{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:48:01Z","timestamp":1792813681935,"version":"4.5.0"},"reference-count":30,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sociedad Espa\u00f1ola de Cirug\u00eda Tor\u00e1cica","award":["180101"],"award-info":[{"award-number":["180101"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16-01315"],"award-info":[{"award-number":["PI16-01315"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The ideal tracheal substitute must have biomechanical properties comparable to the native trachea, but currently there is no standardised approach to evaluating these properties. Here we propose a novel method for evaluating and comparing the properties of tracheal substitutes, thus systematising both measurement and data curation. This system was tested by comparing native rabbit tracheas to frozen and decellularised specimens and determining the histological characteristics of those specimens. We performed radial compression tests on the anteroposterior tracheal axis and longitudinal axial tensile tests with the specimens anastomosed to the jaw connected to a measuring system. All calculations and results were adjusted according to tracheal size, always using variables relative to the tracheal dimensions, thus permitting comparison of different sized organs. The biomechanical properties of the decellularised specimens were only slightly reduced compared to controls and significant in regard to the maximum stress withstood in the longitudinal axis (\u22120.246 MPa CI [\u22120.248, \u22120.145] MPa) and the energy stored per volume unit (\u22120.124 mJ\u00b7mm\u22123 CI [\u22120.195, \u22120.055] mJ\u00b7mm\u22123). The proposed method is suitable for the systematic characterisation of the biomechanical properties of different tracheal substitutes, regardless of the size or nature of the substitute, thus allowing for direct comparisons.<\/jats:p>","DOI":"10.3390\/biom11101461","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T10:36:57Z","timestamp":1633516617000},"page":"1461","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A Standardised Approach to the Biomechanical Evaluation of Tracheal Grafts"],"prefix":"10.3390","volume":"11","author":[{"given":"N\u00e9stor J.","family":"Mart\u00ednez-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Thoracic Surgery Department, Hospital Universitari de la Ribera, 46600 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Mas-Estell\u00e9s","sequence":"additional","affiliation":[{"name":"Biomaterials Center, Universitat Polit\u00e8cnica de Val\u00e8ncia, 46022 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Mili\u00e1n-Medina","sequence":"additional","affiliation":[{"name":"Pathology Department, Medicine and Odontology Faculty, Universitat de Val\u00e8ncia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mart\u00ednez-Ramos","sequence":"additional","affiliation":[{"name":"Biomaterials Center, Universitat Polit\u00e8cnica de Val\u00e8ncia, 46022 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Cer\u00f3n-Navarro","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department, Hospital Universitari i Polit\u00e8cnic la Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1058-0171","authenticated-orcid":false,"given":"Jos\u00e9","family":"Galbis-Caravajal","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department, Hospital Universitari de la Ribera, 46600 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo","family":"Roig-Bataller","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department, Hospital Universitari de la Ribera, 46600 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mata-Roig","sequence":"additional","affiliation":[{"name":"Pathology Department, Medicine and Odontology Faculty, Universitat de Val\u00e8ncia, 46010 Valencia, Spain"},{"name":"Networking Research Center on Respiratory Diseases (CIBERER), ISCIII, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0003-4975(02)04109-7","article-title":"Development of tracheal surgery: A historical review. 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Int."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/10\/1461\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:09:33Z","timestamp":1760166573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/10\/1461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,5]]},"references-count":30,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["biom11101461"],"URL":"https:\/\/doi.org\/10.3390\/biom11101461","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,5]]}}}