{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:35:46Z","timestamp":1790994946289,"version":"4.1.0"},"reference-count":130,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Cannabis (Cannabis sativa), popularly known as marijuana, is the most commonly used psychoactive substance and is considered illicit in most countries worldwide. However, a growing body of research has provided evidence of the therapeutic properties of chemical components of cannabis known as cannabinoids against several diseases including Alzheimer\u2019s disease (AD), multiple sclerosis (MS), Parkinson\u2019s disease, schizophrenia and glaucoma; these have prompted changes in medicinal cannabis legislation. The relaxation of legal restrictions and increased socio-cultural acceptance has led to its increase in both medicinal and recreational usage. Several biochemically active components of cannabis have a range of effects on the biological system. There is an urgent need for more research to better understand the molecular and biochemical effects of cannabis at a cellular level, to understand fully its implications as a pharmaceutical drug. Proteomics technology is an efficient tool to rigorously elucidate the mechanistic effects of cannabis on the human body in a cell and tissue-specific manner, drawing conclusions associated with its toxicity as well as therapeutic benefits, safety and efficacy profiles. This review provides a comprehensive overview of both in vitro and in vivo proteomic studies involving the cellular and molecular effects of cannabis and cannabis-derived compounds.<\/jats:p>","DOI":"10.3390\/biom11101411","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T04:55:33Z","timestamp":1632718533000},"page":"1411","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["A Proteomic View of Cellular and Molecular Effects of Cannabis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4513-7142","authenticated-orcid":false,"given":"Morteza","family":"Abyadeh","sequence":"first","affiliation":[{"name":"ProGene Technologies Pty Ltd., Macquarie Park, Sydney, NSW 2113, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Gupta","sequence":"additional","affiliation":[{"name":"Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4291-413X","authenticated-orcid":false,"given":"Joao A.","family":"Paulo","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veer","family":"Gupta","sequence":"additional","affiliation":[{"name":"School of Medicine, Deakin University, Geelong, VIC 2600, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Chitranshi","sequence":"additional","affiliation":[{"name":"Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Godinez","sequence":"additional","affiliation":[{"name":"Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danit","family":"Saks","sequence":"additional","affiliation":[{"name":"Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mafruha","family":"Hasan","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardeshir","family":"Amirkhani","sequence":"additional","affiliation":[{"name":"Australian Proteome Analysis Facility, Macquarie University, Sydney, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3430-2467","authenticated-orcid":false,"given":"Matthew","family":"McKay","sequence":"additional","affiliation":[{"name":"Bowel Cancer and Biomarker Laboratory, Kolling Institute, Northern Clinical School, The University of Sydney, Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-4721","authenticated-orcid":false,"given":"Ghasem H.","family":"Salekdeh","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences, Macquarie University, Macquarie Park, Sydney, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1472-8249","authenticated-orcid":false,"given":"Paul A.","family":"Haynes","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences, Macquarie University, Macquarie Park, Sydney, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart L.","family":"Graham","sequence":"additional","affiliation":[{"name":"Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Mirzaei","sequence":"additional","affiliation":[{"name":"Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jtho.2017.12.013","article-title":"Cannabis use, lung cancer, and related issues","volume":"13","author":"Jett","year":"2018","journal-title":"J. Thorac. Oncol."},{"key":"ref_2","first-page":"e131","article-title":"Medical Marijuana, Recreational Cannabis, and Cardiovascular Health: A Scientific Statement From the American Heart Association","volume":"142","author":"Ii","year":"2020","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"eaaw1391","DOI":"10.1126\/sciadv.aaw1391","article-title":"The origins of cannabis smoking: Chemical residue evidence from the first millennium BCE in the Pamirs","volume":"5","author":"Ren","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/S0140-6736(19)31789-1","article-title":"Public health implications of legalising the production and sale of cannabis for medicinal and recreational use","volume":"394","author":"Hall","year":"2019","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"546796","DOI":"10.3389\/fpsyt.2020.546796","article-title":"The psychonauts\u2019 world of cognitive enhancers","volume":"11","author":"Napoletano","year":"2020","journal-title":"Front. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3233\/JAD-130137","article-title":"CB2 Cannabinoid Receptor Agonist Ameliorates Alzheimer-like Phenotype in A\u03b2PP\/PS1 Mice","volume":"35","author":"Aso","year":"2013","journal-title":"J. Alzheimer Dis."},{"key":"ref_7","first-page":"37","article-title":"Cannabinoids for treatment of Alzheimer\u2019s disease: Moving toward the clinic","volume":"5","author":"Ferrer","year":"2014","journal-title":"Front. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.neurobiolaging.2012.06.011","article-title":"Activation of the CB2 receptor system reverses amyloid-induced memory deficiency","volume":"34","author":"Wu","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-015-0012-0","article-title":"Promising cannabinoid-based therapies for Parkinson\u2019s disease: Motor symptoms to neuroprotection","volume":"10","author":"More","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s12035-007-0004-3","article-title":"Cannabinoids and Neuroprotection in Basal Ganglia Disorders","volume":"36","author":"Sagredo","year":"2007","journal-title":"Mol. Neurobiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.euroneuro.2013.11.002","article-title":"Cannabidiol as a potential treatment for psychosis","volume":"24","author":"Schubart","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.3389\/fimmu.2018.02009","article-title":"Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age","volume":"9","author":"Crippa","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.pneurobio.2017.10.007","article-title":"The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: Clues for other neuroinflammatory diseases","volume":"160","author":"Centonze","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fncel.2020.00034","article-title":"Perspectives on Cannabis-Based Therapy of Multiple Sclerosis: A Mini-Review","volume":"14","author":"Mecha","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.17305\/bjbms.2018.3532","article-title":"Cannabinoids in cancer treatment: Therapeutic potential and legislation","volume":"19","author":"Verboten","year":"2019","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.intimp.2015.03.006","article-title":"The endocannabinoid system and its therapeutic implications in rheumatoid arthritis","volume":"26","author":"Gui","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/BOR.0000000000000590","article-title":"Joints for joints: Cannabinoids in the treatment of rheumatoid arthritis","volume":"31","author":"Lowin","year":"2019","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s43440-021-00270-y","article-title":"Cannabinoid-based therapy as a future for joint degeneration. Focus on the role of CB2 receptor in the arthritis progression and pain: An updated review","volume":"73","author":"Bryk","year":"2021","journal-title":"Pharmacol. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e809","DOI":"10.1212\/NXI.0000000000000809","article-title":"Recent cannabis use in HIV is associated with reduced inflammatory markers in CSF and blood","volume":"7","author":"Ellis","year":"2020","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jpainsymman.2004.07.011","article-title":"Cannabis Use in HIV for Pain and Other Medical Symptoms","volume":"29","author":"Woolridge","year":"2005","journal-title":"J. Pain Symptom Manag."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e024793","DOI":"10.1136\/bmjopen-2018-024793","article-title":"Oral cannabinoids in people living with HIV on effective antiretroviral therapy: CTN PT028\u2014Study protocol for a pilot randomised trial to assess safety, tolerability and effect on immune activation","volume":"9","author":"Costiniuk","year":"2019","journal-title":"BMJ Open"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1167\/iovs.16-19356","article-title":"Harnessing the Endocannabinoid 2-Arachidonoylglycerol to Lower Intraocular Pressure in a Murine Model","volume":"57","author":"Miller","year":"2016","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2174\/1570159X15666170724104305","article-title":"Neuroprotection by (endo)Cannabinoids in Glaucoma and Retinal Neurodegenerative Diseases","volume":"16","author":"Rapino","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-67527-z","article-title":"Effect of palmitoylethanolamide on inner retinal function in glaucoma: A randomized, single blind, crossover, clinical trial by pattern-electroretinogram","volume":"10","author":"Rossi","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/17474124.2020.1740590","article-title":"An overview of cannabis based treatment in Crohn\u2019s disease","volume":"14","author":"Naftali","year":"2020","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0016-5085(03)00892-8","article-title":"An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice","volume":"125","author":"Izzo","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Stasi\u0142owicz, A., Tomala, A., Podolak, I., and Cielecka-Piontek, J. (2021). Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020778"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2174\/1871530320666200520095900","article-title":"The Cannabis Spread throughout the Continents and its Therapeutic Use in History","volume":"21","author":"Charitos","year":"2021","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"FSO625","DOI":"10.2144\/fsoa-2020-0124","article-title":"Cannabis for COVID-19: Can cannabinoids quell the cytokine storm?","volume":"6","author":"Onaivi","year":"2020","journal-title":"Future Sci. OA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-81049-2","article-title":"Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages","volume":"11","author":"Anil","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fpls.2016.00019","article-title":"Cannabis sativa: The Plant of the Thousand and One Molecules","volume":"7","author":"Andre","year":"2016","journal-title":"Front. Plant Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrn.2016.28","article-title":"Keep off the grass? Cannabis, cognition and addiction","volume":"17","author":"Curran","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_33","first-page":"603","article-title":"A comprehensive review of cannabis potency in the USA in the last decade","volume":"6","author":"ElSohly","year":"2021","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Namdar, D., Anis, O., Poulin, P., and Koltai, H. (2020). Chronological Review and Rational and Future Prospects of Cannabis-Based Drug Development. Molecules, 25.","DOI":"10.3390\/molecules25204821"},{"key":"ref_35","first-page":"485","article-title":"Emerging use of epidiolex (cannabidiol) in epilepsy","volume":"25","author":"Scutt","year":"2020","journal-title":"J. Pediatr. Pharmacol. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Ruiz, J., Sagredo, O., and de Lago, E. (2020). Phytocannabinoids Versus Endocannabinoids. A Modern View of the Endocannabinoid System. New Tools to Interrogate Endocannabinoid Signalling, Royal Society of Chemistry.","DOI":"10.1039\/9781839160752-00010"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1080\/14737175.2020.1776610","article-title":"Cannabis and multiple sclerosis","volume":"20","author":"Fragoso","year":"2020","journal-title":"Expert Rev. Neurother."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"102336","DOI":"10.1016\/j.ctim.2020.102336","article-title":"High expectations: The landscape of clinical trials of medical marijuana in oncology","volume":"49","author":"Goyal","year":"2020","journal-title":"Complement. Ther. Med."},{"key":"ref_39","first-page":"1","article-title":"Epilepsy and cannabidiol: A guide to treatment","volume":"22","author":"Arzimanoglou","year":"2020","journal-title":"Epileptic Disord."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1080\/14737175.2021.1935879","article-title":"Safety and tolerability of nabiximols oromucosal spray: A review of more than 15 years\u2019 accumulated evidence from clinical trials","volume":"21","year":"2021","journal-title":"Expert Rev. Neurother."},{"key":"ref_41","first-page":"235","article-title":"Efficacy and safety of nabiximols (Sativex\u00ae) on multiple sclerosis spasticity in a real-life Italian monocentric study","volume":"37","author":"Nuara","year":"2015","journal-title":"Neurol. Sci."},{"key":"ref_42","first-page":"1","article-title":"Medical Cannabis in Oncology: A Valuable Unappreciated Remedy or an Undesirable Risk?","volume":"22","author":"Salti","year":"2021","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1111\/iwj.13484","article-title":"Topical cannabis-based medicines\u2013A novel paradigm and treatment for non-uremic calciphylaxis leg ulcers: An open label trial","volume":"17","author":"Maida","year":"2020","journal-title":"Int. Wound J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1089\/can.2017.0036","article-title":"An Update on Non-CB1, Non-CB2 Cannabinoid Related G-Protein-Coupled Receptors","volume":"2","author":"Morales","year":"2017","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/bs.apha.2017.04.001","article-title":"Actions and Regulation of Ionotropic Cannabinoid Receptors","volume":"80","author":"Nabissi","year":"2017","journal-title":"Adv. Pharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1080\/19336950.2019.1615824","article-title":"Cannabinoid interactions with ion channels and receptors","volume":"13","author":"Watkins","year":"2019","journal-title":"Channels"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3389\/fphar.2019.00339","article-title":"The endocannabinoid system as a target in cancer diseases: Are we there yet?","volume":"10","author":"Moreno","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41582-019-0284-z","article-title":"Cannabinoids and the expanded endocannabinoid system in neurological disorders","volume":"16","author":"Cristino","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"101301","DOI":"10.1016\/j.isci.2020.101301","article-title":"Cannabinoids and Cannabinoid Receptors: The Story so Far","volume":"23","author":"Shahbazi","year":"2020","journal-title":"iScience"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fphar.2020.00124","article-title":"From Cannabis sativa to Cannabidiol: Promising Therapeutic Candidate for the Treatment of Neurodegenerative Diseases","volume":"11","author":"Cassano","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1089\/pop.2018.0113","article-title":"Trends in Publications on Medical Cannabis from the Year 2000","volume":"22","author":"Freud","year":"2019","journal-title":"Popul. Health Manag."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s40429-020-00342-8","article-title":"Evidence for the Endocannabinoid System as a Therapeutic Target in the Treatment of Cannabis Use Disorder","volume":"7","author":"Martin","year":"2020","journal-title":"Curr. Addict. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"9364091","DOI":"10.1155\/2016\/9364091","article-title":"The Endocannabinoid System as a Therapeutic Target in Glaucoma","volume":"2016","author":"Cairns","year":"2016","journal-title":"Neural Plast."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1007\/s12035-020-02054-6","article-title":"Current Aspects of the Endocannabinoid System and Targeted THC and CBD Phytocannabinoids as Potential Therapeutics for Parkinson\u2019s and Alzheimer\u2019s Diseases: A Review","volume":"57","author":"Cooray","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Passani, A., Posarelli, C., Sframeli, A.T., Perciballi, L., Pellegrini, M., Guidi, G., and Figus, M. (2020). Cannabinoids in Glaucoma Patients: The Never-Ending Story. J. Clin. Med., 9.","DOI":"10.3390\/jcm9123978"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1167\/iovs.11-9294","article-title":"Effects of Palmitoylethanolamide on Aqueous Humor Outflow","volume":"53","author":"Kumar","year":"2012","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/ceo.12992","article-title":"DBA\/2J mouse model for experimental glaucoma: Pitfalls and problems","volume":"45","author":"Turner","year":"2017","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ymthe.2018.09.019","article-title":"Loss of Shp2 Rescues BDNF\/TrkB Signaling and Contributes to Improved Retinal Ganglion Cell Neuroprotection","volume":"27","author":"Chitranshi","year":"2018","journal-title":"Mol. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1167\/iovs.18-24838","article-title":"\u03949-Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure","volume":"59","author":"Miller","year":"2018","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Abyadeh, M., Meyfour, A., Gupta, V., Zabet Moghaddam, M., Fitzhenry, M.J., Shahbazian, S., Hosseini Salekdeh, G., and Mirzaei, M. (2020). Recent Advances of Functional Proteomics in Gastrointestinal Cancers-a Path towards the Identification of Candidate Diagnostic, Prognostic, and Therapeutic Molecular Biomarkers. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228532"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.molcel.2015.06.012","article-title":"The Promise of Proteomics for the Study of ADP-Ribosylation","volume":"58","author":"Daniels","year":"2015","journal-title":"Mol. Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1074\/mcp.O116.065201","article-title":"The Promise of Proteomics in the Study of Oncogenic Viruses","volume":"16","author":"McBride","year":"2017","journal-title":"Mol. Cell. Proteom."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Pascovici, D., Wu, J.X., McKay, M.J., Joseph, C., Noor, Z., Kamath, K., Wu, Y., Ranganathan, S., Gupta, V., and Mirzaei, M. (2018). Clinically Relevant Post-Translational Modification Analyses\u2014Maturing Workflows and Bioinformatics Tools. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20010016"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1126\/science.369.6508.1155","article-title":"Cannabis research data reveals a focus on harms of the drug","volume":"369","year":"2020","journal-title":"Science"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neubiorev.2018.12.026","article-title":"Progress in brain cannabinoid CB2 receptor research: From genes to behavior","volume":"98","author":"Jordan","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_66","first-page":"e9309","article-title":"The Association Between Cannabis Use and Schizophrenia: Causative or Curative? A Systematic Review","volume":"12","author":"Patel","year":"2020","journal-title":"Cureus"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.neures.2013.09.010","article-title":"Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: Utility and limitation of the surrogate tissues in research for brain disorders","volume":"77","author":"Horiuchi","year":"2013","journal-title":"Neurosci. Res."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Gr\u00e9gory, P., Nassila, A., Jean-Louis, M., Jean-Louis, G., Jean-Luc, D., and Carine, B.-P. (2020). The Fate of Transplanted Olfactory Progenitors Is Conditioned by the Cell Phenotypes of the Receiver Brain Tissue in Cocultures. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197249"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1007\/s12035-020-02205-9","article-title":"Olfactory Neuroepithelium Cells from Cannabis Users Display Alterations to the Cytoskeleton and to Markers of Adhesion, Proliferation and Apoptosis","volume":"58","author":"Castro","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Barrera-Conde, M., Ausin, K., Lach\u00e9n-Montes, M., Fern\u00e1ndez-Irigoyen, J., Galindo, L., Cuenca-Royo, A., Fern\u00e1ndez-Avil\u00e9s, C., P\u00e9rez, V., de la Torre, R., and Santamar\u00eda, E. (2021). Cannabis Use Induces Distinctive Proteomic Alterations in Olfactory Neuroepithelial Cells of Schizophrenia Patients. J. Personal. Med., 11.","DOI":"10.3390\/jpm11030160"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/bju.13759","article-title":"Cannabinoids for treating neurogenic lower urinary tract dysfunction in patients with multiple sclerosis: A systematic review and meta-analysis","volume":"119","author":"Youssef","year":"2017","journal-title":"BJU Int."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.juro.2008.11.078","article-title":"Differential Expression of Functional Cannabinoid Receptors in Human Bladder Detrusor and Urothelium","volume":"181","author":"Tyagi","year":"2009","journal-title":"J. Urol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"223.e9","DOI":"10.1016\/j.urology.2017.08.011","article-title":"Impact of Regular Cannabis Use on Biomarkers of Lower Urinary Tract Function","volume":"109","author":"Nedumaran","year":"2017","journal-title":"Urology"},{"key":"ref_74","unstructured":"Hinckley, J.D., Saba, L., Raymond, K., Bartels, K., Klawitter, J., Christians, U., and Hopfer, C. (2020). An Approach to Biomarker Discovery of Cannabis Use Utilizing Proteomic, Metabolomic, and Lipidomic Analyses. Cannabis Cannabinoid Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2007.10.062","article-title":"Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes","volume":"1191","author":"Bindukumar","year":"2008","journal-title":"Brain Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/sj.npp.1301475","article-title":"Adolescent Rats Find Repeated \u03949-THC Less Aversive Than Adult Rats but Display Greater Residual Cognitive Deficits and Changes in Hippocampal Protein Expression Following Exposure","volume":"33","author":"Quinn","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12031-008-9114-2","article-title":"Transcriptomic and Proteomic Analyses of Mouse Cerebellum Reveals Alterations in RasGRF1 Expression Following In Vivo Chronic Treatment with Delta 9-Tetrahydrocannabinol","volume":"37","author":"Colombo","year":"2008","journal-title":"J. Mol. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12640-009-9031-3","article-title":"The Depressive Phenotype Induced in Adult Female Rats by Adolescent Exposure to THC is Associated with Cognitive Impairment and Altered Neuroplasticity in the Prefrontal Cortex","volume":"15","author":"Rubino","year":"2009","journal-title":"Neurotox. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1111\/j.1471-4159.2011.07391.x","article-title":"\u03949-THC increases endogenous AHA1 expression in rat cerebellum and may modulate CB1 receptor function during chronic use","volume":"118","author":"Filipeanu","year":"2011","journal-title":"J. Neurochem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fncel.2013.00015","article-title":"Novel molecular changes induced by Nrg1 hypomorphism and Nrg1-cannabinoid interaction in adolescence: A hippocampal proteomic study in mice","volume":"7","author":"Spencer","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/embj.201386035","article-title":"Miswiring the brain: 9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10\/stathmin-2 degradation pathway","volume":"33","author":"Tortoriello","year":"2014","journal-title":"EMBO J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bcp.2018.08.026","article-title":"\u03949-tetrahydrocannabinol modulates the proteasome system in the brain","volume":"157","author":"Guney","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Beiersdorf, J., Hevesi, Z., Calvigioni, D., Pyszkowski, J., Romanov, R., Szodorai, E., Lubec, G., Shirran, S., Botting, C.H., and Kasper, S. (2020). Adverse effects of \u03949-tetrahydrocannabinol on neuronal bioenergetics during postnatal development. JCI Insight, 5.","DOI":"10.1172\/jci.insight.135418"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"9991","DOI":"10.1073\/pnas.1920866117","article-title":"Cannabinoid exposure in rat adolescence reprograms the initial behavioral, molecular, and epigenetic response to cocaine","volume":"117","author":"Scherma","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"111651","DOI":"10.1016\/j.biopha.2021.111651","article-title":"Tetrahydrocurcumin ameliorates Alzheimer\u2019s pathological phenotypes by inhibition of microglial cell cycle arrest and apoptosis via Ras\/ERK signaling","volume":"139","author":"Xiao","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"112163","DOI":"10.1016\/j.ejmech.2020.112163","article-title":"Overview of cannabidiol (CBD) and its analogues: Structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer\u2019s disease","volume":"192","author":"Li","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fphar.2014.00073","article-title":"Glutathione synthesis is compromised in erythrocytes from individuals with HIV","volume":"5","author":"Morris","year":"2014","journal-title":"Front. Pharmacol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2217\/fnl.11.27","article-title":"Lasting impacts of prenatal cannabis exposure and the role of endogenous cannabinoids in the developing brain","volume":"6","author":"Wu","year":"2011","journal-title":"Future Neurol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/ppe.12505","article-title":"Effects of prenatal marijuana exposure on neuropsychological outcomes in children aged 1-11 years: A systematic review","volume":"32","author":"Sharapova","year":"2018","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ntt.2004.11.002","article-title":"Marijuana impairs growth in mid-gestation fetuses","volume":"27","author":"Hurd","year":"2005","journal-title":"Neurotoxicol. Teratol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Sestan-Pesa, M., Shanabrough, M., Horvath, T.L., and Miletta, M.C. (2020). Peri-adolescent THC exposure does not lead to anxiety-like behavior in adult mice. bioRxiv.","DOI":"10.1101\/2020.08.31.274274"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e961","DOI":"10.1038\/tp.2016.225","article-title":"Are adolescents more vulnerable to the harmful effects of cannabis than adults? A placebo-controlled study in human males","volume":"6","author":"Mokrysz","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1177\/0269881120965931","article-title":"Effects of repeated adolescent exposure to cannabis smoke on cognitive outcomes in adulthood","volume":"35","author":"Hernandez","year":"2020","journal-title":"J. Psychopharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1016\/j.mce.2008.02.003","article-title":"Long lasting consequences of cannabis exposure in adolescence","volume":"286","author":"Rubino","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neulet.2014.05.057","article-title":"Sex differences in \u03949-tetrahydrocannabinol metabolism and in vivo pharmacology following acute and repeated dosing in adolescent rats","volume":"576","author":"Wiley","year":"2014","journal-title":"Neurosci. Lett."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/87565641.2016.1187033","article-title":"Brain development, impulsivity, risky decision making, and cognitive control: Integrating cognitive and socioemotional processes during adolescence\u2014An introduction to the special Issue","volume":"41","author":"Leshem","year":"2016","journal-title":"Dev. Neuropsychol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3389\/fnins.2014.00361","article-title":"Long-term consequences of adolescent cannabinoid exposure in adult psychopathology","volume":"8","author":"Renard","year":"2014","journal-title":"Front. Neurosci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/npp.2017.143","article-title":"The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development","volume":"43","author":"Meyer","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41401-019-0210-3","article-title":"Cannabis, cannabinoid receptors, and endocannabinoid system: Yesterday, today, and tomorrow","volume":"40","author":"Wu","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neuropharm.2015.02.025","article-title":"MAM-2201, a synthetic cannabinoid drug of abuse, suppresses the synaptic input to cerebellar Purkinje cells via activation of presynaptic CB1 receptors","volume":"95","author":"Irie","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/dom.13497","article-title":"Cannabinoid-1 receptor regulates mitochondrial dynamics and function in renal proximal tubular cells","volume":"21","author":"Drori","year":"2018","journal-title":"Diabetes Obes. Metab."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fnmol.2019.00024","article-title":"Amyloid \u03b2 Induces Early Changes in the Ribosomal Machinery, Cytoskeletal Organization and Oxidative Phosphorylation in Retinal Photoreceptor Cells","volume":"12","author":"Deng","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/14789450.2021.1918550","article-title":"Mitochondrial dysfunction in Alzheimer\u2019s disease\u2014A proteomics perspective","volume":"18","author":"Abyadeh","year":"2021","journal-title":"Expert Rev. Proteom."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.1007\/s12035-019-1479-4","article-title":"Upregulation of Proteolytic Pathways and Altered Protein Biosynthesis Underlie Retinal Pathology in a Mouse Model of Alzheimer\u2019s Disease","volume":"56","author":"Mirzaei","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.2174\/138161212802884780","article-title":"Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers","volume":"18","author":"Crippa","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"101321","DOI":"10.1016\/j.redox.2019.101321","article-title":"Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1","volume":"28","author":"Casares","year":"2019","journal-title":"Redox Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2310\/7750.2012.11124","article-title":"Phototherapy in psoriasis: A review of mechanisms of action","volume":"17","author":"Wong","year":"2013","journal-title":"J. Cutan. Med. Surg."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1118\/1.4903963","article-title":"Ultraviolet radiation therapy and UVR dose models","volume":"42","author":"Grimes","year":"2014","journal-title":"Med. Phys."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1751-1097.2007.00226.x","article-title":"The Protective Role of Melanin Against UV Damage in Human Skin\u2020","volume":"84","author":"Brenner","year":"2007","journal-title":"Photochem. Photobiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"8515","DOI":"10.1128\/MCB.00807-06","article-title":"Differential Role of Basal Keratinocytes in UV-Induced Immunosuppression and Skin Cancer","volume":"26","author":"Jans","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"113656","DOI":"10.1016\/j.jpba.2020.113656","article-title":"Therapeutic application of cannabidiol on UVA and UVB irradiated rat skin. A proteomic study","volume":"192","author":"Atalay","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Atalay, S., G\u0119gotek, A., and Skrzydlewska, E. (2021). Protective Effects of Cannabidiol on the Membrane Proteome of UVB-Irradiated Keratinocytes. Antioxidants, 10.","DOI":"10.3390\/antiox10030402"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"G\u0119gotek, A., Atalay, S., Rogowska-Wrzesi\u0144ska, A., and Skrzydlewska, E. (2021). The Effect of Cannabidiol on UV-Induced Changes in Intracellular Signaling of 3D-Cultured Skin Keratinocytes. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031501"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/jcp.24683","article-title":"3D Cell Culture Systems: Advantages and Applications","volume":"230","author":"Ravi","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2016.11.033","article-title":"Antioxidants and HNE in redox homeostasis","volume":"111","author":"Skrzydlewska","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.chemphyslip.2019.03.011","article-title":"Biological effect of protein modifications by lipid peroxidation products","volume":"221","author":"Skrzydlewska","year":"2019","journal-title":"Chem. Phys. Lipids"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1476-5381.2009.00515.x","article-title":"Evidence that the plant cannabinoid cannabigerol is a highly potent \u03b12-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist","volume":"159","author":"Cascio","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Carrillo-Salinas, F.J., Navarrete, C.M., Mecha, M., Feliu, A., Collado, J.A., Cantarero, I., Bellido, M.L., Mu\u00f1oz, E., and Guaza, C. (2014). A Cannabigerol Derivative Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0094733"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1007\/s11481-012-9399-3","article-title":"A Cannabigerol Quinone Alleviates Neuroinflammation in a Chronic Model of Multiple Sclerosis","volume":"7","author":"Granja","year":"2012","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3389\/fphar.2018.00632","article-title":"Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1\u2013CB2 Heteroreceptor Complexes","volume":"9","author":"Navarro","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Di Giacomo, V., Chiavaroli, A., Recinella, L., Orlando, G., Cataldi, A., Rapino, M., Di Valerio, V., Ronci, M., Leone, S., and Brunetti, L. (2020). Antioxidant and Neuroprotective Effects Induced by Cannabidiol and Cannabigerol in Rat CTX-TNA2 Astrocytes and Isolated Cortexes. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103575"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"586110","DOI":"10.3389\/fphar.2020.586110","article-title":"Cannabidiol Treatment for Refractory Epilepsies in Pediatrics","volume":"11","author":"Raucci","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1055\/s-0040-1714329","article-title":"Effect of Cannabinoids on Electroencephalography of a Child with Lennox\u2013Gastaut Syndrome","volume":"11","author":"Prakash","year":"2020","journal-title":"J. Neurosci. Rural Pract."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fnbeh.2011.00060","article-title":"Beyond THC: The New Generation of Cannabinoid Designer Drugs","volume":"5","author":"Fattore","year":"2011","journal-title":"Front. Behav. Neurosci."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Walsh, K.B., and Andersen, H.K. (2020). Molecular Pharmacology of Synthetic Cannabinoids: Delineating CB1 Receptor-Mediated Cell Signaling. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176115"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s00204-015-1569-7","article-title":"Impact of a synthetic cannabinoid (CP-47,497-C8) on protein expression in human cells: Evidence for induction of inflammation and DNA damage","volume":"90","author":"Bileck","year":"2015","journal-title":"Arch. Toxicol."},{"key":"ref_127","first-page":"27","article-title":"Analysis of Synthetic Cannabinoids in Botanical Material: A Review of Analytical Methods and Findings","volume":"25","author":"Presley","year":"2013","journal-title":"Forensic Sci. Rev."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.pbb.2011.09.003","article-title":"Pretreatment with \u03949-tetrahydrocannabinol (THC) increases cocaine-stimulated activity in adolescent but not adult male rats","volume":"100","author":"Izenwasser","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1016\/j.celrep.2018.02.065","article-title":"Cannabinoid Modulation of Eukaryotic Initiation Factors (eIF2\u03b1 and eIF2B1) and Behavioral Cross-Sensitization to Cocaine in Adolescent Rats","volume":"22","author":"Melas","year":"2018","journal-title":"Cell Rep."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1037\/pha0000276","article-title":"Effects of adolescent \u03949-tetrahydrocannabinol exposure on the behavioral effects of cocaine in adult Sprague\u2013Dawley rats","volume":"27","author":"Friedman","year":"2019","journal-title":"Exp. Clin. Psychopharmacol."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/10\/1411\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:05:33Z","timestamp":1760166333000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/10\/1411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,27]]},"references-count":130,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["biom11101411"],"URL":"https:\/\/doi.org\/10.3390\/biom11101411","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,27]]}}}