159.2010.07045.x","article-title":"Locus-wide identification of Egr2\/Krox20 regulatory targets in myelin genes","volume":"115","author":"Jang","year":"2010","journal-title":"J. Neurochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1471-4159.2005.03056.x","article-title":"Regulation of cholesterol\/lipid biosynthetic genes by Egr2\/Krox20 during peripheral nerve myelination","volume":"93","author":"Leblanc","year":"2005","journal-title":"J. Neurochem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5453","DOI":"10.1074\/jbc.M512159200","article-title":"Direct regulation of myelin protein zero expression by the Egr2 transactivator","volume":"281","author":"LeBlanc","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1093\/hmg\/8.7.1245","article-title":"Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies","volume":"8","author":"Warner","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1073\/pnas.0407836102","article-title":"Analysis of congenital hypomyelinating Egr2Lo\/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination","volume":"102","author":"Le","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1242\/dev.127.1.119","article-title":"Nab proteins mediate a negative feedback loop controlling Krox-20 activity in the developing hindbrain","volume":"127","author":"Garel","year":"2000","journal-title":"Development"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nn1490","article-title":"Nab proteins are essential for peripheral nervous system myelination","volume":"8","author":"Le","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1523\/JNEUROSCI.2168-08.2009","article-title":"Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation","volume":"29","author":"Baloh","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1523\/JNEUROSCI.5187-07.2008","article-title":"Disruption of Krox20-Nab interaction in the mouse leads to peripheral neuropathy with biphasic evolution","volume":"28","author":"Desmazieres","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"18187","DOI":"10.1074\/jbc.M803330200","article-title":"Active gene repression by the Egr2.NAB complex during peripheral nerve myelination","volume":"283","author":"Mager","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/embor.2011.152","article-title":"The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators","volume":"12","author":"Charnay","year":"2011","journal-title":"EMBO Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.279.5350.509","article-title":"Rho GTPases and the actin cytoskeleton","volume":"279","author":"Hall","year":"1998","journal-title":"Science"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nature00859","article-title":"Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck","volume":"418","author":"Eden","year":"2002","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1096\/fasebj.13.8.781","article-title":"Regulation of matrix metalloproteinase expression in tumor invasion","volume":"13","author":"Westermarck","year":"1999","journal-title":"FASEB J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/bies.20558","article-title":"GTP-binding proteins of the Rho\/Rac family: Regulation, effectors and functions in vivo","volume":"29","author":"Bustelo","year":"2007","journal-title":"Bioessays"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1002\/glia.20752","article-title":"The function of RhoGTPases in axon ensheathment and myelination","volume":"56","author":"Feltri","year":"2008","journal-title":"Glia"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1177\/1073858415572361","article-title":"How Schwann Cells Sort Axons: New Concepts","volume":"22","author":"Feltri","year":"2016","journal-title":"Neuroscientist"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"19179","DOI":"10.1074\/jbc.M117.808063","article-title":"Beta1 integrin-dependent Rac\/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2\/merlin","volume":"292","author":"Sabra","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"17251","DOI":"10.1523\/JNEUROSCI.2461-12.2012","article-title":"Rac1 controls Schwann cell myelination through cAMP and NF2\/merlin","volume":"32","author":"Guo","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1083\/jcb.200610014","article-title":"Beta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination","volume":"177","author":"Nodari","year":"2007","journal-title":"J. Cell Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/ncb2112","article-title":"SUMOylation of the GTPase Rac1 is required for optimal cell migration","volume":"12","author":"Tatham","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4161\/sgtp.23310","article-title":"The Rac1 hypervariable region in targeting and signaling: A tail of many stories","volume":"4","author":"Lam","year":"2013","journal-title":"Small GTPases"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.yexcr.2018.12.011","article-title":"Role of small ubiquitin-like modifier proteins-1 (SUMO-1) in regulating migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis","volume":"375","author":"Lao","year":"2019","journal-title":"Exp. Cell Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1101\/gad.301564.117","article-title":"Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression","volume":"31","author":"Yue","year":"2017","journal-title":"Genes Dev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1523\/JNEUROSCI.20-10-03776.2000","article-title":"Association of beta 1 integrin with focal adhesion kinase and paxillin in differentiating Schwann cells","volume":"20","author":"Chen","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1083\/jcb.200609021","article-title":"FAK is required for axonal sorting by Schwann cells","volume":"176","author":"Grove","year":"2007","journal-title":"J. Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"13422","DOI":"10.1523\/JNEUROSCI.1764-14.2014","article-title":"FAK is required for Schwann cell spreading on immature basal lamina to coordinate the radial sorting of peripheral axons with myelination","volume":"34","author":"Grove","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"47434","DOI":"10.1074\/jbc.M308562200","article-title":"PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation","volume":"278","author":"Kadare","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1177\/1073858417751112","article-title":"Epigenetic Control of Schwann Cells","volume":"24","author":"Ma","year":"2018","journal-title":"Neuroscientist"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nn.2780","article-title":"HDAC-mediated deacetylation of NF-\u03baB is critical for Schwann cell myelination","volume":"14","author":"Chen","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nn.2762","article-title":"HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells","volume":"14","author":"Jacob","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6112","DOI":"10.1523\/JNEUROSCI.5212-13.2014","article-title":"HDAC1 and HDAC2 control the specification of neural crest cells into peripheral glia","volume":"34","author":"Jacob","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Brugger, V., Engler, S., Pereira, J.A., Ruff, S., Horn, M., Welzl, H., Munger, E., Vaquie, A., Sidiropoulos, P.N., and Egger, B. (2015). HDAC1\/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins. Plos Biol., 13.","DOI":"10.1371\/journal.pbio.1002258"},{"key":"ref_63","first-page":"690848","article-title":"Regulating the regulators: The post-translational code of class I HDAC1 and HDAC2","volume":"2011","author":"Segre","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1128\/MCB.24.13.6021-6028.2004","article-title":"SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1","volume":"24","author":"Cheng","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4161\/epi.4.7.9807","article-title":"SUMO engages multiple corepressors to regulate chromatin structure and transcription","volume":"4","author":"Ouyang","year":"2009","journal-title":"Epigenetics"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/nar\/gkm969","article-title":"Sumo1 negatively regulates BRCA1-mediated transcription, via modulation of promoter occupancy","volume":"36","author":"Park","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-4939-3667-0_2","article-title":"Detection of Sumo Modification of Endogenous Histone Deacetylase 2 (HDAC2) in Mammalian Cells","volume":"1436","author":"Citro","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e427","DOI":"10.1038\/emm.2017.236","article-title":"Sumoylation of histone deacetylase 1 regulates MyoD signaling during myogenesis","volume":"50","author":"Joung","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"7123","DOI":"10.18632\/oncotarget.3344","article-title":"Sumoylation of HDAC2 promotes NF-\u03baB-dependent gene expression","volume":"6","author":"Wagner","year":"2015","journal-title":"Oncotarget"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/jmcb\/mjt032","article-title":"A role for paralog-specific sumoylation in histone deacetylase 1 stability","volume":"5","author":"Citro","year":"2013","journal-title":"J. Mol. Cell Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrneurol.2010.37","article-title":"Signals to promote myelin formation and repair","volume":"6","author":"Taveggia","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cell.2009.03.045","article-title":"The canonical Notch signaling pathway: Unfolding the activation mechanism","volume":"137","author":"Kopan","year":"2009","journal-title":"Cell"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nn.2323","article-title":"Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity","volume":"12","author":"Woodhoo","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41418-017-0002-6","article-title":"Sumoylation of Notch1 represses its target gene expression during cell stress","volume":"25","author":"Antila","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/nn.4322","article-title":"Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination","volume":"19","author":"Wu","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1161\/CIRCRESAHA.117.310696","article-title":"SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling","volume":"121","author":"Zhu","year":"2017","journal-title":"Circ. Res."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Poitelon, Y., Kopec, A.M., and Belin, S. (2020). Myelin Fat Facts: An Overview of Lipids and Fatty Acid Metabolism. Cells, 9.","DOI":"10.3390\/cells9040812"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/83685","article-title":"Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin","volume":"27","author":"Peterfy","year":"2001","journal-title":"Nat. Genet."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"32883","DOI":"10.1074\/jbc.M503885200","article-title":"Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis","volume":"280","author":"Peterfy","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.cmet.2006.08.005","article-title":"Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha\/PPARalpha regulatory pathway","volume":"4","author":"Finck","year":"2006","journal-title":"Cell Metab."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1101\/gad.1116203","article-title":"Local regulation of fat metabolism in peripheral nerves","volume":"17","author":"Verheijen","year":"2003","journal-title":"Genes Dev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cmet.2004.12.002","article-title":"Lipin, a lipodystrophy and obesity gene","volume":"1","author":"Phan","year":"2005","journal-title":"Cell Metab."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1101\/gad.1638008","article-title":"Phosphatidic acid mediates demyelination in Lpin1 mutant mice","volume":"22","author":"Nadra","year":"2008","journal-title":"Genes Dev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"12089","DOI":"10.1523\/JNEUROSCI.2029-09.2009","article-title":"Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis","volume":"29","author":"Douglas","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Liu, G.H., and Gerace, L. (2009). Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells. PLoS One, 4.","DOI":"10.1371\/journal.pone.0007031"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.neulet.2008.04.104","article-title":"Regulation of PGC-1alpha and PGC-1alpha-responsive genes with forskolin-induced Schwann cell differentiation","volume":"439","author":"Cowell","year":"2008","journal-title":"Neurosci. Lett."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Feltri, M.L., Weaver, M.R., Belin, S., and Poitelon, Y. (2021). The Hippo pathway: Horizons for innovative treatments of peripheral nerve diseases. J. Peripher. Nerv. Syst.","DOI":"10.1111\/jns.12431"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.molcel.2008.11.019","article-title":"PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop","volume":"32","author":"Lapi","year":"2008","journal-title":"Mol. Cell"},{"key":"ref_89","first-page":"1207","article-title":"Verteporfin induced SUMOylation of YAP1 in endometrial cancer","volume":"10","author":"Wang","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1038\/ncomms5993","article-title":"The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism","volume":"5","author":"Pooya","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/nn.3809","article-title":"Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance","volume":"17","author":"Beirowski","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1038\/ncomms5991","article-title":"Phosphorylation of LKB1\/Par-4 establishes Schwann cell polarity to initiate and control myelin extent","volume":"5","author":"Shen","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.ebiom.2018.12.031","article-title":"SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer","volume":"40","author":"Simon","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.celrep.2015.07.002","article-title":"A Critical Sumo1 Modification of LKB1 Regulates AMPK Activity during Energy Stress","volume":"12","author":"Ritho","year":"2015","journal-title":"Cell Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"a020529","DOI":"10.1101\/cshperspect.a020529","article-title":"Schwann cell myelination","volume":"7","author":"Salzer","year":"2015","journal-title":"Cold Spring Harb Perspect. Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3389\/fimmu.2019.00314","article-title":"T Cell Receptor (TCR)-Induced PLC-\u03b31 Sumoylation via PIASx\u03b2 and PIAS3 SUMO E3 Ligases Regulates the Microcluster Assembly and Physiological Function of PLC-\u03b31","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1038\/onc.2014.48","article-title":"SUMOylation regulates AKT1 activity","volume":"34","author":"Campagna","year":"2015","journal-title":"Oncogene"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/onc.2015.115","article-title":"SUMO modification of Akt regulates global SUMOylation and substrate SUMOylation specificity through Akt phosphorylation of Ubc9 and Sumo1","volume":"35","author":"Lin","year":"2016","journal-title":"Oncogene"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/glia.23748","article-title":"Epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway involved in long-term potentiation and synaptic plasticity in rats","volume":"68","author":"Saw","year":"2020","journal-title":"Glia"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1074\/jbc.M113.508515","article-title":"PIASx\u03b1 ligase enhances Sumo1 modification of PTEN protein as a SUMO E3 ligase","volume":"289","author":"Wang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/ncb2169","article-title":"Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation","volume":"13","author":"Kubota","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1476-4598-13-95","article-title":"SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1","volume":"13","author":"Qu","year":"2014","journal-title":"Mol. Cancer"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1097-2765(04)00060-7","article-title":"SUMO promotes HDAC-mediated transcriptional repression","volume":"13","author":"Yang","year":"2004","journal-title":"Mol. Cell"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1042\/BJ20091672","article-title":"Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK","volume":"428","author":"Li","year":"2010","journal-title":"Biochem. J."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1208\/s12248-019-0303-4","article-title":"Activation of Protein Kinase A Stimulates SUMOylation, Expression, and Transport Activity of Organic Anion Transporter 3","volume":"21","author":"Wang","year":"2019","journal-title":"AAPS J."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Cox, B., Briscoe, J., and Ulloa, F. (2010). SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors. PLoS One, 5.","DOI":"10.1371\/journal.pone.0011996"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Su, Y.F., Shyu, Y.C., Shen, C.K., and Hwang, J. (2012). Phosphorylation-dependent SUMOylation of the transcription factor NF-E2. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0044608"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1111\/j.1471-4159.2010.07003.x","article-title":"Soluble forms of the cell adhesion molecule L1 produced by insect and baculovirus-transduced mammalian cells enhance Schwann cell motility","volume":"115","author":"Lavdas","year":"2010","journal-title":"J. Neurochem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"10605","DOI":"10.1039\/c3nr02707d","article-title":"Gold nanoparticles functionalized with a fragment of the neural cell adhesion molecule L1 stimulate L1-mediated functions","volume":"5","author":"Schulz","year":"2013","journal-title":"Nanoscale"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1093\/brain\/awp160","article-title":"Ablation of adhesion molecule L1 in mice favours Schwann cell proliferation and functional recovery after peripheral nerve injury","volume":"132","author":"Guseva","year":"2009","journal-title":"Brain"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/jnc.12473","article-title":"Cathepsin E generates a sumoylated intracellular fragment of the cell adhesion molecule L1 to promote neuronal and Schwann cell migration as well as myelination","volume":"128","author":"Lutz","year":"2014","journal-title":"J. Neurochem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF02919404","article-title":"Variants of human L1 cell adhesion molecule arise through alternate splicing of RNA","volume":"3","author":"Reid","year":"1992","journal-title":"J. Mol. Neurosci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1083\/jcb.146.5.1173","article-title":"Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival","volume":"146","author":"Haney","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"8303","DOI":"10.1038\/ncomms9303","article-title":"Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination","volume":"6","author":"Poitelon","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/978-1-4939-7649-2_15","article-title":"The Pseudopod System for Axon-Glia Interactions: Stimulation and Isolation of Schwann Cell Protrusions that Form in Response to Axonal Membranes","volume":"1739","author":"Poitelon","year":"2018","journal-title":"Methods Mol. Biol"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.4161\/auto.26448","article-title":"HSPA8\/HSC70 chaperone protein: Structure, function, and chemical targeting","volume":"9","author":"Stricher","year":"2013","journal-title":"Autophagy"},{"key":"ref_117","first-page":"354","article-title":"Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential","volume":"136","author":"Liu","year":"2012","journal-title":"Pharm."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"12432","DOI":"10.1073\/pnas.1413825111","article-title":"Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli","volume":"111","author":"Impens","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nsmb.2890","article-title":"Uncovering global SUMOylation signaling networks in a site-specific manner","volume":"21","author":"Hendriks","year":"2014","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF02527705","article-title":"Antisense oligonucleotide to the 70-kDa heat shock cognate protein inhibits synthesis of myelin basic protein","volume":"21","author":"Aquino","year":"1996","journal-title":"Neurochem. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1023\/A:1022473904335","article-title":"The constitutive heat shock protein-70 is required for optimal expression of myelin basic protein during differentiation of oligodendrocytes","volume":"23","author":"Aquino","year":"1998","journal-title":"Neurochem. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1083\/jcb.200109021","article-title":"Conditional disruption of beta 1 integrin in Schwann cells impedes interactions with axons","volume":"156","author":"Feltri","year":"2002","journal-title":"J. Cell Biol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"681","DOI":"10.18388\/abp.2008_3027","article-title":"Developmental regulation of Ubc9 in the rat nervous system","volume":"55","author":"Watanabe","year":"2008","journal-title":"Acta Biochim. Pol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1002\/cne.23563","article-title":"Spatiotemporal distribution of SUMOylation components during mouse brain development","volume":"522","author":"Hasegawa","year":"2014","journal-title":"J. Comp. Neurol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/978-3-319-50044-7_16","article-title":"Sumoylation: Implications for Neurodegenerative Diseases","volume":"963","author":"Anderson","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/cdd.2016.161","article-title":"Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against A\u03b2 toxicity in a mouse model of Alzheimer\u2019s disease","volume":"24","author":"Tao","year":"2017","journal-title":"Cell Death Differ."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.4103\/1673-5374.253531","article-title":"Variation in expression of small ubiquitin-like modifiers in injured sciatic nerve of mice","volume":"14","author":"Zhang","year":"2019","journal-title":"Neural Regen. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuron.2012.06.021","article-title":"c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration","volume":"75","author":"Latouche","year":"2012","journal-title":"Neuron"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1083\/jcb.200803013","article-title":"c-Jun is a negative regulator of myelination","volume":"181","author":"Parkinson","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1073\/pnas.052559499","article-title":"Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity","volume":"99","author":"Schmidt","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1128\/MCB.25.16.6964-6979.2005","article-title":"Down-regulation of c-Fos\/c-Jun AP-1 dimer activity by sumoylation","volume":"25","author":"Bossis","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/onc.2013.4","article-title":"SUMOylation of the inducible (c-Fos:c-Jun)\/AP-1 transcription complex occurs on target promoters to limit transcriptional activation","volume":"33","author":"Tempe","year":"2014","journal-title":"Oncogene"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1083\/jcb.201503019","article-title":"Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves","volume":"210","author":"Carty","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1126\/science.1166562","article-title":"Calcineurin\/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation","volume":"323","author":"Kao","year":"2009","journal-title":"Science"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/ncb3114","article-title":"Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB","volume":"17","author":"Medina","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1074\/jbc.M411757200","article-title":"Sumoylation of MITF and its related family members TFE3 and TFEB","volume":"280","author":"Miller","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1002\/glia.23516","article-title":"The miRNA biogenesis pathway prevents inappropriate expression of injury response genes in developing and adult Schwann cells","volume":"66","author":"Gokbuget","year":"2018","journal-title":"Glia"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1523\/JNEUROSCI.0801-10.2010","article-title":"Dicer in Schwann cells is required for myelination and axonal integrity","volume":"30","author":"Pereira","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1002\/glia.23450","article-title":"The deletion of dicer in mature myelinating glial cells causes progressive axonal degeneration but not overt demyelination in adult mice","volume":"66","author":"Li","year":"2018","journal-title":"Glia"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"17358","DOI":"10.1523\/JNEUROSCI.3931-11.2011","article-title":"MicroRNAs modulate Schwann cell response to nerve injury by reinforcing transcriptional silencing of dedifferentiation-related genes","volume":"31","author":"Viader","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"12823","DOI":"10.1074\/jbc.M114.565473","article-title":"A microRNA processing defect in smokers\u2019 macrophages is linked to SUMOylation of the endonuclease DICER","volume":"289","author":"Gross","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.4049\/jimmunol.1001603","article-title":"Identification of an autophagy defect in smokers\u2019 alveolar macrophages","volume":"185","author":"Monick","year":"2010","journal-title":"J. Immunol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4161\/bioa.1.3.16985","article-title":"Rac1 GTPase controls myelination and demyelination","volume":"1","author":"Park","year":"2011","journal-title":"Bioarchitecture"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1242\/bio.20122121","article-title":"Stability of the tumor suppressor merlin depends on its ability to bind paxillin LD3 and associate with \u03b21 integrin and actin at the plasma membrane","volume":"1","author":"Manetti","year":"2012","journal-title":"Biol. Open"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"10472","DOI":"10.1523\/JNEUROSCI.2537-08.2008","article-title":"Tumor suppressor schwannomin\/merlin is critical for the organization of Schwann cell contacts in peripheral nerves","volume":"28","author":"Denisenko","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/onc.2008.427","article-title":"Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas","volume":"28","author":"Lallemand","year":"2009","journal-title":"Oncogene"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1083\/jcb.201606052","article-title":"Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo\/YAP activity","volume":"216","author":"Mindos","year":"2017","journal-title":"J. Cell Biol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.neuroscience.2018.01.054","article-title":"Nf2 Mutation in Schwann Cells Delays Functional Neural Recovery Following Injury","volume":"374","author":"Truong","year":"2018","journal-title":"Neuroscience"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.1038\/onc.2013.438","article-title":"Merlin sumoylation is required for its tumor suppressor activity","volume":"33","author":"Qi","year":"2014","journal-title":"Oncogene"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1523\/JNEUROSCI.4537-10.2011","article-title":"Actin polymerization is essential for myelin sheath fragmentation during Wallerian degeneration","volume":"31","author":"Jung","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Chang, H.M., Shyu, M.K., Tseng, G.F., Liu, C.H., Chang, H.S., Lan, C.T., Hsu, W.M., and Liao, W.C. (2013). Neuregulin facilitates nerve regeneration by speeding Schwann cell migration via ErbB2\/3-dependent FAK pathway. PLoS One, 8.","DOI":"10.1371\/journal.pone.0053444"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"14272","DOI":"10.1038\/ncomms14272","article-title":"Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration","volume":"8","author":"Brugger","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.neuron.2011.11.017","article-title":"Notch signaling inhibits axon regeneration","volume":"73","author":"Hammarlund","year":"2012","journal-title":"Neuron"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/glia.23949","article-title":"YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration","volume":"69","author":"Jeanette","year":"2021","journal-title":"Glia"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1136\/jnnp.62.4.310","article-title":"Epidemiology of peripheral neuropathy","volume":"62","author":"Martyn","year":"1997","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1523\/JNEUROSCI.3819-05.2006","article-title":"Different intracellular pathomechanisms produce diverse Myelin Protein Zero neuropathies in transgenic mice","volume":"26","author":"Wrabetz","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.neuron.2007.12.021","article-title":"Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice","volume":"57","author":"Pennuto","year":"2008","journal-title":"Neuron"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1084\/jem.20122005","article-title":"Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice","volume":"210","author":"Musner","year":"2013","journal-title":"J. Exp. Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"11350","DOI":"10.1523\/JNEUROSCI.1637-16.2016","article-title":"Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse","volume":"36","author":"Sidoli","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"4698","DOI":"10.1093\/hmg\/ddt318","article-title":"Curcumin facilitates a transitory cellular stress response in Trembler-J mice","volume":"22","author":"Okamoto","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/emboj.2013.65","article-title":"SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia","volume":"32","author":"Guo","year":"2013","journal-title":"EMBO J."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.bbrc.2017.10.103","article-title":"SUMOylation represses the transcriptional activity of the Unfolded Protein Response transducer ATF6","volume":"494","author":"Hou","year":"2017","journal-title":"Biochem. Biophys Res. Commun."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/BJ20100193","article-title":"SUMO modification regulates the transcriptional activity of XBP1","volume":"429","author":"Chen","year":"2010","journal-title":"Biochem. J."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1080\/15548627.2019.1647944","article-title":"A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3","volume":"16","author":"Liu","year":"2020","journal-title":"Autophagy"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/jns5.12039","article-title":"CMT4D (NDRG1 mutation): Genotype-phenotype correlations","volume":"18","author":"Ricard","year":"2013","journal-title":"J. Peripher. Nerv. Syst."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.nbd.2011.01.030","article-title":"Ndrg1 in development and maintenance of the myelin sheath","volume":"42","author":"King","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1128\/MCB.24.9.3949-3956.2004","article-title":"Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves","volume":"24","author":"Okuda","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bbrc.2015.02.090","article-title":"SUMO modification regulates the protein stability of NDRG1","volume":"459","author":"Lee","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1074\/mcp.M700173-MCP200","article-title":"In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy","volume":"7","author":"Matic","year":"2008","journal-title":"Mol. Cell Proteom."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.nbd.2005.10.010","article-title":"Alterations in degradative pathways and protein aggregation in a neuropathy model based on PMP22 overexpression","volume":"22","author":"Fortun","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.ajpath.2017.10.021","article-title":"Elevated Peripheral Myelin Protein 22, Reduced Mitotic Potential, and Proteasome Impairment in Dermal Fibroblasts from Charcot-Marie-Tooth Disease Type 1A Patients","volume":"188","author":"Lee","year":"2018","journal-title":"Am. J. Pathol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.nbd.2006.09.018","article-title":"The formation of peripheral myelin protein 22 aggregates is hindered by the enhancement of autophagy and expression of cytoplasmic chaperones","volume":"25","author":"Fortun","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.nbd.2009.01.002","article-title":"Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot-Marie-Tooth disease","volume":"34","author":"Madorsky","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"11388","DOI":"10.1523\/JNEUROSCI.1356-10.2010","article-title":"Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice","volume":"30","author":"Rangaraju","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.nbd.2014.06.023","article-title":"Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice","volume":"70","author":"Nicks","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neuro.2018.02.015","article-title":"SUMOylation, aging and autophagy in neurodegeneration","volume":"66","author":"Vijayakumaran","year":"2018","journal-title":"Neurotoxicology"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"103416","DOI":"10.1016\/j.mcn.2019.103416","article-title":"Ginkgolic acid promotes autophagy-dependent clearance of intracellular alpha-synuclein aggregates","volume":"101","author":"Vijayakumaran","year":"2019","journal-title":"Mol. Cell Neurosci."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"jcs234120","DOI":"10.1242\/jcs.234120","article-title":"Inhibiting Sumo1-mediated SUMOylation induces autophagy-mediated cancer cell death and reduces tumour cell invasion via RAC1","volume":"132","author":"Lorente","year":"2019","journal-title":"J. Cell Sci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1007\/s12017-013-8257-7","article-title":"SUMO and Alzheimer\u2019s disease","volume":"15","author":"Lee","year":"2013","journal-title":"Neuromolecular Med."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"C284","DOI":"10.1152\/ajpcell.00091.2016","article-title":"Ubiquitin-dependent and independent roles of SUMO in proteostasis","volume":"311","author":"Liebelt","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bbrc.2006.06.092","article-title":"SUMO-1 modification increases human SOD1 stability and aggregation","volume":"347","author":"Fei","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000439254","article-title":"Inhibition of Pathogenic Mutant SOD1 Aggregation in Cultured Motor Neuronal Cells by Prevention of Its SUMOylation on Lysine 75","volume":"16","author":"Dangoumau","year":"2016","journal-title":"Neurodegener Dis."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.brainres.2011.01.039","article-title":"Human Polycomb protein 2 promotes \u03b1-synuclein aggregate formation through covalent SUMOylation","volume":"1381","author":"Oh","year":"2011","journal-title":"Brain Res."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1007\/s12035-019-01810-7","article-title":"A role for SUMOylation in the Formation and Cellular Localization of TDP-43 Aggregates in Amyotrophic Lateral Sclerosis","volume":"57","author":"Maurel","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/jnr.20691","article-title":"Molecular alterations resulting from frameshift mutations in peripheral myelin protein 22: Implications for neuropathy severity","volume":"82","author":"Johnson","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/nbdi.2002.0500","article-title":"Aggresome formation in neuropathy models based on peripheral myelin protein 22 mutations","volume":"10","author":"Ryan","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"10672","DOI":"10.1523\/JNEUROSCI.23-33-10672.2003","article-title":"Emerging role for autophagy in the removal of aggresomes in Schwann cells","volume":"23","author":"Fortun","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1111\/j.1471-4159.2004.02987.x","article-title":"Impaired proteasome activity and accumulation of ubiquitinated substrates in a hereditary neuropathy model","volume":"92","author":"Fortun","year":"2005","journal-title":"J. Neurochem."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/glia.20846","article-title":"Peripheral myelin protein 22 is regulated post-transcriptionally by miRNA-29a","volume":"57","author":"Verrier","year":"2009","journal-title":"Glia"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/cne.21051","article-title":"Major myelin protein gene (P0) mutation causes a novel form of axonal degeneration","volume":"498","author":"Li","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1242\/jcs.087114","article-title":"Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways","volume":"124","author":"Lee","year":"2011","journal-title":"J. Cell Sci."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1124\/mol.118.112300","article-title":"Small-Molecule Inhibitors Targeting Protein SUMOylation as Novel Anticancer Compounds","volume":"94","author":"Yang","year":"2018","journal-title":"Mol. Pharm."},{"key":"ref_193","first-page":"3","article-title":"Inhibitors targeting the SUMOylation pathway: A patent review 2012\u20132015 (Review)","volume":"41","author":"Zhou","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.trecan.2020.11.009","article-title":"Targeting SUMO Signaling to Wrestle Cancer","volume":"7","author":"Kroonen","year":"2021","journal-title":"Trends Cancer"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2018.03.006","article-title":"Pharmacological inhibition of SUMO-1 with ginkgolic acid alleviates cardiac fibrosis induced by myocardial infarction in mice","volume":"345","author":"Qiu","year":"2018","journal-title":"Toxicol. Appl. Pharm."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Wang, C., Xiao, Y., Lao, M., Wang, J., Xu, S., Li, R., Xu, X., Kuang, Y., Shi, M., and Zou, Y. (2020). Increased SUMO-activating enzyme SAE1\/UBA2 promotes glycolysis and pathogenic behavior of rheumatoid fibroblast-like synoviocytes. JCI Insight, 5.","DOI":"10.1172\/jci.insight.135935"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.omto.2019.12.005","article-title":"Ginkgolic Acid, a SUMO-1 Inhibitor, Inhibits the Progression of Oral Squamous Cell Carcinoma by Alleviating SUMOylation of SMAD4","volume":"16","author":"Liu","year":"2020","journal-title":"Mol. Oncolytics"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1158\/0008-5472.CAN-17-3361","article-title":"Targeting the SUMO Pathway Primes All-trans Retinoic Acid-Induced Differentiation of Nonpromyelocytic Acute Myeloid Leukemias","volume":"78","author":"Baik","year":"2018","journal-title":"Cancer Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41467-019-14138-6","article-title":"SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis","volume":"11","author":"Zhou","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/s41418-020-00641-7","article-title":"Inhibition of Drp1 SUMOylation by ALR protects the liver from ischemia-reperfusion injury","volume":"28","author":"Huang","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1136\/gutjnl-2018-317856","article-title":"SUMO pathway inhibition targets an aggressive pancreatic cancer subtype","volume":"69","author":"Hassan","year":"2020","journal-title":"Gut"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1021\/acs.jmedchem.0c01491","article-title":"Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer","volume":"64","author":"Langston","year":"2021","journal-title":"J. Med. Chem."},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Huang, W., He, T., Chai, C., Yang, Y., Zheng, Y., Zhou, P., Qiao, X., Zhang, B., Liu, Z., and Wang, J. (2012). Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression. PLoS One, 7.","DOI":"10.1371\/journal.pone.0037693"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"58995","DOI":"10.18632\/oncotarget.10636","article-title":"Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation","volume":"7","author":"Wu","year":"2016","journal-title":"Oncotarget"},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Tokarz, P., and Wo\u017aniak, K. (2021). SENP Proteases as Potential Targets for Cancer Therapy. Cancers, 13.","DOI":"10.3390\/cancers13092059"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1096\/fj.201700711R","article-title":"Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2","volume":"32","author":"Bernstock","year":"2018","journal-title":"FASEB J."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"12913","DOI":"10.1073\/pnas.0611562104","article-title":"Sumoylation in axons triggers retrograde transport of the RNA-binding protein La","volume":"104","author":"Willis","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.neuron.2020.06.037","article-title":"SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes","volume":"107","author":"Agarwal","year":"2020","journal-title":"Neuron"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/7\/1055\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:31:39Z","timestamp":1760164299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/7\/1055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,19]]},"references-count":208,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["biom11071055"],"URL":"https:\/\/doi.org\/10.3390\/biom11071055","relation":{},"ISSN":["2218-273X"],"issn-type":[{"type":"electronic","value":"2218-273X"}],"subject":[],"published":{"date-parts":[[2021,7,19]]}}}