{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T17:56:37Z","timestamp":1767117397103,"version":"build-2065373602"},"reference-count":12,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) is the second most common neurodegenerative age-related disorder worldwide after Alzheimer\u2019s disease [...]<\/jats:p>","DOI":"10.3390\/biom11111640","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T10:33:09Z","timestamp":1636108389000},"page":"1640","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Advances in Parkinson\u2019s Disease Drugs"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3042-2234","authenticated-orcid":false,"given":"Antonio","family":"Di Stefano","sequence":"first","affiliation":[{"name":"Department of Pharmacy, \u201cG. d\u2019Annunzio\u201d University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Marinelli","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \u201cG. d\u2019Annunzio\u201d University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bologna, M., Truong, D., and Jankovic, J. (2021). The etiopathogenetic and pathophysiological spectrum of parkinsonism. J. Neurol. Sci., 120012.","DOI":"10.1016\/j.jns.2021.120012"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijpharm.2015.03.001","article-title":"Solid lipid nanoparticles loaded with lipoyl\u2013memantine codrug: Preparation and characterization","volume":"485","author":"Laserra","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of Parkinson disease: A review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41531-021-00179-6","article-title":"Synucleinopathy-associated pathogenesis in Parkinson\u2019s disease and the potential for brain-derived neurotrophic factor","volume":"7","author":"Miller","year":"2021","journal-title":"NPJ Park. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41572-021-00280-3","article-title":"Parkinson disease-associated cognitive impairment","volume":"7","author":"Aarsland","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/17460441.2018.1429400","article-title":"Advances in prodrug design for Parkinson\u2019s disease","volume":"13","author":"Cacciatore","year":"2018","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nrd.2018.136","article-title":"Therapeutic strategies for Parkinson disease: Beyond dopaminergic drugs","volume":"17","author":"Charvin","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Del Bello, F., Giannella, M., Giorgioni, G., Piergentili, A., and Quaglia, W. (2019). Receptor Ligands as Helping Hands to L-DOPA in the Treatment of Parkinson\u2019s Disease. Biomolecules, 9.","DOI":"10.3390\/biom9040142"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Carrarini, C., Russo, M., Dono, F., Di Pietro, M., Rispoli, M.G., Di Stefano, V., Ferri, L., Barbone, F., Vitale, M., and Thomas, A. (2019). A Stage-Based Approach to Therapy in Parkinson\u2019s Disease. Biomolecules, 9.","DOI":"10.3390\/biom9080388"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ciulla, M., Marinelli, L., Cacciatore, I., and Di Stefano, A. (2019). Role of Dietary Supplements in the Management of Parkinson\u2019s Disease. Biomolecules, 9.","DOI":"10.3390\/biom9070271"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Tosato, M., and Di Marco, V. (2019). Metal Chelation Therapy and Parkinson\u2019s Disease: A Critical Review on the Thermodynamics of Complex Formation between Relevant Metal Ions and Promising or Established Drugs. Biomolecules, 9.","DOI":"10.3390\/biom9070269"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Di Stefano, A., Marinelli, L., Eusepi, P., Ciulla, M., Fulle, S., Di Filippo, E.S., Magliulo, L., Di Biase, G., and Cacciatore, I. (2019). Synthesis and Biological Evaluation of Novel Selenyl and Sulfur-l-Dopa Derivatives as Potential Anti-Parkinson\u2019s Disease Agents. Biomolecules, 9.","DOI":"10.3390\/biom9060239"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/11\/1640\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:26:07Z","timestamp":1760167567000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/11\/11\/1640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,5]]},"references-count":12,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["biom11111640"],"URL":"https:\/\/doi.org\/10.3390\/biom11111640","relation":{},"ISSN":["2218-273X"],"issn-type":[{"type":"electronic","value":"2218-273X"}],"subject":[],"published":{"date-parts":[[2021,11,5]]}}}