{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:29:02Z","timestamp":1791408542617,"version":"4.3.3"},"reference-count":165,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T00:00:00Z","timestamp":1628899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Hyperbaric oxygen therapy (HBOT) is commonly used as treatment in several diseases, such as non-healing chronic wounds, late radiation injuries and carbon monoxide poisoning. Ongoing research into HBOT has shown that preconditioning for surgery is a potential new treatment application, which may reduce complication rates and hospital stay. In this review, the effect of HBOT on oxidative stress, inflammation and angiogenesis is investigated to better understand the potential mechanisms underlying preconditioning for surgery using HBOT. A systematic search was conducted to retrieve studies measuring markers of oxidative stress, inflammation, or angiogenesis in humans. Analysis of the included studies showed that HBOT-induced oxidative stress reduces the concentrations of pro-inflammatory acute phase proteins, interleukins and cytokines and increases growth factors and other pro-angiogenesis cytokines. Several articles only noted this surge after the first HBOT session or for a short duration after each session. The anti-inflammatory status following HBOT may be mediated by hyperoxia interfering with NF-\u03baB and I\u03baB\u03b1. Further research into the effect of HBOT on inflammation and angiogenesis is needed to determine the implications of these findings for clinical practice.<\/jats:p>","DOI":"10.3390\/biom11081210","type":"journal-article","created":{"date-parts":[[2021,8,15]],"date-time":"2021-08-15T21:43:55Z","timestamp":1629063835000},"page":"1210","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":132,"title":["The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis"],"prefix":"10.3390","volume":"11","author":[{"given":"Silke D.","family":"De Wolde","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The Netherlands"},{"name":"Department of Hyperbaric Medicine, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick H.","family":"Hulskes","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The Netherlands"},{"name":"Department of Surgery, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3079-4115","authenticated-orcid":false,"given":"Robert P.","family":"Weenink","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The Netherlands"},{"name":"Department of Hyperbaric Medicine, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus W.","family":"Hollmann","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Van Hulst","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The Netherlands"},{"name":"Department of Hyperbaric Medicine, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,14]]},"reference":[{"key":"ref_1","unstructured":"Moon, R. (2019). Hyperbaric Oxygen Therapy Indications, Best Publishing Company. [14th ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1056\/NEJM199606203342506","article-title":"Hyperbaric-oxygen therapy","volume":"334","author":"Tibbles","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.22462\/01.02.2018.19","article-title":"UHMS Guidelines for credentialing, privileging and supervision of hyperbaric oxygen therapy in the U.S.A","volume":"45","author":"Society","year":"2018","journal-title":"Undersea Hyperb. Med."},{"key":"ref_4","first-page":"2899","article-title":"Preconditioning with hyperbaric oxygen in pancreaticoduodenectomy: A randomized double-blind pilot study","volume":"34","author":"Bosco","year":"2014","journal-title":"Anticancer Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e2417","DOI":"10.1097\/GOX.0000000000002417","article-title":"Hyperbaric oxygen preconditioning can reduce postabdominoplasty complications: A retrospective cohort study","volume":"7","author":"Friedman","year":"2019","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1053\/j.jvca.2011.06.017","article-title":"Preconditioning with repeated hyperbaric oxygen induces myocardial and cerebral protection in patients undergoing coronary artery bypass graft surgery: A prospective, randomized, controlled clinical trial","volume":"25","author":"Li","year":"2011","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.carrev.2009.03.004","article-title":"Hyperbaric oxygen preconditioning improves myocardial function, reduces length of intensive care stay, and limits complications post coronary artery bypass graft surgery","volume":"11","author":"Yogaratnam","year":"2010","journal-title":"Cardiovasc. Revascularization Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/MCC.0b013e3283632f77","article-title":"The long-term effects of postoperative complications","volume":"19","author":"Toner","year":"2013","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e007224","DOI":"10.1136\/bmjopen-2014-007224","article-title":"Surgical complications and their impact on patients\u2019 psychosocial well-being: A systematic review and meta-analysis","volume":"6","author":"Pinto","year":"2016","journal-title":"BMJ Open"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1177\/1077558710396378","article-title":"Excess costs attributable to postoperative complications","volume":"68","author":"Carey","year":"2011","journal-title":"Med. Care Res. Rev."},{"key":"ref_11","first-page":"247","article-title":"Mechanisms of action of hyperbaric oxygen therapy","volume":"41","author":"Camporesi","year":"2014","journal-title":"Undersea Hyperb. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1089\/ars.2014.5940","article-title":"Hyperbaric oxygen, vasculogenic stem cells, and wound healing","volume":"21","author":"Fosen","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.clinbiochem.2005.09.001","article-title":"The effects of hyperbaric oxygen treatment on oxidative stress and SCE frequencies in humans","volume":"38","author":"Eken","year":"2005","journal-title":"Clin. Biochem."},{"key":"ref_15","first-page":"111","article-title":"Genotoxicity of hyperbaric oxygen","volume":"512","author":"Speit","year":"2002","journal-title":"Mutat. Res. Mol. Mech. Mutagen."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3103\/S009639251804003X","article-title":"Role of reactive oxygen species in inflammation: A minireview","volume":"73","author":"Chelombitko","year":"2018","journal-title":"Mosc. Univ. Biol. Sci. Bull."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1524-475X.1997.50206.x","article-title":"Dose-dependent hyperbaric oxygen stimulation of human fibroblast proliferation","volume":"5","author":"Hehenberger","year":"1997","journal-title":"Wound Repair Regen."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.burns.2016.10.016","article-title":"Adjunctive hyperbaric oxygen therapy in severe burns: Experience in Taiwan formosa water park dust explosion disaster","volume":"43","author":"Chiang","year":"2017","journal-title":"Burns"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1046\/j.1524-475x.1999.00053.x","article-title":"Effect of hyperbaric oxygen on human skin cells in culture and in human dermal and skin equivalents","volume":"7","author":"Dimitrijevich","year":"1999","journal-title":"Wound Repair Regen."},{"key":"ref_20","first-page":"3833","article-title":"Hyperbaric oxygen inhibits benign and malignant human mammary epithelial cell proliferation","volume":"25","author":"Granowitz","year":"2005","journal-title":"Anticancer Res."},{"key":"ref_21","first-page":"143","article-title":"Effects of a single hyperbaric oxygen exposure on haematocrit, prothrombin time, serum calcium, and platelet count","volume":"37","author":"Hibbs","year":"2007","journal-title":"Diving Hyperb. Med. South Pac. Underw. Med. Soc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1023\/A:1010145312698","article-title":"The influence of hyperbaric oxygenation (HBO) on proliferation and differentiation of human keratinocyte cultures in vitro","volume":"1","author":"Hollander","year":"2000","journal-title":"Cell Tissue Bank."},{"key":"ref_23","first-page":"305","article-title":"Lack of toxic side effects in neutrophils following hyperbaric oxygen","volume":"30","author":"Scheinichen","year":"2003","journal-title":"Undersea Hyperb. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1524-475X.2007.00215.x","article-title":"Hyperbaric oxygen stimulates epidermal reconstruction in human skin equivalents","volume":"15","author":"Kairuz","year":"2007","journal-title":"Wound Repair Regen."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1177\/0194599815589072","article-title":"Hyperbaric oxygen treatments attenuate the Neutrophil-to-Lymphocyte ratio in patients with idiopathic sudden sensorineural hearing loss","volume":"153","author":"Li","year":"2015","journal-title":"Otolaryngol. Neck Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1177\/1947603518764281","article-title":"Effect of hyperbaric oxygen on proliferation and gene expression of human chondrocytes: An in vitro study","volume":"10","author":"Melcher","year":"2019","journal-title":"Cartilage"},{"key":"ref_27","first-page":"17","article-title":"Assessment of hemostaseologic alterations induced by hyperbaric oxygen therapy using point-of-care analyzers","volume":"41","author":"Monaca","year":"2014","journal-title":"Undersea Hyperb. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1177\/039156031007700109","article-title":"can hyperbaric oxygenation therapy (HOT) modify the blood testosterone concentration?","volume":"77","author":"Passavanti","year":"2010","journal-title":"Urol. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"34","DOI":"10.12659\/AOT.905406","article-title":"Strategies to restore adenosine triphosphate (ATP) level after more than 20 hours of cold ischemia time in human marginal kidney grafts","volume":"23","author":"Ravaioli","year":"2018","journal-title":"Ann. Transplant."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1365-2133.1994.tb04973.x","article-title":"Stimulation of glycosaminoglycan synthesis in cultured fibroblasts by hyperbaric oxygen","volume":"131","author":"Roberts","year":"1994","journal-title":"Br. J. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.12968\/jowc.1994.3.4.189","article-title":"The effects of hyperbaric oxygen on cultured fibroblasts","volume":"3","author":"Roberts","year":"1994","journal-title":"J. Wound Care"},{"key":"ref_32","first-page":"801","article-title":"Effects of hyperbaric oxygen exposure on mobilization of endothelial progenitor cells in healthy volunteers","volume":"33","author":"Vezzani","year":"2017","journal-title":"Acta Med. Mediterr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.22462\/01.02.2018.2","article-title":"Impact of hyperbaric oxygenation on oxidative stress in diabetic patients","volume":"45","year":"2018","journal-title":"Undersea Hyperb. Med. Soc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1080\/10715760601080371","article-title":"Scuba diving enhances endogenous antioxidant defenses in lymphocytes and neutrophils","volume":"41","author":"Ferrer","year":"2007","journal-title":"Free. Radic. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1080\/14756366.2018.1485149","article-title":"Hyperbaric oxygen therapy ameliorates osteonecrosis in patients by modulating inflammation and oxidative stress","volume":"33","author":"Bosco","year":"2018","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3233\/CH-2011-1412","article-title":"An in vitro hyperbaric oxygen system for evaluation of free radical damage and protection by catechins on hemorheological parameters","volume":"48","author":"Chen","year":"2011","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jcyt.2017.08.020","article-title":"Hyperbaric oxygen treatment effects on in vitro cultured umbilical cord blood CD34 (+) cells","volume":"20","author":"Cheung","year":"2018","journal-title":"Cytotherapy"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1152\/japplphysiol.90737.2008","article-title":"DNA damage after long-term repetitive hyperbaric oxygen exposure","volume":"106","author":"Simkova","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1524-475X.2008.00398.x","article-title":"Hyperbaric oxygen attenuates cell growth in skin fibroblasts cultured in a high-glucose medium","volume":"16","author":"Lin","year":"2008","journal-title":"Wound Repair Regen."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.lfs.2008.05.005","article-title":"Hyperbaric oxygen induces placental growth factor expression in bone marrow-derived mesenchymal stem cells","volume":"83","author":"Shyu","year":"2008","journal-title":"Life Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1159\/000491061","article-title":"A novel approach to estimate ROS origination by hyperbaric oxygen exposure, targeted probes and specific inhibitors","volume":"47","author":"Zhou","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/wrr.12108","article-title":"Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation","volume":"21","author":"Kendall","year":"2013","journal-title":"Wound Repair Regen."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1748-1716.2010.02247.x","article-title":"Effect of pre-breathing oxygen at different depth on oxidative status and calcium concentration in lymphocytes of scuba divers","volume":"202","author":"Morabito","year":"2010","journal-title":"Acta Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Grimberg-Peters, D., B\u00fcren, C., Windolf, J., Wahlers, T., and Paunel-G\u00f6rg\u00fcl\u00fc, A. (2016). Hyperbaric oxygen reduces production of reactive oxygen species in neutrophils from polytraumatized patients yielding in the inhibition of p38 MAP kinase and downstream pathways. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0161343"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.freeradbiomed.2019.04.031","article-title":"Tissue-specific role of Nrf2 in the treatment of diabetic foot ulcers during hyperbaric oxygen therapy","volume":"138","author":"Dhamodharan","year":"2019","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.yexcr.2011.10.014","article-title":"Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions","volume":"318","author":"Kendall","year":"2012","journal-title":"Exp. Cell Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1524-475X.2010.00660.x","article-title":"Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: Increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy","volume":"19","author":"Thom","year":"2011","journal-title":"Wound Repair Regen."},{"key":"ref_48","first-page":"4960","article-title":"The role of pi3k\/akt\/enos pathway in spinal cord injury and the recovery of motor function","volume":"13","author":"Wang","year":"2020","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1152\/physiolgenomics.00028.2014","article-title":"Scuba diving induces nitric oxide synthesis and the expression of inflammatory and regulatory genes of the immune response in neutrophils","volume":"46","author":"Sureda","year":"2014","journal-title":"Physiol. Genom."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.diabres.2011.06.016","article-title":"Molecular changes in diabetic foot ulcers","volume":"94","author":"Wang","year":"2011","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jss.2008.01.026","article-title":"extracorporeal shockwave treatment for chronic diabetic foot ulcers","volume":"152","author":"Wang","year":"2009","journal-title":"J. Surg. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-019-1830-1","article-title":"Upregulation of miR-107 expression following hyperbaric oxygen treatment suppresses HMGB1\/RAGE signaling in degenerated human nucleus pulposus cells","volume":"21","author":"Niu","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/2328505","article-title":"Early Effects of hyperbaric oxygen on inducible nitric oxide synthase activity\/expression in lymphocytes of Type 1 diabetes patients: A prospective pilot study","volume":"2019","author":"Resanovic","year":"2019","journal-title":"Int. J. Endocrinol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1749-799X-9-5","article-title":"Effects of low-intensity pulsed ultrasound and hyperbaric oxygen on human osteoarthritic chondrocytes","volume":"9","author":"Yuan","year":"2014","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1249\/MSS.0b013e3181951069","article-title":"Scuba diving increases erythrocyte and plasma antioxidant defenses and spares no without oxidative damage","volume":"41","author":"Sureda","year":"2009","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"49","DOI":"10.22462\/01.02.2018.7","article-title":"Influence of exposure in hyperbaric chambers on selected parametersof oxidative stress in professional divers","volume":"45","author":"Kozakiewicz","year":"2018","journal-title":"Undersea Hyperb. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/01.ASW.0000280198.81130.d5","article-title":"Hyperbaric oxygen therapy mediates increased nitric oxide production associated with wound healing","volume":"20","author":"Boykin","year":"2007","journal-title":"Adv. Ski. Wound Care"},{"key":"ref_58","first-page":"158","article-title":"The effect of hyperbaric oxygen therapy on myocardial perfusion after the implantation of drug-eluting stents","volume":"48","author":"Li","year":"2018","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"145","DOI":"10.22462\/04.06.2019.7","article-title":"Hyperbaric oxygen may improve vascular endothelial function in patients undergoing coronary stent implantation","volume":"46","author":"Li","year":"2019","journal-title":"Undersea Hyperb. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"106","DOI":"10.5603\/CJ.a2017.0132","article-title":"Effects of hyperbaric oxygen on vascular endothelial function in patients with slow coronary flow","volume":"25","author":"Li","year":"2018","journal-title":"Cardiol. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.niox.2014.12.002","article-title":"Effects of hyperbaric oxygen on nitric oxide generation in humans","volume":"44","author":"Eriksson","year":"2015","journal-title":"Nitric Oxide"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Sureda, A., Batle, J.M., Martorell, M., Cap\u00f3, X., Tejada, S., Tur, J.A., and Pons, A. (2016). Antioxidant response of chronic wounds to hyperbaric oxygen therapy. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0163371"},{"key":"ref_63","first-page":"125","article-title":"Oxidative stress, antioxidant defenses and nitric oxide production following hyperoxic exposures","volume":"40","author":"Gasier","year":"2013","journal-title":"Undersea Hyperb. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e00142","DOI":"10.1002\/phy2.142","article-title":"Effect of decompression-induced bubble formation on highly trained divers microvascular function","volume":"1","author":"Lambrechts","year":"2013","journal-title":"Physiol. Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3233\/CH-190796","article-title":"Serum levels of nitric oxide and endothelin-1 in vasculopathy managed with hyperbaric oxygen therapy","volume":"75","author":"Dragic","year":"2020","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.clinbiochem.2008.12.024","article-title":"Hyperbaric oxygen treatment induces platelet aggregation and protein release, without altering expression of activation molecules","volume":"42","author":"Shaw","year":"2009","journal-title":"Clin. Biochem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.clinbiochem.2006.07.007","article-title":"Effects of hyperbaric oxygen therapy on circulating interleukin-8, nitric oxide, and insulin-like growth factors in patients with type 2 diabetes mellitus","volume":"40","author":"Chen","year":"2007","journal-title":"Clin. Biochem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"423","DOI":"10.33549\/physiolres.931702","article-title":"Collagen synthesis, nitric oxide and asymmetric dimethylarginine in diabetic subjects undergoing hyperbaric oxygen therapy","volume":"59","author":"Gurdol","year":"2010","journal-title":"Physiol. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/MI\/2006\/72620","article-title":"Exhaled nitric oxide is decreased by exposure to the hyperbaric oxygen therapy environment","volume":"2006","author":"Puthucheary","year":"2006","journal-title":"Mediat. Inflamm."},{"key":"ref_70","first-page":"321","article-title":"Reduced nitric oxide concentration in exhaled gas after exposure to hyperbaric hyperoxia","volume":"34","author":"Bolann","year":"2007","journal-title":"Undersea Hyperb. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/jor.22209","article-title":"Hyperbaric oxygen treatment suppresses MAPK signaling and mitochondrial apoptotic pathway in degenerated human intervertebral disc cells","volume":"31","author":"Niu","year":"2012","journal-title":"J. Orthop. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/jor.21195","article-title":"Beneficial effects of hyperbaric oxygen on human degenerated intervertebral disk cells via suppression of IL-1\u03b2 and p38 MAPK signal","volume":"29","author":"Niu","year":"2010","journal-title":"J. Orthop. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1097\/BRS.0b013e3181feebde","article-title":"Effect of Hyperbaric Oxygenation on intervertebral disc degeneration","volume":"36","author":"Wang","year":"2011","journal-title":"Spine"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/0-387-26206-7_30","article-title":"Benzoate hydroxylation","volume":"566","author":"Gronow","year":"2006","journal-title":"Oxygen Transport to Tissue XXVI"},{"key":"ref_75","first-page":"231","article-title":"Influence of hyperoxia and physical exercise on *OH-radical stress in humans as measured by dihydroxylated benzoates (DHB) in urine","volume":"40","author":"Koch","year":"2013","journal-title":"Undersea Hyperb. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1080\/10715760412331273197","article-title":"Influence of an orally effective SOD on hyperbaric oxygen-related cell damage","volume":"38","author":"Muth","year":"2004","journal-title":"Free. Radic. Res."},{"key":"ref_77","first-page":"41","article-title":"Early and late effects of hyperbaric oxygen treatment on oxidative stress parameters in diabetic patients","volume":"57","author":"Kocak","year":"2008","journal-title":"Physiol. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.plefa.2017.10.003","article-title":"Hyperbaric oxygen therapy is not associated with oxidative stress assessed using plasma F2-isoprostanes and isofurans. Prostaglandins, Leukot","volume":"127","author":"Corcoran","year":"2017","journal-title":"Essent. Fat. Acids"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.3171\/2009.7.JNS09363","article-title":"A prospective, randomized clinical trial to compare the effect of hyperbaric to normobaric hyperoxia on cerebral metabolism, intracranial pressure, and oxygen toxicity in severe traumatic brain injury","volume":"112","author":"Rockswold","year":"2010","journal-title":"J. Neurosurg."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.clinbiochem.2003.12.001","article-title":"Oxidative stress and antioxidant status in patients undergoing prolonged exposure to hyperbaric oxygen","volume":"37","author":"Benedetti","year":"2004","journal-title":"Clin. Biochem."},{"key":"ref_81","first-page":"18","article-title":"A prospective, randomized, controlled study of hyperbaric oxygen therapy: Effects on healing and oxidative stress of ulcer tissue in patients with a diabetic foot ulcer","volume":"59","author":"Ma","year":"2013","journal-title":"Ostomy Wound Manag."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"587","DOI":"10.7754\/Clin.Lab.2014.140929","article-title":"Application of hyperbaric oxygen reduce oxidative damage of plasmatic carbonyl proteins and 8-OHdG by activating glutathion peroxidase","volume":"61","author":"Matzi","year":"2015","journal-title":"Clin. Lab."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1177\/0960327119867751","article-title":"Evaluation of oxidative stress and antioxidant parameters in children with carbon monoxide poisoning","volume":"38","author":"TekSam","year":"2019","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_84","first-page":"8838","article-title":"Wound healing process and related laboratory indexes in patients with type 2 diabetes mellitus after hyperbaric oxygen intervention","volume":"28","author":"Li","year":"2017","journal-title":"Biomed. Res. India"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/8472346","article-title":"Markers of oxidant-antioxidant equilibrium in patients with sudden sensorineural hearing loss treated with hyperbaric oxygen therapy","volume":"2019","author":"Paprocki","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_86","first-page":"159","article-title":"Oxidative stress during a 3.5-hour exposure to 120 kPa(a) PO2 in human divers","volume":"26","author":"Bearden","year":"1999","journal-title":"Undersea Hyperb. Med."},{"key":"ref_87","first-page":"393","article-title":"Lipid peroxidation, circulating cytokine and endothelin 1 levels in healthy volunteers undergoing hyperbaric oxygenation","volume":"67","author":"Rocco","year":"2001","journal-title":"Minerva Anestesiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s12967-018-1629-x","article-title":"Increased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapy","volume":"16","author":"Chen","year":"2018","journal-title":"J. Transl. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/1835352","article-title":"evaluation of oxidative stress in patients with difficult-to-heal skin wounds treated with hyperbaric oxygen","volume":"2020","author":"Paprocki","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1080\/15438627.2012.660830","article-title":"The effect of the hyperbaric environment on heat shock protein 72 expression in vivo","volume":"20","author":"Taylor","year":"2012","journal-title":"Res. Sports Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/5647407","article-title":"Effects of exercise training under hyperbaric oxygen on oxidative stress markers and endurance performance in young soccer players: A pilot study","volume":"2016","author":"Burgos","year":"2016","journal-title":"J. Nutr. Metab."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1152\/jappl.1987.62.2.533","article-title":"Hyperbaric hyperoxia reversibly inhibits erythrocyte phospholipid fatty acid turnover","volume":"62","author":"Dise","year":"1987","journal-title":"J. Appl. Physiol."},{"key":"ref_93","first-page":"117","article-title":"Oxidative stress during oxygen tolerance test","volume":"54","author":"Kot","year":"2003","journal-title":"Int. Marit. Health"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1383-5742(99)00034-4","article-title":"Antioxidant status in humans after exposure to hyperbaric oxygen","volume":"428","author":"Dennog","year":"1999","journal-title":"Mutat. Res. Mol. Mech. Mutagen."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1093\/carcin\/22.12.1979","article-title":"Involvement of heme oxygenase-1 (HO-1) in the adaptive protection of human lymphocytes after hyperbaric oxygen (HBO) treatment","volume":"22","author":"Rothfuss","year":"2001","journal-title":"Carcinogenesis"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0027-5107(02)00213-0","article-title":"Investigations on the mechanism of hyperbaric oxygen (HBO)-induced adaptive protection against oxidative stress","volume":"508","author":"Rothfuss","year":"2002","journal-title":"Mutat. Res. Mol. Mech. Mutagen."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1093\/carcin\/21.10.1795","article-title":"Induction of heme oxygenase-1 and adaptive protection against the induction of DNA damage after hyperbaric oxygen treatment","volume":"21","author":"Speit","year":"2000","journal-title":"Carcinogenesis"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/10715762.2019.1612890","article-title":"Effect of hyperoxia on the immune status of oxygen divers and endurance athletes","volume":"53","author":"Tillmans","year":"2019","journal-title":"Free. Radic. Res."},{"key":"ref_99","first-page":"327","article-title":"Oxidative metabolism in platelets, platelet aggregation, and hematology in patients undergoing multiple hyperbaric oxygen exposures","volume":"32","author":"Handy","year":"2006","journal-title":"Undersea Hyperb. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1600-0404.1986.tb04643.x","article-title":"Hyperbaric oxygenation and erythrocyte antioxidant enzymes in multiple sclerosis patients","volume":"74","author":"Ansari","year":"1986","journal-title":"Acta Neurol. Scand."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-2431-7-36","article-title":"The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: An open-label pilot study","volume":"7","author":"Rossignol","year":"2007","journal-title":"BMC Pediatr."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Chang, J.S., Chang, E., Lee, Y., Cha, Y.S., Cha, S.-K., Gil Cho, W., Jeong, Y., Kim, H., and Park, K.-S. (2020). Hyperbaric oxygen exposure attenuates circulating stress biomarkers: A pilot interventional study. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17217853"},{"key":"ref_103","first-page":"275","article-title":"Potential benefits of hyperbaric oxygen therapy on atherosclerosis and glycaemic control in patients with diabetic foot","volume":"61","author":"Karadurmus","year":"2010","journal-title":"Endokrynol. Pol."},{"key":"ref_104","first-page":"646","article-title":"The relationship between intoxication severity and blood interleukin 6, interleukin 10 and CRP levels in carbon monoxide-poisoned patients","volume":"45","author":"Akcali","year":"2019","journal-title":"Undersea Hyperb. Med."},{"key":"ref_105","first-page":"189","article-title":"Inflammatory mediators and other biomarkers in co-intoxicated patients after hyperbaric oxygen therapy (HBO2)","volume":"32","author":"Vezzani","year":"2016","journal-title":"Acta Med. Mediterr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/WON.0000000000000374","article-title":"Adjunctive hyperbaric oxygen therapy for healing of chronic diabetic foot ulcers","volume":"44","author":"Chen","year":"2017","journal-title":"J. Wound Ostomy Cont. Nurs."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jinf.2007.06.003","article-title":"Phagocytic activity of neutrophils improves over the course of therapy of diabetic foot infections","volume":"55","author":"Top","year":"2007","journal-title":"J. Infect."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/ijd.12936","article-title":"A prospective randomized controlled trial assessing the efficacy of adjunctive hyperbaric oxygen therapy in the treatment of hidradenitis suppurativa","volume":"55","author":"Yildiz","year":"2015","journal-title":"Int. J. Dermatol."},{"key":"ref_109","first-page":"314","article-title":"Changes of plasma C-reactive protein in patients with craniocerebral injury before and after hyperbaric oxygenation: A randomly controlled study","volume":"2","author":"Xie","year":"2007","journal-title":"Neural Regen. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1177\/108155890405200824","article-title":"Effects of carbon monoxide poisoning on neutrophil responses in patients treated with hyperbaric oxygen","volume":"52","author":"Schnittger","year":"2004","journal-title":"J. Investig. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e19857","DOI":"10.1097\/MD.0000000000019857","article-title":"Effects of hyperbaric oxygen therapy on the expression levels of the inflammatory factors interleukin-12p40, macrophage inflammatory protein-1\u03b2, platelet-derived growth factor-BB, and interleukin-1 receptor antagonist in keloids","volume":"99","author":"Hao","year":"2020","journal-title":"Med. Baltim."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s10803-011-1337-3","article-title":"Brief report: Hyperbaric oxygen therapy (HBOT) in children with autism spectrum disorder: A clinical trial","volume":"42","author":"Bent","year":"2011","journal-title":"J. Autism Dev. Disord."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/567834","article-title":"IGF-1 Increases with hyperbaric oxygen therapy and promotes wound healing in diabetic foot ulcers","volume":"2013","author":"Aydin","year":"2013","journal-title":"J. Diabetes Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"17","DOI":"10.28920\/dhm50.1.17-23","article-title":"Measurement of peripheral arterial tonometry in patients with diabetic foot ulcers during courses of hyperbaric oxygen treatment","volume":"50","author":"Hedetoft","year":"2020","journal-title":"Diving Hyperb. Med. J."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s11626-011-9418-3","article-title":"Keloid skin scars: The influence of hyperbaric oxygenation on fibroblast growth and on the expression of messenger RNA for insulin like growth factor and for transforming growth factor","volume":"47","author":"Flisser","year":"2011","journal-title":"Vitr. Cell. Dev. Biol. Anim."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"569","DOI":"10.13005\/bpj\/1409","article-title":"Effect of hyperbaric oxygen therapy to improve serum albumin for patients with diabetic foot ulcers","volume":"11","author":"Irawan","year":"2018","journal-title":"Biomed. Pharmacol. J."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/6425857","article-title":"A pilot study of short-duration hyperbaric oxygen therapy to improve HbA1c, Leukocyte, and serum creatinine in patients with diabetic foot ulcer Wagner 3\u20134","volume":"2018","author":"Irawan","year":"2018","journal-title":"Sci. World J."},{"key":"ref_118","first-page":"157","article-title":"Characterization of early thermal burns and the effects of hyperbaric oxygen treatment: A pilot study","volume":"43","author":"Chong","year":"2013","journal-title":"Diving Hyperb. Med. J."},{"key":"ref_119","first-page":"4651","article-title":"Effect of hyperbaric oxygen combined with nimodipine on treatment of diffuse brain injury","volume":"15","author":"Sun","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Baiula, M., Greco, R., Ferrazzano, L., Caligiana, A., Hoxha, K., Bandini, D., Longobardi, P., Spampinato, S., and Tolomelli, A. (2020). Integrin-mediated adhesive properties of neutrophils are reduced by hyperbaric oxygen therapy in patients with chronic non-healing wound. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0237746"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1365-2249.2003.02248.x","article-title":"Hyperbaric oxygen inhibits stimulus-induced proinflammatory cytokine synthesis by human blood-derived monocyte-macrophages","volume":"134","author":"Benson","year":"2003","journal-title":"Clin. Exp. Immunol."},{"key":"ref_122","first-page":"5867","article-title":"Effect of the combination of donepezil with hyperbaric oxygen therapy and functional rehabilitation training on parkinson\u2019s disease dementia and the neurological function system","volume":"13","author":"Fan","year":"2020","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_123","first-page":"30","article-title":"Hyperbaric oxygen therapy increases insulin sensitivity in overweight men with and without type 2 diabetes","volume":"45","author":"Wilkinson","year":"2015","journal-title":"Diving Hyperb. Med. J."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1023\/A:1027378532003","article-title":"Modification of in vivo and in vitro TNF-\u03b1, IL-1, and IL-6 secretion by circulating monocytes during hyperbaric oxygen treatment in patients with perianal crohn\u2019s disease","volume":"17","author":"Weisz","year":"1997","journal-title":"J. Clin. Immunol."},{"key":"ref_125","first-page":"35","article-title":"Modification of HIF-1\u03b1, NF-\u03baB, IGFBP-3, VEGF and adiponectin in diabetic foot ulcers treated with hyperbaric oxygen","volume":"46","year":"2019","journal-title":"Undersea Hyperb. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/S0198-8859(00)00214-7","article-title":"Role of CD4+ regulatory T cells in hyperbaric oxygen-mediated immune nonresponsiveness","volume":"61","author":"MacKenzie","year":"2000","journal-title":"Hum. Immunol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.jtcvs.2005.08.018","article-title":"Pretreatment with hyperbaric oxygen and its effect on neuropsychometric dysfunction and systemic inflammatory response after cardiopulmonary bypass: A prospective randomized double-blind trial","volume":"130","author":"Alex","year":"2005","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_128","first-page":"217","article-title":"Whole blood pro-inflammatory cytokines and adhesion molecules post-lipopolysaccharides exposure in hyperbaric conditions","volume":"15","author":"Fildissis","year":"2004","journal-title":"Eur. Cytokine Netw."},{"key":"ref_129","first-page":"3277","article-title":"Hyperbaric oxygen on rehabilitation of brain tumors after surgery and effects on TNF-\u03b1 and IL-6 levels","volume":"17","author":"Hou","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Lin, P.-Y., Sung, P.-H., Chung, S.-Y., Hsu, S.-L., Chung, W.-J., Sheu, J.-J., Hsueh, S.-K., Chen, K.-H., Wu, R.-W., and Yip, H.-K. (2018). Hyperbaric oxygen therapy enhanced circulating levels of endothelial progenitor cells and angiogenesis biomarkers, blood flow, in ischemic areas in patients with peripheral arterial occlusive disease. J. Clin. Med., 7.","DOI":"10.3390\/jcm7120548"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/3172679","article-title":"The effect of hyperbaric oxygen therapy on functional impairments caused by ischemic stroke","volume":"2018","author":"Rosario","year":"2018","journal-title":"Neurol. Res. Int."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1631\/jzus.B1800132","article-title":"Hyperbaric oxygen therapy improves the effect of keloid surgery and radiotherapy by reducing the recurrence rate","volume":"19","author":"Song","year":"2018","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_133","first-page":"81","article-title":"T helper 1 response is correlated with widespread pain, fatigue, sleeping disorders and the quality of life in patients with fibromyalgia and is modulated by hyperbaric oxygen therapy","volume":"37","author":"Guggino","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1423-0127-18-27","article-title":"Tumor necrosis factor-\u03b1 enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells","volume":"18","author":"Wang","year":"2011","journal-title":"J. Biomed. Sci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3109\/14756366.2012.759951","article-title":"Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-\u03b1 and EGF production in chronic leg wound healing","volume":"29","author":"Nasole","year":"2013","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/PRS.0000000000007029","article-title":"The effect of hyperbaric oxygen therapy on human adipose-derived stem cells","volume":"146","author":"Yoshinoya","year":"2020","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_137","first-page":"331","article-title":"Hyperbaric oxygen treatment improves hearing level via attenuating TLR4\/NF-\u03baB mediated inflammation in Sudden sensorineural hearing loss patients","volume":"33","author":"Liu","year":"2020","journal-title":"Biomed. Environ. Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.3889\/oamjms.2019.297","article-title":"The role of VEGF and TNF-Alpha on epithelialization of diabetic foot ulcers after hyperbaric oxygen therapy","volume":"7","author":"Semadi","year":"2019","journal-title":"Open Access Maced. J. Med Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/cbf.1712","article-title":"The effect of acute hyperoxia in vivo on NF kappa B expression in human PBMC","volume":"29","author":"Madden","year":"2010","journal-title":"Cell Biochem. Funct."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neulet.2018.10.059","article-title":"Effect of hyperbaric oxygen therapy on HMGB1\/NF-\u03baB expression and prognosis of acute spinal cord injury: A randomized clinical trial","volume":"692","author":"Sun","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1089\/ten.tea.2012.0629","article-title":"Hyperbaric oxygen treatment of tissue-engineered mucosa enhances secretion of angiogenic factors in vitro","volume":"20","author":"Tra","year":"2014","journal-title":"Tissue Eng. Part A"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11373-005-9037-7","article-title":"Hyperbaric oxygen induces VEGF expression through ERK, JNK and c-Jun\/AP-1 activation in human umbilical vein endothelial cells","volume":"13","author":"Lee","year":"2005","journal-title":"J. Biomed. Sci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1746-160X-6-29","article-title":"The impact of hyperbaric oxygen therapy on serological values of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)","volume":"6","author":"Jung","year":"2010","journal-title":"Head Face Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0006-291X(02)00924-5","article-title":"Hyperbaric oxygen selectively induces angiopoietin-2 in human umbilical vein endothelial cells","volume":"296","author":"Lin","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1055\/s-0035-1555782","article-title":"Antioxidants may attenuate plasma erythropoietin decline after hyperbaric oxygen diving","volume":"36","author":"Mutzbauer","year":"2015","journal-title":"Int. J. Sports Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cccn.2003.09.010","article-title":"Urinary 8-OHdG: A marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics","volume":"339","author":"Wu","year":"2004","journal-title":"Clin. Chim. Acta"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1001\/archfaci.6.1.31","article-title":"Effect of hyperbaric oxygen on the growth factor profile of fibroblasts","volume":"6","author":"Kang","year":"2004","journal-title":"Arch. Facial Plast. Surg."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1001\/archotol.131.9.809","article-title":"Combined effect of hyberbaric oxygen and n-acetylcysteine on fibroblast proliferation","volume":"131","author":"Kunnavatana","year":"2005","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3793\/jaam.7.36","article-title":"Oxidative Stress Markers","volume":"7","author":"Naito","year":"2010","journal-title":"Anti-Aging Med."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"Gabay","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Ansar, W., and Ghosh, S. (2016). Inflammation and Inflammatory Diseases, Markers, and Mediators: Role of CRP in Some Inflammatory Diseases. Biology of C Reactive Protein in Health and Disease, Springer.","DOI":"10.1007\/978-81-322-2680-2_4"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/5698931","article-title":"Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox?","volume":"2016","author":"Biswas","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/ncpneph0283","article-title":"Mechanisms of disease: Oxidative stress and inflammation in the pathogenesis of hypertension","volume":"2","author":"Vaziri","year":"2006","journal-title":"Nat. Clin. Pract. Nephrol."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Chatterjee, S. (2016). Oxidative Stress, Inflammation, and Disease. Oxidative Stress and Biomaterials, Academic Press.","DOI":"10.1016\/B978-0-12-803269-5.00002-4"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"229","DOI":"10.17219\/acem\/92304","article-title":"Thermal imaging and planimetry evaluation of the results of chronic wounds treatment with hyperbaric oxygen therapy","volume":"28","author":"Glik","year":"2019","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_156","first-page":"1465","article-title":"Evaluation of hyperbaric oxygen therapy effects in hard-to-heal wounds using thermal imaging and planimetry","volume":"141","author":"Cholewka","year":"2019","journal-title":"J. Therm. Anal. Calorim."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0008-6363(01)00434-5","article-title":"The inflammatory response in myocardial infarction","volume":"53","author":"Frangogiannis","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF- B pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000196164","article-title":"Hyperbaric oxygen reduces inflammatory response in acute pancreatitis by inhibiting NF-\u03baB activation","volume":"42","author":"Yu","year":"2009","journal-title":"Eur. Surg. Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/iub.1358","article-title":"Cellular and molecular mechanisms of inflammation-induced angiogenesis","volume":"67","author":"Szade","year":"2015","journal-title":"IUBMB Life"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.biopha.2018.12.022","article-title":"Therapeutic targeting of angiogenesis molecular pathways in angiogenesis-dependent diseases","volume":"110","author":"Fallah","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1089\/152308602760598963","article-title":"Redox signaling of angiogenesis","volume":"4","author":"Maulik","year":"2002","journal-title":"Antioxid. Redox Signal."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"S633","DOI":"10.33549\/physiolres.934046","article-title":"repeated exposure to hyperbaric hyperoxia affects mitochondrial functions of the lung fibroblasts","volume":"67","author":"Dejmek","year":"2018","journal-title":"Physiol. Res."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3233\/CH-151952","article-title":"Acute and long-term effects of hyperbaric oxygen therapy on hemorheological parameters in patients with various disorders","volume":"62","author":"Sinan","year":"2016","journal-title":"Clin. Hemorheol. 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