{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:28:35Z","timestamp":1791584915212,"version":"4.3.4"},"reference-count":197,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Periostin is known to be a useful biomarker for various diseases. In this article, we focus on allergic diseases and pulmonary fibrosis, for which we and others are now developing detection systems for periostin as a biomarker. Biomarker-based precision medicine in the management of type 2 inflammation and fibrotic diseases since heterogeneity is of utmost importance. Periostin expression is induced by type 2 cytokines (interleukin-4\/-13) or transforming growth factor-\u03b2, and plays a vital role in the pathogenesis of allergic inflammation or interstitial lung disease, respectively, andits serum levels are correlated disease severity, prognosis and responsiveness to the treatment. We first summarise the importance of type 2 biomarker and then describe the pathological role of periostin in the development and progression of type 2 allergic inflammation and pulmonary fibrosis. In addition, then, we summarise the recent development of assay methods for periostin detection, and analyse the diseases in which periostin concentration is elevated in serum and local biological fluids and its usefulness as a biomarker. Furthermore, we describe recent findings of periostin as a biomarker in the use of biologics or anti-fibrotic therapy. Finally, we describe the factors that influence the change in periostin concentration under the healthy conditions.<\/jats:p>","DOI":"10.3390\/biom11081084","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T22:06:48Z","timestamp":1626991608000},"page":"1084","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Pathological Roles and Clinical Usefulness of Periostin in Type 2 Inflammation and Pulmonary Fibrosis"],"prefix":"10.3390","volume":"11","author":[{"given":"Junya","family":"Ono","sequence":"first","affiliation":[{"name":"Shino-Test Corporation, 2-29-14 Oonodai Minami-ku, Sagamihara, Kanagawa 252-0331, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Takai","sequence":"additional","affiliation":[{"name":"Shino-Test Corporation, 2-29-14 Oonodai Minami-ku, Sagamihara, Kanagawa 252-0331, Japan"},{"name":"Division of Medical Biochemistry, Department of Biomolecular Science, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayami","family":"Kamei","sequence":"additional","affiliation":[{"name":"Shino-Test Corporation, 2-29-14 Oonodai Minami-ku, Sagamihara, Kanagawa 252-0331, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Azuma","sequence":"additional","affiliation":[{"name":"Shino-Test Corporation, 2-29-14 Oonodai Minami-ku, Sagamihara, Kanagawa 252-0331, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6983-907X","authenticated-orcid":false,"given":"Kenji","family":"Izuhara","sequence":"additional","affiliation":[{"name":"Division of Medical Biochemistry, Department of Biomolecular Science, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1042\/bj2940271","article-title":"Osteoblast-specific factor 2: Cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I","volume":"294","author":"Takeshita","year":"1993","journal-title":"Biochem. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1359\/jbmr.1999.14.7.1239","article-title":"Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta","volume":"14","author":"Horiuchi","year":"1999","journal-title":"J. Bone Miner. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s00018-013-1494-y","article-title":"The role of periostin in tissue remodeling across health and disease","volume":"71","author":"Conway","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2332\/allergolint.13-RAI-0663","article-title":"Periostin in allergic inflammation","volume":"63","author":"Izuhara","year":"2014","journal-title":"Allergol. Int."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jaci.2006.02.046","article-title":"Periostin: A novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals","volume":"118","author":"Takayama","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1074\/jbc.M109.051961","article-title":"Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture","volume":"285","author":"Kii","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jcb.21224","article-title":"Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues","volume":"101","author":"Norris","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ydbio.2006.09.048","article-title":"Periostin promotes atrioventricular mesenchyme matrix invasion and remodeling mediated by integrin signaling through Rho\/PI 3-kinase","volume":"302","author":"Butcher","year":"2007","journal-title":"Dev. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/nm1619","article-title":"Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair","volume":"13","author":"Hajjar","year":"2007","journal-title":"Nat. Med."},{"key":"ref_10","first-page":"5358","article-title":"Periostin secreted by epithelial ovarian carcinoma is a ligand for \u03b1V\u03b23 and \u03b1V\u03b25 integrins and promotes cell motility","volume":"62","author":"Gillan","year":"2002","journal-title":"Cancer Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1038\/sj.onc.1210009","article-title":"Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: Role of the beta4 integrin and the PI3k pathway","volume":"26","author":"Baril","year":"2007","journal-title":"Oncogene"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1165\/rcmb.2012-0150OC","article-title":"\u03b1M\u03b22 integrin-mediated adhesion and motility of IL-5-stimulated eosinophils on periostin","volume":"48","author":"Johansson","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1084\/jem.20071297","article-title":"Periostin is essential for cardiac healing after acute myocardial infarction","volume":"205","author":"Shimazaki","year":"2008","journal-title":"J. Exp. Med."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Yang, L., Serada, S., Fujimoto, M., Terao, M., Kotobuki, Y., Kitaba, S., Matsui, S., Kudo, A., Naka, T., and Murota, H. (2012). Periostin facilitates skin sclerosis via PI3K\/Akt dependent mechanism in a mouse model of scleroderma. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0041994"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S1535-6108(04)00081-9","article-title":"Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt\/PKB pathway","volume":"5","author":"Bao","year":"2004","journal-title":"Cancer Cell."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1600-0625.2012.01454.x","article-title":"Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts","volume":"21","author":"Ontsuka","year":"2012","journal-title":"Exp. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1172\/JCI58978","article-title":"Periostin promotes chronic allergic inflammation in response to Th2 cytokines","volume":"122","author":"Masuoka","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Nishiyama, T., Kii, I., Kashima, T.G., Kikuchi, Y., Ohazama, A., Shimazaki, M., Fukayama, M., and Kudo, A. (2011). Delayed re-epithelialization in periostin-deficient mice during cutaneous wound healing. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0018410"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/rccm.200903-0392OC","article-title":"T-helper type 2-driven inflammation defines major subphenotypes of asthma","volume":"180","author":"Woodruff","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1056\/NEJMoa1106469","article-title":"Lebrikizumab treatment in adults with asthma","volume":"365","author":"Corren","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/bjd.12943","article-title":"Periostin levels correlate with disease severity and chronicity in patients with atopic dermatitis","volume":"171","author":"Kou","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"616","DOI":"10.5114\/ada.2018.79728","article-title":"Evaluation of periostin level for predicting severity and chronicity of childhood atopic dermatitis","volume":"36","author":"Ozceker","year":"2019","journal-title":"Postepy Dermatol. Alergol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jaci.2013.04.050","article-title":"Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids","volume":"132","author":"Kanemitsu","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.alit.2014.07.003","article-title":"Phenotype of asthma related with high serum periostin levels","volume":"64","author":"Matsusaka","year":"2015","journal-title":"Allergol. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1111\/all.13814","article-title":"Periostin: An emerging biomarker for allergic diseases","volume":"74","author":"Izuhara","year":"2019","journal-title":"Allergy"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2332\/allergolint.13-RAI-0678","article-title":"Serum periostin: A novel biomarker for asthma management","volume":"63","author":"Matsumoto","year":"2014","journal-title":"Allergol. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1183\/09031936.00059810","article-title":"Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias","volume":"37","author":"Okamoto","year":"2011","journal-title":"Eur. Respir. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.resinv.2014.12.003","article-title":"Serum level of periostin can predict long-term outcome of idiopathic pulmonary fibrosis","volume":"53","author":"Tajiri","year":"2015","journal-title":"Respir. Investig."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ohta, S., Okamoto, M., Fujimoto, K., Sakamoto, N., Takahashi, K., Yamamoto, H., Kushima, H., Ishii, H., Akasaka, K., and Ono, J. (2017). The usefulness of monomeric periostin as a biomarker for idiopathic pulmonary fibrosis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0174547"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/978-981-13-6657-4_9","article-title":"Ability of Periostin as a New Biomarker of Idiopathic Pulmonary Fibrosis","volume":"1132","author":"Okamoto","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1006\/cyto.2002.1972","article-title":"Analysis of novel disease-related genes in bronchial asthma","volume":"19","author":"Yuyama","year":"2002","journal-title":"Cytokine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"24915","DOI":"10.1074\/jbc.M502571200","article-title":"Characterization of the interaction between interleukin-13 and interleukin-13 receptors","volume":"280","author":"Arima","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cyto.2015.05.014","article-title":"IL-4 and IL-13 signaling in allergic airway disease","volume":"75","author":"Gour","year":"2015","journal-title":"Cytokine"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1164\/rccm.201510-2032PP","article-title":"Roles of Periostin in Respiratory Disorders","volume":"193","author":"Izuhara","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI5909","article-title":"Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production","volume":"103","author":"Zhu","year":"1999","journal-title":"J. Clin Investig."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/WOX.0b013e31821188e0","article-title":"Interleukin-13 signaling and its role in asthma","volume":"4","author":"Rael","year":"2011","journal-title":"World Allergy Organ. J."},{"key":"ref_37","first-page":"5397","article-title":"Requirement for IL-13 independently of IL-4 in experimental asthma","volume":"282","author":"Warnock","year":"1998","journal-title":"Science"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1126\/science.282.5397.2258","article-title":"Interleukin-13: Central mediator of allergic asthma","volume":"282","author":"Luyimbazi","year":"1998","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Tomlinson, K.L., Davies, G.C., Sutton, D.J., and Palframan, R.T. (2010). Neutralisation of interleukin-13 in mice prevents airway pathology caused by chronic exposure to house dust mite. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013136"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jaci.2004.08.032","article-title":"Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis","volume":"114","author":"Berry","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/thx.2005.052399","article-title":"Evaluation of airway inflammation by quantitative Th1\/Th2 cytokine mRNA measurement in sputum of asthma patients","volume":"61","author":"Truyen","year":"2006","journal-title":"Thorax"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"204","DOI":"10.2500\/aap.2007.28.2959","article-title":"The effectiveness of asthma therapy alternatives and evaluating the effectivity of asthma therapy by interleukin-13 and interferon gamma levels in children","volume":"28","author":"Karaman","year":"2007","journal-title":"Allergy Asthma. Proc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI8205","article-title":"IgE in asthma and atopy: Cellular and molecular connections","volume":"104","author":"Oettgen","year":"1999","journal-title":"J. Clin. Investig."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jaci.2017.12.1009","article-title":"Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids","volume":"143","author":"Peters","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jim.2005.06.008","article-title":"Immunological methods for quantifying free and total serum IgE levels in allergy patients receiving omalizumab (Xolair) therapy","volume":"303","author":"Hamilton","year":"2005","journal-title":"J. Immunol. Methods"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2183\/pjab.87.463","article-title":"Interleukin-5 and IL-5 receptor in health and diseases","volume":"87","author":"Takatsu","year":"2011","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/S0140-6736(02)11679-5","article-title":"Asthma exacerbations and sputum eosinophil counts: A randomised controlled trial","volume":"360","author":"Green","year":"2002","journal-title":"Lancet"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1183\/09031936.06.00137704","article-title":"Determining asthma treatment by monitoring sputum cell counts: Effect on exacerbations","volume":"27","author":"Jayaram","year":"2006","journal-title":"Eur. Respir. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1700634","DOI":"10.1183\/13993003.00634-2017","article-title":"Severe eosinophilic asthma: A roadmap to consensus","volume":"49","author":"Buhl","year":"2017","journal-title":"Eur. Respir. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1513\/AnnalsATS.201310-354OC","article-title":"Blood eosinophil count is a useful biomarker to identify patients with severe eosinophilic asthma","volume":"11","author":"Katz","year":"2014","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S2213-2600(17)30344-2","article-title":"Predictors of enhanced response with benralizumab for patients with severe asthma: Pooled analysis of the SIROCCO and CALIMA studies","volume":"6","author":"FitzGerald","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/bj3570593","article-title":"Nitric oxide synthases: Structure, function and inhibition","volume":"357","author":"Alderton","year":"2001","journal-title":"Biochem. J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0140-6736(94)90931-8","article-title":"Increased nitric oxide in exhaled air of asthmatic patients","volume":"343","author":"Kharitonov","year":"1994","journal-title":"Lancet"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/j.1365-2222.2008.02969.x","article-title":"IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells","volume":"38","author":"Chibana","year":"2008","journal-title":"Clin. Exp. Allergy"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1164\/rccm.201406-1099OC","article-title":"Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways","volume":"190","author":"Modena","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1183\/09031936.00048513","article-title":"Domiciliary diurnal variation of exhaled nitric oxide fraction for asthma control","volume":"43","author":"Saito","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.resinv.2013.01.002","article-title":"Persistent elevation of exhaled nitric oxide and modification of corticosteroid therapy in asthma","volume":"51","author":"Hirano","year":"2013","journal-title":"Respir. Investig."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1164\/rccm.201208-1414OC","article-title":"Exploring the effects of omalizumab in allergic asthma: An analysis of biomarkers in the EXTRA study","volume":"187","author":"Hanania","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1136\/thoraxjnl-2014-206719","article-title":"Lebrikizumab in moderate-to-severe asthma: Pooled data from two randomised placebo-controlled studies","volume":"70","author":"Hanania","year":"2015","journal-title":"Thorax"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1056\/NEJMoa1804092","article-title":"Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma","volume":"378","author":"Castro","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"21514","DOI":"10.1074\/jbc.271.35.21514","article-title":"Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector","volume":"271","author":"Imai","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/1346-8138.12440","article-title":"Thymus and activation-regulated chemokine as a clinical biomarker in atopic dermatitis","volume":"41","author":"Kataoka","year":"2014","journal-title":"J. Dermatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/ni805","article-title":"Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP","volume":"3","author":"Soumelis","year":"2002","journal-title":"Nat. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/intimm\/dxf044","article-title":"IFN-gamma-inducible expression of thymus and activation-regulated chemokine\/CCL17 and macrophage-derived chemokine\/CCL22 in epidermal keratinocytes and their roles in atopic dermatitis","volume":"14","author":"Horikawa","year":"2002","journal-title":"Int. Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jdermsci.2014.08.009","article-title":"Expression of thymus and activation-regulated chemokine (TARC) by human dermal cells, but not epidermal keratinocytes","volume":"76","author":"Shoda","year":"2014","journal-title":"J. Dermatol. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.4049\/jimmunol.165.4.2205","article-title":"Inducible expression of a Th2-type CC chemokine thymus- and activation-regulated chemokine by human bronchial epithelial cells","volume":"165","author":"Sekiya","year":"2000","journal-title":"J. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1067\/mai.2002.126079","article-title":"Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis","volume":"110","author":"Fujisawa","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1399-3038.2009.00851.x","article-title":"Serum measurement of thymus and activation-regulated chemokine\/CCL17 in children with atopic dermatitis: Elevated normal levels in infancy and age-specific analysis in atopic dermatitis","volume":"20","author":"Fujisawa","year":"2009","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3109\/08830180009088503","article-title":"Development of neonatal Th1\/Th2 function","volume":"19","author":"Adkins","year":"2000","journal-title":"Int. Rev. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Izuhara, K., Yamaguchi, Y., Ohta, S., Nunomura, S., Nanri, Y., Azuma, Y., Nomura, N., Noguchi, Y., and Aihara, M. (2018). Squamous Cell Carcinoma Antigen 2 (SCCA2, SERPINB4): An Emerging Biomarker for Skin Inflammatory Diseases. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19041102"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1258\/acb.2011.011065","article-title":"The usefulness of combined measurements of squamous cell carcinoma antigens 1 and 2 in diagnosing atopic dermatitis","volume":"49","author":"Ohta","year":"2012","journal-title":"Ann. Clin. Biochem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.alit.2017.06.016","article-title":"Serum levels of squamous cell carcinoma antigens 1 and 2 reflect disease severity and clinical type of atopic dermatitis in adult patients","volume":"67","author":"Okawa","year":"2018","journal-title":"Allergol. Int."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1016\/j.jaci.2018.01.021","article-title":"SCCA2 is a reliable biomarker for evaluating pediatric atopic dermatitis","volume":"141","author":"Nagao","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3389\/fonc.2018.00225","article-title":"Periostin: A Matricellular Protein with Multiple Functions in Cancer Development and Progression","volume":"8","author":"Alonso","year":"2018","journal-title":"Front Oncol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"589","DOI":"10.2332\/allergolint.11-OA-0370","article-title":"Expression of pendrin and periostin in allergic rhinitis and chronic rhinosinusitis","volume":"61","author":"Ishida","year":"2012","journal-title":"Allergol. Int."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/bjd.12117","article-title":"Serum periostin levels are correlated with progressive skin sclerosis in patients with systemic sclerosis","volume":"168","author":"Yamaguchi","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.3892\/or.2011.1194","article-title":"Periostin, a matrix protein, has potential as a novel serodiagnostic marker for cholangiocarcinoma","volume":"25","author":"Fujimoto","year":"2011","journal-title":"Oncol. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jaci.2015.11.039","article-title":"The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases","volume":"138","author":"Fujishima","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-981-13-6657-4_11","article-title":"Periostin in the Kidney","volume":"1132","author":"Wallace","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1007\/s00018-017-2650-6","article-title":"Periostin in kidney diseases","volume":"74","author":"Prakoura","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1055\/s-0040-1714037","article-title":"Periostin: Immunomodulatory Effects on Oral Diseases","volume":"14","author":"Khurshid","year":"2020","journal-title":"Eur. J. Dent."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.fob.2013.01.001","article-title":"Structure and function of a bacterial Fasciclin I Domain Protein elucidates function of related cell adhesion proteins such as TGFBIp and periostin","volume":"3","author":"Moody","year":"2013","journal-title":"FEBS Open Bio"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"L1046","DOI":"10.1152\/ajplung.00139.2012","article-title":"Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis","volume":"303","author":"Naik","year":"2012","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1165\/rcmb.2019-0245OC","article-title":"Cross-Talk between Transforming Growth Factor-\u03b2 and Periostin Can Be Targeted for Pulmonary Fibrosis","volume":"62","author":"Nanri","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12931-020-1299-0","article-title":"Periostin plays a critical role in the cell cycle in lung fibroblasts","volume":"21","author":"Yoshihara","year":"2020","journal-title":"Respir. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.alit.2015.04.012","article-title":"Recent developments regarding periostin in bronchial asthma","volume":"64","author":"Izuhara","year":"2015","journal-title":"Allergol. Int."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.jaci.2016.03.010","article-title":"Precision medicine in patients with allergic diseases: Airway diseases and atopic dermatitis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology","volume":"137","author":"Muraro","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1172\/JCI124611","article-title":"Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases","volume":"129","author":"Agache","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1007\/s00018-017-2648-0","article-title":"Periostin in inflammation and allergy","volume":"74","author":"Izuhara","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/jid.2013.500","article-title":"Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1\u03b1\/IL-6 loop","volume":"134","author":"Taniguchi","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s40139-013-0017-8","article-title":"Regulation and Relevance of Myofibroblast Responses in Idiopathic Pulmonary Fibrosis","volume":"1","author":"Moore","year":"2013","journal-title":"Curr. Pathobiol. Rep."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1513\/pats.201203-023AW","article-title":"The impact of TGF-\u03b2 on lung fibrosis: From targeting to biomarkers","volume":"9","author":"Fernandez","year":"2012","journal-title":"Proc. Am. Thorac. Soc."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1183\/13993003.01384-2015","article-title":"Serum periostin in obstructive airways disease","volume":"47","author":"Fingleton","year":"2016","journal-title":"Eur. Respir. J."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/ijc.25591","article-title":"Increased expression and serum levels of the stromal cell-secreted protein periostin in breast cancer bone metastases","volume":"128","author":"Litvin","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1007\/s11033-009-9721-1","article-title":"Expression of periostin in the serum of NSCLC and its function on proliferation and migration of human lung adenocarcinoma cell line (A549) in vitro","volume":"37","author":"Hong","year":"2010","journal-title":"Mol. Biol. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1023\/A:1021899904332","article-title":"Elevated serum periostin levels in patients with bone metastases from breast but not lung cancer","volume":"77","author":"Sasaki","year":"2003","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.alit.2019.05.014","article-title":"Periostin forms a functional complex with IgA in human serum","volume":"69","author":"Ono","year":"2020","journal-title":"Allergol. Int."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.clinbiochem.2016.10.002","article-title":"Multicenter evaluation of analytical characteristics of the Elecsys\u00ae Periostin immunoassay","volume":"50","author":"Palme","year":"2017","journal-title":"Clin. Biochem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cca.2016.10.020","article-title":"Development of a new ARCHITECT automated periostin immunoassay","volume":"464","author":"Jeanblanc","year":"2017","journal-title":"Clin. Chim. Acta"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e22252","DOI":"10.1002\/jcla.22252","article-title":"Characterization of a sandwich ELISA for the quantification of all human periostin isoforms","volume":"32","author":"Gadermaier","year":"2018","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1111\/all.13181","article-title":"Serum periostin relates to type-2 inflammation and lung function in asthma: Data from the large population-based cohort Swedish GA(2)LEN","volume":"72","author":"James","year":"2017","journal-title":"Allergy"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1136\/thoraxjnl-2014-206069","article-title":"Asthma biomarkers: What constitutes a \u2018gold standard\u2019?","volume":"70","author":"Arron","year":"2015","journal-title":"Thorax"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"491","DOI":"10.4168\/aair.2016.8.6.491","article-title":"Using Periostin as a Biomarker in the Treatment of Asthma","volume":"8","author":"Izuhara","year":"2016","journal-title":"Allergy Asthma Immunol. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.alit.2019.07.002","article-title":"Eosinophilic chronic rhinosinusitis","volume":"68","author":"Fujieda","year":"2019","journal-title":"Allergol. Int."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.anl.2020.05.014","article-title":"Periostin in middle ear mucosa according to eosinophilic otitis media severity: Middle ear pathology-based treatment","volume":"47","author":"Esu","year":"2020","journal-title":"Auris Nasus Larynx"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/pai.12575","article-title":"Periostin as a biomarker for the diagnosis of pediatric asthma","volume":"27","author":"Inoue","year":"2016","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Yavuz, S.T., Bagci, S., Bolat, A., Akin, O., and Ganschow, R. (2020). Association of serum periostin levels with clinical features in children with asthma. Pediatr. Allergy Immunol.","DOI":"10.1111\/pai.13444"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.hrtlng.2020.04.017","article-title":"Evaluation serum levels of YKL-40, Periostin, and some inflammatory cytokines together with IL-37, a new anti-inflammatory cytokine, in patients with stable and exacerbated asthma","volume":"50","author":"Yildiz","year":"2021","journal-title":"Heart Lung"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/resp.12687","article-title":"Effect of treatment with inhaled corticosteroid on serum periostin levels in asthma","volume":"21","author":"Hoshino","year":"2016","journal-title":"Respirology"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"00347","DOI":"10.1183\/23120541.00347-2019","article-title":"Serum periostin reflects dynamic hyperinflation in patients with asthma","volume":"6","author":"Asano","year":"2020","journal-title":"ERJ Open Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"988","DOI":"10.3904\/kjim.2019.083","article-title":"Serum potential biomarkers according to sputum inflammatory cell profiles in adult asthmatics","volume":"35","author":"Hur","year":"2020","journal-title":"Korean J. Intern. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.anai.2014.06.014","article-title":"Association of serum periostin with aspirin-exacerbated respiratory disease","volume":"113","author":"Kim","year":"2014","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2500\/aap.2016.37.3945","article-title":"Association of airway wall thickness with serum periostin in steroid-naive asthma","volume":"37","author":"Hoshino","year":"2016","journal-title":"Allergy Asthma Proc."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/0194599817737967","article-title":"Periostin as a Biomarker for Nasal Polyps in Chronic Rhinosinusitis","volume":"158","author":"Maxfield","year":"2018","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Sobkowiak, P., Naro\u017cna, B., Wojsyk-Banaszak, I., Br\u0119borowicz, A., and Szczepankiewicz, A. (2021). Expression of proteins associated with airway fibrosis differs between children with allergic asthma and allergic rhinitis. Int. J. Immunopathol. Pharmacol., 35.","DOI":"10.1177\/2058738421990493"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1016\/j.jaip.2020.11.046","article-title":"Serum Periostin as a Biomarker for Predicting Clinical Response to House Dust Mite Sublingual Immunotherapy in Allergic Rhinitis","volume":"9","author":"Hoshino","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1159\/000509253","article-title":"Increased Serum Periostin Levels and Eosinophils in Nasal Polyps Are Associated with the Preventive Effect of Endoscopic Sinus Surgery for Asthma Exacerbations in Chronic Rhinosinusitis","volume":"181","author":"Kanemitsu","year":"2020","journal-title":"Patients Int. Arch. Allergy Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jaip.2018.06.015","article-title":"Combined Assessment of Serum Periostin and YKL-40 May Identify Asthma-COPD Overlap","volume":"7","author":"Shirai","year":"2019","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"119Ji, L., Liu, Y., Liu, P., Ji, G., He, J., Gan, Y., Zhu, S., Chen, B., and Zhang, W. (2021). Serum periostin and TNF-\u03b1 levels in patients with obstructive sleep apnea-hypopnea syndrome. Sleep Breath., 25, 331\u2013337.","DOI":"10.1007\/s11325-020-02124-y"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Yamauchi, M., Kinjo, T., Parrott, G., Miyagi, K., Haranaga, S., Nakayama, Y., Chibana, K., Fujita, K., Nakamoto, A., and Higa, F. (2020). Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0227636"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/myc.12957","article-title":"Elevated serum levels of periostin in patients with allergic bronchopulmonary aspergillosis","volume":"62","author":"Wu","year":"2019","journal-title":"Mycoses"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/all.14080","article-title":"Dupilumab is very effective in a large cohort of difficult-to-treat adult atopic dermatitis patients: First clinical and biomarker results from the BioDay registry","volume":"75","author":"Bakker","year":"2020","journal-title":"Allergy"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"18746","DOI":"10.18632\/oncotarget.13004","article-title":"Diagnostic and prognostic value of serum periostin in patients with non-small cell lung cancer","volume":"8","author":"Xu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s12020-015-0735-2","article-title":"Serum periostin is a potential biomarker for non-alcoholic fatty liver disease: A case-control study","volume":"51","author":"Zhu","year":"2016","journal-title":"Endocrine"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"37886","DOI":"10.1038\/srep37886","article-title":"Circulating periostin in relation to insulin resistance and nonalcoholic fatty liver disease among overweight and obese subjects","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.ejso.2013.06.023","article-title":"High preoparative levels of serum periostin are associated with poor prognosis in patients with hepatocellular carcinoma after hepatectomy","volume":"39","author":"Lv","year":"2013","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3892\/ol.2017.6250","article-title":"Clustering of patients with intrahepatic cholangiocarcinoma based on serum periostin may be predictive of prognosis","volume":"14","author":"Thuwajit","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s40618-017-0820-x","article-title":"Increased serum periostin concentrations are associated with the presence of diabetic retinopathy in patients with type 2 diabetes mellitus","volume":"41","author":"Ding","year":"2018","journal-title":"J. Endocrinol. Investig."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/MPG.0000000000002957","article-title":"Proton-pump Inhibitor Response Prediction Using Esophageal microRNAs in Children With Eosinophilic Esophagitis","volume":"71","author":"Tabares","year":"2020","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"548","DOI":"10.2174\/138920208786847917","article-title":"Periostin as a heterofunctional regulator of cardiac development and disease","volume":"9","author":"Conway","year":"2008","journal-title":"Curr. Genom."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1007\/s00018-011-0784-5","article-title":"Periostin in fibrillogenesis for tissue regeneration: Periostin actions inside and outside the cell","volume":"68","author":"Kudo","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"11450","DOI":"10.1038\/s41598-018-29612-2","article-title":"Periostin as a novel biomarker for postoperative recurrence of chronic rhinosinitis with nasal polyps","volume":"8","author":"Ninomiya","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/all.12644","article-title":"Novel scoring system and algorithm for classifying chronic rhinosinusitis: The JESREC Study","volume":"70","author":"Tokunaga","year":"2015","journal-title":"Allergy"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2147\/PROM.S144425","article-title":"Impact of novel antifibrotic therapy on patient outcomes in idiopathic pulmonary fibrosis: Patient selection and perspectives","volume":"9","author":"Graney","year":"2018","journal-title":"Patient Relat. Outcome Meas."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.pupt.2017.08.011","article-title":"Safety and efficacy of pirfenidone in severe Idiopathic Pulmonary Fibrosis: A real-world observational study","volume":"46","author":"Tzouvelekis","year":"2017","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"262","DOI":"10.21037\/atm.2019.05.33","article-title":"A retrospective study of the tolerability of nintedanib for severe idiopathic pulmonary fibrosis in the real world","volume":"7","author":"Nakamura","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.rmed.2010.03.012","article-title":"IPF: New insight in diagnosis and prognosis","volume":"104","author":"Caminati","year":"2010","journal-title":"Respir. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1164\/rccm.200209-1112OC","article-title":"Prognostic implications of physiologic and radiographic changes in idiopathic interstitial pneumonia","volume":"168","author":"Flaherty","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21037\/atm-21-414","article-title":"Association of serum monomeric periostin level with outcomes of acute exacerbation of idiopathic pulmonary fibrosis and fibrosing nonspecific interstitial pneumoni","volume":"9","author":"Shimizu","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S2213-2600(20)30355-6","article-title":"Progressive fibrosing interstitial lung disease: Clinical uncertainties, consensus recommendations, and research priorities","volume":"8","author":"George","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1136\/bjophthalmol-2014-305321","article-title":"Overexpression of CD163 in vitreous and fibrovascular membranes of patients with proliferative diabetic retinopathy: Possible involvement of periostin","volume":"99","author":"Kobayashi","year":"2015","journal-title":"Br. J. Ophthalmol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1167\/iovs.10-6625","article-title":"Increased expression of periostin in vitreous and fibrovascular membranes obtained from patients with proliferative diabetic retinopathy","volume":"52","author":"Yoshida","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1096\/fj.13-229740","article-title":"Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy","volume":"28","author":"Ishikawa","year":"2014","journal-title":"FASEB J."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2332\/allergolint.13-RAI-0673","article-title":"Expressions and roles of periostin in otolaryngological diseases","volume":"63","author":"Ohta","year":"2014","journal-title":"Allergol. Int."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.jaci.2020.08.007","article-title":"Heterogeneity of lower airway inflammation in patients with NSAID-exacerbated respiratory disease","volume":"147","author":"Jakiela","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1159\/000494623","article-title":"Elevated Periostin Concentrations in the Bronchoalveolar Lavage Fluid of Patients with Eosinophilic Pneumonia","volume":"178","author":"Nakagome","year":"2019","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_147","first-page":"208","article-title":"Elevated levels of periostin and TGF-\u03b21 in the bronchoalveolar lavage fluid of patients with idiopathic eosinophilic pneumonia","volume":"38","author":"Katoh","year":"2020","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2500\/aap.2021.42.200102","article-title":"Diagnostic value of thymus and activation-regulated chemokine and of periostin in eosinophilic asthma: A prospective study","volume":"42","author":"Yormaz","year":"2020","journal-title":"Allergy Asthma Proc."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Refaat, M.M., el Sayed, E., El-Fattah, W.A., Elbanna, A.H., and Sayed, H.M.E. (2020). Relationship between sputum periostin level and inflammatory asthma phenotypes in Egyptian patients. J. Asthma, 1\u20137.","DOI":"10.1080\/02770903.2020.1786111"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"100078","DOI":"10.1016\/j.waojou.2019.100078","article-title":"Distinct profile of inflammatory and remodelling biomarkers in sputum of severe asthmatic patients with or without persistent airway obstruction","volume":"12","author":"Cianchetti","year":"2019","journal-title":"World Allergy Organ. J."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/all.12580","article-title":"Sputum periostin in patients with different severe asthma phenotypes","volume":"70","author":"Bobolea","year":"2015","journal-title":"Allergy"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Kurokawa, R., Kanemitsu, Y., Fukumitsu, K., Takeda, N., Yap, J.M., Ozawa, Y., Masaki, A., Ono, J., Izuhara, K., and Nishiyama, H. (2021). Nasal polyp eosinophilia and FeNO may predict asthma symptoms development after endoscopic sinus surgery in CRS patients without asthma. J. Asthma, 1\u20139.","DOI":"10.1080\/02770903.2021.1897837"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"100094","DOI":"10.1016\/j.waojou.2019.100094","article-title":"A novel pathophysiologic link between upper and lower airways in patients with chronic rhinosinusitis: Association of sputum periostin levels with upper airway inflammation and olfactory function","volume":"13","author":"Kanemitsu","year":"2020","journal-title":"World Allergy Organ. J."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.chest.2018.08.1032","article-title":"Looking for Airways Periostin in Severe Asthma: Could It Be Useful for Clustering Type 2 Endotype?","volume":"154","author":"Carpagnano","year":"2018","journal-title":"Chest"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"124","DOI":"10.20452\/pamw.3299","article-title":"Comparative study of periostin expression in different respiratory samples in patients with asthma and chronic obstructive pulmonary disease","volume":"126","author":"Krenke","year":"2016","journal-title":"Pol. Arch. Med. Wewn."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2147\/JAA.S230892","article-title":"Confounding Patient Factors Affecting the Proper Interpretation of the Periostin Level as a Biomarker in Asthma Development","volume":"13","author":"Hachim","year":"2020","journal-title":"J. Asthma Allergy"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4103\/jisp.jisp_239_17","article-title":"Periostin levels in saliva of patients with chronic periodontitis","volume":"22","author":"Esfahrood","year":"2018","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_158","first-page":"986","article-title":"Crevicular Fluid and Salivary Periostin Levels in Non-Smoker Subjects With Chronic and Aggressive Periodontitis: Periostin Levels in Chronic and Aggressive Periodontitis","volume":"39","author":"Aral","year":"2016","journal-title":"Inflammation"},{"key":"ref_159","first-page":"e7218","article-title":"Comparative Evaluation of Serum and Gingival Crevicular Fluid Periostin Levels in Periodontal Health and Disease: A Biochemical Study","volume":"12","author":"Sophia","year":"2020","journal-title":"Cureus"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1136\/jim-2019-001135","article-title":"Assessment of two novel renal tubular proteins in type 2 diabetic patients with nephropathy","volume":"68","author":"Ghafar","year":"2020","journal-title":"J. Investig. Med."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1159\/000452228","article-title":"Urinary Periostin Excretion Predicts Renal Outcome in IgA Nephropathy","volume":"44","author":"Hwang","year":"2016","journal-title":"Am. J. Nephrol."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Satirapoj, B., Tassanasorn, S., Charoenpitakchai, M., and Supasyndh, O. (2015). Periostin as a tissue and urinary biomarker of renal injury in type 2 diabetes mellitus. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0124055"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.transproceed.2013.07.069","article-title":"Urine periostin as a biomarker of renal injury in chronic allograft nephropathy","volume":"46","author":"Satirapoj","year":"2014","journal-title":"Transplant. Proc."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.alit.2016.12.004","article-title":"Japanese guidelines for allergic conjunctival diseases 2017","volume":"66","author":"Takamura","year":"2017","journal-title":"Allergol. Int."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13167-016-0065-3","article-title":"Tear fluid biomarkers in ocular and systemic disease: Potential use for predictive, preventive and personalised medicine","volume":"7","author":"Hagan","year":"2016","journal-title":"EPMA J."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0021-5155(02)00630-5","article-title":"Efficacy of tear eosinophil cationic protein level measurement using filter paper for diagnosing allergic conjunctival disorders","volume":"47","author":"Shoji","year":"2003","journal-title":"JPN J. Ophthalmol."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Gottlow, M., Svensson, D.J., Lipkovich, I., Huhn, M., Bowen, K., Wessman, P., and Colice, G. (2019). Application of structured statistical analyses to identify a biomarker predictive of enhanced tralokinumab efficacy in phase III clinical trials for severe, uncontrolled asthma. BMC Pulm. Med., 19.","DOI":"10.1186\/s12890-019-0889-4"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1183\/09031936.00202013","article-title":"International ERS\/ATS guidelines on definition, evaluation and treatment of severe asthma","volume":"43","author":"Chung","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1183\/13993003.00779-2015","article-title":"Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort","volume":"46","author":"Shaw","year":"2015","journal-title":"Eur. Respir. J."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"240","DOI":"10.5114\/ada.2020.94842","article-title":"Serum periostin levels in asthma patients in relation to omalizumab therapy and presence of chronic rhinosinusitis with nasal polyps","volume":"37","author":"Novosad","year":"2020","journal-title":"Postepy Dermatol. Alergol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/cea.12220","article-title":"The effects of lebrikizumab in patients with mild asthma following whole lung allergen challenge","volume":"44","author":"Scheerens","year":"2014","journal-title":"Clin. Exp. Allergy"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"152","DOI":"10.4193\/Rhin16.314","article-title":"The effect of systemic treatments on periostin expression reflects their interference with the eosinophilic inflammation in chronic rhinosinusitis with nasal polyps","volume":"55","author":"Derycke","year":"2017","journal-title":"Rhinology"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1111\/all.12922","article-title":"Utility of serum periostin and free IgE levels in evaluating responsiveness to omalizumab in patients with severe asthma","volume":"71","author":"Tajiri","year":"2016","journal-title":"Allergy"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1164\/rccm.201704-0784OC","article-title":"A Phase 2 Randomized Controlled Study of Tralokinumab in Subjects with Idiopathic Pulmonary Fibrosis","volume":"197","author":"Parker","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S2213-2600(18)30185-1","article-title":"Prognostic and predictive biomarkers for patients with idiopathic pulmonary fibrosis treated with pirfenidone: Post-hoc assessment of the CAPACITY and ASCEND trials","volume":"6","author":"Neighbors","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12931-016-0328-5","article-title":"Pirfenidone and nintedanib modulate properties of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis","volume":"17","author":"Lehtonen","year":"2016","journal-title":"Respir. Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.alit.2015.04.001","article-title":"No increase in the serum periostin level is detected in elementary school-age children with allergic diseases","volume":"64","author":"Inoue","year":"2015","journal-title":"Allergol. Int."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bone.2017.03.041","article-title":"Effect of age and gender on serum periostin: Relationship to cortical measures, bone turnover and hormones","volume":"99","author":"Walsh","year":"2017","journal-title":"Bone"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.alit.2017.11.006","article-title":"Serum periostin is associated with body mass index and allergic rhinitis in healthy and asthmatic subjects","volume":"67","author":"Kimura","year":"2018","journal-title":"Allergol. Int."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ijporl.2016.12.013","article-title":"Serum periostin level is not associated with allergic rhinitis or allergic sensitization in Korean children","volume":"93","author":"Kim","year":"2017","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000501224","article-title":"Serum Periostin Level Has Limited Usefulness as a Biomarker for Allergic Disease in 7-Year-Old Children","volume":"180","author":"Sung","year":"2019","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13223-017-0182-0","article-title":"Day-time variation of serum periostin in asthmatic adults treated with ICS\/LABA and adults without asthma","volume":"13","author":"Cripps","year":"2017","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"100004","DOI":"10.1016\/j.waojou.2018.11.004","article-title":"Serum levels of periostin and exercise-induced bronchoconstriction in asthmatic children","volume":"12","author":"Cho","year":"2019","journal-title":"World Allergy Organ. J."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/all.12599","article-title":"Serum periostin levels correlate with airway hyper-responsiveness to methacholine and mannitol in children with asthma","volume":"70","author":"Song","year":"2015","journal-title":"Allergy"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.alit.2019.02.007","article-title":"Periostin as a predictor of prognosis in chronic bird-related hypersensitivity pneumonitis","volume":"68","author":"Nukui","year":"2019","journal-title":"Allergol. Int."},{"key":"ref_186","unstructured":"Nakamura, Y., Yokoyama, Y., Nakajima, K., Enomoto, T., Fujiwara, K., and Takeuchi, H. (2020). Serum periostin levels in adolescents. Asian Pac. J. Allergy Immunol., 1\u20136."},{"key":"ref_187","first-page":"5141","article-title":"Expression and clinical significance of periostin in oral lichen planus","volume":"15","author":"Zhang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4168\/aair.2017.9.2.126","article-title":"Periostin in Exhaled Breath Condensate and in Serum of Asthmatic Patients: Relationship to Upper and Lower Airway Disease","volume":"9","author":"Makowska","year":"2017","journal-title":"Allergy Asthma Immunol. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bone.2019.04.023","article-title":"Tartrate-resistant acid phosphatase 5b, but not periostin, is useful for assessing Paget\u2019s disease of bone","volume":"124","author":"Filella","year":"2019","journal-title":"Bone"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bone.2019.01.004","article-title":"Serum periostin levels and severity of fibrous dysplasia of bone","volume":"121","author":"Lemaire","year":"2019","journal-title":"Bone"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1800938","DOI":"10.1183\/13993003.00938-2018","article-title":"T2-high in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin","volume":"53","author":"Pavlidis","year":"2019","journal-title":"Eur. Respir. J."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1111\/cea.12763","article-title":"Reference ranges for serum periostin in a population without asthma or chronic obstructive pulmonary disease","volume":"46","author":"Hosking","year":"2016","journal-title":"Clin. Exp. Allergy"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/bjd.17698","article-title":"Fibroblast activation and abnormal extracellular matrix remodelling as common hallmarks in three cancer-prone genodermatoses","volume":"181","author":"Conti","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Kalinauskaite-Zukauske, V., Januskevicius, A., Janulaityte, I., Miliauskas, S., and Malakauskas, K. (2019). Expression of eosinophil \u03b2 chain-signaling cytokines receptors, outer-membrane integrins, and type 2 inflammation biomarkers in severe non-allergic eosinophilic asthma. BMC Pulm. Med., 19.","DOI":"10.1186\/s12890-019-0904-9"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00508-018-1386-0","article-title":"Rheumatoid arthritis in remission: Decreased myostatin and increased serum levels of periostin","volume":"131","author":"Ebenbichler","year":"2019","journal-title":"Wien. Klin. Wochenschr."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Yuan, D., Yao, Y., Sun, W., Shi, Y., and Su, X. (2017). Predictive and prognostic value of serum periostin in advanced non-small cell lung cancer patients receiving chemotherapy. Tumour. Biol., 39.","DOI":"10.1177\/1010428317698367"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.lungcan.2011.10.013","article-title":"Characterization of periostin isoform pattern in non-small cell lung cancer","volume":"76","author":"Morra","year":"2012","journal-title":"Lung Cancer"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/8\/1084\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:33:31Z","timestamp":1760164411000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/8\/1084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,22]]},"references-count":197,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["biom11081084"],"URL":"https:\/\/doi.org\/10.3390\/biom11081084","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,22]]}}}