{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:02:45Z","timestamp":1792587765691,"version":"4.5.0"},"reference-count":30,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["PROCAD AMAZ\u00d4NIA 88881.200581\/201801"],"award-info":[{"award-number":["PROCAD AMAZ\u00d4NIA 88881.200581\/201801"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","award":["FAPEAM - Pr\u00f3-Estado Program"],"award-info":[{"award-number":["FAPEAM - Pr\u00f3-Estado Program"]}],"id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are viruses globally distributed that have been associated with the development and prognosis of many pathologies, including hematological diseases. This study aimed to characterize the epidemiological profile of EBV infection and the infection-correlated hepatic manifestations in patients with hematological diseases of the northern Brazilian state of Amazonas. A total of 228 patients were serologically tested for the presence of anti-EBV and anti-CMV IgG antibodies through an enzyme-linked immunosorbent assay. The coinfection with CMV, sociodemographic and laboratory records of all patients were also assessed. The overall prevalence observed among the study population for EBV infection and EBV\/CMV coinfection was 85.09% (95% CI: 0.80\u20130.90) and 78.51% (95% CI: 0.73\u20130.84), respectively. The age group 31\u201340 years old were more susceptible to EBV\/CMV coinfection (95% CI: 1.59\u201393.41, p = 0.011), while young people aged 1\u201310 years old were less affected for both EBV infection (CI 95%; 0.66\u20130.91, p = 0.001) and EBV\/CMV coinfection (95% CI: 0.52\u20130.81, p &lt; 0.0001). High serum levels of the liver biomarker ferritin were associated with EBV infection (95% CI: 1.03\u20131.54, p = 0.031) and EBV\/CMV coinfection (95% CI: 1.02\u20131.70, p = 0.038). Our findings indicated that the elevated prevalence of EBV infection is not associated with the hematological diseases or transfusion rates, but with the socioeconomic status of the study population. Also, this study suggests that the EBV infection and its coinfection with CMV are related to the increase of serum ferritin levels.<\/jats:p>","DOI":"10.3390\/biom11081151","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T08:47:52Z","timestamp":1628066872000},"page":"1151","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Epidemiological and Liver Biomarkers Profile of Epstein-Barr Virus Infection and Its Coinfection with Cytomegalovirus in Patients with Hematological Diseases"],"prefix":"10.3390","volume":"11","author":[{"given":"Lilian","family":"Ferrari de Freitas","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Hematologia, Universidade do Estado do Amazonas, Manaus 69050-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"de Melo Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Imunologia B\u00e1sica e Aplicada, Universidade Federal do Amazonas (UFAM), Manaus 69067-005, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6112-6190","authenticated-orcid":false,"given":"Anderson","family":"Nogueira Barbosa","sequence":"additional","affiliation":[{"name":"Coordena\u00e7\u00e3o Sociedade, Ambiente e Sa\u00fade, Laborat\u00f3rio de Virologia e Imunologia, Instituto Nacional de Pesquisa da Amaz\u00f4nia (INPA), Manaus 69067-375, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Miranda Santos","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Hematologia, Universidade do Estado do Amazonas, Manaus 69050-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Pinheiro-Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Hematologia, Universidade do Estado do Amazonas, Manaus 69050-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemilson","family":"Soares Pontes","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Hematologia, Universidade do Estado do Amazonas, Manaus 69050-010, Brazil"},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Imunologia B\u00e1sica e Aplicada, Universidade Federal do Amazonas (UFAM), Manaus 69067-005, Brazil"},{"name":"Coordena\u00e7\u00e3o Sociedade, Ambiente e Sa\u00fade, Laborat\u00f3rio de Virologia e Imunologia, Instituto Nacional de Pesquisa da Amaz\u00f4nia (INPA), Manaus 69067-375, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1182\/asheducation-2007.1.204","article-title":"Epstein-barr virus and hodgkin lymphoma","volume":"2007","author":"Ambinder","year":"2007","journal-title":"Hematol. 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