{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T02:48:29Z","timestamp":1784429309107,"version":"3.55.0"},"reference-count":96,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ES R01 07331, R01 ES 20852 and ES R01 10563"],"award-info":[{"award-number":["ES R01 07331, R01 ES 20852 and ES R01 10563"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>BXD recombinant inbred (RI) lines represent a genetic reference population derived from a cross between C57BL\/6J mice (B6) and DBA\/2J mice (D2), which through meiotic recombination events possesses recombinant chromosomes containing B6 or D2 haplotype segments. The quantitative trait loci (QTLs) are the locations of segregating genetic polymorphisms and are fundamental to understanding genetic diversity in human disease susceptibility and severity. QTL mapping represents the typical approach for identifying naturally occurring polymorphisms that influence complex phenotypes. In this process, genotypic values at markers of known genomic locations are associated with phenotypic values measured in a segregating population. Indeed, BXD RI strains provide a powerful tool to study neurotoxicity induced by different substances. In this review, we describe the use of BXD RI lines to understand the underlying mechanisms of neurotoxicity in response to ethanol and cocaine, as well as metals and pesticide exposures.<\/jats:p>","DOI":"10.3390\/biom11121762","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T04:01:28Z","timestamp":1637812888000},"page":"1762","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["BXD Recombinant Inbred Mice as a Model to Study Neurotoxicity"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2157-5984","authenticated-orcid":false,"given":"Airton C.","family":"Martins","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6767-8252","authenticated-orcid":false,"given":"Caridad","family":"L\u00f3pez-Granero","sequence":"additional","affiliation":[{"name":"Departamento de Psicolog\u00eda y Sociolog\u00eda, Campus Ciudad Escolar, Universidad de Zaragoza, 44003 Teruel, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey A.","family":"Tinkov","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Dietetics, IM Sechenov First Moscow State Medical University, 119435 Moscow, Russia"},{"name":"Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, 150003 Yaroslavl, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoly V.","family":"Skalny","sequence":"additional","affiliation":[{"name":"World-Class Research Center \u201cDigital Biodesign and Personalized Healthcare\u201d, IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia"},{"name":"Department of Bioelementology, KG Razumovsky Moscow State University of Technologies and Management, 109004 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1898-6133","authenticated-orcid":false,"given":"Monica M. B.","family":"Paoliello","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2619-1656","authenticated-orcid":false,"given":"Michael","family":"Aschner","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA"},{"name":"Laboratory of Molecular Dietetics, IM Sechenov First Moscow State Medical University, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cels.2020.12.002","article-title":"A platform for experimental precision medicine: The extended BXD mouse family","volume":"12","author":"Ashbrook","year":"2021","journal-title":"Cell Syst."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Peirce, J.L., Lu, L., Gu, J., Silver, L.M., and Williams, R.W. (2004). A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC Genet., 5.","DOI":"10.1186\/1471-2156-5-7"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bbi.2020.06.018","article-title":"Genome-wide transcriptome architecture in a mouse model of Gulf War Illness","volume":"89","author":"Xu","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"10464","DOI":"10.1038\/ncomms10464","article-title":"Joint mouse-human phenome-wide association to test gene function and disease risk","volume":"7","author":"Wang","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.bbadis.2014.06.015","article-title":"Next generation sequencing technology: Advances and applications","volume":"1842","author":"Buermans","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.psyneuen.2017.03.006","article-title":"BXD recombinant inbred strains participate in social preference, anxiety and depression behaviors along sex-differences in cytokines and tactile allodynia","volume":"80","author":"Ferrer","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"13168","DOI":"10.1038\/s41598-020-70213-9","article-title":"The BXD21\/TyJ recombinant inbred strain as a model for innate inflammatory response in distinct brain regions","volume":"10","author":"Ferrer","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00213-015-4147-z","article-title":"Systems genetics of intravenous cocaine self-administration in the BXD recombinant inbred mouse panel","volume":"233","author":"Dickson","year":"2016","journal-title":"Psychopharmacology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e12519","DOI":"10.1111\/gbb.12519","article-title":"Systems genetics of sensation seeking","volume":"18","author":"Dickson","year":"2019","journal-title":"Genes Brain Behav."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1111\/j.1530-0277.2012.01754.x","article-title":"Quantitative trait locus mapping for ethanol teratogenesis in BXD recombinant inbred mice","volume":"36","author":"Downing","year":"2012","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3389\/fgene.2013.00126","article-title":"Expression, covariation, and genetic regulation of miRNA Biogenesis genes in brain supports their role in addiction, psychiatric disorders, and disease","volume":"4","author":"Mulligan","year":"2013","journal-title":"Front. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1038\/npp.2015.42","article-title":"KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction","volume":"40","author":"Padula","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1111\/j.1530-0277.1998.tb03904.x","article-title":"Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice","volume":"22","author":"Risinger","year":"1998","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/acer.13947","article-title":"Genetic Influences on the Amount of Cell Death in the Neural Tube of BXD Mice Exposed to Acute Ethanol at Midgestation","volume":"43","author":"Theberge","year":"2019","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3389\/fnbeh.2014.00341","article-title":"Unique genetic loci identified for emotional behavior in control and chronic stress conditions","volume":"8","author":"Carhuatanta","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e12603","DOI":"10.1111\/gbb.12603","article-title":"Genetic background modifies CNS-mediated sensorimotor decline in the AD-BXD mouse model of genetic diversity in Alzheimer\u2019s disease","volume":"18","author":"Ouellette","year":"2019","journal-title":"Genes Brain Behav."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1601-183X.2009.00540.x","article-title":"High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains","volume":"9","author":"Philip","year":"2010","journal-title":"Genes Brain Behav."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/00268970600691365","article-title":"Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred mice","volume":"9","author":"Jones","year":"2006","journal-title":"Nutr. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/toxsci\/kfaa050","article-title":"Systems Genetics and Systems Biology Analysis of Paraquat Neurotoxicity in BXD Recombinant Inbred Mice","volume":"176","author":"Zhuang","year":"2020","journal-title":"Toxicol. Sci."},{"key":"ref_20","first-page":"173","article-title":"Using BXD mouse strains in vision research: A systems genetics approach","volume":"26","author":"Geisert","year":"2020","journal-title":"Mol. Vis."},{"key":"ref_21","first-page":"115","article-title":"The genetic dissection of Myo7a gene expression in the retinas of BXD mice","volume":"24","author":"Lu","year":"2018","journal-title":"Mol. Vis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/j.1601-183X.2008.00431.x","article-title":"Genetic control of experience-dependent plasticity in the visual cortex","volume":"7","author":"Heimel","year":"2008","journal-title":"Genes Brain Behav."},{"key":"ref_23","first-page":"1","article-title":"An integrated hierarchical Bayesian model for multivariate eQTL mapping","volume":"11","author":"Imholte","year":"2012","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"ref_24","first-page":"35","article-title":"Social and Cultural Contexts of Alcohol Use: Influences in a Social-Ecological Framework","volume":"38","author":"Sudhinaraset","year":"2016","journal-title":"Alcohol. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"110411","DOI":"10.1016\/j.pnpbp.2021.110411","article-title":"Behavioral effects of acute ethanol in larval zebrafish (D. rerio) depend on genotype and volume of experimental well","volume":"112","author":"Abozaid","year":"2021","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_26","first-page":"181","article-title":"Polygenic and single-gene determination of responses to ethanol in BXD\/Ty recombinant inbred mouse strains","volume":"5","author":"Crabbe","year":"1983","journal-title":"Neurobehav. Toxicol. Teratol."},{"key":"ref_27","first-page":"67","article-title":"Use of recombinant inbred strains for studying genetic determinants of responses to alcohol","volume":"2","author":"Crabbe","year":"1994","journal-title":"Alcohol. Alcohol. Suppl."},{"key":"ref_28","first-page":"184","article-title":"Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice","volume":"269","author":"Crabbe","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/BF02245643","article-title":"Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology","volume":"104","author":"McClearn","year":"1991","journal-title":"Psychopharmacology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1007\/s003359900903","article-title":"Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption","volume":"9","author":"Phillips","year":"1998","journal-title":"Mamm. Genome"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1530-0277.1995.tb01502.x","article-title":"Effects of acute and repeated ethanol exposures on the locomotor activity of BXD recombinant inbred mice","volume":"19","author":"Phillips","year":"1995","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/BF02246142","article-title":"Localization of genes influencing ethanol-induced conditioned place preference and locomotor activity in BXD recombinant inbred mice","volume":"120","author":"Cunningham","year":"1995","journal-title":"Psychopharmacology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1523\/JNEUROSCI.19-02-00549.1999","article-title":"Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2","volume":"19","author":"Demarest","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1530-0277.2012.01865.x","article-title":"Use of the expanded panel of BXD mice narrow QTL regions in ethanol-induced locomotor activation and motor incoordination","volume":"37","author":"DuBose","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s003359900911","article-title":"High genetic susceptibility to ethanol withdrawal predicts low ethanol consumption","volume":"9","author":"Metten","year":"1998","journal-title":"Mamm. Genome"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1530-0277.2000.tb04547.x","article-title":"Quantitative trait loci affecting ethanol sensitivity in BXD recombinant inbred mice","volume":"24","author":"Browman","year":"2000","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1023\/A:1010261909853","article-title":"Further characterization and high-resolution mapping of quantitative trait loci for ethanol-induced locomotor activity","volume":"31","author":"Demarest","year":"2001","journal-title":"Behav. Genet."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1530-0277.2002.tb02425.x","article-title":"Gene coding variant in Cas1 between the C57BL\/6J and DBA\/2J inbred mouse strains: Linkage to a QTL for ethanol-induced locomotor activation","volume":"26","author":"Xu","year":"2002","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1097\/01.alc.0000187592.57853.12","article-title":"Acute alcohol withdrawal is associated with c-Fos expression in the basal ganglia and associated circuitry: C57BL\/6J and DBA\/2J inbred mouse strain analyses","volume":"29","author":"Kozell","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Tabakoff, B., Saba, L., Printz, M., Flodman, P., Hodgkinson, C., Goldman, D., Koob, G., Richardson, H.N., Kechris, K., and Bell, R.L. (2009). Genetical genomic determinants of alcohol consumption in rats and humans. BMC Biol., 7.","DOI":"10.1186\/1741-7007-7-70"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3389\/fgene.2018.00602","article-title":"Ethanol\u2019s Effect on Coq7 Expression in the Hippocampus of Mice","volume":"9","author":"Zhou","year":"2018","journal-title":"Front. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1176\/appi.ajp.2013.12060782","article-title":"DSM-5 criteria for substance use disorders: Recommendations and rationale","volume":"170","author":"Hasin","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/jnr.23963","article-title":"Sex differences, gender and addiction","volume":"95","author":"Becker","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jsat.2019.08.014","article-title":"Sociodemographic and clinical outcome differences among individuals seeking treatment for cocaine use disorders. The intersection of gender and race","volume":"106","author":"Miguel","year":"2019","journal-title":"J. Subst. Abus. Treat."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.psc.2012.03.010","article-title":"The genetic basis of addictive disorders","volume":"35","author":"Ducci","year":"2012","journal-title":"Psychiatr. Clin. N. Am."},{"key":"ref_46","first-page":"1","article-title":"Molecular genetics of cocaine use disorders in humans","volume":"2021","author":"Corominas","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00213-013-3135-4","article-title":"Cocaine self-administration behavior in inbred mouse lines segregating different capacities for inhibitory control","volume":"229","author":"Cervantes","year":"2013","journal-title":"Psychopharmacology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00213-018-4834-7","article-title":"Intravenous cocaine self-administration in a panel of inbred mouse strains differing in acute locomotor sensitivity to cocaine","volume":"235","author":"Roberts","year":"2018","journal-title":"Psychopharmacology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/gbb.12209","article-title":"Initial locomotor sensitivity to cocaine varies widely among inbred mouse strains","volume":"14","author":"Wiltshire","year":"2015","journal-title":"Genes Brain Behav."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/BF02245099","article-title":"Chromosomal mapping of loci influencing sensitivity to cocaine-induced seizures in BXD recombinant inbred strains of mice","volume":"117","author":"Miner","year":"1995","journal-title":"Psychopharmacology"},{"key":"ref_51","first-page":"180","article-title":"Cocaine-induced seizure thresholds: Quantitative trait loci detection and mapping in two populations derived from the C57BL\/6 and DBA\/2 mouse strains","volume":"293","author":"Hain","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1176\/ajp.155.6.832","article-title":"Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT","volume":"155","author":"Malison","year":"1998","journal-title":"Am. J. Psychiatry"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1016\/j.neuron.2021.08.012","article-title":"Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors","volume":"109","author":"Gong","year":"2021","journal-title":"Neuron"},{"key":"ref_54","first-page":"634","article-title":"Mapping genes that regulate density of dopamine transporters and correlated behaviors in recombinant inbred mice","volume":"298","author":"Janowsky","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1523\/JNEUROSCI.18-08-03023.1998","article-title":"Localization of genes mediating acute and sensitized locomotor responses to cocaine in BXD\/Ty recombinant inbred mice","volume":"18","author":"Phillips","year":"1998","journal-title":"J. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3389\/fnins.2020.00721","article-title":"Discovery of a Role for Rab3b in Habituation and Cocaine Induced Locomotor Activation in Mice Using Heterogeneous Functional Genomic Analysis","volume":"14","author":"Bubier","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.biochi.2009.04.009","article-title":"Systems genetics analysis of iron regulation in the brain","volume":"91","author":"Jellen","year":"2009","journal-title":"Biochimie"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/978-1-4939-6427-7_22","article-title":"Systems Genetics Analysis of Iron and Its Regulation in Brain and Periphery","volume":"1488","author":"Jones","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/hipo.20399","article-title":"Genetic analysis reveals polygenic influences on iron, copper, and zinc in mouse hippocampus with neurobiological implications","volume":"18","author":"Jones","year":"2008","journal-title":"Hippocampus"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neuroscience.2013.12.056","article-title":"Diurnal variations in brain iron concentrations in BXD RI mice","volume":"263","author":"Unger","year":"2014","journal-title":"Neuroscience"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/(SICI)1098-1136(199606)17:2<83::AID-GLIA1>3.0.CO;2-7","article-title":"Relationship of iron to oligodendrocytes and myelination","volume":"17","author":"Connor","year":"1996","journal-title":"Glia"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/glia.20784","article-title":"Oligodendrocytes and myelination: The role of iron","volume":"57","author":"Todorich","year":"2009","journal-title":"Glia"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10048-012-0321-1","article-title":"Systems genetic analysis of the effects of iron deficiency in mouse brain","volume":"13","author":"Jellen","year":"2012","journal-title":"Neurogenetics"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0165-3806(01)00218-8","article-title":"Neonatal iron exposure induces oxidative stress in adult Wistar rat","volume":"130","author":"Klamt","year":"2001","journal-title":"Dev. Brain Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12974-019-1430-7","article-title":"Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro","volume":"16","author":"Yauger","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.nbd.2008.07.001","article-title":"Genetics of iron regulation and the possible role of iron in Parkinson\u2019s disease","volume":"32","author":"Rhodes","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3233\/JAD-201369","article-title":"The Potential Role of Ferroptosis in Alzheimer\u2019s Disease","volume":"80","author":"Zhang","year":"2021","journal-title":"J. Alzheimer\u2019s Dis. JAD"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/S1474-4422(18)30311-9","article-title":"Comorbidities, treatment, and pathophysiology in restless legs syndrome","volume":"17","author":"Trenkwalder","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/jn\/135.2.267","article-title":"Maternal iron deficiency anemia affects postpartum emotions and cognition","volume":"135","author":"Beard","year":"2005","journal-title":"J. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/DBP.0b013e31815f24a9","article-title":"Selective impairment of cognitive performance in the young monkey following recovery from iron deficiency","volume":"29","author":"Lubach","year":"2008","journal-title":"J. Dev. Behav. Pediatr. JDBP"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1038\/s41467-021-25632-1","article-title":"Gene interfered-ferroptosis therapy for cancers","volume":"12","author":"Gao","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/10284150310001624192","article-title":"Quantitative genetic analysis of ventral midbrain and liver iron in BXD recombinant inbred mice","volume":"6","author":"Jones","year":"2003","journal-title":"Nutr. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.sleep.2014.05.009","article-title":"Altered brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease)","volume":"15","author":"Earley","year":"2014","journal-title":"Sleep Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0091-3057(01)00563-9","article-title":"Iron deficiency decreases dopamine D1 and D2 receptors in rat brain","volume":"69","author":"Erikson","year":"2001","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuroscience.2013.07.058","article-title":"Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice","volume":"252","author":"Jellen","year":"2013","journal-title":"Neuroscience"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1471-4159.2007.04639.x","article-title":"The chemokine stromal cell-derived factor-1\/CXCL12 activates the nigrostriatal dopamine system","volume":"102","author":"Skrzydelski","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"15454","DOI":"10.1073\/pnas.0813216106","article-title":"Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells","volume":"106","author":"Biagioli","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","first-page":"331","article-title":"Circadian variation in plasma iron concentration and reticuloendothelial iron release in the rat","volume":"45","author":"Lynch","year":"1973","journal-title":"Clin. Sci. Mol. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1152\/japplphysiol.91076.2008","article-title":"Diurnal cycle influences peripheral and brain iron levels in mice","volume":"106","author":"Unger","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.tips.2018.10.001","article-title":"Copper and Zinc Dysregulation in Alzheimer\u2019s Disease","volume":"39","author":"Sensi","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ymgme.2018.12.005","article-title":"A systematic review and evidence-based guideline for diagnosis and treatment of Menkes disease","volume":"126","author":"Vairo","year":"2019","journal-title":"Mol. Genet. Metab."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1474-4422(14)70190-5","article-title":"Wilson\u2019s disease and other neurological copper disorders","volume":"14","author":"Bandmann","year":"2015","journal-title":"Lancet Neurol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1437S","DOI":"10.1093\/jn\/130.5.1437S","article-title":"Function and mechanism of zinc metalloenzymes","volume":"130","author":"McCall","year":"2000","journal-title":"J. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/cercor\/13.8.823","article-title":"Boutons containing vesicular zinc define a subpopulation of synapses with low AMPAR content in rat hippocampus","volume":"13","author":"Sindreu","year":"2003","journal-title":"Cereb. Cortex"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s12011-018-1466-z","article-title":"Zinc-Enriched Yeast Improves Learning and Memory Impairments in Zinc-Deficient Rats","volume":"189","author":"Zhang","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S0899-9007(01)00812-7","article-title":"The role of zinc in the growth and development of children","volume":"18","author":"Salgueiro","year":"2002","journal-title":"Nutrition"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12011-017-0941-2","article-title":"Association Between Serum Zinc Levels and the Risk of Parkinson\u2019s Disease: A Meta-Analysis","volume":"179","author":"Sun","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3233\/JAD-141296","article-title":"Zinc in Alzheimer\u2019s Disease: A Meta-Analysis of Serum, Plasma, and Cerebrospinal Fluid Studies","volume":"46","author":"Ventriglia","year":"2015","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"RC79","DOI":"10.1523\/JNEUROSCI.20-11-j0003.2000","article-title":"Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: Evidence against synaptic vesicle origin","volume":"20","author":"Lee","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.biopsych.2007.04.027","article-title":"Twenty-four hour plasma cortisol and adrenocorticotropic hormone in Gulf War veterans: Relationships to posttraumatic stress disorder and health symptoms","volume":"62","author":"Golier","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1515\/reveh-2015-0032","article-title":"Gulf War illness: An overview of events, most prevalent health outcomes, exposures, and clues as to pathogenesis","volume":"30","author":"Kerr","year":"2015","journal-title":"Rev. Environ. Health"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1073\/pnas.0711986105","article-title":"Acetylcholinesterase inhibitors and Gulf War illnesses","volume":"105","author":"Golomb","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ntt.2017.11.002","article-title":"Neuropsychological functioning in military pesticide applicators from the Gulf War: Effects on information processing speed, attention and visual memory","volume":"65","author":"Sullivan","year":"2018","journal-title":"Neurotoxicol Teratol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cortex.2015.08.022","article-title":"Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment","volume":"74","author":"White","year":"2016","journal-title":"Cortex"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: When the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0892-0362(00)00085-4","article-title":"Quantitative trait loci for acute behavioral sensitivity to paraoxon","volume":"22","author":"Risinger","year":"2000","journal-title":"Neurotoxicol. 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