{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:56:31Z","timestamp":1788404191636,"version":"build-2803163510"},"reference-count":58,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"publisher","award":["16-06008S"],"award-info":[{"award-number":["16-06008S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Czech Ministry of Health","award":["AZV 16-27317A"],"award-info":[{"award-number":["AZV 16-27317A"]}]},{"name":"Czech Ministry of Health","award":["RVO-VFN64165\/2021"],"award-info":[{"award-number":["RVO-VFN64165\/2021"]}]},{"DOI":"10.13039\/501100004240","name":"Czech Academy of Sciences","doi-asserted-by":"publisher","award":["RVO-68378050"],"award-info":[{"award-number":["RVO-68378050"]}],"id":[{"id":"10.13039\/501100004240","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Education, Youth and Sports","award":["LM2018100"],"award-info":[{"award-number":["LM2018100"]}]},{"name":"Ministry of Education, Youth and Sports","award":["CZ.1.05\/1.1.00\/02.0109"],"award-info":[{"award-number":["CZ.1.05\/1.1.00\/02.0109"]}]},{"name":"Ministry of Education, Youth and Sports","award":["CZ.1.05\/2.1.00\/19.0395"],"award-info":[{"award-number":["CZ.1.05\/2.1.00\/19.0395"]}]},{"name":"Ministry of Education, Youth and Sports","award":["LM2018126"],"award-info":[{"award-number":["LM2018126"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Milk thistle-based dietary supplements have become increasingly popular. The extract from milk thistle (Silybum marianum) is often used for the treatment of liver diseases because of the presence of its active component, silymarin. However, the co-occurrence of toxic mycotoxins in these preparations is quite frequent as well. The objective of this study was to investigate the changes in composition of liver lipidome and other clinical characteristics of experimental mice fed by a high-fat methionine-choline deficient diet inducing non-alcoholic fatty liver disease. The mice were exposed to (i) silymarin, (ii) mycotoxins (trichothecenes, enniatins, beauvericin, and altertoxins) and (iii) both silymarin and mycotoxins, and results were compared to the controls. The liver tissue extracts were analyzed by ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry. Using tools of univariate and multivariate statistical analysis, we were able to identify 48 lipid species from the classes of diacylglycerols, triacylglycerols, free fatty acids, fatty acid esters of hydroxy fatty acids and phospholipids clearly reflecting the dysregulation of lipid metabolism upon exposure to mycotoxin and\/or silymarin.<\/jats:p>","DOI":"10.3390\/biom11111723","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T08:29:17Z","timestamp":1637310557000},"page":"1723","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Effect of Mycotoxins and Silymarin on Liver Lipidome of Mice with Non-Alcoholic Fatty Liver Disease"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7962-4857","authenticated-orcid":false,"given":"Kamila","family":"Bechynska","sequence":"first","affiliation":[{"name":"Department of Food Chemistry and Analysis, University of Chemistry and Technology, 166 28 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2087-9596","authenticated-orcid":false,"given":"Vit","family":"Kosek","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry and Analysis, University of Chemistry and Technology, 166 28 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9920-6110","authenticated-orcid":false,"given":"Marie","family":"Fenclova","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry and Analysis, University of Chemistry and Technology, 166 28 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2082-1060","authenticated-orcid":false,"given":"Lucie","family":"Muchova","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University, 128 08 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaclav","family":"Smid","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, General University Hospital and 1st Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Suk","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University, 128 08 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Chalupsky","sequence":"additional","affiliation":[{"name":"Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Sticova","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Hurkova","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry and Analysis, University of Chemistry and Technology, 166 28 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Hajslova","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry and Analysis, University of Chemistry and Technology, 166 28 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5318-0151","authenticated-orcid":false,"given":"Libor","family":"Vitek","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and 1st Faculty of Medicine, Charles University, 128 08 Prague, Czech Republic"},{"name":"4th Department of Internal Medicine, General University Hospital and 1st Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Stranska","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry and Analysis, University of Chemistry and Technology, 166 28 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11118","DOI":"10.1038\/s41598-019-47250-0","article-title":"Poor Chemical and Microbiological Quality of the Commercial Milk Thistle-Based Dietary Supplements May Account for Their Reported Unsatisfactory and Non-Reproducible Clinical Outcomes","volume":"9","author":"Fenclova","year":"2019","journal-title":"Sci. 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