{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T10:40:21Z","timestamp":1772620821723,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["480128\/2013-8"],"award-info":[{"award-number":["480128\/2013-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The present study evaluated the IL8-251 A\/T polymorphism in samples from 74 patients with chronic hepatitis B (HBV), 100 patients with chronic hepatitis C (HCV), and 300 healthy donors (CG). The correlations of this polymorphism with plasma IL-8 and disease stage were calculated. Polymorphisms were identified by real-time PCR. IL-8 was measured by enzyme-linked immunosorbent assay. The IL8-251 A\/T genotype was not associated with susceptibility to infection by HBV or HCV. The wild-type allele (A) was associated with higher levels of inflammation (p = 0.0464) and fibrosis scores (p = 0.0016) in the HBV group, representing an increased risk for increased inflammatory activity (OR = 1.84; p = 0.0464) and for high fibrosis scores (OR = 2.63; p = 0.0016). Viral load was higher in HBV patients with polymorphic genotypes (TA and TT) at the IL8-251 A\/T polymorphism than in those with the wild-type genotype (p = 0.0272 and p = 0.0464, respectively). Plasma IL-8 was higher among patients infected with HBV or HCV than in the control group (p = 0.0445 and p = 0.0001, respectively). The polymorphic genotype was associated with lower IL-8 than the wild-type genotype in the HBV group (p = 0.0239) and the HCV group (p = 0.0372). The wild-type genotype for IL8-251 A\/T and high IL-8 were associated with a worse prognosis for infections; therefore, they may contribute to viral persistence and the development of more severe forms of chronic viral liver diseases.<\/jats:p>","DOI":"10.3390\/biom11111664","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T09:19:21Z","timestamp":1636535961000},"page":"1664","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Genetic Profile and Serum Level of IL-8 Are Associated with Chronic Hepatitis B and C Virus Infection"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7079-4844","authenticated-orcid":false,"given":"Ednelza da Silva Gra\u00e7a","family":"Amoras","sequence":"first","affiliation":[{"name":"Laboratory of Virology, Institute of Biological Sciences, Federal University of Par\u00e1 (Universidade Federal do Par\u00e1\u2014UFPA), Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Botelho","family":"de Brito","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Institute of Biological Sciences, Federal University of Par\u00e1 (Universidade Federal do Par\u00e1\u2014UFPA), Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2014-2770","authenticated-orcid":false,"given":"Maria Alice Freitas","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Institute of Biological Sciences, Federal University of Par\u00e1 (Universidade Federal do Par\u00e1\u2014UFPA), Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0278-4972","authenticated-orcid":false,"given":"Simone Regina Souza da Silva","family":"Conde","sequence":"additional","affiliation":[{"name":"Jo\u00e3o de Barros Barreto Hospital, Federal University of Par\u00e1 (Universidade Federal do Par\u00e1\u2014UFPA), Bel\u00e9m 66073-000, Brazil"},{"name":"Institute of Health Sciences, School of Medicine, Federal University of Par\u00e1 (Universidade Federal do Par\u00e1\u2014UFPA), Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izaura Maria Vieira","family":"Cayres Vallinoto","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Institute of Biological Sciences, Federal University of Par\u00e1 (Universidade Federal do Par\u00e1\u2014UFPA), Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Ishak","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Institute of Biological Sciences, Federal University of Par\u00e1 (Universidade Federal do Par\u00e1\u2014UFPA), Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1135-6507","authenticated-orcid":false,"given":"Antonio Carlos Ros\u00e1rio","family":"Vallinoto","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Institute of Biological Sciences, Federal University of Par\u00e1 (Universidade Federal do Par\u00e1\u2014UFPA), Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nri.2016.69","article-title":"Immune responses and immunopathology in acute and chronic viral hepatitis","volume":"16","author":"Shin","year":"2016","journal-title":"Nat. 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