{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T16:09:06Z","timestamp":1770566946817,"version":"3.49.0"},"reference-count":90,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Commission under the framework programme of the European Union, LipiDiDiet","award":["211696"],"award-info":[{"award-number":["211696"]}]},{"name":"EU Joint Programme-Neurodegenerative Disease Research (JPND) and BMBF grants MIND-AD","award":["01ED1509"],"award-info":[{"award-number":["01ED1509"]}]},{"name":"EURO-FINGERS","award":["01ED2003"],"award-info":[{"award-number":["01ED2003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Vitamin D3 hypovitaminosis is associated with several neurological diseases such as Alzheimer\u2019s disease, Parkinson\u2019s disease or multiple sclerosis but also with other diseases such as cancer, diabetes or diseases linked to inflammatory processes. Importantly, in all of these diseases lipids have at least a disease modifying effect. Besides its well-known property to modulate gene-expression via the VDR-receptor, less is known if vitamin D hypovitaminosis influences lipid homeostasis and if these potential changes contribute to the pathology of the diseases themselves. Therefore, we analyzed mouse brain with a mild vitamin D hypovitaminosis via a targeted shotgun lipidomic approach, including phosphatidylcholine, plasmalogens, lyso-phosphatidylcholine, (acyl-\/acetyl-) carnitines and triglycerides. Alterations were compared with neuroblastoma cells cultivated in the presence and with decreased levels of vitamin D. Both in cell culture and in vivo, decreased vitamin D level resulted in changed lipid levels. While triglycerides were decreased, carnitines were increased under vitamin D hypovitaminosis suggesting an impact of vitamin D on energy metabolism. Additionally, lyso-phosphatidylcholines in particular saturated phosphatidylcholine (e.g., PC aa 48:0) and plasmalogen species (e.g., PC ae 42:0) tended to be increased. Our results suggest that vitamin D hypovitaminosis not only may affect gene expression but also may directly influence cellular lipid homeostasis and affect lipid turnover in disease states that are known for vitamin D hypovitaminosis.<\/jats:p>","DOI":"10.3390\/biom11111699","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T20:46:47Z","timestamp":1637009207000},"page":"1699","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of Vitamin D3 Deficiency on Phosphatidylcholine-\/Ethanolamine, Plasmalogen-, Lyso-Phosphatidylcholine-\/Ethanolamine, Carnitine- and Triacyl Glyceride-Homeostasis in Neuroblastoma Cells and Murine Brain"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8327-452X","authenticated-orcid":false,"given":"Anna Andrea","family":"Lauer","sequence":"first","affiliation":[{"name":"Experimental Neurology, Saarland University, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5025-0188","authenticated-orcid":false,"given":"Lea Victoria","family":"Griebsch","sequence":"additional","affiliation":[{"name":"Experimental Neurology, Saarland University, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina Melanie","family":"Pilz","sequence":"additional","affiliation":[{"name":"Experimental Neurology, Saarland University, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8966-0184","authenticated-orcid":false,"given":"Daniel","family":"Janitschke","sequence":"additional","affiliation":[{"name":"Experimental Neurology, Saarland University, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena Leoni","family":"Theiss","sequence":"additional","affiliation":[{"name":"Experimental Neurology, Saarland University, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Reichrath","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Saarland University Hospital, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9422-6569","authenticated-orcid":false,"given":"Christian","family":"Herr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V-Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4391-3240","authenticated-orcid":false,"given":"Christoph","family":"Beisswenger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V-Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Bals","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V-Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7222-2265","authenticated-orcid":false,"given":"Teresa Giovanna","family":"Valencak","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Paris Lodron University Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Germany"},{"name":"College of Animal Sciences, Zijingang Campus, Zhejiang University, Hangzhou 310058, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothea","family":"Portius","sequence":"additional","affiliation":[{"name":"Nutrition Therapy and Counseling, Campus Gera, SRH University of Applied Health Science, 07548 Gera, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike Sabine","family":"Grimm","sequence":"additional","affiliation":[{"name":"Experimental Neurology, Saarland University, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7481-6430","authenticated-orcid":false,"given":"Tobias","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Deutsches Institut f\u00fcr Demenzpr\u00e4vention, Saarland University, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4160-6506","authenticated-orcid":false,"given":"Marcus Otto Walter","family":"Grimm","sequence":"additional","affiliation":[{"name":"Experimental Neurology, Saarland University, 66421 Homburg, Germany"},{"name":"Deutsches Institut f\u00fcr Demenzpr\u00e4vention, Saarland University, 66421 Homburg, Germany"},{"name":"Nutrition Therapy and Counseling, Campus Rheinland, SRH University of Applied Health Science, 51377 Leverkusen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"ref_1","unstructured":"Ross, A.C., Taylor, C.L., Yaktine, A.L., and Del Valle, H.B. 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