{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:02:42Z","timestamp":1767988962659,"version":"3.49.0"},"reference-count":46,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006334","name":"Uniwersytet Jana Kochanowskiego w Kielcach","doi-asserted-by":"publisher","award":["SUPB.RN.21.130"],"award-info":[{"award-number":["SUPB.RN.21.130"]}],"id":[{"id":"10.13039\/501100006334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Galectin-3 (gal-3) is a fibrosis marker and may play a role in fibrosis of the left atrium (LA). Left atrial wall fibrosis may influence the transition from paroxysmal to non-paroxysmal atrial fibrillation (AF). In this study, we assessed the correlation of gal-3 concentration with the main echocardio-graphic parameters evaluating dimensions, volume, compliance, and left atrial contractility during AF and after successful electrical cardioversion (DCCV). The study included 63 patients with left atrial enlargement who qualified for DCCV due to persistent AF. The procedure recovered sinus rhythm in 43 (68.3%) patients. The concentration of gal-3 was negatively correlated with the echocardiographic parameters of LA including dimensions (LA length pre, rho = \u22120.38; p = 0.003), volume (LAV pre, rho = \u22120.39; p = 0.003), compliance (LASr mean post, rho = \u22120.33) and contractility (pLASRct mean post, rho = \u22120.33; p = 0.038). Negative correlations of gal-3 concentration were also observed in relation to the volume and contractility of the left ventricle. The concentration of gal-3 significantly negatively correlates with the size, systolic function, and compliance of the LA wall in patients with persistent AF. Determining gal-3 concentration in patients with persistent AF may help in the assessment of remodeling of the LA wall.<\/jats:p>","DOI":"10.3390\/biom11081108","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T05:23:48Z","timestamp":1627449828000},"page":"1108","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Analysis of the Correlation of Galectin-3 Concentration with the Measurements of Echocardiographic Parameters Assessing Left Atrial Remodeling and Function in Patients with Persistent Atrial Fibrillation"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0632-6573","authenticated-orcid":false,"given":"Pawe\u0142","family":"Wa\u0142ek","sequence":"first","affiliation":[{"name":"Collegium Medicum, The Jan Kochanowski University, 25-317 Kielce, Poland"},{"name":"1st Clinic of Cardiology and Electrotherapy, Swietokrzyskie Cardiology Centre, 25-736 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urszula","family":"Grabowska","sequence":"additional","affiliation":[{"name":"Collegium Medicum, The Jan Kochanowski University, 25-317 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Cie\u015bla","sequence":"additional","affiliation":[{"name":"Collegium Medicum, The Jan Kochanowski University, 25-317 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Sielski","sequence":"additional","affiliation":[{"name":"Collegium Medicum, The Jan Kochanowski University, 25-317 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9658-5909","authenticated-orcid":false,"given":"Joanna","family":"Roskal-Wa\u0142ek","sequence":"additional","affiliation":[{"name":"Collegium Medicum, The Jan Kochanowski University, 25-317 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Wo\u017cakowska-Kap\u0142on","sequence":"additional","affiliation":[{"name":"Collegium Medicum, The Jan Kochanowski University, 25-317 Kielce, Poland"},{"name":"1st Clinic of Cardiology and Electrotherapy, Swietokrzyskie Cardiology Centre, 25-736 Kielce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.disamonth.2012.12.002","article-title":"Atrial fibrillation","volume":"59","author":"Wadke","year":"2013","journal-title":"Dis. Mon."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.ijcard.2012.12.093","article-title":"Atrial fibrillation: Profile and burden of an evolving epidemic in the 21st century","volume":"167","author":"Ball","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.113.005119","article-title":"Worldwide epidemiology of atrial fibrillation: A Global Burden of Disease 2010 Study","volume":"129","author":"Chugh","year":"2014","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.amjcard.2013.05.063","article-title":"Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population","volume":"112","author":"Colilla","year":"2013","journal-title":"Am. J. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1093\/eurheartj\/eht280","article-title":"Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060","volume":"34","author":"Krijthe","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_6","first-page":"213","article-title":"Epidemiology of atrial fibrillation: European perspective","volume":"6","author":"Lercari","year":"2014","journal-title":"Clin. Epidemiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/CIRCOUTCOMES.110.958165","article-title":"Estimation of total incremental health care costs in patients with atrial fibrillation in the United States","volume":"4","author":"Kim","year":"2011","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1097\/01.ede.0000091649.26364.c0","article-title":"Rising rates of hospital admissions for atrial fibrillation","volume":"14","author":"Friberg","year":"2003","journal-title":"Epidemiology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ijcard.2004.08.024","article-title":"Trends in incidence and mortality in the hospital diagnosis of atrial fibrillation or flutter in Denmark, 1980\u20131999","volume":"103","author":"Frost","year":"2005","journal-title":"Int. J. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0002-8703(03)00524-6","article-title":"Cost of care distribution in atrial fibrillation patients: The COCAF study","volume":"147","author":"Paziaud","year":"2004","journal-title":"Am. Heart J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1053\/euhj.2000.2511","article-title":"Trends in hospital activity, morbidity and case fatality related to atrial fibrillation in Scotland, 1986\u20131996","volume":"22","author":"Stewart","year":"2001","journal-title":"Eur. Heart J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1136\/hrt.2002.008748","article-title":"Cost of an emerging epidemic: An economic analysis of atrial fibrillation in the UK","volume":"90","author":"Stewart","year":"2004","journal-title":"Heart"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.exer.2010.11.009","article-title":"Focus on molecules: Galectin-3","volume":"92","author":"Argueso","year":"2011","journal-title":"Exp. Eye Res."},{"key":"ref_14","first-page":"599","article-title":"Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review)","volume":"41","author":"Dong","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/eurjhf\/hfp097","article-title":"Galectin-3: A novel mediator of heart failure development and progression","volume":"11","author":"Voors","year":"2009","journal-title":"Eur. J. Heart Fail"},{"key":"ref_16","first-page":"305","article-title":"Galectin-3 as a multifunctional protein","volume":"9","author":"Krzeslak","year":"2004","journal-title":"Cell Mol. Biol. Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11897-010-0004-x","article-title":"Galectin-3 in cardiac remodeling and heart failure","volume":"7","author":"Yu","year":"2010","journal-title":"Curr. Heart Fail Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0304-4165(99)00177-4","article-title":"Secretion of the galectin family of mammalian carbohydrate-binding proteins","volume":"1473","author":"Hughes","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"H404","DOI":"10.1152\/ajpheart.00747.2008","article-title":"N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion\/growth-regulatory lectin","volume":"296","author":"Liu","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1093\/eurjhf\/hfq091","article-title":"Galectin-3, cardiac structure and function, and long-term mortality in patients with acutely decompensated heart failure","volume":"12","author":"Shah","year":"2010","journal-title":"Eur. J. Heart Fail"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1161\/01.CIR.0000147181.65298.4D","article-title":"Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction","volume":"110","author":"Sharma","year":"2004","journal-title":"Circulation"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clinbiochem.2016.09.008","article-title":"Circulating biomarkers of fibrosis and cardioversion of atrial fibrillation: A prospective, controlled cohort study","volume":"50","author":"Begg","year":"2017","journal-title":"Clin. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ipej.2018.07.003","article-title":"Predictors of the paroxysmal atrial fibrillation recurrence following cryoballoon-based pulmonary vein isolation: Assessment of left atrial volume, left atrial volume index, galectin-3 level and neutrophil-to-lymphocyte ratio","volume":"19","author":"Celik","year":"2019","journal-title":"Indian Pacing Electrophysiol. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"34357","DOI":"10.1038\/srep34357","article-title":"Serum Galectin-3 Levels Predict Recurrences after Ablation of Atrial Fibrillation","volume":"6","author":"Clementy","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_25","first-page":"564","article-title":"Serum galectin-3 level predicts early recurrence following successful direct-current cardioversion in persistent atrial fibrillation patients","volume":"47","author":"Gurses","year":"2019","journal-title":"Turk. Kardiyol. Dern. Ars."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.amjcard.2014.12.021","article-title":"Effects of persistent atrial fibrillation on serum galectin-3 levels","volume":"115","author":"Gurses","year":"2015","journal-title":"Am. J. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Kornej, J., Schmidl, J., Ueberham, L., John, S., Daneschnejad, S., Dinov, B., Hindricks, G., Adams, V., Husser, D., and Bollmann, A. (2015). Galectin-3 in patients with atrial fibrillation undergoing radiofrequency catheter ablation. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0123574"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1093\/europace\/euaa135","article-title":"The prognostic value of soluble suppression of tumourigenicity 2 and galectin-3 for sinus rhythm maintenance after cardioversion due to persistent atrial fibrillation in patients with normal left ventricular systolic function","volume":"22","author":"Walek","year":"2020","journal-title":"Europace"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1093\/europace\/euv045","article-title":"Plasma galectin-3 predicts clinical outcomes after catheter ablation in persistent atrial fibrillation patients without structural heart disease","volume":"17","author":"Wu","year":"2015","journal-title":"Europace"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/jce.12637","article-title":"The Association of Serum Galectin-3 Levels with Atrial Electrical and Structural Remodeling","volume":"26","author":"Yalcin","year":"2015","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4148129","DOI":"10.1155\/2019\/4148129","article-title":"Circulating Galectin-3 and Atrial Fibrillation Recurrence after Catheter Ablation: A Meta-Analysis","volume":"2019","author":"Zhang","year":"2019","journal-title":"Cardiovasc Ther."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Begg, G.A., Karim, R., Oesterlein, T., Graham, L.N., Hogarth, A.J., Page, S.P., Pepper, C.B., Rhode, K., Lip, G.Y.H., and Holden, A.V. (2018). Left atrial voltage, circulating biomarkers of fibrosis, and atrial fibrillation ablation. A prospective cohort study. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0189936"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sethi, A., Sanam, S., Alvala, R., and Alvala, M. (2021). An updated patent review of galectin-1 and galectin-3 inhibitors and their potential therapeutic applications (2016-present). Expert Opin. Ther. Pat., 1\u201313.","DOI":"10.1080\/13543776.2021.1903430"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jacbts.2016.03.003","article-title":"Galectin-3 Regulates Atrial Fibrillation Remodeling and Predicts Catheter Ablation Outcomes","volume":"1","author":"Takemoto","year":"2016","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1093\/europace\/euw295","article-title":"2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS","volume":"18","author":"Kirchhof","year":"2016","journal-title":"Europace"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur. Heart J. Cardiovasc Imaging"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/ehjci\/jew082","article-title":"Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"17","author":"Nagueh","year":"2016","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/ehjci\/jey042","article-title":"Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: A consensus document of the EACVI\/ASE\/Industry Task Force to standardize deformation imaging","volume":"19","author":"Badano","year":"2018","journal-title":"Eur. Heart J. Cardiovasc Imaging"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ajem.2020.05.051","article-title":"When should we measure biomarkers in patients with atrial fibrillation to predict recurrences?","volume":"39","year":"2021","journal-title":"Am. J. Emerg. Med."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Wang, Q., Xu, L., Dong, Y., Fu, Y., Pan, Y., Luan, Q., Liu, Y., Liu, Z., Yang, X., and Chen, M. (2021). Plasma Galectin-3 is associated with progression from paroxysmal to persistent atrial fibrillation. BMC Cardiovasc. Disord., 21.","DOI":"10.1186\/s12872-021-02043-0"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ahj.2017.07.001","article-title":"Galectin-3 and incidence of atrial fibrillation: The Atherosclerosis Risk in Communities (ARIC) study","volume":"192","author":"Fashanu","year":"2017","journal-title":"Am. Heart J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3343\/alm.2018.38.4.306","article-title":"Galectin-3 Reflects the Echocardiographic Grades of Left Ventricular Diastolic Dysfunction","volume":"38","author":"Ansari","year":"2018","journal-title":"Ann. Lab. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.sleep.2021.03.039","article-title":"Galectin-3 and neutrophil-to-lymphocyte ratio are indicative of heart remodelling and disease severity in patients with obstructive sleep apnoea","volume":"82","author":"Cicco","year":"2021","journal-title":"Sleep Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"40378","DOI":"10.1038\/srep40378","article-title":"Galectin-3 as a marker of interstitial atrial remodelling involved in atrial fibrillation","volume":"7","author":"Vilchez","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1093\/europace\/eux090","article-title":"The change in circulating galectin-3 predicts absence of atrial fibrillation after thoracoscopic surgical ablation","volume":"20","author":"Berger","year":"2018","journal-title":"Europace"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.hlc.2018.05.094","article-title":"Circulating Galectin-3 is Associated With Left Atrial Appendage Remodelling and Thrombus Formation in Patients With Atrial Fibrillation","volume":"28","author":"Tang","year":"2019","journal-title":"Heart Lung Circ."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/8\/1108\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:35:58Z","timestamp":1760164558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/8\/1108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,28]]},"references-count":46,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["biom11081108"],"URL":"https:\/\/doi.org\/10.3390\/biom11081108","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,28]]}}}