{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T03:55:11Z","timestamp":1788753311115,"version":"build-2803163510"},"reference-count":194,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Microorganisms including actinomycetes, archaea, bacteria, fungi, yeast, and microalgae are an auspicious source of vital bioactive compounds. In this review, the existing research regarding antimicrobial molecules from microorganisms is summarized. The potential antimicrobial compounds from actinomycetes, particularly Streptomyces spp.; archaea; fungi including endophytic, filamentous, and marine-derived fungi, mushroom; and microalgae are briefly described. Furthermore, this review briefly summarizes bacteriocins, halocins, sulfolobicin, etc., that target multiple-drug resistant pathogens and considers next-generation antibiotics. This review highlights the possibility of using microorganisms as an antimicrobial resource for biotechnological, nutraceutical, and pharmaceutical applications. However, more investigations are required to isolate, separate, purify, and characterize these bioactive compounds and transfer these primary drugs into clinically approved antibiotics.<\/jats:p>","DOI":"10.3390\/biom11121860","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T01:28:11Z","timestamp":1639358891000},"page":"1860","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["A Review on Microbial Products and Their Perspective Application as Antimicrobial Agents"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8181-111X","authenticated-orcid":false,"given":"Alka","family":"Rani","sequence":"first","affiliation":[{"name":"Department of Botany, School of Basic and Applied Sciences, Central University of Punjab, Bathinda 151401, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5768-6507","authenticated-orcid":false,"given":"Khem Chand","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of Botany, School of Basic and Applied Sciences, Central University of Punjab, Bathinda 151401, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Bast","sequence":"additional","affiliation":[{"name":"Department of Botany, School of Basic and Applied Sciences, Central University of Punjab, Bathinda 151401, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6966-7768","authenticated-orcid":false,"given":"Sunita","family":"Varjani","sequence":"additional","affiliation":[{"name":"Gujarat Pollution Control Board, Gandhinagar 382010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1801-4702","authenticated-orcid":false,"given":"Sanjeet","family":"Mehariya","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Ume\u00e5 University, 90187 Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7688-6069","authenticated-orcid":false,"given":"Shashi Kant","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, College of Engineering, Konkuk University, Seoul 05029, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeta","family":"Sharma","sequence":"additional","affiliation":[{"name":"ENEA, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Department of Sustainability-CR Trisaia, SS Jonica 106, km 419 + 500, 75026 Rotondella, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7897-4038","authenticated-orcid":false,"given":"Christiane","family":"Funk","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Ume\u00e5 University, 90187 Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/2475067","article-title":"Mechanisms of antimicrobial resistance in ESKAPE pathogens","volume":"2016","author":"Santajit","year":"2016","journal-title":"Biomed Res. 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